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Q6Q151

- CYP59_ARATH

UniProt

Q6Q151 - CYP59_ARATH

Protein

Peptidyl-prolyl cis-trans isomerase CYP59

Gene

CYP59

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Influences somehow regulation of RNA pol II (CTD) phosphorylation. Binds RNA with preferences for GC-rich sequences. Probably involved in activities connecting transcription and pre-mRNA processing. Involved in brassinostroid response.2 Publications

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri341 – 35717CCHC-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW
    3. protein binding Source: IntAct
    4. RNA binding Source: TAIR
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. protein folding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase, Rotamase

    Keywords - Ligandi

    Metal-binding, RNA-binding, Zinc

    Enzyme and pathway databases

    BioCyciARA:AT1G53720-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase CYP59 (EC:5.2.1.8)
    Short name:
    AtCYP59
    Short name:
    PPIase CYP59
    Alternative name(s):
    Cyclophilin-59
    Gene namesi
    Name:CYP59
    Ordered Locus Names:At1g53720
    ORF Names:F22G10.24
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G53720.

    Subcellular locationi

    Nucleus 1 Publication
    Note: Shows a punctuate localization pattern distinct from the nuclear speckles.

    GO - Cellular componenti

    1. cytosol Source: TAIR
    2. nucleus Source: TAIR

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 506506Peptidyl-prolyl cis-trans isomerase CYP59PRO_0000429607Add
    BLAST

    Proteomic databases

    PRIDEiQ9C8M7.

    Expressioni

    Tissue specificityi

    Ubiquitous.3 Publications

    Gene expression databases

    GenevestigatoriQ6Q151.

    Interactioni

    Subunit structurei

    Component of the BZR1 complex. Interacts with NRPB1 (via CTD domain), SCL28, SCL30, SCL30A, SCL33, SC35, SR30, SR34, RSZ21, RS2Z33, RS31 and RS40.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NRPB1P186163EBI-1625989,EBI-1540537
    SCL33Q9SEU43EBI-1625989,EBI-927103

    Protein-protein interaction databases

    IntActiQ6Q151. 14 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6Q151.
    SMRiQ6Q151. Positions 2-156, 245-316.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 161161PPIase cyclophilin-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini243 – 32179RRMPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi397 – 506110Arg-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cyclophilin-type PPIase family.Curated
    Contains 1 CCHC-type zinc finger.PROSITE-ProRule annotation
    Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation
    Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri341 – 35717CCHC-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG0652.
    HOGENOMiHOG000186284.
    InParanoidiQ6Q151.
    KOiK12735.
    OMAiKDVRIRH.
    PhylomeDBiQ6Q151.

    Family and domain databases

    Gene3Di2.40.100.10. 1 hit.
    3.30.70.330. 1 hit.
    InterProiIPR029000. Cyclophilin-like_dom.
    IPR002130. Cyclophilin-type_PPIase_dom.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    IPR001878. Znf_CCHC.
    [Graphical view]
    PfamiPF00160. Pro_isomerase. 1 hit.
    PF00076. RRM_1. 1 hit.
    PF00098. zf-CCHC. 1 hit.
    [Graphical view]
    PRINTSiPR00153. CSAPPISMRASE.
    SMARTiSM00360. RRM. 1 hit.
    SM00343. ZnF_C2HC. 1 hit.
    [Graphical view]
    SUPFAMiSSF50891. SSF50891. 1 hit.
    PROSITEiPS50072. CSA_PPIASE_2. 1 hit.
    PS50102. RRM. 1 hit.
    PS50158. ZF_CCHC. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6Q151-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSVLIVTSLG DIVIDLHSDK CPLTCKNFLK LCKIKYYNGC LFHTVQKDFT    50
    AQTGDPTGTG AGGDSIYKFL YGEQARFYKD EIHLDLKHSK TGTVAMASGG 100
    ENLNASQFYF TLRDDLDYLD GKHTVFGQIA EGFDTLTRIN EAYVDPKNRP 150
    YKNIRIKHTH ILDDPFDDPP QLAEMMPDAS PEGKPKEEVK DDVRLEDDWV 200
    PMDEELGAQE LEEVIREKAA HSSAVVLESI GDIPEAEVKP PDNVLFVCKL 250
    NPVTEDEDLH TIFSRFGTVV SADVIRDFKT GDSLCYAFIE FENKESCEQA 300
    YFKMDNALID DRRIHVDFSQ SVSKLWSQFR QKDSQKGKGN GCFKCGSTDH 350
    IAKDCVGGPS SKFIVKDQNR QHGGGEGYEM VFEGDVHETP KHNSHERERS 400
    EKIQRRSPHG NGEGKRQHRD ERDDGRRQHD REDARELERK HRERKERESR 450
    EDEDRRRRRR REESRDKESR RERDEDDHRS HRDYKERRRE RDDRHGREAR 500
    HERRDR 506
    Length:506
    Mass (Da):58,829
    Last modified:July 5, 2004 - v1
    Checksum:iEB33E6544794283E
    GO
    Isoform 2 (identifier: Q6Q151-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         441-506: HRERKERESREDEDRRRRRRREESRDKESRRERDEDDHRSHRDYKERRRERDDRHGREARHERRDR → L

