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Q6Q151 (CYP59_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptidyl-prolyl cis-trans isomerase CYP59

Short name=AtCYP59
Short name=PPIase CYP59
EC=5.2.1.8
Alternative name(s):
Cyclophilin-59
Gene names
Name:CYP59
Ordered Locus Names:At1g53720
ORF Names:F22G10.24
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length506 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Influences somehow regulation of RNA pol II (CTD) phosphorylation. Binds RNA with preferences for GC-rich sequences. Probably involved in activities connecting transcription and pre-mRNA processing. Involved in brassinostroid response. Ref.6 Ref.8

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0).

Subunit structure

Component of the BZR1 complex. Interacts with NRPB1 (via CTD domain), SCL28, SCL30, SCL30A, SCL33, SC35, SR30, SR34, RSZ21, RS2Z33, RS31 and RS40. Ref.6 Ref.7

Subcellular location

Nucleus. Note: Shows a punctuate localization pattern distinct from the nuclear speckles. Ref.6

Tissue specificity

Ubiquitous. Ref.1 Ref.5 Ref.6

Sequence similarities

Belongs to the cyclophilin-type PPIase family.

Contains 1 CCHC-type zinc finger.

Contains 1 PPIase cyclophilin-type domain.

Contains 1 RRM (RNA recognition motif) domain.

Sequence caution

The sequence AAG51976.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Binary interactions

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6Q151-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6Q151-2)

The sequence of this isoform differs from the canonical sequence as follows:
     441-506: HRERKERESREDEDRRRRRRREESRDKESRRERDEDDHRSHRDYKERRRERDDRHGREARHERRDR → L

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 506506Peptidyl-prolyl cis-trans isomerase CYP59
PRO_0000429607

Regions

Domain1 – 161161PPIase cyclophilin-type
Domain243 – 32179RRM
Zinc finger341 – 35717CCHC-type
Compositional bias397 – 506110Arg-rich

Natural variations

Alternative sequence441 – 50666HRERK…ERRDR → L in isoform 2.
VSP_055001

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: EB33E6544794283E

FASTA50658,829
        10         20         30         40         50         60 
MSVLIVTSLG DIVIDLHSDK CPLTCKNFLK LCKIKYYNGC LFHTVQKDFT AQTGDPTGTG 

        70         80         90        100        110        120 
AGGDSIYKFL YGEQARFYKD EIHLDLKHSK TGTVAMASGG ENLNASQFYF TLRDDLDYLD 

       130        140        150        160        170        180 
GKHTVFGQIA EGFDTLTRIN EAYVDPKNRP YKNIRIKHTH ILDDPFDDPP QLAEMMPDAS 

       190        200        210        220        230        240 
PEGKPKEEVK DDVRLEDDWV PMDEELGAQE LEEVIREKAA HSSAVVLESI GDIPEAEVKP 

       250        260        270        280        290        300 
PDNVLFVCKL NPVTEDEDLH TIFSRFGTVV SADVIRDFKT GDSLCYAFIE FENKESCEQA 

       310        320        330        340        350        360 
YFKMDNALID DRRIHVDFSQ SVSKLWSQFR QKDSQKGKGN GCFKCGSTDH IAKDCVGGPS 

       370        380        390        400        410        420 
SKFIVKDQNR QHGGGEGYEM VFEGDVHETP KHNSHERERS EKIQRRSPHG NGEGKRQHRD 

       430        440        450        460        470        480 
ERDDGRRQHD REDARELERK HRERKERESR EDEDRRRRRR REESRDKESR RERDEDDHRS 

       490        500 
HRDYKERRRE RDDRHGREAR HERRDR 

« Hide

Isoform 2 [UniParc].

Checksum: 6ECB854A92F03990
Show »

FASTA44150,057

References

« Hide 'large scale' references
[1]"The Arabidopsis cyclophilin gene family."
Romano P.G.N., Horton P., Gray J.E.
Plant Physiol. 134:1268-1282(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, GENE FAMILY, NOMENCLATURE.
[2]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[3]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[4]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: cv. Columbia.
[5]"Immunophilins and parvulins. Superfamily of peptidyl prolyl isomerases in Arabidopsis."
He Z., Li L., Luan S.
Plant Physiol. 134:1248-1267(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE, TISSUE SPECIFICITY.
Strain: cv. Columbia.
[6]"AtCyp59 is a multidomain cyclophilin from Arabidopsis thaliana that interacts with SR proteins and the C-terminal domain of the RNA polymerase II."
Gullerova M., Barta A., Lorkovic Z.J.
RNA 12:631-643(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH NRPB1; SCL28; SCL30; SCL30A; SCL33; SC35; SR30; SR34; RSZ21; RS2Z33; RS31 AND RS40, SUBCELLULAR LOCATION, RNA-BINDING.
[7]"Identification of BZR1-interacting proteins as potential components of the brassinosteroid signaling pathway in Arabidopsis through tandem affinity purification."
Wang C., Shang J.X., Chen Q.X., Oses-Prieto J.A., Bai M.Y., Yang Y., Yuan M., Zhang Y.L., Mu C.C., Deng Z., Wei C.Q., Burlingame A.L., Wang Z.Y., Sun Y.
Mol. Cell. Proteomics 12:3653-3665(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE BZR1 COMPLEX.
[8]"Identification of RNA targets for the nuclear multidomain cyclophilin atCyp59 and their effect on PPIase activity."
Bannikova O., Zywicki M., Marquez Y., Skrahina T., Kalyna M., Barta A.
Nucleic Acids Res. 41:1783-1796(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY568526 mRNA. Translation: AAS75309.1.
AC024260 Genomic DNA. Translation: AAG51976.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE32989.1.
AY059824 mRNA. Translation: AAL24306.1.
PIRE96577.
RefSeqNP_175776.2. NM_104250.4.
UniGeneAt.37348.

3D structure databases

ProteinModelPortalQ6Q151.
SMRQ6Q151. Positions 2-156, 245-316.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ9C8M7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G53720.1; AT1G53720.1; AT1G53720.
GeneID841810.
KEGGath:AT1G53720.

Organism-specific databases

TAIRAT1G53720.

Phylogenomic databases

eggNOGCOG0652.
HOGENOMHOG000186284.
InParanoidQ6Q151.
KOK12735.
OMAKDVRIRH.
PhylomeDBQ6Q151.

Enzyme and pathway databases

BioCycARA:AT1G53720-MONOMER.

Gene expression databases

GenevestigatorQ6Q151.

Family and domain databases

Gene3D2.40.100.10. 1 hit.
3.30.70.330. 1 hit.
InterProIPR029000. Cyclophilin-like_dom.
IPR002130. Cyclophilin-type_PPIase_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR001878. Znf_CCHC.
[Graphical view]
PfamPF00160. Pro_isomerase. 1 hit.
PF00076. RRM_1. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
PRINTSPR00153. CSAPPISMRASE.
SMARTSM00360. RRM. 1 hit.
SM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMSSF50891. SSF50891. 1 hit.
PROSITEPS50072. CSA_PPIASE_2. 1 hit.
PS50102. RRM. 1 hit.
PS50158. ZF_CCHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ6Q151.

Entry information

Entry nameCYP59_ARATH
AccessionPrimary (citable) accession number: Q6Q151
Secondary accession number(s): Q93YQ8, Q9C8M7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 9, 2014
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names