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Protein

Sperm-associated antigen 17

Gene

SPAG17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm-associated antigen 17
Alternative name(s):
Projection protein PF6 homolog
Gene namesi
Name:SPAG17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26620. SPAG17.

Subcellular locationi

  • Cytoplasm By similarity
  • Cytoplasmcytoskeletonflagellum axoneme By similarity

  • Note: Detected in the cytoplasm of round spermatids and in condensing spermatids. Localized to the central pair of the sperm flagellar axoneme. Colocalizes with SPAG6 on microtubules (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi200162.
OpenTargetsiENSG00000155761.
PharmGKBiPA142670888.

Polymorphism and mutation databases

BioMutaiSPAG17.
DMDMi74749284.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003314451 – 2223Sperm-associated antigen 17Add BLAST2223

Proteomic databases

EPDiQ6Q759.
MaxQBiQ6Q759.
PaxDbiQ6Q759.
PeptideAtlasiQ6Q759.
PRIDEiQ6Q759.

PTM databases

iPTMnetiQ6Q759.
PhosphoSitePlusiQ6Q759.

Expressioni

Tissue specificityi

Highly expressed in testis. Expressed in organs that contain cilia-bearing cells including brain, oviduct, lung, and uterus.1 Publication

Gene expression databases

BgeeiENSG00000155761.
CleanExiHS_SPAG17.
ExpressionAtlasiQ6Q759. baseline and differential.
GenevisibleiQ6Q759. HS.

Organism-specific databases

HPAiHPA028597.
HPA028666.

Interactioni

Subunit structurei

Interacts (via the C-terminus) with SPAG6; the interaction probably occurs on polymerized microtubules.By similarity

Protein-protein interaction databases

IntActiQ6Q759. 1 interactor.
STRINGi9606.ENSP00000337804.

Structurei

3D structure databases

ProteinModelPortaliQ6Q759.
SMRiQ6Q759.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili266 – 295Sequence analysisAdd BLAST30
Coiled coili940 – 966Sequence analysisAdd BLAST27
Coiled coili1874 – 1907Sequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi127 – 199Lys-richAdd BLAST73

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGU0. Eukaryota.
ENOG410ZGKQ. LUCA.
GeneTreeiENSGT00390000013693.
HOGENOMiHOG000154383.
HOVERGENiHBG101382.
InParanoidiQ6Q759.
OMAiYKTVMPP.
OrthoDBiEOG091G0194.
PhylomeDBiQ6Q759.
TreeFamiTF328540.

Family and domain databases

InterProiIPR026173. SPAG17.
[Graphical view]
PANTHERiPTHR21963. PTHR21963. 2 hits.

Sequencei

Sequence statusi: Complete.

