Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6Q250

- PA13_POLDO

UniProt

Q6Q250 - PA13_POLDO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Phospholipase A1 3

Gene
N/A
Organism
Polistes dominula (European paper wasp) (Vespa dominula)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Hydrolysis of phosphatidylcholine with phospholipase A1 (EC 3.1.1.32) activity. Has weak hemolytic activity (By similarity).By similarity

Catalytic activityi

Phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei153 – 1531NucleophileBy similarity
Active sitei181 – 1811Charge relay systemPROSITE-ProRule annotation
Active sitei242 – 2421Charge relay systemPROSITE-ProRule annotation

GO - Molecular functioni

  1. 1-acyl-2-lysophosphatidylserine acylhydrolase activity Source: UniProtKB-EC
  2. phosphatidylcholine 1-acylhydrolase activity Source: UniProtKB-EC
  3. phosphatidylserine 1-acylhydrolase activity Source: UniProtKB-EC

GO - Biological processi

  1. hemolysis in other organism Source: UniProtKB-KW
  2. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Cytolysis, Hemolysis, Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase A1 3 (EC:3.1.1.32)
Alternative name(s):
Allergen: Pol d 1.03
OrganismiPolistes dominula (European paper wasp) (Vespa dominula)
Taxonomic identifieri743375 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaePolistinaePolistiniPolistes

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE (By similarity).By similarity

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3435. Pol d 1.0103.
586. Pol d 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei‹1 – 4›4Sequence Analysis
Propeptidei5 – 1410By similarityPRO_0000425188
Chaini15 – 316302Phospholipase A1 3PRO_5000093093Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi20 ↔ 257By similarity
Disulfide bondi103 ↔ 240By similarity
Disulfide bondi192 ↔ 235By similarity
Disulfide bondi197 ↔ 277By similarity
Disulfide bondi252 ↔ 258By similarity
Disulfide bondi284 ↔ 309By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6Q250.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002334. Dol/Ves_allerg.
IPR000734. Lipase.
IPR013818. Lipase_N.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
[Graphical view]
PRINTSiPR00825. DOLALLERGEN.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6Q250-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
ADDLTTLRNG TLDRGITPDC TFNEKDIELH VYSRDKRNGI ILKKEILKNY
60 70 80 90 100
DLFQKSQISH QIAILIHGFL STGNNENFDA MAKALIEIDN FLVISVDWKK
110 120 130 140 150
GACNAFASTN DVLGYSQAVG NTRHVGKYVA DFTKLLVEQY KVPMSNIRLI
160 170 180 190 200
GHSLGAHTSG FAGKEVQRLK LGKYKEIIGL DPAGPSFLTS KCPDRLCETD
210 220 230 240 250
AEYVQAIHTS AILGVYYNVG SVDFYVNYGK SQPGCSEPSC SHTKAVKYLT
260 270 280 290 300
ECIKRECCLI GTPWKSYFST PKPISQCKRD TCVCVGLNAQ SYPAKGSFYV
310
PVDKDAPYCH NEGIKL
Length:316
Mass (Da):35,019
Last modified:July 5, 2004 - v1
Checksum:i12CB3A7748F8FE05
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY566647 mRNA. Translation: AAS67043.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY566647 mRNA. Translation: AAS67043.1 .

3D structure databases

ProteinModelPortali Q6Q250.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 3435. Pol d 1.0103.
586. Pol d 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR002334. Dol/Ves_allerg.
IPR000734. Lipase.
IPR013818. Lipase_N.
[Graphical view ]
PANTHERi PTHR11610. PTHR11610. 1 hit.
Pfami PF00151. Lipase. 1 hit.
[Graphical view ]
PRINTSi PR00825. DOLALLERGEN.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00120. LIPASE_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Moawad T.I.S., Hoffman D.R.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Venom gland.

Entry informationi

Entry nameiPA13_POLDO
AccessioniPrimary (citable) accession number: Q6Q250
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3