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Q6Q2J0

- AOFA_PIG

UniProt

Q6Q2J0 - AOFA_PIG

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Protein

Amine oxidase [flavin-containing] A

Gene

MAOA

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine By similarity.By similarity

Catalytic activityi

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Cofactori

FAD.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei335 – 3351Important for substrate specificityBy similarity
Sitei374 – 3741Important for catalytic activityBy similarity

GO - Molecular functioni

  1. oxidoreductase activity Source: UniProtKB-KW

GO - Biological processi

  1. catecholamine metabolic process Source: UniProtKB-KW
  2. neurotransmitter catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Catecholamine metabolism, Neurotransmitter degradation

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Amine oxidase [flavin-containing] A (EC:1.4.3.4)
Alternative name(s):
Monoamine oxidase type A
Short name:
MAO-A
Gene namesi
Name:MAOA
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 527527Amine oxidase [flavin-containing] APRO_0000099852Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei406 – 4061S-8alpha-FAD cysteineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ6Q2J0.

Interactioni

Subunit structurei

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer By similarity.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000013044.

Structurei

3D structure databases

ProteinModelPortaliQ6Q2J0.
SMRiQ6Q2J0. Positions 12-524.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 497497CytoplasmicBy similarityAdd
BLAST
Topological domaini519 – 5279Mitochondrial intermembraneBy similarity

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei498 – 51821Helical; Anchor for type IV membrane proteinBy similarityAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni520 – 5223Interaction with membrane phospholipid headgroupsBy similarity

Sequence similaritiesi

Belongs to the flavin monoamine oxidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1231.
HOGENOMiHOG000221615.
HOVERGENiHBG004255.
InParanoidiQ6Q2J0.
KOiK00274.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00757. AMINEOXDASEF.

Sequencei

Sequence statusi: Complete.

Q6Q2J0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERQEKANNA GHMVDVVVIG GGISGLSAAK LLNEYGINVL VLEARDRVGG
60 70 80 90 100
RTYTVRNENV DYVDVGGAYV GPTQNRILRL SKELGLETYK VNVNECLVQY
110 120 130 140 150
VKGKSYPFRG AFPPVWNPIA YLDYNNLWRT MDDMGKKIPA DAPWESPHAE
160 170 180 190 200
EWDKMTMKDL IDKICWTKTA KRFASLFVNI NVTSEPHEVS ALWFLWYVKQ
210 220 230 240 250
CGGTTRIFSV TNGGQERKFV GGSGQVSERI MHLLGDRVKL RCPVTYVDQS
260 270 280 290 300
GDNIIVETLN HELYECQYVI SAIPPTLTAK IHFRPELPSE RNQLIQRLPM
310 320 330 340 350
GAIIKCMMYY KEAFWKKKNY CGCMIIEDEE APISITLDDT KPDGSLPAIM
360 370 380 390 400
GFILARKADR LAKVHKEVRK RKICELYAKV LGSQEASHPV HYEEKNWCEE
410 420 430 440 450
QYSGGCYTAY FPPGIMTQYG RVIRQPVGRI FFAGTETATQ WSGYMEGAVE
460 470 480 490 500
AGERAAREIL NALGKVSKKD IWLREPESED VPAFEITRTF WERNLPSVTG
510 520
LLKIIGFSTS VTALWLAVYK FRLLTRS
Length:527
Mass (Da):59,763
Last modified:July 5, 2004 - v1
Checksum:i9A07272AFBFD730B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY563632 mRNA. Translation: AAS68020.1.
RefSeqiNP_001001640.1. NM_001001640.1.
UniGeneiSsc.7297.

Genome annotation databases

GeneIDi414424.
KEGGissc:414424.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY563632 mRNA. Translation: AAS68020.1 .
RefSeqi NP_001001640.1. NM_001001640.1.
UniGenei Ssc.7297.

3D structure databases

ProteinModelPortali Q6Q2J0.
SMRi Q6Q2J0. Positions 12-524.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000013044.

Proteomic databases

PaxDbi Q6Q2J0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 414424.
KEGGi ssc:414424.

Organism-specific databases

CTDi 4128.

Phylogenomic databases

eggNOGi COG1231.
HOGENOMi HOG000221615.
HOVERGENi HBG004255.
InParanoidi Q6Q2J0.
KOi K00274.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01593. Amino_oxidase. 1 hit.
[Graphical view ]
PRINTSi PR00757. AMINEOXDASEF.
ProtoNeti Search...

Publicationsi

  1. "Cloning of the porcine MAO-A and -B gene."
    Bai C.Y., Zhao W., Meng H., Pan Y.C.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiAOFA_PIG
AccessioniPrimary (citable) accession number: Q6Q2J0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3