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Protein

H/ACA ribonucleoprotein complex subunit 3

Gene

NOP10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. Essential for growth.1 Publication

GO - Molecular functioni

  • box H/ACA snoRNA binding Source: GO_Central
  • RNA binding Source: SGD
  • telomerase RNA binding Source: GO_Central

GO - Biological processi

  • cleavage involved in rRNA processing Source: SGD
  • positive regulation of telomerase RNA localization to Cajal body Source: GO_Central
  • rRNA pseudouridine synthesis Source: SGD
  • snRNA pseudouridine synthesis Source: SGD
  • telomere maintenance via telomerase Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-31263-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
H/ACA ribonucleoprotein complex subunit 3
Alternative name(s):
Nucleolar protein 10
Nucleolar protein family A member 3
snoRNP protein NOP10
Gene namesi
Name:NOP10
Ordered Locus Names:YHR072W-A
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR072W-A.
SGDiS000007455. NOP10.

Subcellular locationi

GO - Cellular componenti

  • box H/ACA scaRNP complex Source: GO_Central
  • box H/ACA snoRNP complex Source: SGD
  • box H/ACA telomerase RNP complex Source: GO_Central
  • small nucleolar ribonucleoprotein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001490131 – 58H/ACA ribonucleoprotein complex subunit 3Add BLAST58

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki28Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei36PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ6Q547.
PRIDEiQ6Q547.

PTM databases

iPTMnetiQ6Q547.

Interactioni

Subunit structurei

Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs). The protein component of the H/ACA snoRNP contains CBF5, GAR1, NHP2 and NOP10. The complex contains a stable core composed of CBF5 and NOP10, to which GAR1 and NHP2 subsequently bind.1 Publication

Protein-protein interaction databases

BioGridi36506. 26 interactors.
DIPiDIP-5845N.
IntActiQ6Q547. 10 interactors.
MINTiMINT-2786302.

Structurei

Secondary structure

158
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 7Combined sources4
Beta strandi8 – 12Combined sources5
Beta strandi13 – 17Combined sources5
Beta strandi28 – 31Combined sources4
Beta strandi32 – 35Combined sources4
Beta strandi37 – 39Combined sources3
Helixi42 – 47Combined sources6
Beta strandi49 – 51Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y2YNMR-A1-58[»]
2AQANMR-A2-58[»]
3U28X-ray1.90B1-58[»]
3UAIX-ray3.06B1-58[»]
DisProtiDP00475.
ProteinModelPortaliQ6Q547.
SMRiQ6Q547.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6Q547.

Family & Domainsi

Sequence similaritiesi

Belongs to the NOP10 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000012563.
HOGENOMiHOG000159681.
InParanoidiQ6Q547.
KOiK11130.
OMAiQRVTLKK.
OrthoDBiEOG092C5WQE.

Family and domain databases

InterProiIPR007264. H/ACA_rnp_Nop10.
[Graphical view]
PANTHERiPTHR13305. PTHR13305. 1 hit.
PfamiPF04135. Nop10p. 1 hit.
[Graphical view]
SUPFAMiSSF144210. SSF144210. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6Q547-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLMYTLGPD GKRIYTLKKV TESGEITKSA HPARFSPDDK YSRQRVTLKK

RFGLVPGQ
Length:58
Mass (Da):6,636
Last modified:July 5, 2004 - v1
Checksum:i4718D35AF7911FBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10556 Genomic DNA. No translation available.
AY558548 Genomic DNA. Translation: AAS56874.1.
BK006934 Genomic DNA. Translation: DAA06766.1.
RefSeqiNP_058135.1. NM_001184438.1.

Genome annotation databases

EnsemblFungiiYHR072W-A; YHR072W-A; YHR072W-A.
GeneIDi856471.
KEGGisce:YHR072W-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10556 Genomic DNA. No translation available.
AY558548 Genomic DNA. Translation: AAS56874.1.
BK006934 Genomic DNA. Translation: DAA06766.1.
RefSeqiNP_058135.1. NM_001184438.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y2YNMR-A1-58[»]
2AQANMR-A2-58[»]
3U28X-ray1.90B1-58[»]
3UAIX-ray3.06B1-58[»]
DisProtiDP00475.
ProteinModelPortaliQ6Q547.
SMRiQ6Q547.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36506. 26 interactors.
DIPiDIP-5845N.
IntActiQ6Q547. 10 interactors.
MINTiMINT-2786302.

PTM databases

iPTMnetiQ6Q547.

Proteomic databases

MaxQBiQ6Q547.
PRIDEiQ6Q547.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYHR072W-A; YHR072W-A; YHR072W-A.
GeneIDi856471.
KEGGisce:YHR072W-A.

Organism-specific databases

EuPathDBiFungiDB:YHR072W-A.
SGDiS000007455. NOP10.

Phylogenomic databases

GeneTreeiENSGT00390000012563.
HOGENOMiHOG000159681.
InParanoidiQ6Q547.
KOiK11130.
OMAiQRVTLKK.
OrthoDBiEOG092C5WQE.

Enzyme and pathway databases

BioCyciYEAST:G3O-31263-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ6Q547.
PROiQ6Q547.

Family and domain databases

InterProiIPR007264. H/ACA_rnp_Nop10.
[Graphical view]
PANTHERiPTHR13305. PTHR13305. 1 hit.
PfamiPF04135. Nop10p. 1 hit.
[Graphical view]
SUPFAMiSSF144210. SSF144210. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNOP10_YEAST
AccessioniPrimary (citable) accession number: Q6Q547
Secondary accession number(s): D3DL22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.