Q6PZE0 (MUC19_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mucin-19
Short name=MUC-19

Alternative name(s):
Gel-forming secreted mucin-19
Sublingual apomucin

Gene names

Name:

Muc19

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	7524 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May function in ocular mucus homeostasis By similarity.
Subcellular location	Secreted Potential.
Tissue specificity	Specifically expressed in sublingual salivary glands. Expressed by mucous cells of the submandibular gland and submucosal gland of the trachea. Expression is altered in sld (sublingual gland differentiation arrest) mutants. Ref.1 Ref.2 Ref.3
Sequence similarities	Contains 1 CTCK (C-terminal cystine knot-like) domain. Contains 1 TIL (trypsin inhibitory-like) domain. Contains 2 VWFC domains. Contains 3 VWFD domains.
Sequence caution	The sequence AAO49800.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	Repeat Signal
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Note: Isoform 1 and isoform 2-6 share the first 17 amino acid residues that correspond to the signal sequence.

Isoform 1 (identifier: Q6PZE0-1)

Also known as: Mucin-19;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6JHY2-1)

Also known as: Smgc;

The sequence of this isoform can be found in the external entry Q6JHY2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Isoform 3 (identifier: Q6JHY2-2)

The sequence of this isoform can be found in the external entry Q6JHY2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q6JHY2-3)

The sequence of this isoform can be found in the external entry Q6JHY2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q6JHY2-4)

Also known as: t-Smgc;

The sequence of this isoform can be found in the external entry Q6JHY2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Isoform 6 (identifier: Q6JHY2-5)