Q6Q759-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKKEKGGT VNTSSKIWEP SLIAAQFNQN DWQASIAFVV GNQIEDDLLI
60 70 80 90 100
QALTVAVQVP QRKLFSMVSW QDILQQINEI NTLVGSASSK KAKKPVGGNA
110 120 130 140 150
PLYYEVLTAA KAIMDSGEKL TLPLIGKLLK FQLLQIKFKD QQRRENEKKV
160 170 180 190 200
IEDKPKLEKD KGKAKSPKEK KAPSAKPAKG KGKDQPEANA PVKKTTQLKR
210 220 230 240 250
RGEDDHTNRY IDDEPDDGAQ HYIIVVGFNN PQLLAIMAEL GIPITSVIKI
260 270 280 290 300
SSENYEPLQT HLAAVNQQQE VLLQSEDLEA EKLKKENAIK ELKTFWKYLE
310 320 330 340 350
PVLNNEKPET NLFDVARLEY MVKAADFPSD WSDGEMMLKL GTDIFENIAC
360 370 380 390 400
LMYDILDWKR QHQHYLESMQ LINVPQVVNE KPVLEAMPTS EAPQPAVPAP
410 420 430 440 450
GKKKAQYEEP QAPPPVTSVI TTEVDMRYYN YLLNPIREEF ISVPLILHCM
460 470 480 490 500
LEQVVATEED LVPPSLREPS PRADGLDHRI AAHIVSLLPS LCLSEREKKN
510 520 530 540 550
LHDIFLSEEE NESKAVPKGP LLLNYHDAHA HKKYALQDQK NFDPVQIEQE
560 570 580 590 600
MQSKLPLWEF LQFPLPPPWN NTKRLATIHE LMHFCTSDVL SWNEVERAFK
610 620 630 640 650
VFTFESLKLS EVDEKGKLKP SGMMCGSDSE MFNIPWDNPA RFAKQIRQQY
660 670 680 690 700
VMKMNTQEAK QKADIKIKDR TLFVDQNLSM SVQDNESNRE PSDPSQCDAN
710 720 730 740 750
NMKHSDLNNL KLSVPDNRQL LEQESIMKAQ PQHESLEQTT NNEIKDDAVT
760 770 780 790 800
KADSHEKKPK KMMVEADLED IKKTQQRSLM DWSFTEHFKP KVLLQVLQEA
810 820 830 840 850
HKQYRCVDSY YHTQDNSLLL VFHNPMNRQR LHCEYWNIAL HSNVGFRNYL
860 870 880 890 900
ELVAKSIQDW ITKEEAIYQE SKMNEKIIRT RAELELKSSA NAKLTSASKI
910 920 930 940 950
FSIKESKSNK GISKTEISDQ EKEKEKEKIP FILEGSLKAW KEEQHRLAEE
960 970 980 990 1000
ERLREEKKAE KKGKEAGKKK GKDNAEKEDS RSLKKKSPYK EKSKEEQVKI
1010 1020 1030 1040 1050
QEVTEESPHQ PEPKITYPFH GYNMGNIPTQ ISGSNYYLYP SDGGQIEVEK
1060 1070 1080 1090 1100
TMFEKGPTFI KVRVVKDNHN FMIHLNDPKE IVKKEEKGDY YLEEEEEGDE
1110 1120 1130 1140 1150
EQSLETEVSD AKNKAFSKFG SFSATLENGI CLSISYYGSN GMAPEDKDPD
1160 1170 1180 1190 1200
LETILNIPSA LTPTVVPVIV TVPQSKAKGK IKGKEKPKES LKEEEHPKEE
1210 1220 1230 1240 1250
EKKEEEVEPE PVLQETLDVP TFQSLNVSCP SGLLLTFIGQ ESTGQYVIDE
1260 1270 1280 1290 1300
EPTWDIMVRQ SYPQRVKHYE FYKTVMPPAE QEASRVITSQ GTVVKYMLDG
1310 1320 1330 1340 1350
STQILFADGA VSRSPNSGLI CPPSEMPATP HSGDLMDSIS QQKSETIPSE
1360 1370 1380 1390 1400
ITNTKKGKSH KSQSSMAHKG EIHDPPPEAV QTVTPVEVHI GTWFTTTPEG
1410 1420 1430 1440 1450
NRIGTKGLER IADLTPLLSF QATDPVNGTV MTTREDKVVI VERKDGTRIV
1460 1470 1480 1490 1500
DHADGTRITT FYQVYEDQII LPDDQETTEG PRTVTRQVKC MRVESSRYAT
1510 1520 1530 1540 1550
VIANCEDSSC CATFGDGTTI IAKPQGTYQV LPPNTGSLYI DKDCSAVYCH
1560 1570 1580 1590 1600
ESSSNIYYPF QKREQLRAGR YIMRHTSEVI CEVLDPEGNT FQVMADGSIS
1610 1620 1630 1640 1650
TILPEKKLED DLNEKTEGYD SLSSMHLEKN HQQIYGEHVP RFFVMYADGS
1660 1670 1680 1690 1700
GMELLRDSDI EEYLSLAYKE SNTVVLQEPV QEQPGTLTIT VLRPFHEASP
1710 1720 1730 1740 1750
WQVKKEDTIV PPNLRSRSWE TFPSVEKKTP GPPFGTQIWK GLCIESKQLV
1760 1770 1780 1790 1800
SAPGAILKSP SVLQMRQFIQ HEVIKNEVKL RLQVSLKDYI NYILKKEDEL
1810 1820 1830 1840 1850
QEMMVKDSRT EEERGNAADL LKLVMSFPKM EETTKSHVTE VAAHLTDLFK
1860 1870 1880 1890 1900
QSLATPPKCP PDTFGKDFFE KTWRHTASSK RWKEKIDKTR KEIETTQNYL
1910 1920 1930 1940 1950
MDIKNRIIPP FFKSELNQLY QSQYNHLDSL SKKLPSFTKK NEDANETAVQ
1960 1970 1980 1990 2000
DTSDLNLDFK PHKVSEQKSS SVPSLPKPEI SADKKDFTAQ NQTENLTKSP
2010 2020 2030 2040 2050
EEAESYEPVK IPTQSLLQDV AGQTRKEKVK LPHYLLSSKP KSQPLAKVQD
2060 2070 2080 2090 2100
SVGGKVNTSS VASAAINNAK SSLFGFHLLP SSVKFGVLKE GHTYATVVKL
2110 2120 2130 2140 2150
KNVGVDFCRF KVKQPPPSTG LKVTYKPGPV AAGMQTELNI ELFATAVGED
2160 2170 2180 2190 2200
GAKGSAHISH NIEIMTEHEV LFLPVEATVL TSSNYDKRPK DFPQGKENPM
2210 2220
VQRTSTIYSS TLGVFMSRKV SPH
Length:2,223
Mass (Da):251,742
Last modified:July 5, 2004 - v1
Checksum:i07C248C5B2A5B561
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52A → S in BAC03753 (PubMed:14702039).Curated1
Sequence conflicti211I → M in BAC03753 (PubMed:14702039).Curated1
Sequence conflicti675D → G in BAC03753 (PubMed:14702039).Curated1
Sequence conflicti736L → P in BAC03753 (PubMed:14702039).Curated1
Sequence conflicti816N → H in BAC03753 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042863143R → Q.Corresponds to variant rs12133381dbSNPEnsembl.1
Natural variantiVAR_042864158E → V.Corresponds to variant rs17185492dbSNPEnsembl.1
Natural variantiVAR_0428651253T → P.Corresponds to variant rs34366834dbSNPEnsembl.1
Natural variantiVAR_0428661348P → L.Corresponds to variant rs10923472dbSNPEnsembl.1
Natural variantiVAR_0428671707D → E in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY555274 mRNA. Translation: AAS66753.1.
AL513191, AL121993, AL139345 Genomic DNA. Translation: CAH71478.1.
AL121993, AL139345, AL513191 Genomic DNA. Translation: CAI22740.1.
AL139345, AL121993, AL513191 Genomic DNA. Translation: CAI22957.1.
AK091816 mRNA. Translation: BAC03753.1.
AL137581 mRNA. Translation: CAB70823.1.
CCDSiCCDS899.1.
PIRiT46291.
RefSeqiNP_996879.1. NM_206996.2.
UniGeneiHs.528821.

