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Q6Q3E8

- Q6Q3E8_RAT

UniProt

Q6Q3E8 - Q6Q3E8_RAT

Protein
Submitted name:

Endoglin

Gene

Eng

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. transforming growth factor beta-activated receptor activity Source: RGD
    2. type II transforming growth factor beta receptor binding Source: RGD

    GO - Biological processi

    1. bone development Source: RGD
    2. cellular response to mechanical stimulus Source: RGD
    3. extracellular matrix constituent secretion Source: RGD
    4. positive regulation of collagen biosynthetic process Source: RGD
    5. positive regulation of gene expression Source: RGD
    6. positive regulation of protein phosphorylation Source: RGD
    7. regulation of transforming growth factor beta receptor signaling pathway Source: RGD
    8. response to corticosteroid Source: RGD
    9. response to statin Source: RGD
    10. response to transforming growth factor beta Source: RGD
    11. transmembrane receptor protein serine/threonine kinase signaling pathway Source: GOC

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    EndoglinImported
    Gene namesi
    Name:EngImported
    ORF Names:rCG_45763Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi1593188. Eng.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: RGD
    2. extracellular space Source: RGD
    3. integral component of membrane Source: RGD

    Expressioni

    Gene expression databases

    GenevestigatoriQ6Q3E8.

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG005573.
    KOiK06526.

    Family and domain databases

    InterProiIPR001507. ZP_dom.
    [Graphical view]
    PfamiPF00100. Zona_pellucida. 1 hit.
    [Graphical view]
    SMARTiSM00241. ZP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6Q3E8-1 [UniParc]FASTAAdd to Basket

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    MDRSMLPLVI TLLLVIYSFV PTSLAERVGC DLQRVDSTRG EVTYTTSQVS    50
    EGCVAQVANA AHEVHVLFLN LSRRKSEVEL TLQASKQNGT ETREVFLVFI 100
    SNENVLVKLQ APEIPLHLVY NSSLEVFKGP KVNSTPLPSF TSKTQILDWA 150
    ATKGTITSIA ALDDPKSIVL RLGQDPKAPP FCFPEAQKDM GVTLEWQPRT 200
    QTPVQGCHLE GVTGHKEAYV LRIRSGSEAG PRTVTVTVKL SCTSGDAVLI 250
    LQGPPYVSWL IDTNHNMQIW TTGEYSIKIF PENNIKGFEL PDTPQGLIGE 300
    ARKLNASIVT FVEIPLTSDV SLTVSSCGGG LQTSPAPVVT TPPKDTCSPE 350
    LLMSLIQPKC GNDVMTLALN KKLVQTLQCT ITGLAFWDSS CQAKDQDGHL 400
    VLSSTYSSCG MKVTDHVISN EVIINLPSGL PPLRKKVQCI DMDSLSFQLG 450
    LYLSPHFLQA SNTIELGQQG FVQVSMSPLT SEVTVQLDSC HLDLGPEGDM 500
    VELIQSRAAK GSCVSLLSPS PEGDPRFSFL LRVYMVPTPA AGTLSCNLAL 550
    HPSTLSQEVY KTVSMRLNIV SPDLSGKGLV LPSVLGITFG AFLIGALLTA 600
    ALWYIYSHTR APSKREPVVA VAAPASSESS STNHSIGSTQ STPCSTSSMA 650
    Length:650
    Mass (Da):69,944
    Last modified:July 5, 2004 - v1
    Checksum:i3E7DBC6A178E1E4B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY562420 mRNA. Translation: AAS67893.1.
    CH474001 Genomic DNA. Translation: EDL93221.1.
    RefSeqiNP_001010968.1. NM_001010968.2.
    UniGeneiRn.187025.

    Genome annotation databases

    GeneIDi497010.
    KEGGirno:497010.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY562420 mRNA. Translation: AAS67893.1 .
    CH474001 Genomic DNA. Translation: EDL93221.1 .
    RefSeqi NP_001010968.1. NM_001010968.2.
    UniGenei Rn.187025.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 497010.
    KEGGi rno:497010.

    Organism-specific databases

    CTDi 2022.
    RGDi 1593188. Eng.

    Phylogenomic databases

    HOVERGENi HBG005573.
    KOi K06526.

    Miscellaneous databases

    NextBioi 697672.

    Gene expression databases

    Genevestigatori Q6Q3E8.

    Family and domain databases

    InterProi IPR001507. ZP_dom.
    [Graphical view ]
    Pfami PF00100. Zona_pellucida. 1 hit.
    [Graphical view ]
    SMARTi SM00241. ZP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    2. "Identification of endoglin in rat hepatic stellate cells: new insights into transforming growth factor beta receptor signaling."
      Meurer S.K., Tihaa L., Lahme B., Gressner A.M., Weiskirchen R.
      J. Biol. Chem. 280:3078-3087(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Sprague-DawleyImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.

    Entry informationi

    Entry nameiQ6Q3E8_RAT
    AccessioniPrimary (citable) accession number: Q6Q3E8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)