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Q6PZE0

- MUC19_MOUSE

UniProt

Q6PZE0 - MUC19_MOUSE

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Protein

Mucin-19

Gene

Muc19

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May function in ocular mucus homeostasis.By similarity

GO - Biological processi

  1. cell differentiation involved in salivary gland development Source: MGI
  2. hematopoietic progenitor cell differentiation Source: MGI
  3. negative regulation of inflammatory response Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-19
Short name:
MUC-19
Alternative name(s):
Gel-forming secreted mucin-19
Sublingual apomucin
Gene namesi
Name:Muc19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2676278. Muc19.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 75247504Mucin-19PRO_5000093121Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi? ↔ 7518By similarity
Disulfide bondi79 ↔ 87By similarity
Disulfide bondi7435 ↔ 7482By similarity
Disulfide bondi7449 ↔ 7496By similarity
Disulfide bondi7458 ↔ 7512By similarity
Disulfide bondi7462 ↔ 7514By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ6PZE0.
PRIDEiQ6PZE0.

PTM databases

PhosphoSiteiQ6PZE0.

Expressioni

Tissue specificityi

Specifically expressed in sublingual salivary glands. Expressed by mucous cells of the submandibular gland and submucosal gland of the trachea. Expression is altered in sld (sublingual gland differentiation arrest) mutants.3 Publications

Gene expression databases

BgeeiQ6PZE0.
CleanExiMM_MUC19.
ExpressionAtlasiQ6PZE0. baseline.
GenevestigatoriQ6PZE0.

Structurei

3D structure databases

ProteinModelPortaliQ6PZE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 257202VWFD 1PROSITE-ProRule annotationAdd
BLAST
Domaini298 – 35356TILAdd
BLAST
Domaini392 – 600209VWFD 2PROSITE-ProRule annotationAdd
BLAST
Domaini852 – 1062211VWFD 3PROSITE-ProRule annotationAdd
BLAST
Repeati1321 – 14831631Add
BLAST
Repeati1484 – 16461632Add
BLAST
Repeati1647 – 18091633Add
BLAST
Repeati1810 – 19721634Add
BLAST
Repeati1973 – 21351635Add
BLAST
Repeati2136 – 22981636Add
BLAST
Repeati2299 – 24611637Add
BLAST
Repeati2462 – 26241638Add
BLAST
Repeati2625 – 27871639Add
BLAST
Repeati2788 – 295016310Add
BLAST
Repeati2951 – 311316311Add
BLAST
Repeati3114 – 327616312Add
BLAST
Repeati3277 – 343916313Add
BLAST
Repeati3440 – 360216314Add
BLAST
Repeati3603 – 376516315Add
BLAST
Repeati3766 – 392816316Add
BLAST
Repeati3929 – 409116317Add
BLAST
Repeati4092 – 425416318Add
BLAST
Repeati4255 – 441716319Add
BLAST
Repeati4418 – 458016320Add
BLAST
Repeati4581 – 474316321Add
BLAST
Repeati4744 – 490616322Add
BLAST
Repeati4907 – 506916323Add
BLAST
Repeati5070 – 523216324Add
BLAST
Repeati5233 – 539516325Add
BLAST
Repeati5396 – 555816326Add
BLAST
Repeati5559 – 572116327Add
BLAST
Repeati5722 – 588416328Add
BLAST
Repeati5885 – 604716329Add
BLAST
Repeati6048 – 621016330Add
BLAST
Repeati6211 – 637316331Add
BLAST
Repeati6374 – 653616332Add
BLAST
Repeati6537 – 669916333Add
BLAST
Repeati6700 – 686216334Add
BLAST
Repeati6863 – 702516335Add
BLAST
Repeati7026 – 718816336Add
BLAST
Domaini7302 – 736867VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini7370 – 743263VWFC 2PROSITE-ProRule annotationAdd
BLAST
Domaini7435 – 751985CTCKPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1321 – 71885868Approximate repeatsAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1216 – 72856070Thr-richAdd
BLAST
Compositional biasi1238 – 72496012Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
Contains 2 VWFC domains.PROSITE-ProRule annotation
Contains 3 VWFD domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
InParanoidiQ6PZE0.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF08742. C8. 3 hits.
PF01826. TIL. 1 hit.
PF00094. VWD. 3 hits.
[Graphical view]
SMARTiSM00832. C8. 2 hits.
SM00041. CT. 1 hit.
SM00214. VWC. 2 hits.
SM00216. VWD. 3 hits.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 3 hits.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
PS51233. VWFD. 3 hits.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. Align

Note: Isoform 1 and isoform 2-6 share the first 17 amino acid residues that correspond to the signal sequence.

Isoform 1 (identifier: Q6PZE0-1) [UniParc]FASTAAdd to Basket

Also known as: Mucin-19

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MKLILLYLAV VLCFVGKGAA RSPTTTRTPT PSTSEKASHV PEATPTYSEA
60 70 80 90 100
NEVAGEATMW GKDKYKALNG HIFSFESECT FTFCRDCAEP GGDFNIEIKK
110 120 130 140 150
HKNGDIEEIK ALIDDVEILV VRNSISVNEE RVKVPFSNKM IHIKKQGNHY
160 170 180 190 200
SLKTRRRILS LKWSKDKLSL ILYSHYTTCG LCGNFDSVPG DDVNEHIASS
210 220 230 240 250
KISNDCPSPL SRSNEVCEDG VQYCDKIIET YFEKCSKVSP LSREYKNVCA
260 270 280 290 300
DEYCRKGGGK QTTCDTYSEL ARLCAYDGPG DYEHWRDDSA VVCAKEQCPG
310 320 330 340 350
KHIYKECGPS NPPTCSNVAP FQDSECVSGC TCPEGYLLDD IGEKGKCVLK
360 370 380 390 400
EKCPCESNGK VYKPGKVREG PCGSRCTCQE AKWSCTEARC PGICKVEGSS
410 420 430 440 450
FTTFDDNKFS HPGDCHFLAV HNDEISISVE IHPCGNGQTG SCLTSVMVLQ
460 470 480 490 500
NSSSSSNRYV FNRDGTVTKD GVIIKGYYYS DDVQIFNSSS SYMQAEILSH
510 520 530 540 550
IKLQIQLAPR MQLYVSLAPN TSTDTVGLCG SFNNKAEDDF MSSQNILEST
560 570 580 590 600
AQAFANSWEM MPCSEGSPSS CVSIETEKFA ESNCEILLSS SGPFAACHQT
610 620 630 640 650
VNPKFYHEEC KKYTCSCENG QDCLCTVLGN YVKACAEKEI YLVGWRDGLC
660 670 680 690 700
EVSCPSGLVF NYKVKTCNSS CRSLSARDRS CDIEDIPVDG CTCPDGMYQN
710 720 730 740 750
NEGNCVQKSE CDCYVNDEIV QPGKSILIDD NKCVCQDGVL HCQTPLDLTL
760 770 780 790 800
QNCSRGAEYI DCKDPKAQRR TERTCATRNI PDFEGDLPCK RGCYCPVGMV
810 820 830 840 850
RNSKGICIHP DDCPCSFGDR EYEQGSVTSV GCNECTCIKG SWNCTQNECQ
860 870 880 890 900
STCHVYGEGH FRTFDGESYS FDGLCQYTFL EDYCGQENGT FRILIESVPC
910 920 930 940 950
CENGLTCSRK VIVTFQDQNI ILQDGKVTAV QTAESTDCRE RSANLYSIHT
960 970 980 990 1000
VGLYLIVKLL NGIILIWDKY TKVSVILDPS WQNKVCGLCG NNNGDLKDDF
1010 1020 1030 1040 1050
TTRHSSVAAG ALEFANSWKT SQECSDTVTQ SFPCDSNPYC KAWAEKRCEI
1060 1070 1080 1090 1100
LRDDTFRDCH SKVDPTTYYD ACIEEACSCD MEGKYLGFCT AVAMYAEACN
1110 1120 1130 1140 1150
AAGVCVSWRK PNLCPVYCDY YNAPGECSWH YEPCGTVTAK TCKDQVIGQK
1160 1170 1180 1190 1200
FSSLLEGCYA KCPENAPYLD ENTMKCVQLS ECSCFYNDVI PAGGAVVDDC
1210 1220 1230 1240 1250
GRTCSCSAGE LECSETPPNS TTTTTATTAA VSTATTTSVL STSAAATRAS
1260 1270 1280 1290 1300
SSTSGSVETS VPATTSTSKA QAHITTASST ETSALNSTAV YPKATTREGL
1310 1320 1330 1340 1350
LSSSGPGAFV AERPDNTPRP AVSTTSAGST SARAATTSPG GSSGSSAPAS
1360 1370 1380 1390 1400
STSGRAATTT STSAATTTTT TTATTVGSAG SSAPTASSTA AGSGLREAAN
1410 1420 1430 1440 1450
ATSAPASTSG QPGASTGSSG TSSSVSSTAA ATTAGTTTAA SNETSAPAST
1460 1470 1480 1490 1500
AGPTSSATTA APASSSASSA TTPAETAGST TGPAVSTTSA GSTSARAATT
1510 1520 1530 1540 1550
