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Protein

E3 ubiquitin-protein ligase TRAF7

Gene

TRAF7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed.2 Publications

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri131 – 16535RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri222 – 27655TRAF-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. ubiquitin-protein transferase activity Source: UniProtKB
  3. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. activation of MAPKKK activity Source: UniProtKB
  2. apoptotic process Source: MGI
  3. cellular response to interleukin-6 Source: Ensembl
  4. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  5. positive regulation of apoptotic signaling pathway Source: UniProtKB
  6. positive regulation of MAPK cascade Source: MGI
  7. positive regulation of protein sumoylation Source: Ensembl
  8. protein ubiquitination Source: UniProtKB
  9. regulation of protein localization Source: Ensembl
  10. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ6Q0C0.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRAF7 (EC:6.3.2.-)
Alternative name(s):
RING finger and WD repeat-containing protein 1
RING finger protein 119
TNF receptor-associated factor 7
Gene namesi
Name:TRAF7
Synonyms:RFWD1, RNF119
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:20456. TRAF7.

Subcellular locationi

Cytoplasmic vesicle 1 Publication
Note: Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm.

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
  2. cytosol Source: Ensembl
  3. intracellular membrane-bounded organelle Source: HPA
  4. nucleus Source: Ensembl
  5. perinuclear region of cytoplasm Source: Ensembl
  6. plasma membrane Source: HPA
  7. ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134917323.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 670670E3 ubiquitin-protein ligase TRAF7PRO_0000051296Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei88 – 881Phosphoserine1 Publication
Modified residuei91 – 911Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated by MAP3K3.1 Publication
Ubiquitinates itself upon phosphorylation.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ6Q0C0.
PaxDbiQ6Q0C0.
PRIDEiQ6Q0C0.

PTM databases

PhosphoSiteiQ6Q0C0.

Expressioni

Tissue specificityi

Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta.1 Publication

Gene expression databases

BgeeiQ6Q0C0.
CleanExiHS_TRAF7.
ExpressionAtlasiQ6Q0C0. baseline and differential.
GenevestigatoriQ6Q0C0.

Organism-specific databases

HPAiHPA041229.

Interactioni

Subunit structurei

Homodimer. Interacts with MAP3K3 and promotes the kinase activity of this enzyme.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MAP3K3Q997592EBI-307556,EBI-307281
Ripk4Q9ERK02EBI-307556,EBI-6116422From a different organism.

Protein-protein interaction databases

BioGridi123964. 20 interactions.
IntActiQ6Q0C0. 9 interactions.
MINTiMINT-1161375.
STRINGi9606.ENSP00000318944.

Structurei

3D structure databases

ProteinModelPortaliQ6Q0C0.
SMRiQ6Q0C0. Positions 131-266, 387-668.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati394 – 43340WD 1Sequence AnalysisAdd
BLAST
Repeati437 – 47438WD 2Sequence AnalysisAdd
BLAST
Repeati477 – 51337WD 3Sequence AnalysisAdd
BLAST
Repeati515 – 55440WD 4Sequence AnalysisAdd
BLAST
Repeati557 – 59438WD 5Sequence AnalysisAdd
BLAST
Repeati597 – 63842WD 6Sequence AnalysisAdd
BLAST
Repeati641 – 66929WD 7Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the WD repeat TRAF7 family.Curated
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
Contains 1 TRAF-type zinc finger.PROSITE-ProRule annotation
Contains 7 WD repeats.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri131 – 16535RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri222 – 27655TRAF-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, WD repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00760000119106.
HOGENOMiHOG000220840.
HOVERGENiHBG055270.
InParanoidiQ6Q0C0.
KOiK10646.
OMAiHSESNMS.
OrthoDBiEOG7J17Z8.
PhylomeDBiQ6Q0C0.
TreeFamiTF328643.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
3.30.40.10. 1 hit.
3.90.890.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR013323. SIAH-type.
IPR008974. TRAF-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
IPR001293. Znf_TRAF.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00184. RING. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
PS50145. ZF_TRAF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q6Q0C0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSGKSARYN RFSGGPSNLP TPDVTTGTRM ETTFGPAFSA VTTITKADGT
60 70 80 90 100
STYKQHCRTP SSSSTLAYSP RDEEDSMPPI STPRRSDSAI SVRSLHSESS
110 120 130 140 150
MSLRSTFSLP EEEEEPEPLV FAEQPSVKLC CQLCCSVFKD PVITTCGHTF
160 170 180 190 200
CRRCALKSEK CPVDNVKLTV VVNNIAVAEQ IGELFIHCRH GCRVAGSGKP
210 220 230 240 250
PIFEVDPRGC PFTIKLSARK DHEGSCDYRP VRCPNNPSCP PLLRMNLEAH
260 270 280 290 300
LKECEHIKCP HSKYGCTFIG NQDTYETHLE TCRFEGLKEF LQQTDDRFHE
310 320 330 340 350
MHVALAQKDQ EIAFLRSMLG KLSEKIDQLE KSLELKFDVL DENQSKLSED
360 370 380 390 400
LMEFRRDASM LNDELSHINA RLNMGILGSY DPQQIFKCKG TFVGHQGPVW
410 420 430 440 450
CLCVYSMGDL LFSGSSDKTI KVWDTCTTYK CQKTLEGHDG IVLALCIQGC
460 470 480 490 500
KLYSGSADCT IIVWDIQNLQ KVNTIRAHDN PVCTLVSSHN VLFSGSLKAI
510 520 530 540 550
KVWDIVGTEL KLKKELTGLN HWVRALVAAQ SYLYSGSYQT IKIWDIRTLD
560 570 580 590 600
CIHVLQTSGG SVYSIAVTNH HIVCGTYENL IHVWDIESKE QVRTLTGHVG
610 620 630 640 650
TVYALAVIST PDQTKVFSAS YDRSLRVWSM DNMICTQTLL RHQGSVTALA
660 670
VSRGRLFSGA VDSTVKVWTC
Length:670
Mass (Da):74,609
Last modified:July 4, 2004 - v1
Checksum:i5624045D674849C6
GO
Isoform 21 Publication (identifier: Q6Q0C0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.

