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Protein

E3 ubiquitin-protein ligase TRAF7

Gene

TRAF7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed.2 Publications

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri131 – 165RING-typePROSITE-ProRule annotationAdd BLAST35
Zinc fingeri222 – 276TRAF-typePROSITE-ProRule annotationAdd BLAST55

GO - Molecular functioni

  • ubiquitin-protein transferase activity Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • activation of MAPKKK activity Source: UniProtKB
  • apoptotic process Source: MGI
  • positive regulation of apoptotic signaling pathway Source: UniProtKB
  • positive regulation of MAPK cascade Source: MGI
  • protein ubiquitination Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionTransferase
Biological processApoptosis, Transcription, Transcription regulation, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinkiQ6Q0C0.
SIGNORiQ6Q0C0.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRAF7 (EC:2.3.2.27)
Alternative name(s):
RING finger and WD repeat-containing protein 1
RING finger protein 119
RING-type E3 ubiquitin transferase TRAF7Curated
TNF receptor-associated factor 7
Gene namesi
Name:TRAF7
Synonyms:RFWD1, RNF119
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:20456. TRAF7.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

DisGeNETi84231.
OpenTargetsiENSG00000131653.
PharmGKBiPA134917323.

Polymorphism and mutation databases

BioMutaiTRAF7.
DMDMi54036486.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512961 – 670E3 ubiquitin-protein ligase TRAF7Add BLAST670

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61PhosphoserineCombined sources1
Modified residuei88PhosphoserineCombined sources1
Modified residuei91PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by MAP3K3.1 Publication
Ubiquitinates itself upon phosphorylation.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ6Q0C0.
MaxQBiQ6Q0C0.
PaxDbiQ6Q0C0.
PeptideAtlasiQ6Q0C0.
PRIDEiQ6Q0C0.

PTM databases

iPTMnetiQ6Q0C0.
PhosphoSitePlusiQ6Q0C0.

Expressioni

Tissue specificityi

Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta.1 Publication

Gene expression databases

BgeeiENSG00000131653.
CleanExiHS_TRAF7.
ExpressionAtlasiQ6Q0C0. baseline and differential.
GenevisibleiQ6Q0C0. HS.

Organism-specific databases

HPAiHPA041229.

Interactioni

Subunit structurei

Homodimer. Interacts with MAP3K3 and promotes the kinase activity of this enzyme.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi123964. 45 interactors.
IntActiQ6Q0C0. 12 interactors.
MINTiMINT-1161375.
STRINGi9606.ENSP00000318944.

Structurei

3D structure databases

ProteinModelPortaliQ6Q0C0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati394 – 433WD 1Sequence analysisAdd BLAST40
Repeati437 – 474WD 2Sequence analysisAdd BLAST38
Repeati477 – 513WD 3Sequence analysisAdd BLAST37
Repeati515 – 554WD 4Sequence analysisAdd BLAST40
Repeati557 – 594WD 5Sequence analysisAdd BLAST38
Repeati597 – 638WD 6Sequence analysisAdd BLAST42
Repeati641 – 669WD 7Sequence analysisAdd BLAST29

Sequence similaritiesi

Belongs to the WD repeat TRAF7 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri131 – 165RING-typePROSITE-ProRule annotationAdd BLAST35
Zinc fingeri222 – 276TRAF-typePROSITE-ProRule annotationAdd BLAST55

Keywords - Domaini

Repeat, WD repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0274. Eukaryota.
KOG0297. Eukaryota.
ENOG410XNP5. LUCA.
GeneTreeiENSGT00760000119106.
HOGENOMiHOG000220840.
HOVERGENiHBG055270.
InParanoidiQ6Q0C0.
KOiK10646.
OMAiHSESNMS.
OrthoDBiEOG091G02YZ.
PhylomeDBiQ6Q0C0.
TreeFamiTF328643.

Family and domain databases

CDDicd00162. RING. 1 hit.
Gene3Di2.130.10.10. 2 hits.
3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR020472. G-protein_beta_WD-40_rep.
IPR008974. TRAF-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR027370. Znf-RING_LisH.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
IPR001293. Znf_TRAF.
PfamiView protein in Pfam
PF00400. WD40. 4 hits.
PF13445. zf-RING_UBOX. 1 hit.
PRINTSiPR00320. GPROTEINBRPT.
SMARTiView protein in SMART
SM00184. RING. 1 hit.
SM00320. WD40. 7 hits.
SUPFAMiSSF49599. SSF49599. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
PS50145. ZF_TRAF. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q6Q0C0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSGKSARYN RFSGGPSNLP TPDVTTGTRM ETTFGPAFSA VTTITKADGT
60 70 80 90 100
STYKQHCRTP SSSSTLAYSP RDEEDSMPPI STPRRSDSAI SVRSLHSESS
110 120 130 140 150
MSLRSTFSLP EEEEEPEPLV FAEQPSVKLC CQLCCSVFKD PVITTCGHTF
160 170 180 190 200
CRRCALKSEK CPVDNVKLTV VVNNIAVAEQ IGELFIHCRH GCRVAGSGKP
210 220 230 240 250
PIFEVDPRGC PFTIKLSARK DHEGSCDYRP VRCPNNPSCP PLLRMNLEAH
260 270 280 290 300
LKECEHIKCP HSKYGCTFIG NQDTYETHLE TCRFEGLKEF LQQTDDRFHE
310 320 330 340 350
MHVALAQKDQ EIAFLRSMLG KLSEKIDQLE KSLELKFDVL DENQSKLSED
360 370 380 390 400
LMEFRRDASM LNDELSHINA RLNMGILGSY DPQQIFKCKG TFVGHQGPVW
410 420 430 440 450
CLCVYSMGDL LFSGSSDKTI KVWDTCTTYK CQKTLEGHDG IVLALCIQGC
460 470 480 490 500
KLYSGSADCT IIVWDIQNLQ KVNTIRAHDN PVCTLVSSHN VLFSGSLKAI
510 520 530 540 550
KVWDIVGTEL KLKKELTGLN HWVRALVAAQ SYLYSGSYQT IKIWDIRTLD
560 570 580 590 600
CIHVLQTSGG SVYSIAVTNH HIVCGTYENL IHVWDIESKE QVRTLTGHVG
610 620 630 640 650
TVYALAVIST PDQTKVFSAS YDRSLRVWSM DNMICTQTLL RHQGSVTALA
660 670
VSRGRLFSGA VDSTVKVWTC
Length:670
Mass (Da):74,609
Last modified:July 5, 2004 - v1
Checksum:i5624045D674849C6
GO
Isoform 21 Publication (identifier: Q6Q0C0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.

Show »
Length:594
Mass (Da):66,541
Checksum:i25F8742FBD322058
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0516071 – 76Missing in isoform 2. 2 PublicationsAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY569455 mRNA. Translation: AAS68363.1.
AL136921 mRNA. Translation: CAB66855.1.
CCDSiCCDS10461.1. [Q6Q0C0-1]
RefSeqiNP_115647.2. NM_032271.2. [Q6Q0C0-1]
UniGeneiHs.713632.

Genome annotation databases

EnsembliENST00000326181; ENSP00000318944; ENSG00000131653. [Q6Q0C0-1]
GeneIDi84231.
KEGGihsa:84231.
UCSCiuc002cow.4. human. [Q6Q0C0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTRAF7_HUMAN
AccessioniPrimary (citable) accession number: Q6Q0C0
Secondary accession number(s): Q9H073
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: July 5, 2004
Last modified: May 10, 2017
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families