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Protein

Cysteine-rich protein 3

Gene

Crip3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • T cell proliferation Source: MGI

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich protein 3
Short name:
CRP-3
Alternative name(s):
Thymus LIM protein
Short name:
m17TLP
Gene namesi
Name:Crip3
Synonyms:Tlp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2152434 Crip3

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002256391 – 243Cysteine-rich protein 3Add BLAST243

Proteomic databases

PRIDEiQ6Q6R3

PTM databases

PhosphoSitePlusiQ6Q6R3

Expressioni

Tissue specificityi

Expressed specifically by the thymus.1 Publication

Gene expression databases

BgeeiENSMUSG00000023968
CleanExiMM_CRIP3
ExpressionAtlasiQ6Q6R3 baseline and differential
GenevisibleiQ6Q6R3 MM

Structurei

3D structure databases

ProteinModelPortaliQ6Q6R3
SMRiQ6Q6R3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 64LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST62
Domaini122 – 182LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

GeneTreeiENSGT00550000074548
HOGENOMiHOG000111234
HOVERGENiHBG051143
InParanoidiQ6Q6R3
PhylomeDBiQ6Q6R3
TreeFamiTF313758

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 1 hit
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 2 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6Q6R3-1) [UniParc]FASTAAdd to basket
Also known as: TLP-C

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSWTCPRCQQ PVYFAEKVSS LGKNWHRFCL KCERCHSILS PGGHAEHNGR
60 70 80 90 100
PYCHKPCYGA LFGPRGVNIG GVGCYLYNLP TPPPASRISL SPSNFSPPRP
110 120 130 140 150
RTGLSRAKKR PPYLKTFTGE TSLCPGCGDP VFFAEKVMSL GKIGTTLPEV
160 170 180 190 200
PTCRKTLTAG SHAEHDGMPY CHIPCYGYLF GPKGGQSDPR HWTYENVWTT
210 220 230 240
SLVVRHLDPS PIPSDLHPLA NKALGDRALS FRCEHWRCGL LHL
Length:243
Mass (Da):26,915
Last modified:July 5, 2004 - v1
Checksum:i2C4587ED23E3E27A
GO
Isoform 2 (identifier: Q6Q6R3-2) [UniParc]FASTAAdd to basket
Also known as: TLP-B

The sequence of this isoform differs from the canonical sequence as follows:
     142-152: KIGTTLPEVPT → RNWHRPCLRCQR
     206-243: Missing.

Show »
Length:206
Mass (Da):23,116
Checksum:iBA30993BE66C14B4
GO
Isoform 3 (identifier: Q6Q6R3-3) [UniParc]FASTAAdd to basket
Also known as: TLP-A

The sequence of this isoform differs from the canonical sequence as follows:
     142-152: KIGTTLPEVPT → RNWHRPCLRCQR
     185-243: GQSDPRHWTY...EHWRCGLLHL → VNIGDVGCYIYDPVDIRSK

Show »
Length:204
Mass (Da):22,710
Checksum:i9CFD3919C7432831
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017394142 – 152KIGTTLPEVPT → RNWHRPCLRCQR in isoform 2 and isoform 3. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_017395185 – 243GQSDP…GLLHL → VNIGDVGCYIYDPVDIRSK in isoform 3. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_017396206 – 243Missing in isoform 2. 2 PublicationsAdd BLAST38

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF367970 mRNA Translation: AAK60524.1
AF367971 mRNA Translation: AAK60525.1
AF367972 Genomic DNA Translation: AAK60926.1
AF367972 Genomic DNA Translation: AAK60925.1
AY555745 mRNA Translation: AAS66891.1
AK080272 mRNA Translation: BAC37863.1
CCDSiCCDS28828.1 [Q6Q6R3-3]
RefSeqiNP_444480.1, NM_053250.2
NP_858050.1, NM_181664.2 [Q6Q6R3-3]
UniGeneiMm.25168

Genome annotation databases

EnsembliENSMUST00000024764; ENSMUSP00000024764; ENSMUSG00000023968 [Q6Q6R3-3]
GeneIDi114570
KEGGimmu:114570
UCSCiuc008csu.1 mouse [Q6Q6R3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCRIP3_MOUSE
AccessioniPrimary (citable) accession number: Q6Q6R3
Secondary accession number(s): Q91V23, Q91V60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 5, 2004
Last modified: July 5, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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