Show »
Length:594
Mass (Da):66,541
Checksum:i25F8742FBD322058
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7676Missing in isoform 2. 2 PublicationsVSP_051607Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY569455 mRNA. Translation: AAS68363.1.
AL136921 mRNA. Translation: CAB66855.1.
CCDSiCCDS10461.1. [Q6Q0C0-1]
RefSeqiNP_115647.2. NM_032271.2. [Q6Q0C0-1]
UniGeneiHs.713632.

Genome annotation databases

EnsembliENST00000326181; ENSP00000318944; ENSG00000131653. [Q6Q0C0-1]
GeneIDi84231.
KEGGihsa:84231.
UCSCiuc002cow.3. human. [Q6Q0C0-1]

Polymorphism databases

DMDMi54036486.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY569455 mRNA. Translation: AAS68363.1.
AL136921 mRNA. Translation: CAB66855.1.
CCDSiCCDS10461.1. [Q6Q0C0-1]
RefSeqiNP_115647.2. NM_032271.2. [Q6Q0C0-1]
UniGeneiHs.713632.

3D structure databases

ProteinModelPortaliQ6Q0C0.
SMRiQ6Q0C0. Positions 131-266, 387-668.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123964. 20 interactions.
IntActiQ6Q0C0. 9 interactions.
MINTiMINT-1161375.
STRINGi9606.ENSP00000318944.

PTM databases

PhosphoSiteiQ6Q0C0.

Polymorphism databases

DMDMi54036486.

Proteomic databases

MaxQBiQ6Q0C0.
PaxDbiQ6Q0C0.
PRIDEiQ6Q0C0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326181; ENSP00000318944; ENSG00000131653. [Q6Q0C0-1]
GeneIDi84231.
KEGGihsa:84231.
UCSCiuc002cow.3. human. [Q6Q0C0-1]

Organism-specific databases

CTDi84231.
GeneCardsiGC16P002205.
HGNCiHGNC:20456. TRAF7.
HPAiHPA041229.
MIMi606692. gene.
neXtProtiNX_Q6Q0C0.
PharmGKBiPA134917323.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00760000119106.
HOGENOMiHOG000220840.
HOVERGENiHBG055270.
InParanoidiQ6Q0C0.
KOiK10646.
OMAiHSESNMS.
OrthoDBiEOG7J17Z8.
PhylomeDBiQ6Q0C0.
TreeFamiTF328643.

Enzyme and pathway databases

UniPathwayiUPA00143.
SignaLinkiQ6Q0C0.

Miscellaneous databases

ChiTaRSiTRAF7. human.
GenomeRNAii84231.
NextBioi73692.
PROiQ6Q0C0.
SOURCEiSearch...

Gene expression databases

BgeeiQ6Q0C0.
CleanExiHS_TRAF7.
ExpressionAtlasiQ6Q0C0. baseline and differential.
GenevestigatoriQ6Q0C0.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
3.30.40.10. 1 hit.
3.90.890.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR013323. SIAH-type.
IPR008974. TRAF-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
IPR001293. Znf_TRAF.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00184. RING. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
PS50145. ZF_TRAF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis."
    Xu L.-G., Li L.-Y., Shu H.-B.
    J. Biol. Chem. 279:17278-17282(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING, INTERACTION WITH MAP3K3.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Uterus.
  3. Cited for: FUNCTION, PHOSPHORYLATION, SUBCELLULAR LOCATION, HOMODIMERIZATION, INTERACTION WITH MAP3K3.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-88 AND SER-91, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiTRAF7_HUMAN
AccessioniPrimary (citable) accession number: Q6Q0C0
Secondary accession number(s): Q9H073
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2004
Last sequence update: July 4, 2004
Last modified: March 3, 2015
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.