    Show »
    Length:441
    Mass (Da):50,057
    Checksum:i6ECB854A92F03990
    GO

    Sequence cautioni

    The sequence AAG51976.1 differs from that shown. Reason: Erroneous gene model prediction.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei441 – 50666HRERK…ERRDR → L in isoform 2. 1 PublicationVSP_055001Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY568526 mRNA. Translation: AAS75309.1.
    AC024260 Genomic DNA. Translation: AAG51976.1. Sequence problems.
    CP002684 Genomic DNA. Translation: AEE32989.1.
    AY059824 mRNA. Translation: AAL24306.1.
    PIRiE96577.
    RefSeqiNP_175776.2. NM_104250.4.
    UniGeneiAt.37348.

    Genome annotation databases

    EnsemblPlantsiAT1G53720.1; AT1G53720.1; AT1G53720. [Q6Q151-1]
    GeneIDi841810.
    KEGGiath:AT1G53720.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY568526 mRNA. Translation: AAS75309.1 .
    AC024260 Genomic DNA. Translation: AAG51976.1 . Sequence problems.
    CP002684 Genomic DNA. Translation: AEE32989.1 .
    AY059824 mRNA. Translation: AAL24306.1 .
    PIRi E96577.
    RefSeqi NP_175776.2. NM_104250.4.
    UniGenei At.37348.

    3D structure databases

    ProteinModelPortali Q6Q151.
    SMRi Q6Q151. Positions 2-156, 245-316.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q6Q151. 14 interactions.

    Proteomic databases

    PRIDEi Q9C8M7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G53720.1 ; AT1G53720.1 ; AT1G53720 . [Q6Q151-1 ]
    GeneIDi 841810.
    KEGGi ath:AT1G53720.

    Organism-specific databases

    TAIRi AT1G53720.

    Phylogenomic databases

    eggNOGi COG0652.
    HOGENOMi HOG000186284.
    InParanoidi Q6Q151.
    KOi K12735.
    OMAi KDVRIRH.
    PhylomeDBi Q6Q151.

    Enzyme and pathway databases

    BioCyci ARA:AT1G53720-MONOMER.

    Miscellaneous databases

    PROi Q6Q151.

    Gene expression databases

    Genevestigatori Q6Q151.

    Family and domain databases

    Gene3Di 2.40.100.10. 1 hit.
    3.30.70.330. 1 hit.
    InterProi IPR029000. Cyclophilin-like_dom.
    IPR002130. Cyclophilin-type_PPIase_dom.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    IPR001878. Znf_CCHC.
    [Graphical view ]
    Pfami PF00160. Pro_isomerase. 1 hit.
    PF00076. RRM_1. 1 hit.
    PF00098. zf-CCHC. 1 hit.
    [Graphical view ]
    PRINTSi PR00153. CSAPPISMRASE.
    SMARTi SM00360. RRM. 1 hit.
    SM00343. ZnF_C2HC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50891. SSF50891. 1 hit.
    PROSITEi PS50072. CSA_PPIASE_2. 1 hit.
    PS50102. RRM. 1 hit.
    PS50158. ZF_CCHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, GENE FAMILY, NOMENCLATURE.
    2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: cv. Columbia.
    5. "Immunophilins and parvulins. Superfamily of peptidyl prolyl isomerases in Arabidopsis."
      He Z., Li L., Luan S.
      Plant Physiol. 134:1248-1267(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE, TISSUE SPECIFICITY.
      Strain: cv. Columbia.
    6. "AtCyp59 is a multidomain cyclophilin from Arabidopsis thaliana that interacts with SR proteins and the C-terminal domain of the RNA polymerase II."
      Gullerova M., Barta A., Lorkovic Z.J.
      RNA 12:631-643(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH NRPB1; SCL28; SCL30; SCL30A; SCL33; SC35; SR30; SR34; RSZ21; RS2Z33; RS31 AND RS40, SUBCELLULAR LOCATION, RNA-BINDING.
    7. "Identification of BZR1-interacting proteins as potential components of the brassinosteroid signaling pathway in Arabidopsis through tandem affinity purification."
      Wang C., Shang J.X., Chen Q.X., Oses-Prieto J.A., Bai M.Y., Yang Y., Yuan M., Zhang Y.L., Mu C.C., Deng Z., Wei C.Q., Burlingame A.L., Wang Z.Y., Sun Y.
      Mol. Cell. Proteomics 12:3653-3665(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE BZR1 COMPLEX.
    8. "Identification of RNA targets for the nuclear multidomain cyclophilin atCyp59 and their effect on PPIase activity."
      Bannikova O., Zywicki M., Marquez Y., Skrahina T., Kalyna M., Barta A.
      Nucleic Acids Res. 41:1783-1796(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiCYP59_ARATH
    AccessioniPrimary (citable) accession number: Q6Q151
    Secondary accession number(s): Q93YQ8, Q9C8M7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 9, 2014
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3