Genome annotation databases

EnsembliENST00000336338; ENSP00000337804; ENSG00000155761.
GeneIDi200162.
KEGGihsa:200162.
UCSCiuc001ehk.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY555274 mRNA. Translation: AAS66753.1.
AL513191, AL121993, AL139345 Genomic DNA. Translation: CAH71478.1.
AL121993, AL139345, AL513191 Genomic DNA. Translation: CAI22740.1.
AL139345, AL121993, AL513191 Genomic DNA. Translation: CAI22957.1.
AK091816 mRNA. Translation: BAC03753.1.
AL137581 mRNA. Translation: CAB70823.1.
CCDSiCCDS899.1.
PIRiT46291.
RefSeqiNP_996879.1. NM_206996.2.
UniGeneiHs.528821.

3D structure databases

ProteinModelPortaliQ6Q759.
SMRiQ6Q759.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6Q759. 1 interactor.
STRINGi9606.ENSP00000337804.

PTM databases

iPTMnetiQ6Q759.
PhosphoSitePlusiQ6Q759.

Polymorphism and mutation databases

BioMutaiSPAG17.
DMDMi74749284.

Proteomic databases

EPDiQ6Q759.
MaxQBiQ6Q759.
PaxDbiQ6Q759.
PeptideAtlasiQ6Q759.
PRIDEiQ6Q759.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336338; ENSP00000337804; ENSG00000155761.
GeneIDi200162.
KEGGihsa:200162.
UCSCiuc001ehk.3. human.

Organism-specific databases

CTDi200162.
DisGeNETi200162.
GeneCardsiSPAG17.
HGNCiHGNC:26620. SPAG17.
HPAiHPA028597.
HPA028666.
MIMi616554. gene.
neXtProtiNX_Q6Q759.
OpenTargetsiENSG00000155761.
PharmGKBiPA142670888.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGU0. Eukaryota.
ENOG410ZGKQ. LUCA.
GeneTreeiENSGT00390000013693.
HOGENOMiHOG000154383.
HOVERGENiHBG101382.
InParanoidiQ6Q759.
OMAiYKTVMPP.
OrthoDBiEOG091G0194.
PhylomeDBiQ6Q759.
TreeFamiTF328540.

Miscellaneous databases

ChiTaRSiSPAG17. human.
GenomeRNAii200162.
PROiQ6Q759.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000155761.
CleanExiHS_SPAG17.
ExpressionAtlasiQ6Q759. baseline and differential.
GenevisibleiQ6Q759. HS.

Family and domain databases

InterProiIPR026173. SPAG17.
[Graphical view]
PANTHERiPTHR21963. PTHR21963. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiSPG17_HUMAN
AccessioniPrimary (citable) accession number: Q6Q759
Secondary accession number(s): Q8NAZ1, Q9NT21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.