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Q6Q3E8

- Q6Q3E8_RAT

UniProt

Q6Q3E8 - Q6Q3E8_RAT

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Protein
Submitted name: Endoglin
Gene
Eng, rCG_45763
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. transforming growth factor beta-activated receptor activity Source: RGD
  2. type II transforming growth factor beta receptor binding Source: RGD
Complete GO annotation...

GO - Biological processi

  1. bone development Source: RGD
  2. cellular response to mechanical stimulus Source: RGD
  3. extracellular matrix constituent secretion Source: RGD
  4. positive regulation of collagen biosynthetic process Source: RGD
  5. positive regulation of gene expression Source: RGD
  6. positive regulation of protein phosphorylation Source: RGD
  7. regulation of transforming growth factor beta receptor signaling pathway Source: RGD
  8. response to corticosteroid Source: RGD
  9. response to statin Source: RGD
  10. response to transforming growth factor beta Source: RGD
  11. transmembrane receptor protein serine/threonine kinase signaling pathway Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
EndoglinImported
Gene namesi
Name:EngImported
ORF Names:rCG_45763Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi1593188. Eng.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: RGD
  2. extracellular space Source: RGD
  3. integral component of membrane Source: RGD
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ6Q3E8.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG005573.
KOiK06526.

Family and domain databases

InterProiIPR001507. ZP_dom.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
SMARTiSM00241. ZP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6Q3E8-1 [UniParc]FASTAAdd to Basket

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MDRSMLPLVI TLLLVIYSFV PTSLAERVGC DLQRVDSTRG EVTYTTSQVS    50
EGCVAQVANA AHEVHVLFLN LSRRKSEVEL TLQASKQNGT ETREVFLVFI 100
SNENVLVKLQ APEIPLHLVY NSSLEVFKGP KVNSTPLPSF TSKTQILDWA 150
ATKGTITSIA ALDDPKSIVL RLGQDPKAPP FCFPEAQKDM GVTLEWQPRT 200
QTPVQGCHLE GVTGHKEAYV LRIRSGSEAG PRTVTVTVKL SCTSGDAVLI 250
LQGPPYVSWL IDTNHNMQIW TTGEYSIKIF PENNIKGFEL PDTPQGLIGE 300
ARKLNASIVT FVEIPLTSDV SLTVSSCGGG LQTSPAPVVT TPPKDTCSPE 350
LLMSLIQPKC GNDVMTLALN KKLVQTLQCT ITGLAFWDSS CQAKDQDGHL 400
VLSSTYSSCG MKVTDHVISN EVIINLPSGL PPLRKKVQCI DMDSLSFQLG 450
LYLSPHFLQA SNTIELGQQG FVQVSMSPLT SEVTVQLDSC HLDLGPEGDM 500
VELIQSRAAK GSCVSLLSPS PEGDPRFSFL LRVYMVPTPA AGTLSCNLAL 550
HPSTLSQEVY KTVSMRLNIV SPDLSGKGLV LPSVLGITFG AFLIGALLTA 600
ALWYIYSHTR APSKREPVVA VAAPASSESS STNHSIGSTQ STPCSTSSMA 650
Length:650
Mass (Da):69,944
Last modified:July 5, 2004 - v1
Checksum:i3E7DBC6A178E1E4B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY562420 mRNA. Translation: AAS67893.1.
CH474001 Genomic DNA. Translation: EDL93221.1.
RefSeqiNP_001010968.1. NM_001010968.2.
UniGeneiRn.187025.

Genome annotation databases

GeneIDi497010.
KEGGirno:497010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY562420 mRNA. Translation: AAS67893.1 .
CH474001 Genomic DNA. Translation: EDL93221.1 .
RefSeqi NP_001010968.1. NM_001010968.2.
UniGenei Rn.187025.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 497010.
KEGGi rno:497010.

Organism-specific databases

CTDi 2022.
RGDi 1593188. Eng.

Phylogenomic databases

HOVERGENi HBG005573.
KOi K06526.

Miscellaneous databases

NextBioi 697672.

Gene expression databases

Genevestigatori Q6Q3E8.

Family and domain databases

InterProi IPR001507. ZP_dom.
[Graphical view ]
Pfami PF00100. Zona_pellucida. 1 hit.
[Graphical view ]
SMARTi SM00241. ZP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  2. "Identification of endoglin in rat hepatic stellate cells: new insights into transforming growth factor beta receptor signaling."
    Meurer S.K., Tihaa L., Lahme B., Gressner A.M., Weiskirchen R.
    J. Biol. Chem. 280:3078-3087(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.

Entry informationi

Entry nameiQ6Q3E8_RAT
AccessioniPrimary (citable) accession number: Q6Q3E8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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