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Q6Q250 (PA13_POLDO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phospholipase A1 3

EC=3.1.1.32
Alternative name(s):
Allergen=Pol d 1.03
OrganismPolistes dominula (European paper wasp) (Vespa dominula)
Taxonomic identifier743375 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaePolistinaePolistiniPolistes

Protein attributes

Sequence length316 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Hydrolysis of phosphatidylcholine with phospholipase A1 (EC 3.1.1.32) activity. Has weak hemolytic activity By similarity.

Catalytic activity

Phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate.

Subunit structure

Monomer By similarity.

Subcellular location

Secreted By similarity.

Tissue specificity

Expressed by the venom gland.

Allergenic properties

Causes an allergic reaction in human. Binds to IgE By similarity.

Sequence similarities

Belongs to the AB hydrolase superfamily. Lipase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide‹1 – 4›4 Potential
Propeptide5 – 1410 By similarity
PRO_0000425188
Chain15 – 316302Phospholipase A1 3
PRO_5000093093

Sites

Active site1531Nucleophile By similarity
Active site1811Charge relay system By similarity
Active site2421Charge relay system By similarity

Amino acid modifications

Disulfide bond20 ↔ 257 By similarity
Disulfide bond103 ↔ 240 By similarity
Disulfide bond192 ↔ 235 By similarity
Disulfide bond197 ↔ 277 By similarity
Disulfide bond252 ↔ 258 By similarity
Disulfide bond284 ↔ 309 By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
Q6Q250 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 12CB3A7748F8FE05

FASTA31635,019
        10         20         30         40         50         60 
ADDLTTLRNG TLDRGITPDC TFNEKDIELH VYSRDKRNGI ILKKEILKNY DLFQKSQISH 

        70         80         90        100        110        120 
QIAILIHGFL STGNNENFDA MAKALIEIDN FLVISVDWKK GACNAFASTN DVLGYSQAVG 

       130        140        150        160        170        180 
NTRHVGKYVA DFTKLLVEQY KVPMSNIRLI GHSLGAHTSG FAGKEVQRLK LGKYKEIIGL 

       190        200        210        220        230        240 
DPAGPSFLTS KCPDRLCETD AEYVQAIHTS AILGVYYNVG SVDFYVNYGK SQPGCSEPSC 

       250        260        270        280        290        300 
SHTKAVKYLT ECIKRECCLI GTPWKSYFST PKPISQCKRD TCVCVGLNAQ SYPAKGSFYV 

       310 
PVDKDAPYCH NEGIKL 

« Hide

References

[1]Moawad T.I.S., Hoffman D.R.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Venom gland.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY566647 mRNA. Translation: AAS67043.1.

3D structure databases

ProteinModelPortalQ6Q250.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome3435. Pol d 1.0103.
586. Pol d 1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002334. Dol/Ves_allerg.
IPR000734. Lipase.
IPR013818. Lipase_N.
[Graphical view]
PANTHERPTHR11610. PTHR11610. 1 hit.
PfamPF00151. Lipase. 1 hit.
[Graphical view]
PRINTSPR00825. DOLALLERGEN.
PROSITEPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePA13_POLDO
AccessionPrimary (citable) accession number: Q6Q250
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries