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Protein

Cell surface glycoprotein CD200 receptor 2

Gene

CD200R1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be a receptor for the CD200/OX2 cell surface glycoprotein.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciZFISH:G66-33578-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell surface glycoprotein CD200 receptor 2
Alternative name(s):
CD200 cell surface glycoprotein receptor-like 2
Short name:
CD200 receptor-like 2
Short name:
HuCD200R2
CD200 cell surface glycoprotein receptor-like a
Short name:
CD200RLa
Cell surface glycoprotein CD200 receptor 1-like
Cell surface glycoprotein OX2 receptor 2
Gene namesi
Name:CD200R1L
Synonyms:CD200R2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:24665. CD200R1L.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 239ExtracellularSequence analysisAdd BLAST216
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Topological domaini261 – 271CytoplasmicSequence analysisAdd BLAST11

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000206531.
PharmGKBiPA164717784.

Polymorphism and mutation databases

BioMutaiCD200R1L.
DMDMi205829216.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000034645124 – 271Cell surface glycoprotein CD200 receptor 2Add BLAST248

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi30N-linked (GlcNAc...)Sequence analysis1
Glycosylationi39N-linked (GlcNAc...)Sequence analysis1
Glycosylationi86N-linked (GlcNAc...)Sequence analysis1
Glycosylationi92N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi160 ↔ 209PROSITE-ProRule annotation
Glycosylationi189N-linked (GlcNAc...)Sequence analysis1
Glycosylationi217N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6Q8B3.
PeptideAtlasiQ6Q8B3.
PRIDEiQ6Q8B3.

Expressioni

Gene expression databases

BgeeiENSG00000206531.
CleanExiHS_CD200R1L.
ExpressionAtlasiQ6Q8B3. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000381272.

Structurei

3D structure databases

ProteinModelPortaliQ6Q8B3.
SMRiQ6Q8B3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 132Ig-like V-typeAdd BLAST87
Domaini133 – 221Ig-like C2-typeAdd BLAST89

Sequence similaritiesi

Belongs to the CD200R family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IUJX. Eukaryota.
ENOG4112DF0. LUCA.
GeneTreeiENSGT00390000014496.
HOGENOMiHOG000113622.
HOVERGENiHBG108141.
InParanoidiQ6Q8B3.
OMAiTGFVFFQ.
OrthoDBiEOG091G0IYA.
PhylomeDBiQ6Q8B3.
TreeFamiTF335960.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6Q8B3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAPRLLISI IIMVSASSSS CMGGKQMTQN YSTIFAEGNI SQPVLMDINA
60 70 80 90 100
VLCCPPIALR NLIIITWEII LRGQPSCTKA YKKETNETKE TNCTVERITW
110 120 130 140 150
VSRPDQNSDL QIRPVDTTHD GYYRGIVVTP DGNFHRGYHL QVLVTPEVNL
160 170 180 190 200
FQSRNITAVC KAVTGKPAAQ ISWIPEGSIL ATKQEYWGNG TVTVKSTCPW
210 220 230 240 250
EGHKSTVTCH VSHLTGNKSL SVKLNSGLRT SGSPALSLLI ILYVKLSLFV
260 270
VILVTTGFVF FQRINHVRKV L
Length:271
Mass (Da):29,920
Last modified:September 2, 2008 - v2
Checksum:i9D8E3074F7D34F90
GO
Isoform 2 (identifier: Q6Q8B3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.

Show »
Length:250
Mass (Da):27,771
Checksum:i43D0AA1BE1B56BC3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_045897113R → L.1 PublicationCorresponds to variant rs4682119dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0350021 – 21Missing in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY284976 mRNA. Translation: AAQ19773.1.
AY552790 mRNA. Translation: AAT00538.1.
AC074044 Genomic DNA. No translation available.
AC092892 Genomic DNA. No translation available.
CCDSiCCDS43131.1. [Q6Q8B3-1]
CCDS56267.1. [Q6Q8B3-2]
RefSeqiNP_001008784.2. NM_001008784.2. [Q6Q8B3-1]
NP_001186144.1. NM_001199215.1. [Q6Q8B3-2]
XP_011511065.1. XM_011512763.2. [Q6Q8B3-2]
XP_016861789.1. XM_017006300.1. [Q6Q8B3-2]
UniGeneiHs.531814.

Genome annotation databases

EnsembliENST00000398214; ENSP00000381272; ENSG00000206531. [Q6Q8B3-1]
ENST00000488794; ENSP00000418413; ENSG00000206531. [Q6Q8B3-2]
GeneIDi344807.
KEGGihsa:344807.
UCSCiuc003dzi.1. human. [Q6Q8B3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY284976 mRNA. Translation: AAQ19773.1.
AY552790 mRNA. Translation: AAT00538.1.
AC074044 Genomic DNA. No translation available.
AC092892 Genomic DNA. No translation available.
CCDSiCCDS43131.1. [Q6Q8B3-1]
CCDS56267.1. [Q6Q8B3-2]
RefSeqiNP_001008784.2. NM_001008784.2. [Q6Q8B3-1]
NP_001186144.1. NM_001199215.1. [Q6Q8B3-2]
XP_011511065.1. XM_011512763.2. [Q6Q8B3-2]
XP_016861789.1. XM_017006300.1. [Q6Q8B3-2]
UniGeneiHs.531814.

3D structure databases

ProteinModelPortaliQ6Q8B3.
SMRiQ6Q8B3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000381272.

Polymorphism and mutation databases

BioMutaiCD200R1L.
DMDMi205829216.

Proteomic databases

PaxDbiQ6Q8B3.
PeptideAtlasiQ6Q8B3.
PRIDEiQ6Q8B3.

Protocols and materials databases

DNASUi344807.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398214; ENSP00000381272; ENSG00000206531. [Q6Q8B3-1]
ENST00000488794; ENSP00000418413; ENSG00000206531. [Q6Q8B3-2]
GeneIDi344807.
KEGGihsa:344807.
UCSCiuc003dzi.1. human. [Q6Q8B3-1]

Organism-specific databases

CTDi344807.
GeneCardsiCD200R1L.
H-InvDBHIX0030777.
HGNCiHGNC:24665. CD200R1L.
neXtProtiNX_Q6Q8B3.
OpenTargetsiENSG00000206531.
PharmGKBiPA164717784.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUJX. Eukaryota.
ENOG4112DF0. LUCA.
GeneTreeiENSGT00390000014496.
HOGENOMiHOG000113622.
HOVERGENiHBG108141.
InParanoidiQ6Q8B3.
OMAiTGFVFFQ.
OrthoDBiEOG091G0IYA.
PhylomeDBiQ6Q8B3.
TreeFamiTF335960.

Enzyme and pathway databases

BioCyciZFISH:G66-33578-MONOMER.

Miscellaneous databases

ChiTaRSiCD200R1L. human.
GenomeRNAii344807.
PROiQ6Q8B3.

Gene expression databases

BgeeiENSG00000206531.
CleanExiHS_CD200R1L.
ExpressionAtlasiQ6Q8B3. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMO2R2_HUMAN
AccessioniPrimary (citable) accession number: Q6Q8B3
Secondary accession number(s): Q6WHB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: November 30, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.