SPGGSSGSSA PASSTSGRAA TTTSTATTTT TTTTTATTVG SAGSSAPTAS
1560 1570 1580 1590 1600
STAAGSGLRE AANATSAPAS TSGQPGASTG SSGTSSSVSS TAAATTAGTT
1610 1620 1630 1640 1650
TAASNETSAP ASTAGPTSSA TTAAPASSSA SSATTPAETA GSTTGPAVST
1660 1670 1680 1690 1700
TSAGSTSARA ATTSPGGSSG SSAPASSTSG RAATTTSTAT TTTTTTTTAT
1710 1720 1730 1740 1750
TVGSAGSSAP TASSTAAGSG LREAANATSA PASTSGQPGA STGSSGTSSS
1760 1770 1780 1790 1800
VSSTAAATTA GTTTAASNET SAPASTAGPT SSATTAAPAS SSASSATTPA
1810 1820 1830 1840 1850
ETAGSTTGPA VSTTSAGSTS ARAATTSPGG SSGSSAPASS TSGRAATTTS
1860 1870 1880 1890 1900
TATTTTTTTT TATTVGSAGS SAPTASSTAA GSGLREAANA TSAPASTSGQ
1910 1920 1930 1940 1950
PGASTGSSGT SSSVSSTAAA TTAGTTTAAS NETSAPASTA GPTSSATTAA
1960 1970 1980 1990 2000
PASSSASSAT TPAETAGSTT GPAVSTTSAG STSARAATTS PGGSSGSSAP
2010 2020 2030 2040 2050
ASSTSGRAAT TTSTATTTTT TTTTATTVGS AGSSAPTASS TAAGSGLREA
2060 2070 2080 2090 2100
ANATSAPAST SGQPGASTGS SGTSSSVSST AAATTAGTTT AASNETSAPA
2110 2120 2130 2140 2150
STAGPTSSAT TAAPASSSAS SATTPAETAG STTGPAVSTT SAGSTSARAA
2160 2170 2180 2190 2200
TTSPGGSSGS SAPASSTSGR AATTTSTATT TTTTTTTATT VGSAGSSAPT
2210 2220 2230 2240 2250
ASSTAAGSGL REAANATSAP ASTSGQPGAS TGSSGTSSSV SSTAAATTAG
2260 2270 2280 2290 2300
TTTAASNETS APASTAGPTS SATTAAPASS SASSATTPAE TAGSTTGPAV
2310 2320 2330 2340 2350
STTSAGSTSA RAATTSPGGS SGSSAPASST SGRAATTTST ATTTTTTTTT
2360 2370 2380 2390 2400
ATTVGSAGSS APTASSTAAG SGLREAANAT SAPASTSGQP GASTGSSGTS
2410 2420 2430 2440 2450
SSVSSTAAAT TAGTTTAASN ETSAPASTAG PTSSATTAAP ASSSASSATT
2460 2470 2480 2490 2500
PAETAGSTTG PAVSTTSAGS TSARAATTSP GGSSGSSAPA SSTSGRAATT
2510 2520 2530 2540 2550
TSTATTTTTT TTTATTVGSA GSSAPTASST AAGSGLREAA NATSAPASTS
2560 2570 2580 2590 2600
GQPGASTGSS GTSSSVSSTA AATTAGTTTA ASNETSAPAS TAGPTSSATT
2610 2620 2630 2640 2650
AAPASSSASS ATTPAETAGS TTGPAVSTTS AGSTSARAAT TSPGGSSGSS
2660 2670 2680 2690 2700
APASSTSGRA ATTTSTATTT TTTTTTATTV GSAGSSAPTA SSTAAGSGLR
2710 2720 2730 2740 2750
EAANATSAPA STSGQPGAST GSSGTSSSVS STAAATTAGT TTAASNETSA
2760 2770 2780 2790 2800
PASTAGPTSS ATTAAPASSS ASSATTPAET AGSTTGPAVS TTSAGSTSAR
2810 2820 2830 2840 2850
AATTSPGGSS GSSAPASSTS GRAATTTSTA TTTTTTTTTA TTVGSAGSSA
2860 2870 2880 2890 2900
PTASSTAAGS GLREAANATS APASTSGQPG ASTGSSGTSS SVSSTAAATT
2910 2920 2930 2940 2950
AGTTTAASNE TSAPASTAGP TSSATTAAPA SSSASSATTP AETAGSTTGP
2960 2970 2980 2990 3000
AVSTTSAGST SARAATTSPG GSSGSSAPAS STSGRAATTT STATTTTTTT
3010 3020 3030 3040 3050
TTATTVGSAG SSAPTASSTA AGSGLREAAN ATSAPASTSG QPGASTGSSG