The sequence of this isoform can be found in the external entry Q6JHY2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 7524	7504	Mucin-19		PRO_5000093121
Regions
	Domain	56 – 257	202	VWFD 1
	Domain	298 – 353	56	TIL
	Domain	392 – 600	209	VWFD 2
	Domain	852 – 1062	211	VWFD 3
	Repeat	1321 – 1483	163	1
	Repeat	1484 – 1646	163	2
	Repeat	1647 – 1809	163	3
	Repeat	1810 – 1972	163	4
	Repeat	1973 – 2135	163	5
	Repeat	2136 – 2298	163	6
	Repeat	2299 – 2461	163	7
	Repeat	2462 – 2624	163	8
	Repeat	2625 – 2787	163	9
	Repeat	2788 – 2950	163	10
	Repeat	2951 – 3113	163	11
	Repeat	3114 – 3276	163	12
	Repeat	3277 – 3439	163	13
	Repeat	3440 – 3602	163	14
	Repeat	3603 – 3765	163	15
	Repeat	3766 – 3928	163	16
	Repeat	3929 – 4091	163	17
	Repeat	4092 – 4254	163	18
	Repeat	4255 – 4417	163	19
	Repeat	4418 – 4580	163	20
	Repeat	4581 – 4743	163	21
	Repeat	4744 – 4906	163	22
	Repeat	4907 – 5069	163	23
	Repeat	5070 – 5232	163	24
	Repeat	5233 – 5395	163	25
	Repeat	5396 – 5558	163	26
	Repeat	5559 – 5721	163	27
	Repeat	5722 – 5884	163	28
	Repeat	5885 – 6047	163	29
	Repeat	6048 – 6210	163	30
	Repeat	6211 – 6373	163	31
	Repeat	6374 – 6536	163	32
	Repeat	6537 – 6699	163	33
	Repeat	6700 – 6862	163	34
	Repeat	6863 – 7025	163	35
	Repeat	7026 – 7188	163	36
	Domain	7302 – 7368	67	VWFC 1
	Domain	7370 – 7432	63	VWFC 2
	Domain	7435 – 7519	85	CTCK
	Region	1321 – 7188	5868	Approximate repeats
	Compositional bias	1216 – 7285	6070	Thr-rich
	Compositional bias	1238 – 7249	6012	Ser-rich
Amino acid modifications
	Disulfide bond	79 ↔ 87		By similarity
	Disulfide bond	7435 ↔ 7482		By similarity
	Disulfide bond	7449 ↔ 7496		By similarity
	Disulfide bond	7458 ↔ 7512		By similarity
	Disulfide bond	7462 ↔ 7514		By similarity
	Disulfide bond	? ↔ 7518		By similarity
Experimental info
	Sequence conflict	7111	1	V → A in AAO49800. Ref.3
	Sequence conflict	7178	1	P → L in AAO38851. Ref.2
	Sequence conflict	7178	1	P → L in AAO49800. Ref.3
	Sequence conflict	7293	1	E → V in AAO38851. Ref.2
	Sequence conflict	7293	1	E → V in AAO49800. Ref.3
	Sequence conflict	7293	1	E → V in AAH61502. Ref.4
	Sequence conflict	7333	1	V → L in AAO38851. Ref.2
	Sequence conflict	7333	1	V → L in AAH61502. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Mucin-19) [UniParc]. Last modified October 25, 2004. Version 2. Checksum: B99A4519CE1EF6D4	FASTA	7,524	693,499
