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Q6PZE0

- MUC19_MOUSE

UniProt

Q6PZE0 - MUC19_MOUSE

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Protein
Mucin-19
Gene
Muc19
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May function in ocular mucus homeostasis By similarity.

GO - Biological processi

  1. cell differentiation involved in salivary gland development Source: MGI
  2. hematopoietic progenitor cell differentiation Source: MGI
  3. negative regulation of inflammatory response Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_198517. O-linked glycosylation of mucins.
REACT_198575. Termination of O-glycan biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-19
Short name:
MUC-19
Alternative name(s):
Gel-forming secreted mucin-19
Sublingual apomucin
Gene namesi
Name:Muc19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2676278. Muc19.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 75247504Mucin-19
PRO_5000093121Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi? ↔ 7518 By similarity
Disulfide bondi79 ↔ 87 By similarity
Disulfide bondi7435 ↔ 7482 By similarity
Disulfide bondi7449 ↔ 7496 By similarity
Disulfide bondi7458 ↔ 7512 By similarity
Disulfide bondi7462 ↔ 7514 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ6PZE0.
PRIDEiQ6PZE0.

PTM databases

PhosphoSiteiQ6PZE0.

Expressioni

Tissue specificityi

Specifically expressed in sublingual salivary glands. Expressed by mucous cells of the submandibular gland and submucosal gland of the trachea. Expression is altered in sld (sublingual gland differentiation arrest) mutants.3 Publications

Gene expression databases

BgeeiQ6PZE0.
CleanExiMM_MUC19.
GenevestigatoriQ6PZE0.

Structurei

3D structure databases

ProteinModelPortaliQ6PZE0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 257202VWFD 1
Add
BLAST
Domaini298 – 35356TIL
Add
BLAST
Domaini392 – 600209VWFD 2
Add
BLAST
Domaini852 – 1062211VWFD 3
Add
BLAST
Repeati1321 – 14831631
Add
BLAST
Repeati1484 – 16461632
Add
BLAST
Repeati1647 – 18091633
Add
BLAST
Repeati1810 – 19721634
Add
BLAST
Repeati1973 – 21351635
Add
BLAST
Repeati2136 – 22981636
Add
BLAST
Repeati2299 – 24611637
Add
BLAST
Repeati2462 – 26241638
Add
BLAST
Repeati2625 – 27871639
Add
BLAST
Repeati2788 – 295016310
Add
BLAST
Repeati2951 – 311316311
Add
BLAST
Repeati3114 – 327616312
Add
BLAST
Repeati3277 – 343916313
Add
BLAST
Repeati3440 – 360216314
Add
BLAST
Repeati3603 – 376516315
Add
BLAST
Repeati3766 – 392816316
Add
BLAST
Repeati3929 – 409116317
Add
BLAST
Repeati4092 – 425416318
Add
BLAST
Repeati4255 – 441716319
Add
BLAST
Repeati4418 – 458016320
Add
BLAST
Repeati4581 – 474316321
Add
BLAST
Repeati4744 – 490616322
Add
BLAST
Repeati4907 – 506916323
Add
BLAST
Repeati5070 – 523216324
Add
BLAST
Repeati5233 – 539516325
Add
BLAST
Repeati5396 – 555816326
Add
BLAST
Repeati5559 – 572116327
Add
BLAST
Repeati5722 – 588416328
Add
BLAST
Repeati5885 – 604716329
Add
BLAST
Repeati6048 – 621016330
Add
BLAST
Repeati6211 – 637316331
Add
BLAST
Repeati6374 – 653616332
Add
BLAST
Repeati6537 – 669916333
Add
BLAST
Repeati6700 – 686216334
Add
BLAST
Repeati6863 – 702516335
Add
BLAST
Repeati7026 – 718816336
Add
BLAST
Domaini7302 – 736867VWFC 1
Add
BLAST
Domaini7370 – 743263VWFC 2
Add
BLAST
Domaini7435 – 751985CTCK
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1321 – 71885868Approximate repeats
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1216 – 72856070Thr-rich
Add
BLAST
Compositional biasi1238 – 72496012Ser-rich
Add
BLAST