3060 3070 3080 3090 3100
TSSSVSSTAA ATTAGTTTAA SNETSAPAST AGPTSSATTA APASSSASSA
3110 3120 3130 3140 3150
TTPAETAGST TGPAVSTTSA GSTSARAATT SPGGSSGSSA PASSTSGRAA
3160 3170 3180 3190 3200
TTTSTATTTT TTTTTATTVG SAGSSAPTAS STAAGSGLRE AANATSAPAS
3210 3220 3230 3240 3250
TSGQPGASTG SSGTSSSVSS TAAATTAGTT TAASNETSAP ASTAGPTSSA
3260 3270 3280 3290 3300
TTAAPASSSA SSATTPAETA GSTTGPAVST TSAGSTSARA ATTSPGGSSG
3310 3320 3330 3340 3350
SSAPASSTSG RAATTTSTAT TTTTTTTTAT TVGSAGSSAP TASSTAAGSG
3360 3370 3380 3390 3400
LREAANATSA PASTSGQPGA STGSSGTSSS VSSTAAATTA GTTTAASNET
3410 3420 3430 3440 3450
SAPASTAGPT SSATTAAPAS SSASSATTPA ETAGSTTGPA VSTTSAGSTS
3460 3470 3480 3490 3500
ARAATTSPGG SSGSSAPASS TSGRAATTTS TATTTTTTTT TATTVGSAGS
3510 3520 3530 3540 3550
SAPTASSTAA GSGLREAANA TSAPASTSGQ PGASTGSSGT SSSVSSTAAA
3560 3570 3580 3590 3600
TTAGTTTAAS NETSAPASTA GPTSSATTAA PASSSASSAT TPAETAGSTT
3610 3620 3630 3640 3650
GPAVSTTSAG STSARAATTS PGGSSGSSAP ASSTSGRAAT TTSTATTTTT
3660 3670 3680 3690 3700
TTTTATTVGS AGSSAPTASS TAAGSGLREA ANATSAPAST SGQPGASTGS
3710 3720 3730 3740 3750
SGTSSSVSST AAATTAGTTT AASNETSAPA STAGPTSSAT TAAPASSSAS
3760 3770 3780 3790 3800
SATTPAETAG STTGPAVSTT SAGSTSARAA TTSPGGSSGS SAPASSTSGR
3810 3820 3830 3840 3850
AATTTSTATT TTTTTTTATT VGSAGSSAPT ASSTAAGSGL REAANATSAP
3860 3870 3880 3890 3900
ASTSGQPGAS TGSSGTSSSV SSTAAATTAG TTTAASNETS APASTAGPTS
3910 3920 3930 3940 3950
SATTAAPASS SASSATTPAE TAGSTTGPAV STTSAGSTSA RAATTSPGGS
3960 3970 3980 3990 4000
SGSSAPASST SGRAATTTST ATTTTTTTTT ATTVGSAGSS APTASSTAAG
4010 4020 4030 4040 4050
SGLREAANAT SAPASTSGQP GASTGSSGTS SSVSSTAAAT TAGTTTAASN
4060 4070 4080 4090 4100
ETSAPASTAG PTSSATTAAP ASSSASSATT PAETAGSTTG PAVSTTSAGS
4110 4120 4130 4140 4150
TSARAATTSP GGSSGSSAPA SSTSGRAATT TSTATTTTTT TTTATTVGSA
4160 4170 4180 4190 4200
GSSAPTASST AAGSGLREAA NATSAPASTS GQPGASTGSS GTSSSVSSTA
4210 4220 4230 4240 4250
AATTAGTTTA ASNETSAPAS TAGPTSSATT AAPASSSASS ATTPAETAGS
4260 4270 4280 4290 4300
TTGPAVSTTS AGSTSARAAT TSPGGSSGSS APASSTSGRA ATTTSTATTT
4310 4320 4330 4340 4350
TTTTTTATTV GSAGSSAPTA SSTAAGSGLR EAANATSAPA STSGQPGAST
4360 4370 4380 4390 4400
GSSGTSSSVS STAAATTAGT TTAASNETSA PASTAGPTSS ATTAAPASSS
4410 4420 4430 4440 4450
ASSATTPAET AGSTTGPAVS TTSAGSTSAR AATTSPGGSS GSSAPASSTS
4460 4470 4480 4490 4500
GRAATTTSTA TTTTTTTTTA TTVGSAGSSA PTASSTAAGS GLREAANATS
4510 4520 4530 4540 4550
APASTSGQPG ASTGSSGTSS SVSSTAAATT AGTTTAASNE TSAPASTAGP
4560 4570 4580 4590 4600