	10 20 30 40 50 60 MKLILLYLAV VLCFVGKGAA RSPTTTRTPT PSTSEKASHV PEATPTYSEA NEVAGEATMW 70 80 90 100 110 120 GKDKYKALNG HIFSFESECT FTFCRDCAEP GGDFNIEIKK HKNGDIEEIK ALIDDVEILV 130 140 150 160 170 180 VRNSISVNEE RVKVPFSNKM IHIKKQGNHY SLKTRRRILS LKWSKDKLSL ILYSHYTTCG 190 200 210 220 230 240 LCGNFDSVPG DDVNEHIASS KISNDCPSPL SRSNEVCEDG VQYCDKIIET YFEKCSKVSP 250 260 270 280 290 300 LSREYKNVCA DEYCRKGGGK QTTCDTYSEL ARLCAYDGPG DYEHWRDDSA VVCAKEQCPG 310 320 330 340 350 360 KHIYKECGPS NPPTCSNVAP FQDSECVSGC TCPEGYLLDD IGEKGKCVLK EKCPCESNGK 370 380 390 400 410 420 VYKPGKVREG PCGSRCTCQE AKWSCTEARC PGICKVEGSS FTTFDDNKFS HPGDCHFLAV 430 440 450 460 470 480 HNDEISISVE IHPCGNGQTG SCLTSVMVLQ NSSSSSNRYV FNRDGTVTKD GVIIKGYYYS 490 500 510 520 530 540 DDVQIFNSSS SYMQAEILSH IKLQIQLAPR MQLYVSLAPN TSTDTVGLCG SFNNKAEDDF 550 560 570 580 590 600 MSSQNILEST AQAFANSWEM MPCSEGSPSS CVSIETEKFA ESNCEILLSS SGPFAACHQT 610 620 630 640 650 660 VNPKFYHEEC KKYTCSCENG QDCLCTVLGN YVKACAEKEI YLVGWRDGLC EVSCPSGLVF 670 680 690 700 710 720 NYKVKTCNSS CRSLSARDRS CDIEDIPVDG CTCPDGMYQN NEGNCVQKSE CDCYVNDEIV 730 740 750 760 770 780 QPGKSILIDD NKCVCQDGVL HCQTPLDLTL QNCSRGAEYI DCKDPKAQRR TERTCATRNI 790 800 810 820 830 840 PDFEGDLPCK RGCYCPVGMV RNSKGICIHP DDCPCSFGDR EYEQGSVTSV GCNECTCIKG 850 860 870 880 890 900 SWNCTQNECQ STCHVYGEGH FRTFDGESYS FDGLCQYTFL EDYCGQENGT FRILIESVPC 910 920 930 940 950 960 CENGLTCSRK VIVTFQDQNI ILQDGKVTAV QTAESTDCRE RSANLYSIHT VGLYLIVKLL 970 980 990 1000 1010 1020 NGIILIWDKY TKVSVILDPS WQNKVCGLCG NNNGDLKDDF TTRHSSVAAG ALEFANSWKT 1030 1040 1050 1060 1070 1080 SQECSDTVTQ SFPCDSNPYC KAWAEKRCEI LRDDTFRDCH SKVDPTTYYD ACIEEACSCD 1090 1100 1110 1120 1130 1140 MEGKYLGFCT AVAMYAEACN AAGVCVSWRK PNLCPVYCDY YNAPGECSWH YEPCGTVTAK 1150 1160 1170 1180 1190 1200 TCKDQVIGQK FSSLLEGCYA KCPENAPYLD ENTMKCVQLS ECSCFYNDVI PAGGAVVDDC 1210 1220 1230 1240 1250 1260 GRTCSCSAGE LECSETPPNS TTTTTATTAA VSTATTTSVL STSAAATRAS SSTSGSVETS 1270 1280 1290 1300 1310 1320 VPATTSTSKA QAHITTASST ETSALNSTAV YPKATTREGL LSSSGPGAFV AERPDNTPRP 1330 1340 1350 1360 1370 1380 AVSTTSAGST SARAATTSPG GSSGSSAPAS STSGRAATTT STSAATTTTT TTATTVGSAG 1390 1400 1410 1420 1430 1440 SSAPTASSTA AGSGLREAAN ATSAPASTSG QPGASTGSSG TSSSVSSTAA ATTAGTTTAA 1450 1460 1470 1480 1490 1500 SNETSAPAST AGPTSSATTA APASSSASSA TTPAETAGST TGPAVSTTSA GSTSARAATT 1510 1520 1530 1540 1550 1560 SPGGSSGSSA PASSTSGRAA TTTSTATTTT TTTTTATTVG SAGSSAPTAS STAAGSGLRE 1570 1580 1590 1600 1610 1620 AANATSAPAS TSGQPGASTG SSGTSSSVSS TAAATTAGTT TAASNETSAP ASTAGPTSSA 1630 1640 