Q6Q595 (SCS22_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vesicle-associated membrane protein-associated protein SCS22
Short name=VAMP-associated protein SCS22

Alternative name(s):
VAP homolog 2

Gene names

Name:	SCS22
Ordered Locus Names:	YBL091C-A

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	175 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Targets proteins containing a FFAT motif to membranes By similarity. Involved in regulation of phospholipid metabolism. Ref.7
Subcellular location	Membrane; Single-pass type IV membrane protein Potential.
Domain	The MSP domain is required for binding to the FFAT motif of target proteins By similarity.
Miscellaneous	Present with 358 molecules/cell in log phase SD medium. Ref.6
Sequence similarities	Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family. [View classification] Contains 1 MSP domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from genetic interaction Ref.7. Source: SGD
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 175	175	Vesicle-associated membrane protein-associated protein SCS22		PRO_0000213468
Regions
	Topological domain	1 – 154	154	Cytoplasmic Potential
	Transmembrane	155 – 175	21	Helical; Anchor for type IV membrane protein; Potential
	Domain	1 – 125	125	MSP
Experimental info
	Sequence conflict	169	1	L → P in AAS56619. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q6Q595 [UniParc]. Last modified December 6, 2005. Version 2. Checksum: F738A09B9F94489D	FASTA	175	19,678
	10 20 30 40 50 60 MRIVPEKLVF KAPLNKQSTE YIKLENDGEK RVIFKVRTSA PTKYCVRPNV AIIGAHESVN 70 80 90 100 110 120 VQIVFLGLPK STADDEMDQK RDKFLIVTLP IPAAYQNVED GELLSDWPNL EEQYKDDIVF 130 140 150 160 170 KKIKIFHSVL PKRKPSGNHD AESARAPSAG NGQSLSSRAL LIITVIALLV GWIYY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence analysis of a 78.6 kb segment of the left end of Saccharomyces cerevisiae chromosome II." Obermaier B., Gassenhuber J., Piravandi E., Domdey H. Yeast 11:1103-1112(1995) [PubMed: 7502586] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete DNA sequence of yeast chromosome II." Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K. EMBO J. 13:5795-5809(1994) [PubMed: 7813418] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 77-175. Strain: ATCC 204508 / S288c.
[5]	"Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii." Brachat S., Dietrich F.S., Voegeli S., Zhang Z., Stuart L., Lerch A., Gates K., Gaffney T.D., Philippsen P. Genome Biol. 4:R45.1-R45.13(2003) [PubMed: 12844361] [Abstract] Cited for: REVISION OF GENE MODEL.
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]	"A highly conserved binding site in vesicle-associated membrane protein-associated protein (VAP) for the FFAT motif of lipid-binding proteins." Loewen C.J.R., Levine T.P. J. Biol. Chem. 280:14097-14104(2005) [PubMed: 15668246] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X79489 Genomic DNA. No translation available. Z35852 Genomic DNA. No translation available. Z35853 Genomic DNA. No translation available. AY558293 Genomic DNA. Translation: AAS56619.1. BK006936 Genomic DNA. Translation: DAA07032.1.
RefSeq	NP_009461.2. NM_001184321.1.
3D structure databases
ProteinModelPortal	Q6Q595.
SMR	Q6Q595. Positions 1-131.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6Q595. 4 interactions.
STRING	Q6Q595.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YBL091C-A; YBL091C-A; YBL091C-A.
GeneID	852186.
KEGG	sce:YBL091C-A.
NMPDR	fig|4932.3.peg.147.
Organism-specific databases
CYGD	YBL091c-a.
SGD	S000007228. SCS22.
Phylogenomic databases
eggNOG	fuNOG09956.
GeneTree	EFGT00050000005423.
OMA	STADDEM.
OrthoDB	EOG469V40.
Gene expression databases
ArrayExpress	Q6Q595.
Genevestigator	Q6Q595.
GermOnline	YBL091C-A. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR000535. Major_sperm. IPR008962. PapD-like. [Graphical view]
Gene3D	G3DSA:2.60.40.360. MSP. 1 hit.
Pfam	PF00635. Motile_Sperm. 1 hit. [Graphical view]
SUPFAM	SSF49354. PapD-like. 1 hit.
PROSITE	PS50202. MSP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	970655.

Entry information

Entry name

SCS22_YEAST

Accession

Primary (citable) accession number: Q6Q595
Secondary accession number(s): D6VPR2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	December 6, 2005
Last modified:	December 14, 2011
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program