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Protein

Peptidyl-prolyl cis-trans isomerase CYP59

Gene

CYP59

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Influences somehow regulation of RNA pol II (CTD) phosphorylation. Binds RNA with preferences for GC-rich sequences. Probably involved in activities connecting transcription and pre-mRNA processing. Involved in brassinostroid response.2 Publications

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri341 – 357CCHC-typePROSITE-ProRule annotationAdd BLAST17

GO - Molecular functioni

  • peptidyl-prolyl cis-trans isomerase activity Source: GO_Central
  • RNA binding Source: TAIR
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionIsomerase, RNA-binding, Rotamase
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-ATH-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase CYP59 (EC:5.2.1.8)
Short name:
AtCYP59
Short name:
PPIase CYP59
Alternative name(s):
Cyclophilin-59
Gene namesi
Name:CYP59
Ordered Locus Names:At1g53720
ORF Names:F22G10.24
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G53720
TAIRilocus:2024852 AT1G53720

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004296071 – 506Peptidyl-prolyl cis-trans isomerase CYP59Add BLAST506

Proteomic databases

PaxDbiQ6Q151
PRIDEiQ6Q151

PTM databases

iPTMnetiQ6Q151

Expressioni

Tissue specificityi

Ubiquitous.3 Publications

Gene expression databases

ExpressionAtlasiQ6Q151 baseline and differential
GenevisibleiQ6Q151 AT

Interactioni

Subunit structurei

Component of the BZR1 complex. Interacts with NRPB1 (via CTD domain), SCL28, SCL30, SCL30A, SCL33, SC35, SR30, SR34, RSZ21, RS2Z33, RS31 and RS40.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi27035, 13 interactors
IntActiQ6Q151, 14 interactors
STRINGi3702.AT1G53720.1

Structurei

3D structure databases

ProteinModelPortaliQ6Q151
SMRiQ6Q151
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 161PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST161
Domaini243 – 321RRMPROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi397 – 506Arg-richAdd BLAST110

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri341 – 357CCHC-typePROSITE-ProRule annotationAdd BLAST17

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0415 Eukaryota
COG0652 LUCA
HOGENOMiHOG000186284
InParanoidiQ6Q151
KOiK12735
OMAiPRIHHSS
OrthoDBiEOG09360BJU
PhylomeDBiQ6Q151

Family and domain databases

CDDicd01921 cyclophilin_RRM, 1 hit
Gene3Di2.40.100.10, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR035542 CRIP
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR002130 Cyclophilin-type_PPIase_dom
IPR035538 Cyclophilin_PPIL4
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR001878 Znf_CCHC
PANTHERiPTHR11071 PTHR11071, 2 hits
PTHR11071:SF156 PTHR11071:SF156, 2 hits
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PF00076 RRM_1, 1 hit
PF00098 zf-CCHC, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SM00343 ZnF_C2HC, 1 hit
SUPFAMiSSF50891 SSF50891, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50072 CSA_PPIASE_2, 1 hit
PS50102 RRM, 1 hit
PS50158 ZF_CCHC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6Q151-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVLIVTSLG DIVIDLHSDK CPLTCKNFLK LCKIKYYNGC LFHTVQKDFT
60 70 80 90 100
AQTGDPTGTG AGGDSIYKFL YGEQARFYKD EIHLDLKHSK TGTVAMASGG
110 120 130 140 150
ENLNASQFYF TLRDDLDYLD GKHTVFGQIA EGFDTLTRIN EAYVDPKNRP
160 170 180 190 200
YKNIRIKHTH ILDDPFDDPP QLAEMMPDAS PEGKPKEEVK DDVRLEDDWV
210 220 230 240 250
PMDEELGAQE LEEVIREKAA HSSAVVLESI GDIPEAEVKP PDNVLFVCKL
260 270 280 290 300
NPVTEDEDLH TIFSRFGTVV SADVIRDFKT GDSLCYAFIE FENKESCEQA
310 320 330 340 350
YFKMDNALID DRRIHVDFSQ SVSKLWSQFR QKDSQKGKGN GCFKCGSTDH
360 370 380 390 400
IAKDCVGGPS SKFIVKDQNR QHGGGEGYEM VFEGDVHETP KHNSHERERS
410 420 430 440 450
EKIQRRSPHG NGEGKRQHRD ERDDGRRQHD REDARELERK HRERKERESR
460 470 480 490 500
EDEDRRRRRR REESRDKESR RERDEDDHRS HRDYKERRRE RDDRHGREAR

HERRDR
Length:506
Mass (Da):58,829
Last modified:July 5, 2004 - v1
Checksum:iEB33E6544794283E
GO
Isoform 2 (identifier: Q6Q151-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     441-506: HRERKERESREDEDRRRRRRREESRDKESRRERDEDDHRSHRDYKERRRERDDRHGREARHERRDR → L

Show »
Length:441
Mass (Da):50,057
Checksum:i6ECB854A92F03990
GO

Sequence cautioni

The sequence AAG51976 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055001441 – 506HRERK…ERRDR → L in isoform 2. 1 PublicationAdd BLAST66

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY568526 mRNA Translation: AAS75309.1
AC024260 Genomic DNA Translation: AAG51976.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE32989.1
AY059824 mRNA Translation: AAL24306.1
PIRiE96577
RefSeqiNP_175776.2, NM_104250.5 [Q6Q151-1]
UniGeneiAt.37348

Genome annotation databases

EnsemblPlantsiAT1G53720.1; AT1G53720.1; AT1G53720 [Q6Q151-1]
GeneIDi841810
GrameneiAT1G53720.1; AT1G53720.1; AT1G53720 [Q6Q151-1]
KEGGiath:AT1G53720

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCYP59_ARATH
AccessioniPrimary (citable) accession number: Q6Q151
Secondary accession number(s): Q93YQ8, Q9C8M7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 9, 2014
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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