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Q6Q0C0 (TRAF7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
E3 ubiquitin-protein ligase TRAF7

EC=6.3.2.-
Alternative name(s):
RING finger and WD repeat-containing protein 1
RING finger protein 119
TNF receptor-associated factor 7
Gene names
Name:TRAF7
Synonyms:RFWD1, RNF119
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length670 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed. Ref.1 Ref.3

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Homodimer. Interacts with MAP3K3 and promotes the kinase activity of this enzyme. Ref.1 Ref.3

Subcellular location

Cytoplasmic vesicle. Note: Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm. Ref.3

Tissue specificity

Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta. Ref.1

Post-translational modification

Phosphorylated by MAP3K3. Ref.3

Ubiquitinates itself upon phosphorylation.

Sequence similarities

Belongs to the WD repeat TRAF7 family.

Contains 1 RING-type zinc finger.

Contains 1 TRAF-type zinc finger.

Contains 7 WD repeats.

Ontologies

Keywords
   Biological processApoptosis
Transcription
Transcription regulation
Ubl conjugation pathway
   Cellular componentCytoplasmic vesicle
   Coding sequence diversityAlternative splicing
   DomainRepeat
WD repeat
Zinc-finger
   LigandMetal-binding
Zinc
   Molecular functionLigase
   PTMPhosphoprotein
Ubl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactivation of MAPKKK activity

Inferred from direct assay Ref.3. Source: UniProtKB

apoptotic process

Inferred from direct assay Ref.1. Source: MGI

positive regulation of MAPK cascade

Inferred from direct assay Ref.1. Source: MGI

positive regulation of apoptotic signaling pathway

Inferred from mutant phenotype Ref.1. Source: UniProtKB

protein ubiquitination

Inferred from direct assay Ref.3. Source: UniProtKB

regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasmic membrane-bounded vesicle

Inferred from electronic annotation. Source: UniProtKB-SubCell

ubiquitin ligase complex

Inferred from direct assay Ref.3. Source: UniProtKB

   Molecular_functionprotein binding

Inferred from physical interaction Ref.3Ref.1PubMed 21903422. Source: IntAct

ubiquitin-protein transferase activity

Inferred from direct assay Ref.3. Source: UniProtKB

zinc ion binding

Non-traceable author statement Ref.3. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

MAP3K3Q997592EBI-307556,EBI-307281
Ripk4Q9ERK02EBI-307556,EBI-6116422From a different organism.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.1 (identifier: Q6Q0C0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.1 (identifier: Q6Q0C0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 670670E3 ubiquitin-protein ligase TRAF7
PRO_0000051296

Regions

Repeat394 – 43340WD 1
Repeat437 – 47438WD 2
Repeat477 – 51337WD 3
Repeat515 – 55440WD 4
Repeat557 – 59438WD 5
Repeat597 – 63842WD 6
Repeat641 – 66929WD 7
Zinc finger131 – 16535RING-type
Zinc finger222 – 27655TRAF-type

Amino acid modifications

Modified residue881Phosphoserine Ref.4
Modified residue911Phosphoserine Ref.4

Natural variations

Alternative sequence1 – 7676Missing in isoform 2. Ref.1
VSP_051607

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 5624045D674849C6

FASTA67074,609
        10         20         30         40         50         60 
MSSGKSARYN RFSGGPSNLP TPDVTTGTRM ETTFGPAFSA VTTITKADGT STYKQHCRTP 

        70         80         90        100        110        120 
SSSSTLAYSP RDEEDSMPPI STPRRSDSAI SVRSLHSESS MSLRSTFSLP EEEEEPEPLV 

       130        140        150        160        170        180 
FAEQPSVKLC CQLCCSVFKD PVITTCGHTF CRRCALKSEK CPVDNVKLTV VVNNIAVAEQ 

       190        200        210        220        230        240 
IGELFIHCRH GCRVAGSGKP PIFEVDPRGC PFTIKLSARK DHEGSCDYRP VRCPNNPSCP 

       250        260        270        280        290        300 
PLLRMNLEAH LKECEHIKCP HSKYGCTFIG NQDTYETHLE TCRFEGLKEF LQQTDDRFHE 

       310        320        330        340        350        360 
MHVALAQKDQ EIAFLRSMLG KLSEKIDQLE KSLELKFDVL DENQSKLSED LMEFRRDASM 

       370        380        390        400        410        420 
LNDELSHINA RLNMGILGSY DPQQIFKCKG TFVGHQGPVW CLCVYSMGDL LFSGSSDKTI 

