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Protein

H/ACA ribonucleoprotein complex subunit 3

Gene

NOP10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. Essential for growth.1 Publication

GO - Molecular functioni

  • box H/ACA snoRNA binding Source: GO_Central
  • RNA binding Source: SGD
  • telomerase RNA binding Source: GO_Central

GO - Biological processi

  • cleavage involved in rRNA processing Source: SGD
  • positive regulation of telomerase RNA localization to Cajal body Source: GO_Central
  • rRNA pseudouridine synthesis Source: SGD
  • snRNA pseudouridine synthesis Source: SGD
  • telomere maintenance via telomerase Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein
Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-31263-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
H/ACA ribonucleoprotein complex subunit 3
Alternative name(s):
Nucleolar protein 10
Nucleolar protein family A member 3
snoRNP protein NOP10
Gene namesi
Name:NOP10
Ordered Locus Names:YHR072W-A
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR072W-A
SGDiS000007455 NOP10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001490131 – 58H/ACA ribonucleoprotein complex subunit 3Add BLAST58

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki28Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei36PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ6Q547
PaxDbiQ6Q547
PRIDEiQ6Q547

PTM databases

iPTMnetiQ6Q547

Interactioni

Subunit structurei

Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs). The protein component of the H/ACA snoRNP contains CBF5, GAR1, NHP2 and NOP10. The complex contains a stable core composed of CBF5 and NOP10, to which GAR1 and NHP2 subsequently bind.1 Publication

Protein-protein interaction databases

BioGridi36506, 107 interactors
DIPiDIP-5845N
IntActiQ6Q547, 12 interactors
MINTiQ6Q547
STRINGi4932.YHR072W-A

Structurei

Secondary structure

158
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 7Combined sources4
Beta strandi8 – 12Combined sources5
Beta strandi13 – 17Combined sources5
Beta strandi28 – 31Combined sources4
Beta strandi32 – 35Combined sources4
Beta strandi37 – 39Combined sources3
Helixi42 – 47Combined sources6
Beta strandi49 – 51Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y2YNMR-A1-58[»]
2AQANMR-A2-58[»]
3U28X-ray1.90B1-58[»]
3UAIX-ray3.06B1-58[»]
DisProtiDP00475
ProteinModelPortaliQ6Q547
SMRiQ6Q547
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6Q547

Family & Domainsi

Sequence similaritiesi

Belongs to the NOP10 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000012563
HOGENOMiHOG000159681
InParanoidiQ6Q547
KOiK11130
OMAiKYSRERI
OrthoDBiEOG092C5WQE

Family and domain databases

Gene3Di2.20.28.40, 1 hit
InterProiView protein in InterPro
IPR007264 H/ACA_rnp_Nop10
IPR036756 H/ACA_rnp_Nop10_sf
PANTHERiPTHR13305 PTHR13305, 1 hit
PfamiView protein in Pfam
PF04135 Nop10p, 1 hit
SUPFAMiSSF144210 SSF144210, 1 hit

Sequencei

Sequence statusi: Complete.

Q6Q547-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLMYTLGPD GKRIYTLKKV TESGEITKSA HPARFSPDDK YSRQRVTLKK

RFGLVPGQ
Length:58
Mass (Da):6,636
Last modified:July 5, 2004 - v1
Checksum:i4718D35AF7911FBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10556 Genomic DNA No translation available.
AY558548 Genomic DNA Translation: AAS56874.1
BK006934 Genomic DNA Translation: DAA06766.1
RefSeqiNP_058135.1, NM_001184438.1

Genome annotation databases

EnsemblFungiiYHR072W-A; YHR072W-A; YHR072W-A
GeneIDi856471
KEGGisce:YHR072W-A

Similar proteinsi

Entry informationi

Entry nameiNOP10_YEAST
AccessioniPrimary (citable) accession number: Q6Q547
Secondary accession number(s): D3DL22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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