Sequence similaritiesi

Contains 2 VWFC domains.
Contains 3 VWFD domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
InParanoidiQ6PZE0.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF08742. C8. 3 hits.
PF01826. TIL. 1 hit.
PF00094. VWD. 3 hits.
[Graphical view]
SMARTiSM00832. C8. 2 hits.
SM00041. CT. 1 hit.
SM00214. VWC. 2 hits.
SM00216. VWD. 3 hits.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 3 hits.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
PS51233. VWFD. 3 hits.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. Align

Note: Isoform 1 and isoform 2-6 share the first 17 amino acid residues that correspond to the signal sequence.

Isoform 1 (identifier: Q6PZE0-1) [UniParc]FASTAAdd to Basket

Also known as: Mucin-19

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKLILLYLAV VLCFVGKGAA RSPTTTRTPT PSTSEKASHV PEATPTYSEA     50
NEVAGEATMW GKDKYKALNG HIFSFESECT FTFCRDCAEP GGDFNIEIKK 100
HKNGDIEEIK ALIDDVEILV VRNSISVNEE RVKVPFSNKM IHIKKQGNHY 150
SLKTRRRILS LKWSKDKLSL ILYSHYTTCG LCGNFDSVPG DDVNEHIASS 200
KISNDCPSPL SRSNEVCEDG VQYCDKIIET YFEKCSKVSP LSREYKNVCA 250
DEYCRKGGGK QTTCDTYSEL ARLCAYDGPG DYEHWRDDSA VVCAKEQCPG 300
KHIYKECGPS NPPTCSNVAP FQDSECVSGC TCPEGYLLDD IGEKGKCVLK 350
EKCPCESNGK VYKPGKVREG PCGSRCTCQE AKWSCTEARC PGICKVEGSS 400
FTTFDDNKFS HPGDCHFLAV HNDEISISVE IHPCGNGQTG SCLTSVMVLQ 450
NSSSSSNRYV FNRDGTVTKD GVIIKGYYYS DDVQIFNSSS SYMQAEILSH 500
IKLQIQLAPR MQLYVSLAPN TSTDTVGLCG SFNNKAEDDF MSSQNILEST 550
AQAFANSWEM MPCSEGSPSS CVSIETEKFA ESNCEILLSS SGPFAACHQT 600
VNPKFYHEEC KKYTCSCENG QDCLCTVLGN YVKACAEKEI YLVGWRDGLC 650
EVSCPSGLVF NYKVKTCNSS CRSLSARDRS CDIEDIPVDG CTCPDGMYQN 700
NEGNCVQKSE CDCYVNDEIV QPGKSILIDD NKCVCQDGVL HCQTPLDLTL 750
QNCSRGAEYI DCKDPKAQRR TERTCATRNI PDFEGDLPCK RGCYCPVGMV 800
RNSKGICIHP DDCPCSFGDR EYEQGSVTSV GCNECTCIKG SWNCTQNECQ 850
STCHVYGEGH FRTFDGESYS FDGLCQYTFL EDYCGQENGT FRILIESVPC 900
CENGLTCSRK VIVTFQDQNI ILQDGKVTAV QTAESTDCRE RSANLYSIHT 950
VGLYLIVKLL NGIILIWDKY TKVSVILDPS WQNKVCGLCG NNNGDLKDDF 1000
