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Q6Q3E8 (Q6Q3E8_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
Gene names
Name:Eng RGD 1593188 EMBL EDL93221.1
ORF Names:rCG_45763 EMBL EDL93221.1
OrganismRattus norvegicus (Rat) EMBL AAS67893.1
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length650 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Gene Ontology (GO)
   Biological_processbone development

Inferred from expression pattern PubMed 20865666. Source: RGD

cellular response to mechanical stimulus

Inferred from expression pattern PubMed 22941949. Source: RGD

extracellular matrix constituent secretion

Inferred from mutant phenotype PubMed 15539634. Source: RGD

positive regulation of collagen biosynthetic process

Inferred from mutant phenotype PubMed 20156938. Source: RGD

positive regulation of gene expression

Inferred from mutant phenotype PubMed 21146604. Source: RGD

positive regulation of protein phosphorylation

Inferred from mutant phenotype PubMed 21146604. Source: RGD

regulation of transforming growth factor beta receptor signaling pathway

Inferred from direct assay PubMed 17376778. Source: RGD

response to corticosteroid

Inferred from expression pattern PubMed 19481784. Source: RGD

response to statin

Inferred from expression pattern PubMed 20156938. Source: RGD

response to transforming growth factor beta

Inferred from expression pattern PubMed 22941949. Source: RGD

transmembrane receptor protein serine/threonine kinase signaling pathway

Non-traceable author statement PubMed 15539634. Source: GOC

   Cellular_componentcell surface

Inferred from direct assay Ref.2. Source: RGD

extracellular space

Inferred from direct assay PubMed 19075097. Source: RGD

integral component of membrane

Non-traceable author statement Ref.2. Source: RGD

   Molecular_functiontransforming growth factor beta-activated receptor activity

Non-traceable author statement PubMed 15539634. Source: RGD

type II transforming growth factor beta receptor binding

Inferred from physical interaction PubMed 21146604. Source: RGD

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q6Q3E8 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 3E7DBC6A178E1E4B

FASTA65069,944
        10         20         30         40         50         60 
MDRSMLPLVI TLLLVIYSFV PTSLAERVGC DLQRVDSTRG EVTYTTSQVS EGCVAQVANA 

        70         80         90        100        110        120 
AHEVHVLFLN LSRRKSEVEL TLQASKQNGT ETREVFLVFI SNENVLVKLQ APEIPLHLVY 

       130        140        150        160        170        180 
NSSLEVFKGP KVNSTPLPSF TSKTQILDWA ATKGTITSIA ALDDPKSIVL RLGQDPKAPP 

       190        200        210        220        230        240 
FCFPEAQKDM GVTLEWQPRT QTPVQGCHLE GVTGHKEAYV LRIRSGSEAG PRTVTVTVKL 

       250        260        270        280        290        300 
SCTSGDAVLI LQGPPYVSWL IDTNHNMQIW TTGEYSIKIF PENNIKGFEL PDTPQGLIGE 

       310        320        330        340        350        360 
ARKLNASIVT FVEIPLTSDV SLTVSSCGGG LQTSPAPVVT TPPKDTCSPE LLMSLIQPKC 

       370        380        390        400        410        420 
GNDVMTLALN KKLVQTLQCT ITGLAFWDSS CQAKDQDGHL VLSSTYSSCG MKVTDHVISN 

       430        440        450        460        470        480 
EVIINLPSGL PPLRKKVQCI DMDSLSFQLG LYLSPHFLQA SNTIELGQQG FVQVSMSPLT 

       490        500        510        520        530        540 
SEVTVQLDSC HLDLGPEGDM VELIQSRAAK GSCVSLLSPS PEGDPRFSFL LRVYMVPTPA 

       550        560        570        580        590        600 
AGTLSCNLAL HPSTLSQEVY KTVSMRLNIV SPDLSGKGLV LPSVLGITFG AFLIGALLTA 

       610        620        630        640        650 
ALWYIYSHTR APSKREPVVA VAAPASSESS STNHSIGSTQ STPCSTSSMA 

« Hide

References

[1]"Gene and alternative splicing annotation with AIR."
Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G.
Genome Res. 15:54-66(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BN EMBL EDL93221.1.
[2]"Identification of endoglin in rat hepatic stellate cells: new insights into transforming growth factor beta receptor signaling."
Meurer S.K., Tihaa L., Lahme B., Gressner A.M., Weiskirchen R.
J. Biol. Chem. 280:3078-3087(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Sprague-Dawley EMBL AAS67893.1.
[3]Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. expand/collapse author list , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BN EMBL EDL93221.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY562420 mRNA. Translation: AAS67893.1.
CH474001 Genomic DNA. Translation: EDL93221.1.
RefSeqNP_001010968.1. NM_001010968.2.
UniGeneRn.187025.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID497010.
KEGGrno:497010.

Organism-specific databases

CTD2022.
RGD1593188. Eng.

Phylogenomic databases

HOVERGENHBG005573.
KOK06526.
PhylomeDBQ6Q3E8.

Gene expression databases

GenevestigatorQ6Q3E8.

Family and domain databases

InterProIPR001507. ZP_dom.
[Graphical view]
PfamPF00100. Zona_pellucida. 1 hit.
[Graphical view]
SMARTSM00241. ZP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio697672.

Entry information

Entry nameQ6Q3E8_RAT
AccessionPrimary (citable) accession number: Q6Q3E8
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)