       430        440        450        460        470        480 
KVWDTCTTYK CQKTLEGHDG IVLALCIQGC KLYSGSADCT IIVWDIQNLQ KVNTIRAHDN 

       490        500        510        520        530        540 
PVCTLVSSHN VLFSGSLKAI KVWDIVGTEL KLKKELTGLN HWVRALVAAQ SYLYSGSYQT 

       550        560        570        580        590        600 
IKIWDIRTLD CIHVLQTSGG SVYSIAVTNH HIVCGTYENL IHVWDIESKE QVRTLTGHVG 

       610        620        630        640        650        660 
TVYALAVIST PDQTKVFSAS YDRSLRVWSM DNMICTQTLL RHQGSVTALA VSRGRLFSGA 

       670 
VDSTVKVWTC 

« Hide

Isoform 2 [UniParc].

Checksum: 25F8742FBD322058
Show »

FASTA59466,541

References

« Hide 'large scale' references
[1]"TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis."
Xu L.-G., Li L.-Y., Shu H.-B.
J. Biol. Chem. 279:17278-17282(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING, INTERACTION WITH MAP3K3.
[2]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Uterus.
[3]"A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway."
Bouwmeester T., Bauch A., Ruffner H., Angrand P.-O., Bergamini G., Croughton K., Cruciat C., Eberhard D., Gagneur J., Ghidelli S., Hopf C., Huhse B., Mangano R., Michon A.-M., Schirle M., Schlegl J., Schwab M., Stein M.A. expand/collapse author list , Bauer A., Casari G., Drewes G., Gavin A.-C., Jackson D.B., Joberty G., Neubauer G., Rick J., Kuster B., Superti-Furga G.
Nat. Cell Biol. 6:97-105(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, PHOSPHORYLATION, SUBCELLULAR LOCATION, HOMODIMERIZATION, INTERACTION WITH MAP3K3.
[4]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-88 AND SER-91, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY569455 mRNA. Translation: AAS68363.1.
AL136921 mRNA. Translation: CAB66855.1.
CCDSCCDS10461.1. [Q6Q0C0-1]
RefSeqNP_115647.2. NM_032271.2. [Q6Q0C0-1]
UniGeneHs.713632.

3D structure databases

ProteinModelPortalQ6Q0C0.
SMRQ6Q0C0. Positions 131-266, 387-668.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123964. 10 interactions.
IntActQ6Q0C0. 9 interactions.
MINTMINT-1161375.
STRING9606.ENSP00000318944.

PTM databases

PhosphoSiteQ6Q0C0.

Polymorphism databases

DMDM54036486.

Proteomic databases

MaxQBQ6Q0C0.
PaxDbQ6Q0C0.
PRIDEQ6Q0C0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000326181; ENSP00000318944; ENSG00000131653. [Q6Q0C0-1]
GeneID84231.
KEGGhsa:84231.
UCSCuc002cow.3. human. [Q6Q0C0-1]

Organism-specific databases

CTD84231.
GeneCardsGC16P002205.
HGNCHGNC:20456. TRAF7.
HPAHPA041229.
MIM606692. gene.
neXtProtNX_Q6Q0C0.
PharmGKBPA134917323.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2319.
HOGENOMHOG000220840.
HOVERGENHBG055270.
InParanoidQ6Q0C0.
KOK10646.
OMAHSESNMS.
OrthoDBEOG7J17Z8.
PhylomeDBQ6Q0C0.
TreeFamTF328643.

Enzyme and pathway databases

SignaLinkQ6Q0C0.
UniPathwayUPA00143.

Gene expression databases

ArrayExpressQ6Q0C0.
BgeeQ6Q0C0.
CleanExHS_TRAF7.
GenevestigatorQ6Q0C0.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
3.30.40.10. 1 hit.
3.90.890.10. 1 hit.
InterProIPR020472. G-protein_beta_WD-40_rep.
IPR013323. SIAH-type.
IPR008974. TRAF-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
IPR001293. Znf_TRAF.
[Graphical view]
PfamPF00400. WD40. 7 hits.
[Graphical view]
PRINTSPR00320. GPROTEINBRPT.
SMARTSM00184. RING. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMSSF49599. SSF49599. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
PS50145. ZF_TRAF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTRAF7. human.
GenomeRNAi84231.
NextBio73692.
PROQ6Q0C0.
SOURCESearch...

Entry information

Entry nameTRAF7_HUMAN
AccessionPrimary (citable) accession number: Q6Q0C0
Secondary accession number(s): Q9H073
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM