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Protein
Submitted name:

Potassium channel TREK-2

Gene

KCNK10

Organism
Oryctolagus cuniculus (Rabbit)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotationImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium channel TREK-2Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:KCNK10Imported
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 20

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei72 – 93HelicalSequence analysisAdd BLAST22
Transmembranei154 – 173HelicalSequence analysisAdd BLAST20
Transmembranei185 – 203HelicalSequence analysisAdd BLAST19
Transmembranei233 – 255HelicalSequence analysisAdd BLAST23
Transmembranei267 – 288HelicalSequence analysisAdd BLAST22
Transmembranei300 – 322HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000013373.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini147 – 205Ion_trans_2InterPro annotationAdd BLAST59
Domaini244 – 323Ion_trans_2InterPro annotationAdd BLAST80

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000013106.
HOVERGENiHBG052234.
KOiK04920.
OMAiKQVNWDP.
OrthoDBiEOG091G0E3R.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003976. 2pore_dom_K_chnl_TREK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01499. TREKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q6Q834-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFPIETPRK QVNWDPKVAV PAAAPPVCQP KSATNGHPAA PRLSISSRAT
60 70 80 90 100
VVARMEGTSQ GGLQSVMKWK TVVAIFVVVV VYLVTGGLVF RALEQPFESS
110 120 130 140 150
QKNTIALEKA EFLRDHICVS PQELETLIQH ALDADNAGVS PIGNSSNNSS
160 170 180 190 200
HWDLGSAFFF AGTVITTIGY GNIAPSTEGG KIFCILYAIF GIPLFGFLLA
210 220 230 240 250
GIGDQLGTIF GKSIARVEKV FRKKQVSQTK IRVISTILFI LAGCIVFVTI
260 270 280 290 300
PAVIFKYIEG WTALESIYFV VVTLTTVGFG DFVAGGNAGI NYREWYKPLV
310 320 330 340 350
WFWILVGLAY FAAVLSMIGD WLRVLSKKTK EEVGEIKAHA AEWKANVTAE
360 370 380 390 400
FRETRRRLSV EIHDKLQRAA TIRSMERRRL GLDQRAHSLD MLSPEKRSVF
410 420 430 440 450
AALDTGRFKA SSQESINNRP NNLRLKGSEQ LNKHGQGASE DNIINKFGST
460 470 480 490 500
SRLTKRKNKD LKKTLPEDVQ KIYKTFRNYS LDEEKKEEES EKMCNSDNSS
510 520 530
TAMLTDCVQQ HDEMENGVVP TDTKDRELEN NSLLEDRN
Length:538
Mass (Da):59,845
Last modified:July 5, 2004 - v1
Checksum:i1F06C8EA0DE8CB4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAGW02048934 Genomic DNA. No translation available.
AAGW02048935 Genomic DNA. No translation available.
AAGW02048936 Genomic DNA. No translation available.
AAGW02048937 Genomic DNA. No translation available.
AAGW02048938 Genomic DNA. No translation available.
AY553324 mRNA. Translation: AAS66991.1.
RefSeqiNP_001076205.1. NM_001082736.1.
UniGeneiOcu.3126.

Genome annotation databases

EnsembliENSOCUT00000015562; ENSOCUP00000013373; ENSOCUG00000015561.
GeneIDi100009503.
KEGGiocu:100009503.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAGW02048934 Genomic DNA. No translation available.
AAGW02048935 Genomic DNA. No translation available.
AAGW02048936 Genomic DNA. No translation available.
AAGW02048937 Genomic DNA. No translation available.
AAGW02048938 Genomic DNA. No translation available.
AY553324 mRNA. Translation: AAS66991.1.
RefSeqiNP_001076205.1. NM_001082736.1.
UniGeneiOcu.3126.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000013373.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000015562; ENSOCUP00000013373; ENSOCUG00000015561.
GeneIDi100009503.
KEGGiocu:100009503.

Organism-specific databases

CTDi54207.

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000013106.
HOVERGENiHBG052234.
KOiK04920.
OMAiKQVNWDP.
OrthoDBiEOG091G0E3R.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003976. 2pore_dom_K_chnl_TREK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01499. TREKCHANNEL.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6Q834_RABIT
AccessioniPrimary (citable) accession number: Q6Q834
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.