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Protein

Calsyntenin-1

Gene

Clstn1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. As intracellular fragment AlcICD, suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Calsyntenin-1
Alternative name(s):
Alcadein-alpha
Short name:
Alc-alpha
Cleaved into the following 2 chains:
Soluble Alc-alpha
Short name:
SAlc-alpha
Alternative name(s):
C-terminal fragment 1-alpha
Gene namesi
Name:Clstn1
Synonyms:Cs1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1306458. Clstn1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 830802ExtracellularSequence analysisAdd
BLAST
Transmembranei831 – 85121HelicalSequence analysisAdd
BLAST
Topological domaini852 – 952101CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828By similarityAdd
BLAST
Chaini29 – 952924Calsyntenin-1PRO_0000323601Add
BLAST
Chaini29 – 796768Soluble Alc-alphaBy similarityPRO_0000323602Add
BLAST
Chaini797 – 952156CTF1-alphaBy similarityPRO_0000323603Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi356 – 3561N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Proteolytically processed under normal cellular conditions. A primary zeta-cleavage generates a large extracellular (soluble) N-terminal domain (sAlc) and a short C-terminal transmembrane fragment (CTF1). A secondary cleavage catalyzed by presenilin gamma-secretase within the transmembrane domain releases the beta-Alc-alpha chain in the extracellular milieu and produces an intracellular fragment (AlcICD). Beta-Alc-alpha secretion is largely dependent upon PSEN1 and PSEN2. This processing is strongly suppressed in the tripartite complex formed with APBA2 and APP, which seems to prevent the association with PSEN1 (By similarity).By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6Q0N0.
PRIDEiQ6Q0N0.

Expressioni

Tissue specificityi

Preferentially expressed in the retina and brain.1 Publication

Gene expression databases

GenevisibleiQ6Q0N0. RN.

Interactioni

Subunit structurei

Directly interacts with APBA2. Forms a tripartite complex with APBA2 and APP. The CTF1 chain interacts with PSEN1. The intracellular fragment AlcICD interacts with APBB1; this interaction stabilizes AlcICD metabolism. Interacts with KLC1 and APBB1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047223.

Structurei

3D structure databases

ProteinModelPortaliQ6Q0N0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 154117Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini155 – 255101Cadherin 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi887 – 92842Glu-richAdd
BLAST

Domaini

The cytoplasmic domain is involved in interaction with APBA2, as well as the binding of synaptic Ca2+.By similarity