1650 1660 1670 1680 TTAAPASSSA SSATTPAETA GSTTGPAVST TSAGSTSARA ATTSPGGSSG SSAPASSTSG 1690 1700 1710 1720 1730 1740 RAATTTSTAT TTTTTTTTAT TVGSAGSSAP TASSTAAGSG LREAANATSA PASTSGQPGA 1750 1760 1770 1780 1790 1800 STGSSGTSSS VSSTAAATTA GTTTAASNET SAPASTAGPT SSATTAAPAS SSASSATTPA 1810 1820 1830 1840 1850 1860 ETAGSTTGPA VSTTSAGSTS ARAATTSPGG SSGSSAPASS TSGRAATTTS TATTTTTTTT 1870 1880 1890 1900 1910 1920 TATTVGSAGS SAPTASSTAA GSGLREAANA TSAPASTSGQ PGASTGSSGT SSSVSSTAAA 1930 1940 1950 1960 1970 1980 TTAGTTTAAS NETSAPASTA GPTSSATTAA PASSSASSAT TPAETAGSTT GPAVSTTSAG 1990 2000 2010 2020 2030 2040 STSARAATTS PGGSSGSSAP ASSTSGRAAT TTSTATTTTT TTTTATTVGS AGSSAPTASS 2050 2060 2070 2080 2090 2100 TAAGSGLREA ANATSAPAST SGQPGASTGS SGTSSSVSST AAATTAGTTT AASNETSAPA 2110 2120 2130 2140 2150 2160 STAGPTSSAT TAAPASSSAS SATTPAETAG STTGPAVSTT SAGSTSARAA TTSPGGSSGS 2170 2180 2190 2200 2210 2220 SAPASSTSGR AATTTSTATT TTTTTTTATT VGSAGSSAPT ASSTAAGSGL REAANATSAP 2230 2240 2250 2260 2270 2280 ASTSGQPGAS TGSSGTSSSV SSTAAATTAG TTTAASNETS APASTAGPTS SATTAAPASS 2290 2300 2310 2320 2330 2340 SASSATTPAE TAGSTTGPAV STTSAGSTSA RAATTSPGGS SGSSAPASST SGRAATTTST 2350 2360 2370 2380 2390 2400 ATTTTTTTTT ATTVGSAGSS APTASSTAAG SGLREAANAT SAPASTSGQP GASTGSSGTS 2410 2420 2430 2440 2450 2460 SSVSSTAAAT TAGTTTAASN ETSAPASTAG PTSSATTAAP ASSSASSATT PAETAGSTTG 2470 2480 2490 2500 2510 2520 PAVSTTSAGS TSARAATTSP GGSSGSSAPA SSTSGRAATT TSTATTTTTT TTTATTVGSA 2530 2540 2550 2560 2570 2580 GSSAPTASST AAGSGLREAA NATSAPASTS GQPGASTGSS GTSSSVSSTA AATTAGTTTA 2590 2600 2610 2620 2630 2640 ASNETSAPAS TAGPTSSATT AAPASSSASS ATTPAETAGS TTGPAVSTTS AGSTSARAAT 2650 2660 2670 2680 2690 2700 TSPGGSSGSS APASSTSGRA ATTTSTATTT TTTTTTATTV GSAGSSAPTA SSTAAGSGLR 2710 2720 2730 2740 2750 2760 EAANATSAPA STSGQPGAST GSSGTSSSVS STAAATTAGT TTAASNETSA PASTAGPTSS 2770 2780 2790 2800 2810 2820 ATTAAPASSS ASSATTPAET AGSTTGPAVS TTSAGSTSAR AATTSPGGSS GSSAPASSTS 2830 2840 2850 2860 2870 2880 GRAATTTSTA TTTTTTTTTA TTVGSAGSSA PTASSTAAGS GLREAANATS APASTSGQPG 2890 2900 2910 2920 2930 2940 ASTGSSGTSS SVSSTAAATT AGTTTAASNE TSAPASTAGP TSSATTAAPA SSSASSATTP 2950 2960 2970 2980 2990 3000 AETAGSTTGP AVSTTSAGST SARAATTSPG GSSGSSAPAS STSGRAATTT STATTTTTTT 3010 3020 3030 3040 3050 3060 TTATTVGSAG SSAPTASSTA AGSGLREAAN ATSAPASTSG QPGASTGSSG TSSSVSSTAA 3070 3080 3090 3100 3110 3120 ATTAGTTTAA SNETSAPAST AGPTSSATTA APASSSASSA TTPAETAGST TGPAVSTTSA 3130 3140 3150 3160 3170 3180 GSTSARAATT SPGGSSGSSA PASSTSGRAA TTTSTATTTT TTTTTATTVG SAGSSAPTAS 3190 3200 3210 3220 3230 3240 STAAGSGLRE AANATSAPAS TSGQPGASTG SSGTSSSVSS TAAATTAGTT TAASNETSAP 3250 3260 3270 3280 3290 3300 ASTAGPTSSA TTAAPASSSA SSATTPAETA GSTTGPAVST TSAGSTSARA ATTSPGGSSG 3310 3320 3330 3340 3350 3360 SSAPASSTSG RAATTTSTAT TTTTTTTTAT TVGSAGSSAP TASSTAAGSG LREAANATSA 3370 3380 3390 3400 3410 3420 PASTSGQPGA STGSSGTSSS VSSTAAATTA GTTTAASNET SAPASTAGPT SSATTAAPAS 3430 3440 3450 3460 3470 3480 SSASSATTPA ETAGSTTGPA VSTTSAGSTS ARAATTSPGG SSGSSAPASS TSGRAATTTS 3490 3500 3510 3520 3530 3540 TATTTTTTTT TATTVGSAGS SAPTASSTAA GSGLREAANA TSAPASTSGQ PGASTGSSGT 3550 3560 3570 3580 3590 3600 SSSVSSTAAA TTAGTTTAAS NETSAPASTA GPTSSATTAA PASSSASSAT TPAETAGSTT 3610 3620 3630 3640 3650 3660 GPAVSTTSAG STSARAATTS PGGSSGSSAP ASSTSGRAAT TTSTATTTTT TTTTATTVGS 3670 3680 3690 3700 3710 3720 AGSSAPTASS TAAGSGLREA ANATSAPAST SGQPGASTGS SGTSSSVSST AAATTAGTTT 3730 3740 3750 3760 3770 3780 AASNETSAPA STAGPTSSAT TAAPASSSAS SATTPAETAG STTGPAVSTT SAGSTSARAA 3790 3800 3810 3820 3830 3840 TTSPGGSSGS SAPASSTSGR AATTTSTATT TTTTTTTATT VGSAGSSAPT ASSTAAGSGL 3850 3860 3870 3880 3890 3900 REAANATSAP ASTSGQPGAS TGSSGTSSSV SSTAAATTAG TTTAASNETS APASTAGPTS 3910 3920 3930 3940 3950 3960 SATTAAPASS SASSATTPAE TAGSTTGPAV STTSAGSTSA RAATTSPGGS SGSSAPASST 3970 3980 3990 4000 4010 4020 SGRAATTTST ATTTTTTTTT ATTVGSAGSS APTASSTAAG SGLREAANAT SAPASTSGQP 4030 4040 4050 4060 4070 4080 GASTGSSGTS SSVSSTAAAT TAGTTTAASN ETSAPASTAG PTSSATTAAP ASSSASSATT 4090 4100 4110 4120 4130 4140 PAETAGSTTG PAVSTTSAGS TSARAATTSP GGSSGSSAPA SSTSGRAATT TSTATTTTTT 4150 4160 4170 4180 4190 4200 TTTATTVGSA GSSAPTASST AAGSGLREAA NATSAPASTS GQPGASTGSS GTSSSVSSTA 4210 4220 4230 4240 4250 4260 AATTAGTTTA ASNETSAPAS TAGPTSSATT AAPASSSASS ATTPAETAGS TTGPAVSTTS 4270 4280 4290 4300 4310 4320 AGSTSARAAT TSPGGSSGSS APASSTSGRA ATTTSTATTT TTTTTTATTV GSAGSSAPTA 4330 4340 4350 4360 4370 4380 SSTAAGSGLR EAANATSAPA STSGQPGAST GSSGTSSSVS STAAATTAGT TTAASNETSA 4390 4400 4410 4420 4430 4440 PASTAGPTSS ATTAAPASSS ASSATTPAET AGSTTGPAVS TTSAGSTSAR AATTSPGGSS 4450 4460 4470 4480 4490 4500 GSSAPASSTS GRAATTTSTA TTTTTTTTTA TTVGSAGSSA PTASSTAAGS GLREAANATS 4510 4520 4530 4540 4550 4560 APASTSGQPG ASTGSSGTSS SVSSTAAATT AGTTTAASNE TSAPASTAGP TSSATTAAPA 4570 4580 4590 4600 4610 4620 SSSASSATTP AETAGSTTGP AVSTTSAGST SARAATTSPG GSSGSSAPAS STSGRAATTT 4630 4640 4650 4660 4670 4680 