TTRHSSVAAG ALEFANSWKT SQECSDTVTQ SFPCDSNPYC KAWAEKRCEI 1050
LRDDTFRDCH SKVDPTTYYD ACIEEACSCD MEGKYLGFCT AVAMYAEACN 1100
AAGVCVSWRK PNLCPVYCDY YNAPGECSWH YEPCGTVTAK TCKDQVIGQK 1150
FSSLLEGCYA KCPENAPYLD ENTMKCVQLS ECSCFYNDVI PAGGAVVDDC 1200
GRTCSCSAGE LECSETPPNS TTTTTATTAA VSTATTTSVL STSAAATRAS 1250
SSTSGSVETS VPATTSTSKA QAHITTASST ETSALNSTAV YPKATTREGL 1300
LSSSGPGAFV AERPDNTPRP AVSTTSAGST SARAATTSPG GSSGSSAPAS 1350
STSGRAATTT STSAATTTTT TTATTVGSAG SSAPTASSTA AGSGLREAAN 1400
ATSAPASTSG QPGASTGSSG TSSSVSSTAA ATTAGTTTAA SNETSAPAST 1450
AGPTSSATTA APASSSASSA TTPAETAGST TGPAVSTTSA GSTSARAATT 1500
SPGGSSGSSA PASSTSGRAA TTTSTATTTT TTTTTATTVG SAGSSAPTAS 1550
STAAGSGLRE AANATSAPAS TSGQPGASTG SSGTSSSVSS TAAATTAGTT 1600
TAASNETSAP ASTAGPTSSA TTAAPASSSA SSATTPAETA GSTTGPAVST 1650
TSAGSTSARA ATTSPGGSSG SSAPASSTSG RAATTTSTAT TTTTTTTTAT 1700
TVGSAGSSAP TASSTAAGSG LREAANATSA PASTSGQPGA STGSSGTSSS 1750
VSSTAAATTA GTTTAASNET SAPASTAGPT SSATTAAPAS SSASSATTPA 1800
ETAGSTTGPA VSTTSAGSTS ARAATTSPGG SSGSSAPASS TSGRAATTTS 1850
TATTTTTTTT TATTVGSAGS SAPTASSTAA GSGLREAANA TSAPASTSGQ 1900
PGASTGSSGT SSSVSSTAAA TTAGTTTAAS NETSAPASTA GPTSSATTAA 1950
PASSSASSAT TPAETAGSTT GPAVSTTSAG STSARAATTS PGGSSGSSAP 2000
ASSTSGRAAT TTSTATTTTT TTTTATTVGS AGSSAPTASS TAAGSGLREA 2050
ANATSAPAST SGQPGASTGS SGTSSSVSST AAATTAGTTT AASNETSAPA 2100
STAGPTSSAT TAAPASSSAS SATTPAETAG STTGPAVSTT SAGSTSARAA 2150
TTSPGGSSGS SAPASSTSGR AATTTSTATT TTTTTTTATT VGSAGSSAPT 2200
ASSTAAGSGL REAANATSAP ASTSGQPGAS TGSSGTSSSV SSTAAATTAG 2250
TTTAASNETS APASTAGPTS SATTAAPASS SASSATTPAE TAGSTTGPAV 2300
STTSAGSTSA RAATTSPGGS SGSSAPASST SGRAATTTST ATTTTTTTTT 2350
ATTVGSAGSS APTASSTAAG SGLREAANAT SAPASTSGQP GASTGSSGTS 2400
SSVSSTAAAT TAGTTTAASN ETSAPASTAG PTSSATTAAP ASSSASSATT 2450
PAETAGSTTG PAVSTTSAGS TSARAATTSP GGSSGSSAPA SSTSGRAATT 2500
TSTATTTTTT TTTATTVGSA GSSAPTASST AAGSGLREAA NATSAPASTS 2550
GQPGASTGSS GTSSSVSSTA AATTAGTTTA ASNETSAPAS TAGPTSSATT 2600
AAPASSSASS ATTPAETAGS TTGPAVSTTS AGSTSARAAT TSPGGSSGSS 2650
APASSTSGRA ATTTSTATTT TTTTTTATTV GSAGSSAPTA SSTAAGSGLR 2700
