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Protein

Phospholipase A1 1

Gene
N/A
Organism
Polistes dominula (European paper wasp) (Vespa dominula)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolysis of phosphatidylcholine with phospholipase A1 (EC 3.1.1.32) activity. Has weak hemolytic activity (By similarity).By similarity

Catalytic activityi

Phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei174 – 1741NucleophileBy similarity
Active sitei202 – 2021Charge relay systemPROSITE-ProRule annotation
Active sitei263 – 2631Charge relay systemPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Cytolysis, Hemolysis, Lipid degradation, Lipid metabolism

Protein family/group databases

ESTHERipoldo-q6q252. Phospholipase.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase A1 1 (EC:3.1.1.32)
Alternative name(s):
Allergen: Pol d 1.01
OrganismiPolistes dominula (European paper wasp) (Vespa dominula)
Taxonomic identifieri743375 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaePolistinaePolistiniPolistes

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE (By similarity).By similarity

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3433. Pol d 1.0101.
586. Pol d 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Propeptidei22 – 3514By similarityPRO_5000093090Add
BLAST
Chaini36 – 337302Phospholipase A1 1PRO_5000093091Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 278By similarity
Disulfide bondi124 ↔ 261By similarity
Disulfide bondi213 ↔ 256By similarity
Disulfide bondi218 ↔ 298By similarity
Disulfide bondi273 ↔ 279By similarity
Disulfide bondi305 ↔ 330By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6Q252.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002334. Allerg_PlipaseA1.
IPR013818. Lipase_N.
IPR000734. TAG_lipase.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
[Graphical view]
PRINTSiPR00825. DOLALLERGEN.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6Q252-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFKYSILFI CFVKVLDNCY AADDLTTLRN GTLDRGITPD CTFNEKDIEL
60 70 80 90 100
HVYSRDKRNG IILKKEILKN YDLFQKSQIS HQIAILIHGF LSTGNNENFD
110 120 130 140 150
AMAKALIEID NFLVISVDWK KGACNAFAST NDVLGYSQAV GNTRHVGKYV
160 170 180 190 200
ADFTKLLVEQ YKVPMSNIRL IGHSLGAHTS GFAGKEVQRL KLGKYKEIIG
210 220 230 240 250
LDPAGPSFLT NKCPNRLCET DAEYVQAIHT SAILGVYYNV GSVDFYVNYG
260 270 280 290 300
KSQPGCSEPS CSHTKAVKYL TECIKRECCL IGTPWKSYFS TPKPISQCKR
310 320 330
DTCVCVGLNA QSYPAKGSFY VPVDKDAPYC HNEGIKL
Length:337
Mass (Da):37,559
Last modified:July 5, 2004 - v1
Checksum:iC0A7E0E5EBDE448C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY566645 mRNA. Translation: AAS67041.1.
RefSeqiXP_015187185.1. XM_015331699.1.

Genome annotation databases

GeneIDi107072087.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY566645 mRNA. Translation: AAS67041.1.
RefSeqiXP_015187185.1. XM_015331699.1.

3D structure databases

ProteinModelPortaliQ6Q252.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3433. Pol d 1.0101.
586. Pol d 1.
ESTHERipoldo-q6q252. Phospholipase.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi107072087.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002334. Allerg_PlipaseA1.
IPR013818. Lipase_N.
IPR000734. TAG_lipase.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
[Graphical view]
PRINTSiPR00825. DOLALLERGEN.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Moawad T.I.S., Hoffman D.R.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Venom gland.

Entry informationi

Entry nameiPA11_POLDO
AccessioniPrimary (citable) accession number: Q6Q252
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: March 16, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.