STATTTTTTT TTATTVGSAG SSAPTASSTA AGSGLREAAN ATSAPASTSG QPGASTGSSG 4690 4700 4710 4720 4730 4740 TSSSVSSTAA ATTAGTTTAA SNETSAPAST AGPTSSATTA APASSSASSA TTPAETAGST 4750 4760 4770 4780 4790 4800 TGPAVSTTSA GSTSARAATT SPGGSSGSSA PASSTSGRAA TTTSTATTTT TTTTTATTVG 4810 4820 4830 4840 4850 4860 SAGSSAPTAS STAAGSGLRE AANATSAPAS TSGQPGASTG SSGTSSSVSS TAAATTAGTT 4870 4880 4890 4900 4910 4920 TAASNETSAP ASTAGPTSSA TTAAPASSSA SSATTPAETA GSTTGPAVST TSAGSTSARA 4930 4940 4950 4960 4970 4980 ATTSPGGSSG SSAPASSTSG RAATTTSTAT TTTTTTTTAT TVGSAGSSAP TASSTAAGSG 4990 5000 5010 5020 5030 5040 LREAANATSA PASTSGQPGA STGSSGTSSS VSSTAAATTA GTTTAASNET SAPASTAGPT 5050 5060 5070 5080 5090 5100 SSATTAAPAS SSASSATTPA ETAGSTTGPA VSTTSAGSTS ARAATTSPGG SSGSSAPASS 5110 5120 5130 5140 5150 5160 TSGRAATTTS TATTTTTTTT TATTVGSAGS SAPTASSTAA GSGLREAANA TSAPASTSGQ 5170 5180 5190 5200 5210 5220 PGASTGSSGT SSSVSSTAAA TTAGTTTAAS NETSAPASTA GPTSSATTAA PASSSASSAT 5230 5240 5250 5260 5270 5280 TPAETAGSTT GPAVSTTSAG STSARAATTS PGGSSGSSAP ASSTSGRAAT TTSTATTTTT 5290 5300 5310 5320 5330 5340 TTTTATTVGS AGSSAPTASS TAAGSGLREA ANATSAPAST SGQPGASTGS SGTSSSVSST 5350 5360 5370 5380 5390 5400 AAATTAGTTT AASNETSAPA STAGPTSSAT TAAPASSSAS SATTPAETAG STTGPAVSTT 5410 5420 5430 5440 5450 5460 SAGSTSARAA TTSPGGSSGS SAPASSTSGR AATTTSTATT TTTTTTTATT VGSAGSSAPT 5470 5480 5490 5500 5510 5520 ASSTAAGSGL REAANATSAP ASTSGQPGAS TGSSGTSSSV SSTAAATTAG TTTAASNETS 5530 5540 5550 5560 5570 5580 APASTAGPTS SATTAAPASS SASSATTPAE TAGSTTGPAV STTSAGSTSA RAATTSPGGS 5590 5600 5610 5620 5630 5640 SGSSAPASST SGRAATTTST ATTTTTTTTT ATTVGSAGSS APTASSTAAG SGLREAANAT 5650 5660 5670 5680 5690 5700 SAPASTSGQP GASTGSSGTS SSVSSTAAAT TAGTTTAASN ETSAPASTAG PTSSATTAAP 5710 5720 5730 5740 5750 5760 ASSSASSATT PAETAGSTTG PAVSTTSAGS TSARAATTSP GGSSGSSAPA SSTSGRAATT 5770 5780 5790 5800 5810 5820 TSTATTTTTT TTTATTVGSA GSSAPTASST AAGSGLREAA NATSAPASTS GQPGASTGSS 5830 5840 5850 5860 5870 5880 GTSSSVSSTA AATTAGTTTA ASNETSAPAS TAGPTSSATT AAPASSSASS ATTPAETAGS 5890 5900 5910 5920 5930 5940 TTGPAVSTTS AGSTSARAAT TSPGGSSGSS APASSTSGRA ATTTSTATTT TTTTTTATTV 5950 5960 5970 5980 5990 6000 GSAGSSAPTA SSTAAGSGLR EAANATSAPA STSGQPGAST GSSGTSSSVS STAAATTAGT 6010 6020 6030 6040 6050 6060 TTAASNETSA PASTAGPTSS ATTAAPASSS ASSATTPAET AGSTTGPAVS TTSAGSTSAR 6070 6080 6090 6100 6110 6120 AATTSPGGSS GSSAPASSTS GRAATTTSTA TTTTTTTTTA TTVGSAGSSA PTASSTAAGS 6130 6140 6150 6160 6170 6180 GLREAANATS