Q6Q6R5 (CRIP3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cysteine-rich protein 3
Short name=CRP-3

Alternative name(s):
Chromosome 6 LIM domain only protein
Short name=h6LIMo

Gene names

Name:	CRIP3
Synonyms:	CRP3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	217 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cytoplasm By similarity.
Tissue specificity	Expressed in most tissues, but not in skeletal muscle. Ref.1
Sequence similarities	Contains 2 LIM zinc-binding domains.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Domain	LIM domain Repeat
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	T cell proliferation Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6Q6R5-1)

Also known as: C;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6Q6R5-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     205-217: HGLWVCVDNFPCG → V

Isoform 3 (identifier: Q6Q6R5-3)

Also known as: A;

The sequence of this isoform differs from the canonical sequence as follows:
     186-217: GQPHPRHWDGMYMPEVWHVHGLWVCVDNFPCG → VNIGDVGCYIYDPVKIKFK

Isoform 4 (identifier: Q6Q6R5-4)

Also known as: D;

The sequence of this isoform differs from the canonical sequence as follows:
     166-217: HDGVPYCHVPCYGYLFGPKGGQPHPRHWDGMYMPEVWHVHGLWVCVDNFPCG → V

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 217	217	Cysteine-rich protein 3		PRO_0000225638
Regions
	Domain	3 – 64	62	LIM zinc-binding 1
	Domain	122 – 183	62	LIM zinc-binding 2
Natural variations
	Alternative sequence	166 – 217	52	HDGVP…NFPCG → V in isoform 4.		VSP_017391
	Alternative sequence	186 – 217	32	GQPHP…NFPCG → VNIGDVGCYIYDPVKIKFK in isoform 3.		VSP_017393
	Alternative sequence	205 – 217	13	HGLWV…NFPCG → V in isoform 2.		VSP_017392
Experimental info
	Sequence conflict	141	1	G → S in AAS66887. Ref.1
	Sequence conflict	141	1	G → S in AAS66888. Ref.1
	Sequence conflict	141	1	G → S in AAS66889. Ref.1
	Sequence conflict	141	1	G → S in AAS66890. Ref.1
	Sequence conflict	148	1	C → R in AAS66887. Ref.1
	Sequence conflict	148	1	C → R in AAS66888. Ref.1
	Sequence conflict	148	1	C → R in AAS66889. Ref.1
	Sequence conflict	148	1	C → R in AAS66890. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (C) [UniParc]. Last modified March 7, 2006. Version 2. Checksum: B8FC618E29AE244F	FASTA	217	24,088
	10 20 30 40 50 60 MSWTCPRCQQ PVFFAEKVSS LGKNWHRFCL KCERCHSILS PGGHAEHNGR PYCHKPCYGA 70 80 90 100 110 120 LFGPRGVNIG GVGSYLYNPP TPSPGCTTPL SPSSFSPPRP RTGLPQGKKS PPHMKTFTGE 130 140 150 160 170 180 TSLCPGCGEP VYFAEKVMSL GRNWHRPCLR CQRCHKTLTA GSHAEHDGVP YCHVPCYGYL 190 200 210 FGPKGGQPHP RHWDGMYMPE VWHVHGLWVC VDNFPCG
	Isoform 2 (B) [UniParc]. Checksum: CB6EC36C400C72C4	FASTA	205	22,758
	10 20 30 40 50 60 MSWTCPRCQQ PVFFAEKVSS LGKNWHRFCL KCERCHSILS PGGHAEHNGR PYCHKPCYGA 70 80 90 100 110 120 LFGPRGVNIG GVGSYLYNPP TPSPGCTTPL SPSSFSPPRP RTGLPQGKKS PPHMKTFTGE 130 140 150 160 170 180 TSLCPGCGEP VYFAEKVMSL GRNWHRPCLR CQRCHKTLTA GSHAEHDGVP YCHVPCYGYL 190 200 FGPKGGQPHP RHWDGMYMPE VWHVV