TSSATTAAPA SSSASSATTP AETAGSTTGP AVSTTSAGST SARAATTSPG
4610 4620 4630 4640 4650
GSSGSSAPAS STSGRAATTT STATTTTTTT TTATTVGSAG SSAPTASSTA
4660 4670 4680 4690 4700
AGSGLREAAN ATSAPASTSG QPGASTGSSG TSSSVSSTAA ATTAGTTTAA
4710 4720 4730 4740 4750
SNETSAPAST AGPTSSATTA APASSSASSA TTPAETAGST TGPAVSTTSA
4760 4770 4780 4790 4800
GSTSARAATT SPGGSSGSSA PASSTSGRAA TTTSTATTTT TTTTTATTVG
4810 4820 4830 4840 4850
SAGSSAPTAS STAAGSGLRE AANATSAPAS TSGQPGASTG SSGTSSSVSS
4860 4870 4880 4890 4900
TAAATTAGTT TAASNETSAP ASTAGPTSSA TTAAPASSSA SSATTPAETA
4910 4920 4930 4940 4950
GSTTGPAVST TSAGSTSARA ATTSPGGSSG SSAPASSTSG RAATTTSTAT
4960 4970 4980 4990 5000
TTTTTTTTAT TVGSAGSSAP TASSTAAGSG LREAANATSA PASTSGQPGA
5010 5020 5030 5040 5050
STGSSGTSSS VSSTAAATTA GTTTAASNET SAPASTAGPT SSATTAAPAS
5060 5070 5080 5090 5100
SSASSATTPA ETAGSTTGPA VSTTSAGSTS ARAATTSPGG SSGSSAPASS
5110 5120 5130 5140 5150
TSGRAATTTS TATTTTTTTT TATTVGSAGS SAPTASSTAA GSGLREAANA
5160 5170 5180 5190 5200
TSAPASTSGQ PGASTGSSGT SSSVSSTAAA TTAGTTTAAS NETSAPASTA
5210 5220 5230 5240 5250
GPTSSATTAA PASSSASSAT TPAETAGSTT GPAVSTTSAG STSARAATTS
5260 5270 5280 5290 5300
PGGSSGSSAP ASSTSGRAAT TTSTATTTTT TTTTATTVGS AGSSAPTASS
5310 5320 5330 5340 5350
TAAGSGLREA ANATSAPAST SGQPGASTGS SGTSSSVSST AAATTAGTTT
5360 5370 5380 5390 5400
AASNETSAPA STAGPTSSAT TAAPASSSAS SATTPAETAG STTGPAVSTT
5410 5420 5430 5440 5450
SAGSTSARAA TTSPGGSSGS SAPASSTSGR AATTTSTATT TTTTTTTATT
5460 5470 5480 5490 5500
VGSAGSSAPT ASSTAAGSGL REAANATSAP ASTSGQPGAS TGSSGTSSSV
5510 5520 5530 5540 5550
SSTAAATTAG TTTAASNETS APASTAGPTS SATTAAPASS SASSATTPAE
5560 5570 5580 5590 5600
TAGSTTGPAV STTSAGSTSA RAATTSPGGS SGSSAPASST SGRAATTTST
5610 5620 5630 5640 5650
ATTTTTTTTT ATTVGSAGSS APTASSTAAG SGLREAANAT SAPASTSGQP
5660 5670 5680 5690 5700
GASTGSSGTS SSVSSTAAAT TAGTTTAASN ETSAPASTAG PTSSATTAAP
5710 5720 5730 5740 5750
ASSSASSATT PAETAGSTTG PAVSTTSAGS TSARAATTSP GGSSGSSAPA
5760 5770 5780 5790 5800
SSTSGRAATT TSTATTTTTT TTTATTVGSA GSSAPTASST AAGSGLREAA
5810 5820 5830 5840 5850
NATSAPASTS GQPGASTGSS GTSSSVSSTA AATTAGTTTA ASNETSAPAS
5860 5870 5880 5890 5900
TAGPTSSATT AAPASSSASS ATTPAETAGS TTGPAVSTTS AGSTSARAAT
5910 5920 5930 5940 5950
TSPGGSSGSS APASSTSGRA ATTTSTATTT TTTTTTATTV GSAGSSAPTA
5960 5970 5980 5990 6000
SSTAAGSGLR EAANATSAPA STSGQPGAST GSSGTSSSVS STAAATTAGT
6010 6020 6030 6040 6050
TTAASNETSA PASTAGPTSS ATTAAPASSS ASSATTPAET AGSTTGPAVS
6060 6070 6080 6090 6100
TTSAGSTSAR AATTSPGGSS GSSAPASSTS GRAATTTSTA TTTTTTTTTA
