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Protein

Ubiquitin-like modifier HUB1

Gene

HUB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Forms conjugate with SPH1 and HBT1. Involved in morphogenesis.1 Publication

GO - Molecular functioni

  • protein tag Source: SGD

GO - Biological processi

  • cell morphogenesis involved in conjugation with cellular fusion Source: SGD
  • cellular protein modification process Source: SGD
  • mRNA splicing, via spliceosome Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:G3O-33397-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like modifier HUB1
Gene namesi
Name:HUB1
Ordered Locus Names:YNR032C-A
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNR032C-A.
SGDiS000007251. HUB1.

Subcellular locationi

GO - Cellular componenti

  • mating projection Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7373Ubiquitin-like modifier HUB1PRO_0000114879Add
BLAST

Proteomic databases

MaxQBiQ6Q546.

Interactioni

Protein-protein interaction databases

BioGridi35857. 54 interactions.
IntActiQ6Q546. 1 interaction.

Structurei

Secondary structure

73
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1 – 77Combined sources
Turni9 – 113Combined sources
Beta strandi13 – 197Combined sources
Helixi24 – 3512Combined sources
Helixi39 – 413Combined sources
Beta strandi42 – 465Combined sources
Helixi58 – 603Combined sources
Beta strandi67 – 726Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1M94NMR-A1-73[»]
3PLUX-ray1.40A/B1-73[»]
3PLVX-ray1.90A1-73[»]
ProteinModelPortaliQ6Q546.
SMRiQ6Q546. Positions 1-73.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6Q546.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 7373Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000001945.
HOGENOMiHOG000234933.
InParanoidiQ6Q546.
KOiK13113.
OMAiKDHISLE.
OrthoDBiEOG73RBQX.

Family and domain databases

InterProiIPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6Q546-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEVVVNDRL GKKVRVKCLA EDSVGDFKKV LSLQIGTQPN KIVLQKGGSV
60 70
LKDHISLEDY EVHDQTNLEL YYL
Length:73
Mass (Da):8,272
Last modified:September 13, 2005 - v2
Checksum:i2D5EFB83483F2ABA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121K → E in AAS56885 (PubMed:17322287).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71648 Genomic DNA. No translation available.
AY558559 Genomic DNA. Translation: AAS56885.1.
BK006947 Genomic DNA. Translation: DAA10573.1.
RefSeqiNP_014430.1. NM_001184344.1.

Genome annotation databases

EnsemblFungiiYNR032C-A; YNR032C-A; YNR032C-A.
GeneIDi855767.
KEGGisce:YNR032C-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71648 Genomic DNA. No translation available.
AY558559 Genomic DNA. Translation: AAS56885.1.
BK006947 Genomic DNA. Translation: DAA10573.1.
RefSeqiNP_014430.1. NM_001184344.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1M94NMR-A1-73[»]
3PLUX-ray1.40A/B1-73[»]
3PLVX-ray1.90A1-73[»]
ProteinModelPortaliQ6Q546.
SMRiQ6Q546. Positions 1-73.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35857. 54 interactions.
IntActiQ6Q546. 1 interaction.

Proteomic databases

MaxQBiQ6Q546.

Protocols and materials databases

DNASUi855767.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNR032C-A; YNR032C-A; YNR032C-A.
GeneIDi855767.
KEGGisce:YNR032C-A.

Organism-specific databases

EuPathDBiFungiDB:YNR032C-A.
SGDiS000007251. HUB1.

Phylogenomic databases

GeneTreeiENSGT00390000001945.
HOGENOMiHOG000234933.
InParanoidiQ6Q546.
KOiK13113.
OMAiKDHISLE.
OrthoDBiEOG73RBQX.

Enzyme and pathway databases

BioCyciYEAST:G3O-33397-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ6Q546.
NextBioi980211.
PROiQ6Q546.

Family and domain databases

InterProiIPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Role of a ubiquitin-like modification in polarized morphogenesis."
    Dittmar G.A.G., Wilkinson C.R.M., Jedrzejewski P.T., Finley D.
    Science 295:2442-2446(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiHUB1_YEAST
AccessioniPrimary (citable) accession number: Q6Q546
Secondary accession number(s): D6W1K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2005
Last modified: May 11, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.