EAANATSAPA STSGQPGAST GSSGTSSSVS STAAATTAGT TTAASNETSA 2750
PASTAGPTSS ATTAAPASSS ASSATTPAET AGSTTGPAVS TTSAGSTSAR 2800
AATTSPGGSS GSSAPASSTS GRAATTTSTA TTTTTTTTTA TTVGSAGSSA 2850
PTASSTAAGS GLREAANATS APASTSGQPG ASTGSSGTSS SVSSTAAATT 2900
AGTTTAASNE TSAPASTAGP TSSATTAAPA SSSASSATTP AETAGSTTGP 2950
AVSTTSAGST SARAATTSPG GSSGSSAPAS STSGRAATTT STATTTTTTT 3000
TTATTVGSAG SSAPTASSTA AGSGLREAAN ATSAPASTSG QPGASTGSSG 3050
TSSSVSSTAA ATTAGTTTAA SNETSAPAST AGPTSSATTA APASSSASSA 3100
TTPAETAGST TGPAVSTTSA GSTSARAATT SPGGSSGSSA PASSTSGRAA 3150
TTTSTATTTT TTTTTATTVG SAGSSAPTAS STAAGSGLRE AANATSAPAS 3200
TSGQPGASTG SSGTSSSVSS TAAATTAGTT TAASNETSAP ASTAGPTSSA 3250
TTAAPASSSA SSATTPAETA GSTTGPAVST TSAGSTSARA ATTSPGGSSG 3300
SSAPASSTSG RAATTTSTAT TTTTTTTTAT TVGSAGSSAP TASSTAAGSG 3350
LREAANATSA PASTSGQPGA STGSSGTSSS VSSTAAATTA GTTTAASNET 3400
SAPASTAGPT SSATTAAPAS SSASSATTPA ETAGSTTGPA VSTTSAGSTS 3450
ARAATTSPGG SSGSSAPASS TSGRAATTTS TATTTTTTTT TATTVGSAGS 3500
SAPTASSTAA GSGLREAANA TSAPASTSGQ PGASTGSSGT SSSVSSTAAA 3550
TTAGTTTAAS NETSAPASTA GPTSSATTAA PASSSASSAT TPAETAGSTT 3600
GPAVSTTSAG STSARAATTS PGGSSGSSAP ASSTSGRAAT TTSTATTTTT 3650
TTTTATTVGS AGSSAPTASS TAAGSGLREA ANATSAPAST SGQPGASTGS 3700
SGTSSSVSST AAATTAGTTT AASNETSAPA STAGPTSSAT TAAPASSSAS 3750
SATTPAETAG STTGPAVSTT SAGSTSARAA TTSPGGSSGS SAPASSTSGR 3800
AATTTSTATT TTTTTTTATT VGSAGSSAPT ASSTAAGSGL REAANATSAP 3850
ASTSGQPGAS TGSSGTSSSV SSTAAATTAG TTTAASNETS APASTAGPTS 3900
SATTAAPASS SASSATTPAE TAGSTTGPAV STTSAGSTSA RAATTSPGGS 3950
SGSSAPASST SGRAATTTST ATTTTTTTTT ATTVGSAGSS APTASSTAAG 4000
SGLREAANAT SAPASTSGQP GASTGSSGTS SSVSSTAAAT TAGTTTAASN 4050
ETSAPASTAG PTSSATTAAP ASSSASSATT PAETAGSTTG PAVSTTSAGS 4100
TSARAATTSP GGSSGSSAPA SSTSGRAATT TSTATTTTTT TTTATTVGSA 4150
GSSAPTASST AAGSGLREAA NATSAPASTS GQPGASTGSS GTSSSVSSTA 4200
AATTAGTTTA ASNETSAPAS TAGPTSSATT AAPASSSASS ATTPAETAGS 4250
TTGPAVSTTS AGSTSARAAT TSPGGSSGSS APASSTSGRA ATTTSTATTT 4300
TTTTTTATTV GSAGSSAPTA SSTAAGSGLR EAANATSAPA STSGQPGAST 4350
