Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histone-lysine N-methyltransferase KMT5C

Gene

Kmt5c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2).1 Publication

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation1 Publication

GO - Molecular functioni

  • histone methyltransferase activity (H4-K20 specific) Source: MGI

GO - Biological processi

  • histone H4-K20 trimethylation Source: MGI
  • histone methylation Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-MMU-3214841. PKMTs methylate histone lysines.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase KMT5CCurated (EC:2.1.1.43)
Alternative name(s):
Lysine-specific methyltransferase 5CBy similarity
Suppressor of variegation 4-20 homolog 2
Short name:
Su(var)4-20 homolog 2
Short name:
Suv4-20h2
Gene namesi
Name:Kmt5cBy similarity
Synonyms:Suv420h2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2385262. Suv420h2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002817941 – 468Histone-lysine N-methyltransferase KMT5CAdd BLAST468

Proteomic databases

MaxQBiQ6Q783.
PaxDbiQ6Q783.
PeptideAtlasiQ6Q783.
PRIDEiQ6Q783.

PTM databases

iPTMnetiQ6Q783.
PhosphoSitePlusiQ6Q783.

Expressioni

Gene expression databases

BgeeiENSMUSG00000059851.
ExpressionAtlasiQ6Q783. baseline and differential.
GenevisibleiQ6Q783. MM.

Interactioni

Subunit structurei

Interacts with HP1 proteins CBX1, CBX3 and CBX5. Interacts with RB1 family proteins RB1, RBL1 and RBL2.3 Publications

Protein-protein interaction databases

BioGridi231299. 3 interactors.
STRINGi10090.ENSMUSP00000096452.

Structurei

Secondary structure

1468
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 21Combined sources14
Helixi23 – 27Combined sources5
Helixi45 – 58Combined sources14
Helixi61 – 68Combined sources8
Helixi74 – 77Combined sources4
Turni78 – 81Combined sources4
Helixi83 – 99Combined sources17
Helixi102 – 104Combined sources3
Beta strandi106 – 111Combined sources6
Beta strandi118 – 127Combined sources10
Beta strandi134 – 144Combined sources11
Helixi147 – 152Combined sources6
Turni155 – 157Combined sources3
Beta strandi160 – 165Combined sources6
Turni166 – 169Combined sources4
Beta strandi170 – 176Combined sources7
Helixi177 – 180Combined sources4
Beta strandi188 – 193Combined sources6
Beta strandi195 – 205Combined sources11
Turni219 – 222Combined sources4
Helixi232 – 237Combined sources6
Helixi240 – 243Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AU7X-ray2.07A/B1-246[»]
ProteinModelPortaliQ6Q783.
SMRiQ6Q783.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 218SETPROSITE-ProRule annotationAdd BLAST115

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni348 – 441Required for heterochromatin localizationAdd BLAST94

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2589. Eukaryota.
ENOG410XPH8. LUCA.
GeneTreeiENSGT00520000055640.
HOGENOMiHOG000154453.
HOVERGENiHBG095676.
InParanoidiQ6Q783.
KOiK11429.
OMAiFCAACQP.
OrthoDBiEOG091G0IUY.
PhylomeDBiQ6Q783.
TreeFamiTF106433.

Family and domain databases

InterProiIPR025790. Hist-Lys_N-MTase_Suvar4-20.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51570. SAM_MT43_SUVAR420_2. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6Q783-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPDRVTARE LCENDDLATS LVLDPYLGFR THKMNVSPVP TLRRQHHLRS
60 70 80 90 100
ALEAFLRQRD LEAAFRALTL GGWMAHYFQS RAPRQEAALK THIFCYLRAF
110 120 130 140 150
LPESGFTILP CTRYSMETNG AKIVSTRAWK KNEKLELLVG CIAELREEDE
160 170 180 190 200
DLLRAGENDF SIMYSTRKRS AQLWLGPAAF INHDCKPNCK FVPSDGNTAC
210 220 230 240 250
VKVLRDIEPG DEVTCFYGEG FFGEKNEHCE CYTCERKGEG AFRLQPREPE
260 270 280 290 300
LRPKPLDKYE LRETKRRLQQ GLVSSQQSLM SRWACSHLSP LRPDPFCAAC
310 320 330 340 350
QPSCLLPASP HMDYLPLWLQ RAPQPQPIVP PRKRHRRRRP RIRQASLPPV
360 370 380 390 400
LRTACVPLHR WGGCGPHCQL RAEAMVTLHL RPQTRWTPQQ DWYWARRYGL
410 420 430 440 450
PSVGRVELTR LAPALPAAPA PAGNPGPVPT PDFIPKQALA FAPFCPPKRL
460
RLVVSHGSID LDINSGEP
Length:468
Mass (Da):53,159
Last modified:July 5, 2004 - v1
Checksum:iD43D7A25DBDF3BB1
GO

