Q6Q3E8 (Q6Q3E8_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Endoglin EMBL AAS67893.1

Gene names

Name:	Eng RGD 1593188 EMBL EDL93221.1
ORF Names:	rCG_45763 EMBL EDL93221.1

Organism

Rattus norvegicus (Rat) EMBL AAS67893.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	650 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological_process	extracellular matrix constituent secretion Inferred from mutant phenotype PubMed 15539634. Source: RGD regulation of transforming growth factor beta receptor signaling pathway Inferred from direct assay PubMed 17376778. Source: RGD response to corticosteroid stimulus Inferred from expression pattern PubMed 19481784. Source: RGD
Cellular_component	cell surface Inferred from direct assay Ref.2. Source: RGD extracellular space Inferred from direct assay PubMed 19075097. Source: RGD integral to membrane Non-traceable author statement Ref.2. Source: RGD
Molecular_function	transforming growth factor beta-activated receptor activity Non-traceable author statement PubMed 15539634. Source: RGD
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6Q3E8 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 3E7DBC6A178E1E4B	FASTA	650	69,944
	10 20 30 40 50 60 MDRSMLPLVI TLLLVIYSFV PTSLAERVGC DLQRVDSTRG EVTYTTSQVS EGCVAQVANA 70 80 90 100 110 120 AHEVHVLFLN LSRRKSEVEL TLQASKQNGT ETREVFLVFI SNENVLVKLQ APEIPLHLVY 130 140 150 160 170 180 NSSLEVFKGP KVNSTPLPSF TSKTQILDWA ATKGTITSIA ALDDPKSIVL RLGQDPKAPP 190 200 210 220 230 240 FCFPEAQKDM GVTLEWQPRT QTPVQGCHLE GVTGHKEAYV LRIRSGSEAG PRTVTVTVKL 250 260 270 280 290 300 SCTSGDAVLI LQGPPYVSWL IDTNHNMQIW TTGEYSIKIF PENNIKGFEL PDTPQGLIGE 310 320 330 340 350 360 ARKLNASIVT FVEIPLTSDV SLTVSSCGGG LQTSPAPVVT TPPKDTCSPE LLMSLIQPKC 370 380 390 400 410 420 GNDVMTLALN KKLVQTLQCT ITGLAFWDSS CQAKDQDGHL VLSSTYSSCG MKVTDHVISN 430 440 450 460 470 480 EVIINLPSGL PPLRKKVQCI DMDSLSFQLG LYLSPHFLQA SNTIELGQQG FVQVSMSPLT 490 500 510 520 530 540 SEVTVQLDSC HLDLGPEGDM VELIQSRAAK GSCVSLLSPS PEGDPRFSFL LRVYMVPTPA 550 560 570 580 590 600 AGTLSCNLAL HPSTLSQEVY KTVSMRLNIV SPDLSGKGLV LPSVLGITFG AFLIGALLTA 610 620 630 640 650 ALWYIYSHTR APSKREPVVA VAAPASSESS STNHSIGSTQ STPCSTSSMA

References

[1]	"Gene and alternative splicing annotation with AIR." Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G. Genome Res. 15:54-66(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDL93221.1.
[2]	"Identification of endoglin in rat hepatic stellate cells: new insights into transforming growth factor beta receptor signaling." Meurer S.K., Tihaa L., Lahme B., Gressner A.M., Weiskirchen R. J. Biol. Chem. 280:3078-3087(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Sprague-Dawley EMBL AAS67893.1.
[3]	Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDL93221.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY562420 mRNA. Translation: AAS67893.1. CH474001 Genomic DNA. Translation: EDL93221.1.
IPI	IPI00454534.
RefSeq	NP_001010968.1. NM_001010968.2.
UniGene	Rn.187025.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	497010.
KEGG	rno:497010.
Organism-specific databases
CTD	2022.
RGD	1593188. Eng.
Phylogenomic databases
HOVERGEN	HBG005573.
KO	K06526.
Gene expression databases
Genevestigator	Q6Q3E8.
Family and domain databases
InterPro	IPR001507. ZP_dom. [Graphical view]
Pfam	PF00100. Zona_pellucida. 1 hit. [Graphical view]
SMART	SM00241. ZP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	697672.

Entry information

Entry name

Q6Q3E8_RAT

Accession

Primary (citable) accession number: Q6Q3E8

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	October 3, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)