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Protein

Cell surface glycoprotein CD200 receptor 2

Gene

CD200R1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be a receptor for the CD200/OX2 cell surface glycoprotein.By similarity

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Cell surface glycoprotein CD200 receptor 2
Alternative name(s):
CD200 cell surface glycoprotein receptor-like 2
Short name:
CD200 receptor-like 2
Short name:
HuCD200R2
CD200 cell surface glycoprotein receptor-like a
Short name:
CD200RLa
Cell surface glycoprotein CD200 receptor 1-like
Cell surface glycoprotein OX2 receptor 2
Gene namesi
Name:CD200R1L
Synonyms:CD200R2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:24665. CD200R1L.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 239216ExtracellularSequence analysisAdd
BLAST
Transmembranei240 – 26021HelicalSequence analysisAdd
BLAST
Topological domaini261 – 27111CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164717784.

Polymorphism and mutation databases

BioMutaiCD200R1L.
DMDMi205829216.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 271248Cell surface glycoprotein CD200 receptor 2PRO_0000346451Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi30 – 301N-linked (GlcNAc...)Sequence analysis
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence analysis
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence analysis
Glycosylationi92 – 921N-linked (GlcNAc...)Sequence analysis
Disulfide bondi160 ↔ 209PROSITE-ProRule annotation
Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence analysis
Glycosylationi217 – 2171N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6Q8B3.
PRIDEiQ6Q8B3.

Expressioni

Gene expression databases

BgeeiQ6Q8B3.
CleanExiHS_CD200R1L.
ExpressionAtlasiQ6Q8B3. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000381272.

Structurei

3D structure databases

ProteinModelPortaliQ6Q8B3.
SMRiQ6Q8B3. Positions 39-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 13287Ig-like V-typeAdd
BLAST
Domaini133 – 22189Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Belongs to the CD200R family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IUJX. Eukaryota.
ENOG4112DF0. LUCA.
GeneTreeiENSGT00390000014496.
HOGENOMiHOG000113622.
HOVERGENiHBG108141.
InParanoidiQ6Q8B3.
OMAiTGFVFFQ.
OrthoDBiEOG7RZ5QQ.
PhylomeDBiQ6Q8B3.
TreeFamiTF335960.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6Q8B3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAPRLLISI IIMVSASSSS CMGGKQMTQN YSTIFAEGNI SQPVLMDINA
60 70 80 90 100
VLCCPPIALR NLIIITWEII LRGQPSCTKA YKKETNETKE TNCTVERITW
110 120 130 140 150
VSRPDQNSDL QIRPVDTTHD GYYRGIVVTP DGNFHRGYHL QVLVTPEVNL
160 170 180 190 200
FQSRNITAVC KAVTGKPAAQ ISWIPEGSIL ATKQEYWGNG TVTVKSTCPW
210 220 230 240 250
EGHKSTVTCH VSHLTGNKSL SVKLNSGLRT SGSPALSLLI ILYVKLSLFV
260 270
VILVTTGFVF FQRINHVRKV L
Length:271
Mass (Da):29,920
Last modified:September 2, 2008 - v2
Checksum:i9D8E3074F7D34F90
GO
Isoform 2 (identifier: Q6Q8B3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.

Show »
Length:250
Mass (Da):27,771
Checksum:i43D0AA1BE1B56BC3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti113 – 1131R → L.1 Publication
Corresponds to variant rs4682119 [ dbSNP | Ensembl ].
VAR_045897

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2121Missing in isoform 2. 1 PublicationVSP_035002Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY284976 mRNA. Translation: AAQ19773.1.
AY552790 mRNA. Translation: AAT00538.1.
AC074044 Genomic DNA. No translation available.
AC092892 Genomic DNA. No translation available.
CCDSiCCDS43131.1. [Q6Q8B3-1]
CCDS56267.1. [Q6Q8B3-2]
RefSeqiNP_001008784.2. NM_001008784.2. [Q6Q8B3-1]
NP_001186144.1. NM_001199215.1. [Q6Q8B3-2]
XP_011511065.1. XM_011512763.1. [Q6Q8B3-2]
UniGeneiHs.531814.

Genome annotation databases

EnsembliENST00000398214; ENSP00000381272; ENSG00000206531. [Q6Q8B3-1]
ENST00000488794; ENSP00000418413; ENSG00000206531. [Q6Q8B3-2]
GeneIDi344807.
KEGGihsa:344807.
UCSCiuc003dzi.1. human. [Q6Q8B3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY284976 mRNA. Translation: AAQ19773.1.
AY552790 mRNA. Translation: AAT00538.1.
AC074044 Genomic DNA. No translation available.
AC092892 Genomic DNA. No translation available.
CCDSiCCDS43131.1. [Q6Q8B3-1]
CCDS56267.1. [Q6Q8B3-2]
RefSeqiNP_001008784.2. NM_001008784.2. [Q6Q8B3-1]
NP_001186144.1. NM_001199215.1. [Q6Q8B3-2]
XP_011511065.1. XM_011512763.1. [Q6Q8B3-2]
UniGeneiHs.531814.

3D structure databases

ProteinModelPortaliQ6Q8B3.
SMRiQ6Q8B3. Positions 39-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000381272.

Polymorphism and mutation databases

BioMutaiCD200R1L.
DMDMi205829216.

Proteomic databases

PaxDbiQ6Q8B3.
PRIDEiQ6Q8B3.

Protocols and materials databases

DNASUi344807.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398214; ENSP00000381272; ENSG00000206531. [Q6Q8B3-1]
ENST00000488794; ENSP00000418413; ENSG00000206531. [Q6Q8B3-2]
GeneIDi344807.
KEGGihsa:344807.
UCSCiuc003dzi.1. human. [Q6Q8B3-1]

Organism-specific databases

CTDi344807.
GeneCardsiCD200R1L.
H-InvDBHIX0030777.
HGNCiHGNC:24665. CD200R1L.
neXtProtiNX_Q6Q8B3.
PharmGKBiPA164717784.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUJX. Eukaryota.
ENOG4112DF0. LUCA.
GeneTreeiENSGT00390000014496.
HOGENOMiHOG000113622.
HOVERGENiHBG108141.
InParanoidiQ6Q8B3.
OMAiTGFVFFQ.
OrthoDBiEOG7RZ5QQ.
PhylomeDBiQ6Q8B3.
TreeFamiTF335960.

Miscellaneous databases

ChiTaRSiCD200R1L. human.
GenomeRNAii344807.
NextBioi98770.
PROiQ6Q8B3.

Gene expression databases

BgeeiQ6Q8B3.
CleanExiHS_CD200R1L.
ExpressionAtlasiQ6Q8B3. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Peripheral blood.
  2. "Structural and functional heterogeneity in the CD200R family of immunoregulatory molecules and their expression at the feto-maternal interface."
    Gorczynski R.M., Chen Z., Clark D.A., Kai Y., Lee L., Nachman J., Wong S., Marsden P.
    Am. J. Reprod. Immunol. 52:147-163(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT LEU-113.
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiMO2R2_HUMAN
AccessioniPrimary (citable) accession number: Q6Q8B3
Secondary accession number(s): Q6WHB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: November 11, 2015
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.