Sequence cautioni

The sequence AAH24816 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH85473 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY555193 mRNA. Translation: AAT00540.1.
AK154848 mRNA. Translation: BAE32874.1.
BC024816 mRNA. Translation: AAH24816.1. Different initiation.
BC085473 mRNA. Translation: AAH85473.2. Different initiation.
CCDSiCCDS20743.2.
RefSeqiNP_001108490.1. NM_001115018.1.
NP_666289.2. NM_146177.2.
XP_006539837.1. XM_006539774.1.
UniGeneiMm.247844.

Genome annotation databases

EnsembliENSMUST00000098853; ENSMUSP00000096452; ENSMUSG00000059851.
ENSMUST00000108582; ENSMUSP00000104223; ENSMUSG00000059851.
ENSMUST00000108583; ENSMUSP00000104224; ENSMUSG00000059851.
GeneIDi232811.
KEGGimmu:232811.
UCSCiuc009eyi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY555193 mRNA. Translation: AAT00540.1.
AK154848 mRNA. Translation: BAE32874.1.
BC024816 mRNA. Translation: AAH24816.1. Different initiation.
BC085473 mRNA. Translation: AAH85473.2. Different initiation.
CCDSiCCDS20743.2.
RefSeqiNP_001108490.1. NM_001115018.1.
NP_666289.2. NM_146177.2.
XP_006539837.1. XM_006539774.1.
UniGeneiMm.247844.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AU7X-ray2.07A/B1-246[»]
ProteinModelPortaliQ6Q783.
SMRiQ6Q783.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231299. 3 interactors.
STRINGi10090.ENSMUSP00000096452.

PTM databases

iPTMnetiQ6Q783.
PhosphoSitePlusiQ6Q783.

Proteomic databases

MaxQBiQ6Q783.
PaxDbiQ6Q783.
PeptideAtlasiQ6Q783.
PRIDEiQ6Q783.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098853; ENSMUSP00000096452; ENSMUSG00000059851.
ENSMUST00000108582; ENSMUSP00000104223; ENSMUSG00000059851.
ENSMUST00000108583; ENSMUSP00000104224; ENSMUSG00000059851.
GeneIDi232811.
KEGGimmu:232811.
UCSCiuc009eyi.2. mouse.

Organism-specific databases

CTDi232811.
MGIiMGI:2385262. Suv420h2.

Phylogenomic databases

eggNOGiKOG2589. Eukaryota.
ENOG410XPH8. LUCA.
GeneTreeiENSGT00520000055640.
HOGENOMiHOG000154453.
HOVERGENiHBG095676.
InParanoidiQ6Q783.
KOiK11429.
OMAiFCAACQP.
OrthoDBiEOG091G0IUY.
PhylomeDBiQ6Q783.
TreeFamiTF106433.

Enzyme and pathway databases

ReactomeiR-MMU-3214841. PKMTs methylate histone lysines.

Miscellaneous databases

ChiTaRSiSuv420h2. mouse.
PROiQ6Q783.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000059851.
ExpressionAtlasiQ6Q783. baseline and differential.
GenevisibleiQ6Q783. MM.

Family and domain databases

InterProiIPR025790. Hist-Lys_N-MTase_Suvar4-20.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51570. SAM_MT43_SUVAR420_2. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKMT5C_MOUSE
AccessioniPrimary (citable) accession number: Q6Q783
Secondary accession number(s): Q5RKP6, Q8R1C5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.