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Protein

Potassium channel subfamily K member 18

Gene

Kcnk18

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Outward rectifying potassium channel. Produces rapidly activating outward rectifier K+ currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiR-RNO-1299344. TWIK-related spinal cord K+ channel (TRESK).

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 18
Alternative name(s):
Tresk-2
Two-pore-domain potassium channel TRESK
Gene namesi
Name:Kcnk18
Synonyms:Tresk-2, Tresk2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1303091. Kcnk18.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei43 – 6321HelicalSequence analysisAdd
BLAST
Intramembranei125 – 15127Pore-forming; Name=Pore-forming 1Sequence analysisAdd
BLAST
Transmembranei153 – 17321HelicalSequence analysisAdd
BLAST
Transmembranei304 – 32421HelicalSequence analysisAdd
BLAST
Intramembranei337 – 35115Pore-forming; Name=Pore-forming 2Sequence analysisAdd
BLAST
Transmembranei358 – 37821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405Potassium channel subfamily K member 18PRO_0000312502Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence analysis
Modified residuei275 – 2751PhosphoserineBy similarity

Post-translational modificationi

N-glycosylated.By similarity
Phosphorylation of Ser-275 is required for the binding of 14-3-3eta/YWHAH. Calcineurin-mediated dephosphorylation of Ser-287 enhances channel activity (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6Q1P3.
PRIDEiQ6Q1P3.

Expressioni

Gene expression databases

ExpressionAtlasiQ6Q1P3. baseline and differential.

Interactioni

Subunit structurei

Interacts with calcineurin. Interacts with YWHAH, in a phosphorylation-dependent manner.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039866.

Structurei

3D structure databases

ProteinModelPortaliQ6Q1P3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni221 – 2266Interaction with calcineurinBy similarity
Regioni272 – 2776Interaction with YWHAHBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00700000104522.
HOGENOMiHOG000074045.
HOVERGENiHBG104673.
InParanoidiQ6Q1P3.
OMAiAFKLVQN.
OrthoDBiEOG7MPRDX.
PhylomeDBiQ6Q1P3.
TreeFamiTF316115.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01095. TASKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q6Q1P3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAEEPPEAR RRCPEALGKA SGCCPEAPGK ARGCCPEALG KLLPGLCFLC
60 70 80 90 100
CLVTYALVGA ALFSAVEGRP DPEAEENPEL KKFLDKLCNI LKCNLTVVEG
110 120 130 140 150
SRKDLCEHLQ QLKPQWFKAP EDWSFLSALF FCCTVFSTVG YGHMYPVTRL
160 170 180 190 200
GKFLCMLYAL FGIPLMFLVL TDIGDILAAI LSRAYSRFQA LLCLPRDISK
210 220 230 240 250
WRPLLLCRKQ TDSKPADEAI PQIVIDAGAD ELLDPQPSRE PASPSCNVEL
260 270 280 290 300
FERLVAREKQ NELQPPMRPV ERSNSCPELV LGRLSCSILS NLDEVGQQVE
310 320 330 340 350
RLDIPLPVIA LVIFAYISCA AAILPFWETD LGFEDAFYFC FVTLTTIGFG
360 370 380 390 400
DIVLVHPHFF LFFSIYIIVG MEILFIAFKL MQNRLLHTYK TLMLFVCQRE

VSLPC
Length:405
Mass (Da):45,351
Last modified:July 5, 2004 - v1
Checksum:i1E71325617575A8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY567970 mRNA. Translation: AAS68516.1.
RefSeqiNP_001003820.1. NM_001003820.1.
UniGeneiRn.124394.

Genome annotation databases

EnsembliENSRNOT00000042977; ENSRNOP00000039866; ENSRNOG00000032706.
GeneIDi445371.
KEGGirno:445371.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY567970 mRNA. Translation: AAS68516.1.
RefSeqiNP_001003820.1. NM_001003820.1.
UniGeneiRn.124394.

3D structure databases

ProteinModelPortaliQ6Q1P3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039866.

Proteomic databases

PaxDbiQ6Q1P3.
PRIDEiQ6Q1P3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000042977; ENSRNOP00000039866; ENSRNOG00000032706.
GeneIDi445371.
KEGGirno:445371.

Organism-specific databases

CTDi338567.
RGDi1303091. Kcnk18.

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00700000104522.
HOGENOMiHOG000074045.
HOVERGENiHBG104673.
InParanoidiQ6Q1P3.
OMAiAFKLVQN.
OrthoDBiEOG7MPRDX.
PhylomeDBiQ6Q1P3.
TreeFamiTF316115.

Enzyme and pathway databases

ReactomeiR-RNO-1299344. TWIK-related spinal cord K+ channel (TRESK).

Miscellaneous databases

NextBioi697102.
PROiQ6Q1P3.

Gene expression databases

ExpressionAtlasiQ6Q1P3. baseline and differential.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01095. TASKCHANNEL.
ProtoNetiSearch...

Publicationsi

  1. "Species-specific differences in response to anesthetics and other modulators by the K2P channel TRESK."
    Keshavaprasad B., Liu C., Au J.D., Kindler C.H., Cotten J.F., Yost C.S.
    Anesth. Analg. 101:1042-1049(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: Sprague-Dawley.
    Tissue: Spinal cord.

Entry informationi

Entry nameiKCNKI_RAT
AccessioniPrimary (citable) accession number: Q6Q1P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.