	Isoform 3 (A) [UniParc]. Checksum: 5E037096ACA17061	FASTA	204	22,471
	10 20 30 40 50 60 MSWTCPRCQQ PVFFAEKVSS LGKNWHRFCL KCERCHSILS PGGHAEHNGR PYCHKPCYGA 70 80 90 100 110 120 LFGPRGVNIG GVGSYLYNPP TPSPGCTTPL SPSSFSPPRP RTGLPQGKKS PPHMKTFTGE 130 140 150 160 170 180 TSLCPGCGEP VYFAEKVMSL GRNWHRPCLR CQRCHKTLTA GSHAEHDGVP YCHVPCYGYL 190 200 FGPKGVNIGD VGCYIYDPVK IKFK
	Isoform 4 (D) [UniParc]. Checksum: D71B84378DC7488D	FASTA	166	18,225
	10 20 30 40 50 60 MSWTCPRCQQ PVFFAEKVSS LGKNWHRFCL KCERCHSILS PGGHAEHNGR PYCHKPCYGA 70 80 90 100 110 120 LFGPRGVNIG GVGSYLYNPP TPSPGCTTPL SPSSFSPPRP RTGLPQGKKS PPHMKTFTGE 130 140 150 160 TSLCPGCGEP VYFAEKVMSL GRNWHRPCLR CQRCHKTLTA GSHAEV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human and mouse orthologous LIM-only proteins respectively encoded in chromosome 6 and 17 show a different expression pattern." Casrouge A., Veitia R., Kirchner J., Bevan M.J., Kanellopoulos J. Microbes Infect. 6:1063-1072(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), TISSUE SPECIFICITY.
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY555741 mRNA. Translation: AAS66887.1. AY555742 mRNA. Translation: AAS66888.1. AY555743 mRNA. Translation: AAS66889.1. AY555744 mRNA. Translation: AAS66890.1. AL583834 Genomic DNA. Translation: CAI14469.1. AL583834 Genomic DNA. Translation: CAM20552.1.
IPI	IPI00410146. IPI00645306. IPI00735865. IPI00738893.
RefSeq	NP_996805.2. NM_206922.2.
UniGene	Hs.653165.
3D structure databases
ProteinModelPortal	Q6Q6R5.
ModBase	Search...
PTM databases
PhosphoSite	Q6Q6R5.
Polymorphism databases
DMDM	92087061.
Proteomic databases
PaxDb	Q6Q6R5.
PRIDE	Q6Q6R5.
Protocols and materials databases
DNASU	401262.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000274990; ENSP00000274990; ENSG00000146215. ENST00000372569; ENSP00000361650; ENSG00000146215.
GeneID	401262.
KEGG	hsa:401262.
UCSC	uc003ouu.1. human. uc010jyn.2. human.
Organism-specific databases
CTD	401262.
GeneCards	GC06M043267.
HGNC	HGNC:17751. CRIP3.
HPA	HPA036198.
neXtProt	NX_Q6Q6R5.
PharmGKB	PA134929489.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG246818.
HOGENOM	HOG000111234.
HOVERGEN	HBG051143.
InParanoid	Q6Q6R5.
OMA	CEHCHSV.
PhylomeDB	Q6Q6R5.
Gene expression databases
ArrayExpress	Q6Q6R5.
Bgee	Q6Q6R5.
CleanEx	HS_CRIP3.
Genevestigator	Q6Q6R5.
GermOnline	ENSG00000146215. Homo sapiens.
Family and domain databases
Gene3D	2.10.110.10. 2 hits.
InterPro	IPR001781. Znf_LIM. [Graphical view]
Pfam	PF00412. LIM. 2 hits. [Graphical view]
SMART	SM00132. LIM. 2 hits. [Graphical view]
PROSITE	PS00478. LIM_DOMAIN_1. 2 hits. PS50023. LIM_DOMAIN_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	401262.
NextBio	106676.

Entry information

Entry name

CRIP3_HUMAN

Accession

Primary (citable) accession number: Q6Q6R5
Secondary accession number(s): A2A436 , Q5T043, Q6Q6R4, Q6Q6R6, Q6Q6R7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	March 7, 2006
Last modified:	May 1, 2013
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.