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Q6Q250

- PA13_POLDO

UniProt

Q6Q250 - PA13_POLDO

Protein

Phospholipase A1 3

Gene
N/A
Organism
Polistes dominula (European paper wasp) (Vespa dominula)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Hydrolysis of phosphatidylcholine with phospholipase A1 (EC 3.1.1.32) activity. Has weak hemolytic activity By similarity.By similarity

    Catalytic activityi

    Phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei153 – 1531NucleophileBy similarity
    Active sitei181 – 1811Charge relay systemPROSITE-ProRule annotation
    Active sitei242 – 2421Charge relay systemPROSITE-ProRule annotation

    GO - Molecular functioni

    1. 1-acyl-2-lysophosphatidylserine acylhydrolase activity Source: UniProtKB-EC
    2. phosphatidylcholine 1-acylhydrolase activity Source: UniProtKB-EC
    3. phosphatidylserine 1-acylhydrolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. hemolysis in other organism Source: UniProtKB-KW
    2. lipid catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Cytolysis, Hemolysis, Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phospholipase A1 3 (EC:3.1.1.32)
    Alternative name(s):
    Allergen: Pol d 1.03
    OrganismiPolistes dominula (European paper wasp) (Vespa dominula)
    Taxonomic identifieri743375 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaePolistinaePolistiniPolistes

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human. Binds to IgE By similarity.By similarity

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei3435. Pol d 1.0103.
    586. Pol d 1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei‹1 – 4›4Sequence Analysis
    Propeptidei5 – 1410By similarityPRO_0000425188
    Chaini15 – 316302Phospholipase A1 3PRO_5000093093Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi20 ↔ 257By similarity
    Disulfide bondi103 ↔ 240By similarity
    Disulfide bondi192 ↔ 235By similarity
    Disulfide bondi197 ↔ 277By similarity
    Disulfide bondi252 ↔ 258By similarity
    Disulfide bondi284 ↔ 309By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6Q250.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AB hydrolase superfamily. Lipase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR002334. Dol/Ves_allerg.
    IPR000734. Lipase.
    IPR013818. Lipase_N.
    [Graphical view]
    PANTHERiPTHR11610. PTHR11610. 1 hit.
    PfamiPF00151. Lipase. 1 hit.
    [Graphical view]
    PRINTSiPR00825. DOLALLERGEN.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00120. LIPASE_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6Q250-1 [UniParc]FASTAAdd to Basket

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    ADDLTTLRNG TLDRGITPDC TFNEKDIELH VYSRDKRNGI ILKKEILKNY    50
    DLFQKSQISH QIAILIHGFL STGNNENFDA MAKALIEIDN FLVISVDWKK 100
    GACNAFASTN DVLGYSQAVG NTRHVGKYVA DFTKLLVEQY KVPMSNIRLI 150
    GHSLGAHTSG FAGKEVQRLK LGKYKEIIGL DPAGPSFLTS KCPDRLCETD 200
    AEYVQAIHTS AILGVYYNVG SVDFYVNYGK SQPGCSEPSC SHTKAVKYLT 250
    ECIKRECCLI GTPWKSYFST PKPISQCKRD TCVCVGLNAQ SYPAKGSFYV 300
    PVDKDAPYCH NEGIKL 316
    Length:316
    Mass (Da):35,019
    Last modified:July 5, 2004 - v1
    Checksum:i12CB3A7748F8FE05
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY566647 mRNA. Translation: AAS67043.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY566647 mRNA. Translation: AAS67043.1 .

    3D structure databases

    ProteinModelPortali Q6Q250.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 3435. Pol d 1.0103.
    586. Pol d 1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR002334. Dol/Ves_allerg.
    IPR000734. Lipase.
    IPR013818. Lipase_N.
    [Graphical view ]
    PANTHERi PTHR11610. PTHR11610. 1 hit.
    Pfami PF00151. Lipase. 1 hit.
    [Graphical view ]
    PRINTSi PR00825. DOLALLERGEN.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00120. LIPASE_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Moawad T.I.S., Hoffman D.R.
      Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Venom gland.

    Entry informationi

    Entry nameiPA13_POLDO
    AccessioniPrimary (citable) accession number: Q6Q250
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3