6110 6120 6130 6140 6150
TTVGSAGSSA PTASSTAAGS GLREAANATS APASTSGQPG ASTGSSGTSS
6160 6170 6180 6190 6200
SVSSTAAATT AGTTTAASNE TSAPASTAGP TSSATTAAPA SSSASSATTP
6210 6220 6230 6240 6250
AETAGSTTGP AVSTTSAGST SARAATTSPG GSSGSSAPAS STSGRAATTT
6260 6270 6280 6290 6300
STATTTTTTT TTATTVGSAG SSAPTASSTA AGSGLREAAN ATSAPASTSG
6310 6320 6330 6340 6350
QPGASTGSSG TSSSVSSTAA ATTAGTTTAA SNETSAPAST AGPTSSATTA
6360 6370 6380 6390 6400
APASSSASSA TTPAETAGST TGPAVSTTSA GSTSARAATT SPGGSSGSSA
6410 6420 6430 6440 6450
PASSTSGRAA TTTSTATTTT TTTTTATTVG SAGSSAPTAS STAAGSGLRE
6460 6470 6480 6490 6500
AANATSAPAS TSGQPGASTG SSGTSSSVSS TAAATTAGTT TAASNETSAP
6510 6520 6530 6540 6550
ASTAGPTSSA TTAAPASSSA SSATTPAETA GSTTGPAVST TSAGSTSARA
6560 6570 6580 6590 6600
ATTSPGGSSG SSAPASSTSG RAATTTSTAT TTTTTTTTAT TVGSAGSSAP
6610 6620 6630 6640 6650
TASSTAAGSG LREAANATSA PASTSGQPGA STGSSGTSSS VSSTAAATTA
6660 6670 6680 6690 6700
GTTTAASNET SAPASTAGPT SSATTAAPAS SSASSATTPA ETAGSTTGPA
6710 6720 6730 6740 6750
VSTTSAGSTS ARAATTSPGG SSGSSAPASS TSGRAATTTS TATTTTTTTT
6760 6770 6780 6790 6800
TATTVGSAGS SAPTASSTAA GSGLREAANA TSAPASTSGQ PGASTGSSGT
6810 6820 6830 6840 6850
SSSVSSTAAA TTAGTTTAAS NETSAPASTA GPTSSATTAA PASSSASSAT
6860 6870 6880 6890 6900
TPAETAGSTT GPAVSTTSAG STSARAATTS PGGSSGSSAP ASSTSGRAAT
6910 6920 6930 6940 6950
TTSTATTTTT TTTTATTVGS AGSSAPTASS TAAGSGLREA ANATSAPAST
6960 6970 6980 6990 7000
SGQPGASTGS SGTSSSVSST AAATTAGTTT AASNETSAPA STAGPTSSAT
7010 7020 7030 7040 7050
TAAPASSSAS SATTPAETAG STTGPAVSTT SAGSTSARAA TTSPGGSSGS
7060 7070 7080 7090 7100
SAPASSTSGR AATTTSTATT TTTTTTTATT VGSAGSSAPT ASSTAAGSGL
7110 7120 7130 7140 7150
REAANATSAP VSTSGQPGAS TGSSGTSSSV SSTAAATTAG TTTAASNETS
7160 7170 7180 7190 7200
APASTAGPTS SATTAAPASS SASSATTPAE TAGSTTGPAV STTSAGSTSA
7210 7220 7230 7240 7250
RAATTSPGGS SGSSSLAIST MSVSSSSFIS PSGHPVPSTA SVAFLSSPSV
7260 7270 7280 7290 7300
IKTGGTTGTT AKSNETTGRT TSMPASTSVA PGVTTSPNIS QPECPDSLPP
7310 7320 7330 7340 7350
TPVCHGPLGE EKSPGDVWIS NCHQCTCTEK QAVDCKPKEC PSPPTCKDGE
7360 7370 7380 7390 7400
KLMKFKSNDS CCEIGHCEPR TCLFNNTDYA IGSSFDDPSN PCLSYTCNPT
7410 7420 7430 7440 7450
GLVAVVQDCP KQTWCAEEER IYDSNKCCYK CKNDCRTTPV NVTVKYNGCR
7460 7470 7480 7490 7500
KRVEMARCIG ECKRSVKYNY ETFQLENSCS CCREENYEFR DIALECSDGS
7510 7520
TIPYRYRHTT TCSCRDQCEQ SKAS
Length:7,524
Mass (Da):693,499
Last modified:October 25, 2004 - v2
Checksum:iB99A4519CE1EF6D4
GO
Isoform 2 (identifier: Q6JHY2-1) [UniParc]FASTAAdd to Basket