Sequence similaritiesi

Contains 2 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1834. Eukaryota.
ENOG410XT2J. LUCA.
GeneTreeiENSGT00390000010858.
HOGENOMiHOG000037537.
HOVERGENiHBG051146.
InParanoidiQ6Q0N0.
OMAiITSTVKC.
OrthoDBiEOG7SFHVX.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
2.60.40.60. 2 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR026914. Calsyntenin.
IPR013320. ConA-like_dom.
[Graphical view]
PANTHERiPTHR14139. PTHR14139. 1 hit.
PfamiPF00028. Cadherin. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 2 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS50268. CADHERIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6Q0N0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRRPAPALA RAVRLLLAGL LYGGGVWAAR VNKHKPWLEP TYHGIVTEND
60 70 80 90 100
NTVLLDPPLI ALDKDSPLRF AGEICGFKIH GQNVPFDAVV VDKSTGEGII
110 120 130 140 150
RSKEKLDCEL QKDYTFTIQA YDCGKGPDGT GVKKSHKATV HIQVNDVNEY
160 170 180 190 200
APVFKEKSYK AAVVEGKQHG SILRVEAVDA DCSPQFSQIC SYEILTPDVP
210 220 230 240 250
FTVDKDGYIK NTEKLNYGKE HQYKLTVTAY DCGKKRATED VLVKISVKPT
260 270 280 290 300
CSPGWQGWSS RIEYEPGTGA LAVFPSIHLE TCDEPVASVQ ATVELETSHI
310 320 330 340 350
GKGCDRDTYS EKSLHRLCGA AAGTSELLPS PSSSFNWTVG LPTDNGHDSD
360 370 380 390 400
QVFEFNGTQA VRIPDGVVTL DPKEPFTISV WMRHGPFGRK KETILCSSDK
410 420 430 440 450
TDMNRHHYSL YVHGCRLIFL LRQDPSEEKK YRPAEFHWKL NQVCDEDWHH
460 470 480 490 500
FVLNVEVPSV TLYVDGVSHE PFSVTEDYPL HPTKIETQLV VGACWQGGDL
510 520 530 540 550
HMTQFFRGNL AGLTVRSGKL ADKKVIDCLY TCKEGLDLQV PEDGNRGVQI
560 570 580 590 600
QTSSSQAVLT LEGENVGELD KAMQHISYLN SRQFPTPGIR RLKITSTVKC
610 620 630 640 650
FNEAACIEVP PVEGYVMVLQ PEEPKISLSG VHHFARAASE FESPEGVSLF
660 670 680 690 700
PELKIISTIT REVEPEADGA EDPTVQESLV SEEIVHDLDT CEVTVEGEEL
710 720 730 740 750
NAEQESLEVD VARLQQKGIE VNHSDLGVVF TGVETMASYE EVLHLLRYRN
760 770 780 790 800
WHTRSLLDRK FKLICSELNG RYLSNEFKVE VNVIHTANPV EHANHMAAQP
810 820 830 840 850
QFVHPEHRSF VDLSGHNLAS PHPFAVVPST ATVVIVVCVS FLVFMIILGV
860 870 880 890 900
FRIRAAHQRT MRDQDTGKEN EMDWDDSALT ITVNPMETYE DQHSSEEEEE
910 920 930 940 950
EEEEEESEDG EEEEDITSAE SESSEEEEGG PGDGQNTTRQ QQLEWDYSTL

SY
Length:952
Mass (Da):106,261
Last modified:July 5, 2004 - v1
Checksum:iDBE2185AF20F9713
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY569014 mRNA. Translation: AAS75317.1.
RefSeqiNP_001007093.1. NM_001007092.1.
UniGeneiRn.99876.

Genome annotation databases

EnsembliENSRNOT00000045063; ENSRNOP00000047223; ENSRNOG00000016398.
GeneIDi313717.
KEGGirno:313717.
UCSCiRGD:1306458. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY569014 mRNA. Translation: AAS75317.1.
RefSeqiNP_001007093.1. NM_001007092.1.
UniGeneiRn.99876.

3D structure databases

ProteinModelPortaliQ6Q0N0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047223.

Proteomic databases

PaxDbiQ6Q0N0.
PRIDEiQ6Q0N0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000045063; ENSRNOP00000047223; ENSRNOG00000016398.
GeneIDi313717.
KEGGirno:313717.
UCSCiRGD:1306458. rat.

Organism-specific databases

CTDi22883.
RGDi1306458. Clstn1.

Phylogenomic databases

eggNOGiKOG1834. Eukaryota.
ENOG410XT2J. LUCA.
GeneTreeiENSGT00390000010858.
HOGENOMiHOG000037537.
HOVERGENiHBG051146.
InParanoidiQ6Q0N0.
OMAiITSTVKC.
OrthoDBiEOG7SFHVX.

Miscellaneous databases

NextBioi666700.
PROiQ6Q0N0.

Gene expression databases

GenevisibleiQ6Q0N0. RN.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
2.60.40.60. 2 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR026914. Calsyntenin.
IPR013320. ConA-like_dom.
[Graphical view]
PANTHERiPTHR14139. PTHR14139. 1 hit.
PfamiPF00028. Cadherin. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 2 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS50268. CADHERIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Gene expression profile of the rat eye iridocorneal angle: NEIBank expressed sequence tag analysis."
    Ahmed F., Torrado M., Zinovieva R.D., Senatorov V.V., Wistow G., Tomarev S.I.
    Invest. Ophthalmol. Vis. Sci. 45:3081-3090(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Wistar.
    Tissue: Eye.

Entry informationi

Entry nameiCSTN1_RAT
AccessioniPrimary (citable) accession number: Q6Q0N0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2004
Last modified: November 11, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.