APASTSGQPG ASTGSSGTSS SVSSTAAATT AGTTTAASNE TSAPASTAGP 6190 6200 6210 6220 6230 6240 TSSATTAAPA SSSASSATTP AETAGSTTGP AVSTTSAGST SARAATTSPG GSSGSSAPAS 6250 6260 6270 6280 6290 6300 STSGRAATTT STATTTTTTT TTATTVGSAG SSAPTASSTA AGSGLREAAN ATSAPASTSG 6310 6320 6330 6340 6350 6360 QPGASTGSSG TSSSVSSTAA ATTAGTTTAA SNETSAPAST AGPTSSATTA APASSSASSA 6370 6380 6390 6400 6410 6420 TTPAETAGST TGPAVSTTSA GSTSARAATT SPGGSSGSSA PASSTSGRAA TTTSTATTTT 6430 6440 6450 6460 6470 6480 TTTTTATTVG SAGSSAPTAS STAAGSGLRE AANATSAPAS TSGQPGASTG SSGTSSSVSS 6490 6500 6510 6520 6530 6540 TAAATTAGTT TAASNETSAP ASTAGPTSSA TTAAPASSSA SSATTPAETA GSTTGPAVST 6550 6560 6570 6580 6590 6600 TSAGSTSARA ATTSPGGSSG SSAPASSTSG RAATTTSTAT TTTTTTTTAT TVGSAGSSAP 6610 6620 6630 6640 6650 6660 TASSTAAGSG LREAANATSA PASTSGQPGA STGSSGTSSS VSSTAAATTA GTTTAASNET 6670 6680 6690 6700 6710 6720 SAPASTAGPT SSATTAAPAS SSASSATTPA ETAGSTTGPA VSTTSAGSTS ARAATTSPGG 6730 6740 6750 6760 6770 6780 SSGSSAPASS TSGRAATTTS TATTTTTTTT TATTVGSAGS SAPTASSTAA GSGLREAANA 6790 6800 6810 6820 6830 6840 TSAPASTSGQ PGASTGSSGT SSSVSSTAAA TTAGTTTAAS NETSAPASTA GPTSSATTAA 6850 6860 6870 6880 6890 6900 PASSSASSAT TPAETAGSTT GPAVSTTSAG STSARAATTS PGGSSGSSAP ASSTSGRAAT 6910 6920 6930 6940 6950 6960 TTSTATTTTT TTTTATTVGS AGSSAPTASS TAAGSGLREA ANATSAPAST SGQPGASTGS 6970 6980 6990 7000 7010 7020 SGTSSSVSST AAATTAGTTT AASNETSAPA STAGPTSSAT TAAPASSSAS SATTPAETAG 7030 7040 7050 7060 7070 7080 STTGPAVSTT SAGSTSARAA TTSPGGSSGS SAPASSTSGR AATTTSTATT TTTTTTTATT 7090 7100 7110 7120 7130 7140 VGSAGSSAPT ASSTAAGSGL REAANATSAP VSTSGQPGAS TGSSGTSSSV SSTAAATTAG 7150 7160 7170 7180 7190 7200 TTTAASNETS APASTAGPTS SATTAAPASS SASSATTPAE TAGSTTGPAV STTSAGSTSA 7210 7220 7230 7240 7250 7260 RAATTSPGGS SGSSSLAIST MSVSSSSFIS PSGHPVPSTA SVAFLSSPSV IKTGGTTGTT 7270 7280 7290 7300 7310 7320 AKSNETTGRT TSMPASTSVA PGVTTSPNIS QPECPDSLPP TPVCHGPLGE EKSPGDVWIS 7330 7340 7350 7360 7370 7380 NCHQCTCTEK QAVDCKPKEC PSPPTCKDGE KLMKFKSNDS CCEIGHCEPR TCLFNNTDYA 7390 7400 7410 7420 7430 7440 IGSSFDDPSN PCLSYTCNPT GLVAVVQDCP KQTWCAEEER IYDSNKCCYK CKNDCRTTPV 7450 7460 7470 7480 7490 7500 NVTVKYNGCR KRVEMARCIG ECKRSVKYNY ETFQLENSCS CCREENYEFR DIALECSDGS 7510 7520 TIPYRYRHTT TCSCRDQCEQ SKAS
	Isoform 2 (Smgc) [UniParc]. See Q6JHY2.		–	–
	Isoform 3 [UniParc]. See Q6JHY2.		–	–
	Isoform 4 [UniParc]. See Q6JHY2.		–	–
	Isoform 5 (t-Smgc) [UniParc]. See Q6JHY2.		–	–
	Isoform 6 [UniParc]. See Q6JHY2.		–	–