Also known as: Smgc

The sequence of this isoform can be found in the external entry Q6JHY2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:733
Mass (Da):74,383
GO
Isoform 3 (identifier: Q6JHY2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry Q6JHY2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: No experimental confirmation available.

Length:700
Mass (Da):70,835
GO
Isoform 4 (identifier: Q6JHY2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry Q6JHY2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: No experimental confirmation available.

Length:341
Mass (Da):34,128
GO
Isoform 5 (identifier: Q6JHY2-4) [UniParc]FASTAAdd to Basket

Also known as: t-Smgc

The sequence of this isoform can be found in the external entry Q6JHY2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:128
Mass (Da):12,633
GO
Isoform 6 (identifier: Q6JHY2-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry Q6JHY2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:431
Mass (Da):43,160
GO

Sequence cautioni

The sequence AAO49800.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7111 – 71111V → A in AAO49800. (PubMed:12882755)Curated
Sequence conflicti7178 – 71781P → L in AAO38851. (PubMed:12847143)Curated
Sequence conflicti7178 – 71781P → L in AAO49800. (PubMed:12882755)Curated
Sequence conflicti7293 – 72931E → V in AAO38851. (PubMed:12847143)Curated
Sequence conflicti7293 – 72931E → V in AAO49800. (PubMed:12882755)Curated
Sequence conflicti7293 – 72931E → V in AAH61502. (PubMed:15489334)Curated
Sequence conflicti7333 – 73331V → L in AAO38851. (PubMed:12847143)Curated
Sequence conflicti7333 – 73331V → L in AAH61502. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY570293 mRNA. Translation: AAS77382.2.
EU089955 mRNA. Translation: ABU50842.1.
EU089956 mRNA. Translation: ABU50843.1.
EU089957 mRNA. Translation: ABU50844.1.
EU089959 mRNA. Translation: ABU50846.1.
AY172172 mRNA. Translation: AAO38851.1.
AY193891 mRNA. Translation: AAO49800.1. Sequence problems.
BC061502 mRNA. Translation: AAH61502.1.
RefSeqiNP_997126.2. NM_207243.2. [Q6PZE0-1]
UniGeneiMm.486225.

