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Q6Q2J0

- AOFA_PIG

UniProt

Q6Q2J0 - AOFA_PIG

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Protein

Amine oxidase [flavin-containing] A

Gene
MAOA
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine By similarity.

Catalytic activityi

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Cofactori

FAD By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei335 – 3351Important for substrate specificity By similarity
Sitei374 – 3741Important for catalytic activity By similarity

GO - Molecular functioni

  1. oxidoreductase activity Source: UniProtKB-KW

GO - Biological processi

  1. catecholamine metabolic process Source: UniProtKB-KW
  2. neurotransmitter catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Catecholamine metabolism, Neurotransmitter degradation

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Amine oxidase [flavin-containing] A (EC:1.4.3.4)
Alternative name(s):
Monoamine oxidase type A
Short name:
MAO-A
Gene namesi
Name:MAOA
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 497497Cytoplasmic By similarityAdd
BLAST
Transmembranei498 – 51821Helical; Anchor for type IV membrane protein; By similarityAdd
BLAST
Topological domaini519 – 5279Mitochondrial intermembrane By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 527527Amine oxidase [flavin-containing] APRO_0000099852Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei406 – 4061S-8alpha-FAD cysteine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ6Q2J0.

Interactioni

Subunit structurei

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer By similarity.

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000013044.

Structurei

3D structure databases

ProteinModelPortaliQ6Q2J0.
SMRiQ6Q2J0. Positions 12-524.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni520 – 5223Interaction with membrane phospholipid headgroups By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1231.
HOGENOMiHOG000221615.
HOVERGENiHBG004255.
KOiK00274.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00757. AMINEOXDASEF.

Sequencei

Sequence statusi: Complete.

Q6Q2J0-1 [UniParc]FASTAAdd to Basket

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MERQEKANNA GHMVDVVVIG GGISGLSAAK LLNEYGINVL VLEARDRVGG    50
RTYTVRNENV DYVDVGGAYV GPTQNRILRL SKELGLETYK VNVNECLVQY 100
VKGKSYPFRG AFPPVWNPIA YLDYNNLWRT MDDMGKKIPA DAPWESPHAE 150
EWDKMTMKDL IDKICWTKTA KRFASLFVNI NVTSEPHEVS ALWFLWYVKQ 200
CGGTTRIFSV TNGGQERKFV GGSGQVSERI MHLLGDRVKL RCPVTYVDQS 250
GDNIIVETLN HELYECQYVI SAIPPTLTAK IHFRPELPSE RNQLIQRLPM 300
GAIIKCMMYY KEAFWKKKNY CGCMIIEDEE APISITLDDT KPDGSLPAIM 350
GFILARKADR LAKVHKEVRK RKICELYAKV LGSQEASHPV HYEEKNWCEE 400
QYSGGCYTAY FPPGIMTQYG RVIRQPVGRI FFAGTETATQ WSGYMEGAVE 450
AGERAAREIL NALGKVSKKD IWLREPESED VPAFEITRTF WERNLPSVTG 500
LLKIIGFSTS VTALWLAVYK FRLLTRS 527
Length:527
Mass (Da):59,763
Last modified:July 5, 2004 - v1
Checksum:i9A07272AFBFD730B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY563632 mRNA. Translation: AAS68020.1.
RefSeqiNP_001001640.1. NM_001001640.1.
UniGeneiSsc.7297.

Genome annotation databases

GeneIDi414424.
KEGGissc:414424.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY563632 mRNA. Translation: AAS68020.1 .
RefSeqi NP_001001640.1. NM_001001640.1.
UniGenei Ssc.7297.

3D structure databases

ProteinModelPortali Q6Q2J0.
SMRi Q6Q2J0. Positions 12-524.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000013044.

Proteomic databases

PaxDbi Q6Q2J0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 414424.
KEGGi ssc:414424.

Organism-specific databases

CTDi 4128.

Phylogenomic databases

eggNOGi COG1231.
HOGENOMi HOG000221615.
HOVERGENi HBG004255.
KOi K00274.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01593. Amino_oxidase. 1 hit.
[Graphical view ]
PRINTSi PR00757. AMINEOXDASEF.
ProtoNeti Search...

Publicationsi

  1. "Cloning of the porcine MAO-A and -B gene."
    Bai C.Y., Zhao W., Meng H., Pan Y.C.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiAOFA_PIG
AccessioniPrimary (citable) accession number: Q6Q2J0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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