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Q6Q0C0

- TRAF7_HUMAN

UniProt

Q6Q0C0 - TRAF7_HUMAN

Protein

E3 ubiquitin-protein ligase TRAF7

Gene

TRAF7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed.2 Publications

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri131 – 16535RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri222 – 27655TRAF-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. ubiquitin-protein transferase activity Source: UniProtKB
    4. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. activation of MAPKKK activity Source: UniProtKB
    2. apoptotic process Source: MGI
    3. positive regulation of apoptotic signaling pathway Source: UniProtKB
    4. positive regulation of MAPK cascade Source: MGI
    5. protein ubiquitination Source: UniProtKB
    6. regulation of transcription, DNA-templated Source: UniProtKB-KW
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Apoptosis, Transcription, Transcription regulation, Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    SignaLinkiQ6Q0C0.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E3 ubiquitin-protein ligase TRAF7 (EC:6.3.2.-)
    Alternative name(s):
    RING finger and WD repeat-containing protein 1
    RING finger protein 119
    TNF receptor-associated factor 7
    Gene namesi
    Name:TRAF7
    Synonyms:RFWD1, RNF119
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:20456. TRAF7.

    Subcellular locationi

    Cytoplasmic vesicle 1 Publication
    Note: Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm.

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
    2. ubiquitin ligase complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasmic vesicle

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134917323.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 670670E3 ubiquitin-protein ligase TRAF7PRO_0000051296Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei88 – 881Phosphoserine2 Publications
    Modified residuei91 – 911Phosphoserine2 Publications

    Post-translational modificationi

    Phosphorylated by MAP3K3.1 Publication
    Ubiquitinates itself upon phosphorylation.

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ6Q0C0.
    PaxDbiQ6Q0C0.
    PRIDEiQ6Q0C0.

    PTM databases

    PhosphoSiteiQ6Q0C0.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta.1 Publication

    Gene expression databases

    ArrayExpressiQ6Q0C0.
    BgeeiQ6Q0C0.
    CleanExiHS_TRAF7.
    GenevestigatoriQ6Q0C0.

    Organism-specific databases

    HPAiHPA041229.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with MAP3K3 and promotes the kinase activity of this enzyme.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MAP3K3Q997592EBI-307556,EBI-307281
    Ripk4Q9ERK02EBI-307556,EBI-6116422From a different organism.

    Protein-protein interaction databases

    BioGridi123964. 9 interactions.
    IntActiQ6Q0C0. 9 interactions.
    MINTiMINT-1161375.
    STRINGi9606.ENSP00000318944.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6Q0C0.
    SMRiQ6Q0C0. Positions 131-266, 387-668.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati394 – 43340WD 1Sequence AnalysisAdd
    BLAST
    Repeati437 – 47438WD 2Sequence AnalysisAdd
    BLAST
    Repeati477 – 51337WD 3Sequence AnalysisAdd
    BLAST
    Repeati515 – 55440WD 4Sequence AnalysisAdd
    BLAST
    Repeati557 – 59438WD 5Sequence AnalysisAdd
    BLAST
    Repeati597 – 63842WD 6Sequence AnalysisAdd
    BLAST
    Repeati641 – 66929WD 7Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the WD repeat TRAF7 family.Curated
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
    Contains 1 TRAF-type zinc finger.PROSITE-ProRule annotation
    Contains 7 WD repeats.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri131 – 16535RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri222 – 27655TRAF-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, WD repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG2319.
    HOGENOMiHOG000220840.
    HOVERGENiHBG055270.
    InParanoidiQ6Q0C0.
    KOiK10646.
    OMAiHSESNMS.
    OrthoDBiEOG7J17Z8.
    PhylomeDBiQ6Q0C0.
    TreeFamiTF328643.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    3.30.40.10. 1 hit.
    3.90.890.10. 1 hit.
    InterProiIPR020472. G-protein_beta_WD-40_rep.
    IPR013323. SIAH-type.
    IPR008974. TRAF-like.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    IPR001293. Znf_TRAF.
    [Graphical view]
    PfamiPF00400. WD40. 7 hits.
    [Graphical view]
    PRINTSiPR00320. GPROTEINBRPT.
    SMARTiSM00184. RING. 1 hit.
    SM00320. WD40. 7 hits.
    [Graphical view]
    SUPFAMiSSF49599. SSF49599. 2 hits.
    SSF50978. SSF50978. 1 hit.
    PROSITEiPS00678. WD_REPEATS_1. 2 hits.
    PS50082. WD_REPEATS_2. 5 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    PS50145. ZF_TRAF. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: Q6Q0C0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSGKSARYN RFSGGPSNLP TPDVTTGTRM ETTFGPAFSA VTTITKADGT    50
    STYKQHCRTP SSSSTLAYSP RDEEDSMPPI STPRRSDSAI SVRSLHSESS 100
    MSLRSTFSLP EEEEEPEPLV FAEQPSVKLC CQLCCSVFKD PVITTCGHTF 150
    CRRCALKSEK CPVDNVKLTV VVNNIAVAEQ IGELFIHCRH GCRVAGSGKP 200
    PIFEVDPRGC PFTIKLSARK DHEGSCDYRP VRCPNNPSCP PLLRMNLEAH 250
    LKECEHIKCP HSKYGCTFIG NQDTYETHLE TCRFEGLKEF LQQTDDRFHE 300
    MHVALAQKDQ EIAFLRSMLG KLSEKIDQLE KSLELKFDVL DENQSKLSED 350
    LMEFRRDASM LNDELSHINA RLNMGILGSY DPQQIFKCKG TFVGHQGPVW 400
    CLCVYSMGDL LFSGSSDKTI KVWDTCTTYK CQKTLEGHDG IVLALCIQGC 450
    KLYSGSADCT IIVWDIQNLQ KVNTIRAHDN PVCTLVSSHN VLFSGSLKAI 500
    KVWDIVGTEL KLKKELTGLN HWVRALVAAQ SYLYSGSYQT IKIWDIRTLD 550
    CIHVLQTSGG SVYSIAVTNH HIVCGTYENL IHVWDIESKE QVRTLTGHVG 600
    TVYALAVIST PDQTKVFSAS YDRSLRVWSM DNMICTQTLL RHQGSVTALA 650
    VSRGRLFSGA VDSTVKVWTC 670
    Length:670
    Mass (Da):74,609
    Last modified:July 5, 2004 - v1
    Checksum:i5624045D674849C6
    GO
    Isoform 21 Publication (identifier: Q6Q0C0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-76: Missing.