Genome annotation databases

GeneIDi239611.
KEGGimmu:239611.
UCSCiuc007xie.1. mouse. [Q6PZE0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Mucin database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY570293 mRNA. Translation: AAS77382.2 .
EU089955 mRNA. Translation: ABU50842.1 .
EU089956 mRNA. Translation: ABU50843.1 .
EU089957 mRNA. Translation: ABU50844.1 .
EU089959 mRNA. Translation: ABU50846.1 .
AY172172 mRNA. Translation: AAO38851.1 .
AY193891 mRNA. Translation: AAO49800.1 . Sequence problems.
BC061502 mRNA. Translation: AAH61502.1 .
RefSeqi NP_997126.2. NM_207243.2. [Q6PZE0-1 ]
UniGenei Mm.486225.

3D structure databases

ProteinModelPortali Q6PZE0.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q6PZE0.

Proteomic databases

MaxQBi Q6PZE0.
PRIDEi Q6PZE0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 239611.
KEGGi mmu:239611.
UCSCi uc007xie.1. mouse. [Q6PZE0-1 ]

Organism-specific databases

CTDi 283463.
MGIi MGI:2676278. Muc19.

Phylogenomic databases

eggNOGi NOG12793.
InParanoidi Q6PZE0.

Miscellaneous databases

NextBioi 384199.
SOURCEi Search...

Gene expression databases

Bgeei Q6PZE0.
CleanExi MM_MUC19.
ExpressionAtlasi Q6PZE0. baseline.
Genevestigatori Q6PZE0.

Family and domain databases

InterProi IPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view ]
Pfami PF08742. C8. 3 hits.
PF01826. TIL. 1 hit.
PF00094. VWD. 3 hits.
[Graphical view ]
SMARTi SM00832. C8. 2 hits.
SM00041. CT. 1 hit.
SM00214. VWC. 2 hits.
SM00216. VWD. 3 hits.
[Graphical view ]
SUPFAMi SSF57567. SSF57567. 3 hits.
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
PS51233. VWFD. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The gene encoding mouse Muc19: cDNA, genomic organization and relationship to Smgc."
    Culp D.J., Latchney L.R., Fallon M.A., Denny P.A., Denny P.C., Couwenhoven R.I., Chuang S.
    Physiol. Genomics 19:303-318(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: NFS.
    Tissue: Sublingual gland.
  2. "The sld mutation is specific for sublingual salivary mucous cells and disrupts apomucin gene expression."
    Fallon M.A., Latchney L.R., Hand A.R., Johar A., Denny P.A., Georgel P.T., Denny P.C., Culp D.J.
    Physiol. Genomics 14:95-106(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6711-7524, TISSUE SPECIFICITY.
    Strain: Swiss Webster.
    Tissue: Sublingual gland.
  3. "Genome-wide search and identification of a novel gel-forming mucin MUC19/Muc19 in glandular tissues."
    Chen Y., Zhao Y.H., Kalaslavadi T.B., Hamati E., Nehrke K., Le A.D., Ann D.K., Wu R.
    Am. J. Respir. Cell Mol. Biol. 30:155-165(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6918-7524, TISSUE SPECIFICITY.
    Strain: C57BL/6 X DBA/2.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7276-7524.
    Strain: FVB/N.
    Tissue: Salivary gland.

Entry informationi

Entry nameiMUC19_MOUSE
AccessioniPrimary (citable) accession number: Q6PZE0
Secondary accession number(s): A7UN62
, A7UN63, A7UN64, A7UN66, Q6P7U5, Q6Y0X6, Q80UR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: October 25, 2004
Last modified: November 26, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3