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Protein
Submitted name:

Endoglin

Gene

Eng

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • transforming growth factor beta-activated receptor activity Source: RGD
  • type II transforming growth factor beta receptor binding Source: RGD

GO - Biological processi

  • bone development Source: RGD
  • cellular response to mechanical stimulus Source: RGD
  • extracellular matrix constituent secretion Source: RGD
  • positive regulation of collagen biosynthetic process Source: RGD
  • positive regulation of gene expression Source: RGD
  • positive regulation of protein phosphorylation Source: RGD
  • regulation of transforming growth factor beta receptor signaling pathway Source: RGD
  • response to corticosteroid Source: RGD
  • response to drug Source: RGD
  • response to transforming growth factor beta Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
EndoglinImported
Gene namesi
Name:EngImported
ORF Names:rCG_45763Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi1593188. Eng.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei579 – 60628HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: RGD
  • extracellular space Source: RGD
  • integral component of membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 650625Sequence analysisPRO_5007709128Add
BLAST

Interactioni

GO - Molecular functioni

  • type II transforming growth factor beta receptor binding Source: RGD

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini360 – 510151ZPInterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOVERGENiHBG005573.
KOiK06526.
PhylomeDBiQ6Q3E8.

Family and domain databases

InterProiIPR001507. ZP_dom.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6Q3E8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRSMLPLVI TLLLVIYSFV PTSLAERVGC DLQRVDSTRG EVTYTTSQVS
60 70 80 90 100
EGCVAQVANA AHEVHVLFLN LSRRKSEVEL TLQASKQNGT ETREVFLVFI
110 120 130 140 150
SNENVLVKLQ APEIPLHLVY NSSLEVFKGP KVNSTPLPSF TSKTQILDWA
160 170 180 190 200
ATKGTITSIA ALDDPKSIVL RLGQDPKAPP FCFPEAQKDM GVTLEWQPRT
210 220 230 240 250
QTPVQGCHLE GVTGHKEAYV LRIRSGSEAG PRTVTVTVKL SCTSGDAVLI
260 270 280 290 300
LQGPPYVSWL IDTNHNMQIW TTGEYSIKIF PENNIKGFEL PDTPQGLIGE
310 320 330 340 350
ARKLNASIVT FVEIPLTSDV SLTVSSCGGG LQTSPAPVVT TPPKDTCSPE
360 370 380 390 400
LLMSLIQPKC GNDVMTLALN KKLVQTLQCT ITGLAFWDSS CQAKDQDGHL
410 420 430 440 450
VLSSTYSSCG MKVTDHVISN EVIINLPSGL PPLRKKVQCI DMDSLSFQLG
460 470 480 490 500
LYLSPHFLQA SNTIELGQQG FVQVSMSPLT SEVTVQLDSC HLDLGPEGDM
510 520 530 540 550
VELIQSRAAK GSCVSLLSPS PEGDPRFSFL LRVYMVPTPA AGTLSCNLAL
560 570 580 590 600
HPSTLSQEVY KTVSMRLNIV SPDLSGKGLV LPSVLGITFG AFLIGALLTA
610 620 630 640 650
ALWYIYSHTR APSKREPVVA VAAPASSESS STNHSIGSTQ STPCSTSSMA
Length:650
Mass (Da):69,944
Last modified:July 5, 2004 - v1
Checksum:i3E7DBC6A178E1E4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY562420 mRNA. Translation: AAS67893.1.
CH474001 Genomic DNA. Translation: EDL93221.1.
RefSeqiNP_001010968.1. NM_001010968.2.
UniGeneiRn.187025.

Genome annotation databases

GeneIDi497010.
KEGGirno:497010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY562420 mRNA. Translation: AAS67893.1.
CH474001 Genomic DNA. Translation: EDL93221.1.
RefSeqiNP_001010968.1. NM_001010968.2.
UniGeneiRn.187025.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi497010.
KEGGirno:497010.

Organism-specific databases

CTDi2022.
RGDi1593188. Eng.

Phylogenomic databases

HOVERGENiHBG005573.
KOiK06526.
PhylomeDBiQ6Q3E8.

Family and domain databases

InterProiIPR001507. ZP_dom.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6Q3E8_RAT
AccessioniPrimary (citable) accession number: Q6Q3E8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.