Reviewed, UniProtKB/Swiss-Prot Q6Q2J0 (AOFA_PIG)

Names and origin

Protein names

Recommended name:
    Amine oxidase [flavin-containing] A
    EC=1.4.3.4
Alternative name(s):
    Monoamine oxidase type A
      Short name=MAO-A

Gene names

Name:

MAOA

Organism

Sus scrofa (Pig)

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	527 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine By similarity.
Catalytic activity	RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2).
Cofactor	FAD By similarity.
Subunit structure	Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer By similarity.
Subcellular location	Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic sideBy similarity.
Sequence similarities	Belongs to the flavin monoamine oxidase family.

Ontologies

Keywords
Biological process	Catecholamine metabolism Neurotransmitter degradation
Cellular component	Membrane Mitochondrion Mitochondrion outer membrane
Domain	Transmembrane
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	catecholamine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW neurotransmitter catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial outer membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amine oxidase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 527	527	Amine oxidase [flavin-containing] A		PRO_0000099852
Regions
	Topological domain	1 – 497	497	Cytoplasmic Potential
	Transmembrane	498 – 518	21	Anchor for type IV membrane protein Potential
	Topological domain	519 – 527	9	Mitochondrial intermembrane Potential
Sites
	Site	335	1	Important for substrate specificity By similarity
	Site	374	1	Important for catalytic activity By similarity
Amino acid modifications
	Modified residue	406	1	S-8alpha-FAD cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6Q2J0-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 9A07272AFBFD730B	FASTA	527	59,763
	10 20 30 40 50 60 MERQEKANNA GHMVDVVVIG GGISGLSAAK LLNEYGINVL VLEARDRVGG RTYTVRNENV 70 80 90 100 110 120 DYVDVGGAYV GPTQNRILRL SKELGLETYK VNVNECLVQY VKGKSYPFRG AFPPVWNPIA 130 140 150 160 170 180 YLDYNNLWRT MDDMGKKIPA DAPWESPHAE EWDKMTMKDL IDKICWTKTA KRFASLFVNI 190 200 210 220 230 240 NVTSEPHEVS ALWFLWYVKQ CGGTTRIFSV TNGGQERKFV GGSGQVSERI MHLLGDRVKL 250 260 270 280 290 300 RCPVTYVDQS GDNIIVETLN HELYECQYVI SAIPPTLTAK IHFRPELPSE RNQLIQRLPM 310 320 330 340 350 360 GAIIKCMMYY KEAFWKKKNY CGCMIIEDEE APISITLDDT KPDGSLPAIM GFILARKADR 370 380 390 400 410 420 LAKVHKEVRK RKICELYAKV LGSQEASHPV HYEEKNWCEE QYSGGCYTAY FPPGIMTQYG 430 440 450 460 470 480 RVIRQPVGRI FFAGTETATQ WSGYMEGAVE AGERAAREIL NALGKVSKKD IWLREPESED 490 500 510 520 VPAFEITRTF WERNLPSVTG LLKIIGFSTS VTALWLAVYK FRLLTRS

References

[1]	"Cloning of the porcine MAO-A and -B gene." Bai C.Y., Zhao W., Meng H., Pan Y.C. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY563632 mRNA. Translation: AAS68020.1.
RefSeq	NP_001001640.1.
UniGene	Ssc.23505
3D structure databases
SMR	Q6Q2J0. Positions 23-509.
ModBase	Search...
Genome annotation databases
GeneID	414424.
KEGG	ssc:414424.
Phylogenomic databases
HOVERGEN	Q6Q2J0.
Family and domain databases
InterPro	IPR001613. Amineoxid_fl. IPR002937. Amino_oxidase. [Graphical view]
Pfam	PF01593. Amino_oxidase. 1 hit. [Graphical view]
PRINTS	PR00757. AMINEOXDASEF.
ProtoNet	Search...

Entry information

Entry name

AOFA_PIG

Accession

Primary (citable) accession number: Q6Q2J0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	July 5, 2004
Last modified:	November 25, 2008
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)