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Protein

Peptidyl-prolyl cis-trans isomerase CYP59

Gene

CYP59

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Influences somehow regulation of RNA pol II (CTD) phosphorylation. Binds RNA with preferences for GC-rich sequences. Probably involved in activities connecting transcription and pre-mRNA processing. Involved in brassinostroid response.2 Publications

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri341 – 357CCHC-typePROSITE-ProRule annotationAdd BLAST17

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase CYP59 (EC:5.2.1.8)
Short name:
AtCYP59
Short name:
PPIase CYP59
Alternative name(s):
Cyclophilin-59
Gene namesi
Name:CYP59
Ordered Locus Names:At1g53720
ORF Names:F22G10.24
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G53720.

Subcellular locationi

  • Nucleus 1 Publication

  • Note: Shows a punctuate localization pattern distinct from the nuclear speckles.

GO - Cellular componenti

  • cytosol Source: TAIR
  • nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004296071 – 506Peptidyl-prolyl cis-trans isomerase CYP59Add BLAST506

Proteomic databases

PaxDbiQ6Q151.

PTM databases

iPTMnetiQ6Q151.

Expressioni

Tissue specificityi

Ubiquitous.3 Publications

Gene expression databases

GenevisibleiQ6Q151. AT.

Interactioni

Subunit structurei

Component of the BZR1 complex. Interacts with NRPB1 (via CTD domain), SCL28, SCL30, SCL30A, SCL33, SC35, SR30, SR34, RSZ21, RS2Z33, RS31 and RS40.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NRPB1P186163EBI-1625989,EBI-1540537
SCL33Q9SEU43EBI-1625989,EBI-927103

Protein-protein interaction databases

BioGridi27035. 13 interactors.
IntActiQ6Q151. 14 interactors.
STRINGi3702.AT1G53720.1.

Structurei

3D structure databases

ProteinModelPortaliQ6Q151.
SMRiQ6Q151.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 161PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST161
Domaini243 – 321RRMPROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi397 – 506Arg-richAdd BLAST110

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated
Contains 1 CCHC-type zinc finger.PROSITE-ProRule annotation
Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri341 – 357CCHC-typePROSITE-ProRule annotationAdd BLAST17

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0415. Eukaryota.
COG0652. LUCA.
HOGENOMiHOG000186284.
InParanoidiQ6Q151.
KOiK12735.
OMAiHERERSE.
OrthoDBiEOG09360BJU.
PhylomeDBiQ6Q151.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
3.30.70.330. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR002130. Cyclophilin-type_PPIase_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR001878. Znf_CCHC.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
PF00076. RRM_1. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SMARTiSM00360. RRM. 1 hit.
SM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF50891. SSF50891. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiPS50072. CSA_PPIASE_2. 1 hit.
PS50102. RRM. 1 hit.
PS50158. ZF_CCHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6Q151-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVLIVTSLG DIVIDLHSDK CPLTCKNFLK LCKIKYYNGC LFHTVQKDFT
60 70 80 90 100
AQTGDPTGTG AGGDSIYKFL YGEQARFYKD EIHLDLKHSK TGTVAMASGG
110 120 130 140 150
ENLNASQFYF TLRDDLDYLD GKHTVFGQIA EGFDTLTRIN EAYVDPKNRP
160 170 180 190 200
YKNIRIKHTH ILDDPFDDPP QLAEMMPDAS PEGKPKEEVK DDVRLEDDWV
210 220 230 240 250
PMDEELGAQE LEEVIREKAA HSSAVVLESI GDIPEAEVKP PDNVLFVCKL
260 270 280 290 300
NPVTEDEDLH TIFSRFGTVV SADVIRDFKT GDSLCYAFIE FENKESCEQA
310 320 330 340 350
YFKMDNALID DRRIHVDFSQ SVSKLWSQFR QKDSQKGKGN GCFKCGSTDH
360 370 380 390 400
IAKDCVGGPS SKFIVKDQNR QHGGGEGYEM VFEGDVHETP KHNSHERERS
410 420 430 440 450
EKIQRRSPHG NGEGKRQHRD ERDDGRRQHD REDARELERK HRERKERESR
460 470 480 490 500
EDEDRRRRRR REESRDKESR RERDEDDHRS HRDYKERRRE RDDRHGREAR

HERRDR
Length:506
Mass (Da):58,829
Last modified:July 5, 2004 - v1
Checksum:iEB33E6544794283E
GO
Isoform 2 (identifier: Q6Q151-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     441-506: HRERKERESREDEDRRRRRRREESRDKESRRERDEDDHRSHRDYKERRRERDDRHGREARHERRDR → L

Show »
Length:441
Mass (Da):50,057
Checksum:i6ECB854A92F03990
GO

Sequence cautioni

The sequence AAG51976 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055001441 – 506HRERK…ERRDR → L in isoform 2. 1 PublicationAdd BLAST66

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY568526 mRNA. Translation: AAS75309.1.
AC024260 Genomic DNA. Translation: AAG51976.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE32989.1.
AY059824 mRNA. Translation: AAL24306.1.
PIRiE96577.
RefSeqiNP_175776.2. NM_104250.5. [Q6Q151-1]
UniGeneiAt.37348.

Genome annotation databases

EnsemblPlantsiAT1G53720.1; AT1G53720.1; AT1G53720. [Q6Q151-1]
GeneIDi841810.
GrameneiAT1G53720.1; AT1G53720.1; AT1G53720.
KEGGiath:AT1G53720.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY568526 mRNA. Translation: AAS75309.1.
AC024260 Genomic DNA. Translation: AAG51976.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE32989.1.
AY059824 mRNA. Translation: AAL24306.1.
PIRiE96577.
RefSeqiNP_175776.2. NM_104250.5. [Q6Q151-1]
UniGeneiAt.37348.

3D structure databases

ProteinModelPortaliQ6Q151.
SMRiQ6Q151.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi27035. 13 interactors.
IntActiQ6Q151. 14 interactors.
STRINGi3702.AT1G53720.1.

PTM databases

iPTMnetiQ6Q151.

Proteomic databases

PaxDbiQ6Q151.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G53720.1; AT1G53720.1; AT1G53720. [Q6Q151-1]
GeneIDi841810.
GrameneiAT1G53720.1; AT1G53720.1; AT1G53720.
KEGGiath:AT1G53720.

Organism-specific databases

TAIRiAT1G53720.

Phylogenomic databases

eggNOGiKOG0415. Eukaryota.
COG0652. LUCA.
HOGENOMiHOG000186284.
InParanoidiQ6Q151.
KOiK12735.
OMAiHERERSE.
OrthoDBiEOG09360BJU.
PhylomeDBiQ6Q151.

Miscellaneous databases

PROiQ6Q151.

Gene expression databases

GenevisibleiQ6Q151. AT.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
3.30.70.330. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR002130. Cyclophilin-type_PPIase_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR001878. Znf_CCHC.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
PF00076. RRM_1. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SMARTiSM00360. RRM. 1 hit.
SM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF50891. SSF50891. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiPS50072. CSA_PPIASE_2. 1 hit.
PS50102. RRM. 1 hit.
PS50158. ZF_CCHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYP59_ARATH
AccessioniPrimary (citable) accession number: Q6Q151
Secondary accession number(s): Q93YQ8, Q9C8M7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 9, 2014
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.