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The gene encoding mouse Muc19: cDNA, genomic organization and relationship to Smgc." Culp D.J., Latchney L.R., Fallon M.A., Denny P.A., Denny P.C., Couwenhoven R.I., Chuang S. Physiol. Genomics 19:303-318(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Strain: NFS. Tissue: Sublingual gland.
[2]	"The sld mutation is specific for sublingual salivary mucous cells and disrupts apomucin gene expression." Fallon M.A., Latchney L.R., Hand A.R., Johar A., Denny P.A., Georgel P.T., Denny P.C., Culp D.J. Physiol. Genomics 14:95-106(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6711-7524, TISSUE SPECIFICITY. Strain: Swiss Webster. Tissue: Sublingual gland.
[3]	"Genome-wide search and identification of a novel gel-forming mucin MUC19/Muc19 in glandular tissues." Chen Y., Zhao Y.H., Kalaslavadi T.B., Hamati E., Nehrke K., Le A.D., Ann D.K., Wu R. Am. J. Respir. Cell Mol. Biol. 30:155-165(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6918-7524, TISSUE SPECIFICITY. Strain: C57BL/6 X DBA/2.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7276-7524. Strain: FVB/N. Tissue: Salivary gland.
+	Additional computationally mapped references.

Web resources

Mucin database

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY570293 mRNA. Translation: AAS77382.2. EU089955 mRNA. Translation: ABU50842.1. EU089956 mRNA. Translation: ABU50843.1. EU089957 mRNA. Translation: ABU50844.1. EU089959 mRNA. Translation: ABU50846.1. AY172172 mRNA. Translation: AAO38851.1. AY193891 mRNA. Translation: AAO49800.1. Sequence problems. BC061502 mRNA. Translation: AAH61502.1.
IPI	IPI00464259.
RefSeq	NP_997126.2. NM_207243.2.
UniGene	Mm.486225.
3D structure databases
HSSP	HSSP built from PDB template 1CCV based on UniProtKB P56682.
ProteinModelPortal	Q6PZE0.
SMR	Q6PZE0. Positions 297-353, 633-724, 793-823.
ModBase	Search...
PTM databases
PhosphoSite	Q6PZE0.
Proteomic databases
PRIDE	Q6PZE0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	239611.
KEGG	mmu:239611.
UCSC	uc007xie.1. mouse.
Organism-specific databases
CTD	283463.
MGI	MGI:2676278. Muc19.
Phylogenomic databases
eggNOG	NOG12793.
InParanoid	Q6PZE0.
OrthoDB	EOG4WQ127.
Gene expression databases
ArrayExpress	Q6PZE0.
Bgee	Q6PZE0.
CleanEx	MM_MUC19.
Genevestigator	Q6PZE0.
Family and domain databases
InterPro	IPR006207. Cys_knot_C. IPR020922. Nucleoside-triphosphatase. IPR005665. SecF_bac. IPR002919. TIL_dom. IPR014853. Unchr_dom_Cys-rich. IPR001007. VWF_C. IPR001846. VWF_type-D. [Graphical view]
Pfam	PF08742. C8. 3 hits. PF01826. TIL. 1 hit. PF00094. VWD. 3 hits. [Graphical view]
SMART	SM00832. C8. 2 hits. SM00041. CT. 1 hit. SM00214. VWC. 2 hits. SM00216. VWD. 3 hits. [Graphical view]
SUPFAM	SSF57567. Cysrich_TIL. 4 hits.
PROSITE	PS01185. CTCK_1. 1 hit. PS01225. CTCK_2. 1 hit. PS01208. VWFC_1. 1 hit. PS50184. VWFC_2. 1 hit. PS51233. VWFD. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	384199.
SOURCE	Search...

Entry information

Entry name

MUC19_MOUSE

Accession

Primary (citable) accession number: Q6PZE0
Secondary accession number(s): A7UN62 , A7UN63, A7UN64, A7UN66, Q6P7U5, Q6Y0X6, Q80UR5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	October 25, 2004
Last modified:	May 1, 2013
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program