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Protein

Ubiquitin-like modifier HUB1

Gene

HUB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Forms conjugate with SPH1 and HBT1. Involved in morphogenesis.1 Publication

GO - Molecular functioni

  • protein tag Source: SGD

GO - Biological processi

  • cell morphogenesis involved in conjugation with cellular fusion Source: SGD
  • cellular protein modification process Source: SGD
  • mRNA splicing, via spliceosome Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:G3O-33397-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like modifier HUB1
Gene namesi
Name:HUB1
Ordered Locus Names:YNR032C-A
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNR032C-A.
SGDiS000007251. HUB1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • mating projection Source: SGD
  • nucleus Source: GO_Central
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001148791 – 73Ubiquitin-like modifier HUB1Add BLAST73

Proteomic databases

MaxQBiQ6Q546.
PRIDEiQ6Q546.

Interactioni

Protein-protein interaction databases

BioGridi35857. 54 interactors.
IntActiQ6Q546. 1 interactor.

Structurei

Secondary structure

173
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1 – 7Combined sources7
Turni9 – 11Combined sources3
Beta strandi13 – 19Combined sources7
Helixi24 – 35Combined sources12
Helixi39 – 41Combined sources3
Beta strandi42 – 46Combined sources5
Helixi58 – 60Combined sources3
Beta strandi67 – 72Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M94NMR-A1-73[»]
3PLUX-ray1.40A/B1-73[»]
3PLVX-ray1.90A1-73[»]
ProteinModelPortaliQ6Q546.
SMRiQ6Q546.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6Q546.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 73Ubiquitin-likePROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000001945.
HOGENOMiHOG000234933.
InParanoidiQ6Q546.
KOiK13113.
OMAiKDHISLE.
OrthoDBiEOG092C5VC9.

Family and domain databases

InterProiIPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6Q546-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEVVVNDRL GKKVRVKCLA EDSVGDFKKV LSLQIGTQPN KIVLQKGGSV
60 70
LKDHISLEDY EVHDQTNLEL YYL
Length:73
Mass (Da):8,272
Last modified:September 13, 2005 - v2
Checksum:i2D5EFB83483F2ABA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12K → E in AAS56885 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71648 Genomic DNA. No translation available.
AY558559 Genomic DNA. Translation: AAS56885.1.
BK006947 Genomic DNA. Translation: DAA10573.1.
RefSeqiNP_014430.1. NM_001184344.1.

Genome annotation databases

EnsemblFungiiYNR032C-A; YNR032C-A; YNR032C-A.
GeneIDi855767.
KEGGisce:YNR032C-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71648 Genomic DNA. No translation available.
AY558559 Genomic DNA. Translation: AAS56885.1.
BK006947 Genomic DNA. Translation: DAA10573.1.
RefSeqiNP_014430.1. NM_001184344.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M94NMR-A1-73[»]
3PLUX-ray1.40A/B1-73[»]
3PLVX-ray1.90A1-73[»]
ProteinModelPortaliQ6Q546.
SMRiQ6Q546.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35857. 54 interactors.
IntActiQ6Q546. 1 interactor.

Proteomic databases

MaxQBiQ6Q546.
PRIDEiQ6Q546.

Protocols and materials databases

DNASUi855767.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNR032C-A; YNR032C-A; YNR032C-A.
GeneIDi855767.
KEGGisce:YNR032C-A.

Organism-specific databases

EuPathDBiFungiDB:YNR032C-A.
SGDiS000007251. HUB1.

Phylogenomic databases

GeneTreeiENSGT00390000001945.
HOGENOMiHOG000234933.
InParanoidiQ6Q546.
KOiK13113.
OMAiKDHISLE.
OrthoDBiEOG092C5VC9.

Enzyme and pathway databases

BioCyciYEAST:G3O-33397-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ6Q546.
PROiQ6Q546.

Family and domain databases

InterProiIPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHUB1_YEAST
AccessioniPrimary (citable) accession number: Q6Q546
Secondary accession number(s): D6W1K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2005
Last modified: November 2, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.