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Protein

Vesicle transport protein SEC20

Gene

Bnip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. Required for maintenance of ER network. Implicated in the suppression of cell death. May be involved in mitochondrial autophagy (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Autophagy, ER-Golgi transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle transport protein SEC20
Gene namesi
Name:Bnip1Imported
Synonyms:Sec20Imported, Sec20l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:109328. Bnip1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 199199CytoplasmicSequence analysisAdd
BLAST
Transmembranei200 – 22021Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini221 – 2288LumenalSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228Vesicle transport protein SEC20PRO_0000232417Add
BLAST

Post-translational modificationi

'Lys-63'-linked polyubiquitination by RNF185 allows recruiting of autophagy receptor SQSTM1, which simultaneously binds both ubiquitin and LC3 to link ubiquitination and autophagy.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiQ6QD59.
MaxQBiQ6QD59.
PaxDbiQ6QD59.
PRIDEiQ6QD59.

PTM databases

iPTMnetiQ6QD59.
PhosphoSiteiQ6QD59.

Expressioni

Gene expression databases

BgeeiQ6QD59.
CleanExiMM_BNIP1.
ExpressionAtlasiQ6QD59. baseline and differential.
GenevisibleiQ6QD59. MM.

Interactioni

Subunit structurei

Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L and SEC22B. Interacts directly with STX18, RINT1/TIP20L and NAPA. Interacts with ZW10 through RINT1. Interacts with BCL2 and adenovirus E1B protein (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015725.

Structurei

3D structure databases

ProteinModelPortaliQ6QD59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili37 – 9054Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the SEC20 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE4Q. Eukaryota.
ENOG4111Q80. LUCA.
GeneTreeiENSGT00390000014412.
HOGENOMiHOG000007218.
HOVERGENiHBG050708.
InParanoidiQ6QD59.
KOiK08497.
OMAiDDWARDM.
OrthoDBiEOG7D2FG0.
PhylomeDBiQ6QD59.
TreeFamiTF324339.

Family and domain databases

InterProiIPR005606. Sec20.
[Graphical view]
PfamiPF03908. Sec20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6QD59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPQDVHVR ICNQEIVKFD LEVKALIQDI RDCSGPLSEL TELNTKVKEK
60 70 80 90 100
FQQLKQRIQE LEQSAREQDK ESEKQLLLQE VENHKKQMLS NQTSWRKANL
110 120 130 140 150
TCKLAIDNLE KAELLQGGDS LRQRKTTKES LAQTSSSITE SLMGISRMMS
160 170 180 190 200
QQVQQSEEAM QTLVSSSRTL LDANEEFKSM SGTIQLGRKL ITKYNRRELT
210 220
DKLLIFLALA LFLATVLYIV KKRLFPFL
Length:228
Mass (Da):26,175
Last modified:July 5, 2004 - v1
Checksum:iFA7E3922DC1AF2E3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti125 – 1251K → N in AAH86888 (PubMed:15489334).Curated
Sequence conflicti165 – 1651S → G in AAH86888 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY547731 mRNA. Translation: AAS55065.1.
CT025550 Genomic DNA. Translation: CAQ11912.1.
BC086888 mRNA. Translation: AAH86888.1.
CCDSiCCDS28555.1.
RefSeqiNP_742161.4. NM_172149.5.
UniGeneiMm.21795.

Genome annotation databases

EnsembliENSMUST00000015725; ENSMUSP00000015725; ENSMUSG00000024191.
GeneIDi224630.
KEGGimmu:224630.
UCSCiuc008ben.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY547731 mRNA. Translation: AAS55065.1.
CT025550 Genomic DNA. Translation: CAQ11912.1.
BC086888 mRNA. Translation: AAH86888.1.
CCDSiCCDS28555.1.
RefSeqiNP_742161.4. NM_172149.5.
UniGeneiMm.21795.

3D structure databases

ProteinModelPortaliQ6QD59.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015725.

PTM databases

iPTMnetiQ6QD59.
PhosphoSiteiQ6QD59.

Proteomic databases

EPDiQ6QD59.
MaxQBiQ6QD59.
PaxDbiQ6QD59.
PRIDEiQ6QD59.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015725; ENSMUSP00000015725; ENSMUSG00000024191.
GeneIDi224630.
KEGGimmu:224630.
UCSCiuc008ben.2. mouse.

Organism-specific databases

CTDi662.
MGIiMGI:109328. Bnip1.

Phylogenomic databases

eggNOGiENOG410IE4Q. Eukaryota.
ENOG4111Q80. LUCA.
GeneTreeiENSGT00390000014412.
HOGENOMiHOG000007218.
HOVERGENiHBG050708.
InParanoidiQ6QD59.
KOiK08497.
OMAiDDWARDM.
OrthoDBiEOG7D2FG0.
PhylomeDBiQ6QD59.
TreeFamiTF324339.

Miscellaneous databases

ChiTaRSiBnip1. mouse.
NextBioi377265.
PROiQ6QD59.
SOURCEiSearch...

Gene expression databases

BgeeiQ6QD59.
CleanExiMM_BNIP1.
ExpressionAtlasiQ6QD59. baseline and differential.
GenevisibleiQ6QD59. MM.

Family and domain databases

InterProiIPR005606. Sec20.
[Graphical view]
PfamiPF03908. Sec20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "SNARE proteins involved in Golgi-endoplasmic reticulum transport in mammalian cells."
    Verrier S., Willmann M., Fischer von Mollard G., Soeling H.-D.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: KidneyImported.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiSEC20_MOUSE
AccessioniPrimary (citable) accession number: Q6QD59
Secondary accession number(s): B0V2Q1, Q5M9M2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: July 5, 2004
Last modified: March 16, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.