    Show »
    Length:594
    Mass (Da):66,541
    Checksum:i25F8742FBD322058
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7676Missing in isoform 2. 2 PublicationsVSP_051607Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY569455 mRNA. Translation: AAS68363.1.
    AL136921 mRNA. Translation: CAB66855.1.
    CCDSiCCDS10461.1. [Q6Q0C0-1]
    RefSeqiNP_115647.2. NM_032271.2. [Q6Q0C0-1]
    UniGeneiHs.713632.

    Genome annotation databases

    EnsembliENST00000326181; ENSP00000318944; ENSG00000131653. [Q6Q0C0-1]
    GeneIDi84231.
    KEGGihsa:84231.
    UCSCiuc002cow.3. human. [Q6Q0C0-1]

    Polymorphism databases

    DMDMi54036486.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY569455 mRNA. Translation: AAS68363.1 .
    AL136921 mRNA. Translation: CAB66855.1 .
    CCDSi CCDS10461.1. [Q6Q0C0-1 ]
    RefSeqi NP_115647.2. NM_032271.2. [Q6Q0C0-1 ]
    UniGenei Hs.713632.

    3D structure databases

    ProteinModelPortali Q6Q0C0.
    SMRi Q6Q0C0. Positions 131-266, 387-668.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123964. 9 interactions.
    IntActi Q6Q0C0. 9 interactions.
    MINTi MINT-1161375.
    STRINGi 9606.ENSP00000318944.

    PTM databases

    PhosphoSitei Q6Q0C0.

    Polymorphism databases

    DMDMi 54036486.

    Proteomic databases

    MaxQBi Q6Q0C0.
    PaxDbi Q6Q0C0.
    PRIDEi Q6Q0C0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000326181 ; ENSP00000318944 ; ENSG00000131653 . [Q6Q0C0-1 ]
    GeneIDi 84231.
    KEGGi hsa:84231.
    UCSCi uc002cow.3. human. [Q6Q0C0-1 ]

    Organism-specific databases

    CTDi 84231.
    GeneCardsi GC16P002205.
    HGNCi HGNC:20456. TRAF7.
    HPAi HPA041229.
    MIMi 606692. gene.
    neXtProti NX_Q6Q0C0.
    PharmGKBi PA134917323.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2319.
    HOGENOMi HOG000220840.
    HOVERGENi HBG055270.
    InParanoidi Q6Q0C0.
    KOi K10646.
    OMAi HSESNMS.
    OrthoDBi EOG7J17Z8.
    PhylomeDBi Q6Q0C0.
    TreeFami TF328643.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    SignaLinki Q6Q0C0.

    Miscellaneous databases

    ChiTaRSi TRAF7. human.
    GenomeRNAii 84231.
    NextBioi 73692.
    PROi Q6Q0C0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6Q0C0.
    Bgeei Q6Q0C0.
    CleanExi HS_TRAF7.
    Genevestigatori Q6Q0C0.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    3.30.40.10. 1 hit.
    3.90.890.10. 1 hit.
    InterProi IPR020472. G-protein_beta_WD-40_rep.
    IPR013323. SIAH-type.
    IPR008974. TRAF-like.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    IPR001293. Znf_TRAF.
    [Graphical view ]
    Pfami PF00400. WD40. 7 hits.
    [Graphical view ]
    PRINTSi PR00320. GPROTEINBRPT.
    SMARTi SM00184. RING. 1 hit.
    SM00320. WD40. 7 hits.
    [Graphical view ]
    SUPFAMi SSF49599. SSF49599. 2 hits.
    SSF50978. SSF50978. 1 hit.
    PROSITEi PS00678. WD_REPEATS_1. 2 hits.
    PS50082. WD_REPEATS_2. 5 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    PS50145. ZF_TRAF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis."
      Xu L.-G., Li L.-Y., Shu H.-B.
      J. Biol. Chem. 279:17278-17282(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING, INTERACTION WITH MAP3K3.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Uterus.
    3. Cited for: FUNCTION, PHOSPHORYLATION, SUBCELLULAR LOCATION, HOMODIMERIZATION, INTERACTION WITH MAP3K3.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-88 AND SER-91, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiTRAF7_HUMAN
    AccessioniPrimary (citable) accession number: Q6Q0C0
    Secondary accession number(s): Q9H073
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3