GSSGTSSSVS STAAATTAGT TTAASNETSA PASTAGPTSS ATTAAPASSS 4400
ASSATTPAET AGSTTGPAVS TTSAGSTSAR AATTSPGGSS GSSAPASSTS 4450
GRAATTTSTA TTTTTTTTTA TTVGSAGSSA PTASSTAAGS GLREAANATS 4500
APASTSGQPG ASTGSSGTSS SVSSTAAATT AGTTTAASNE TSAPASTAGP 4550
TSSATTAAPA SSSASSATTP AETAGSTTGP AVSTTSAGST SARAATTSPG 4600
GSSGSSAPAS STSGRAATTT STATTTTTTT TTATTVGSAG SSAPTASSTA 4650
AGSGLREAAN ATSAPASTSG QPGASTGSSG TSSSVSSTAA ATTAGTTTAA 4700
SNETSAPAST AGPTSSATTA APASSSASSA TTPAETAGST TGPAVSTTSA 4750
GSTSARAATT SPGGSSGSSA PASSTSGRAA TTTSTATTTT TTTTTATTVG 4800
SAGSSAPTAS STAAGSGLRE AANATSAPAS TSGQPGASTG SSGTSSSVSS 4850
TAAATTAGTT TAASNETSAP ASTAGPTSSA TTAAPASSSA SSATTPAETA 4900
GSTTGPAVST TSAGSTSARA ATTSPGGSSG SSAPASSTSG RAATTTSTAT 4950
TTTTTTTTAT TVGSAGSSAP TASSTAAGSG LREAANATSA PASTSGQPGA 5000
STGSSGTSSS VSSTAAATTA GTTTAASNET SAPASTAGPT SSATTAAPAS 5050
SSASSATTPA ETAGSTTGPA VSTTSAGSTS ARAATTSPGG SSGSSAPASS 5100
TSGRAATTTS TATTTTTTTT TATTVGSAGS SAPTASSTAA GSGLREAANA 5150
TSAPASTSGQ PGASTGSSGT SSSVSSTAAA TTAGTTTAAS NETSAPASTA 5200
GPTSSATTAA PASSSASSAT TPAETAGSTT GPAVSTTSAG STSARAATTS 5250
PGGSSGSSAP ASSTSGRAAT TTSTATTTTT TTTTATTVGS AGSSAPTASS 5300
TAAGSGLREA ANATSAPAST SGQPGASTGS SGTSSSVSST AAATTAGTTT 5350
AASNETSAPA STAGPTSSAT TAAPASSSAS SATTPAETAG STTGPAVSTT 5400
SAGSTSARAA TTSPGGSSGS SAPASSTSGR AATTTSTATT TTTTTTTATT 5450
VGSAGSSAPT ASSTAAGSGL REAANATSAP ASTSGQPGAS TGSSGTSSSV 5500
SSTAAATTAG TTTAASNETS APASTAGPTS SATTAAPASS SASSATTPAE 5550
TAGSTTGPAV STTSAGSTSA RAATTSPGGS SGSSAPASST SGRAATTTST 5600
ATTTTTTTTT ATTVGSAGSS APTASSTAAG SGLREAANAT SAPASTSGQP 5650
GASTGSSGTS SSVSSTAAAT TAGTTTAASN ETSAPASTAG PTSSATTAAP 5700
ASSSASSATT PAETAGSTTG PAVSTTSAGS TSARAATTSP GGSSGSSAPA 5750
SSTSGRAATT TSTATTTTTT TTTATTVGSA GSSAPTASST AAGSGLREAA 5800
NATSAPASTS GQPGASTGSS GTSSSVSSTA AATTAGTTTA ASNETSAPAS 5850
TAGPTSSATT AAPASSSASS ATTPAETAGS TTGPAVSTTS AGSTSARAAT 5900
TSPGGSSGSS APASSTSGRA ATTTSTATTT TTTTTTATTV GSAGSSAPTA 5950
SSTAAGSGLR EAANATSAPA STSGQPGAST GSSGTSSSVS STAAATTAGT 6000
TTAASNETSA PASTAGPTSS ATTAAPASSS ASSATTPAET AGSTTGPAVS 6050
TTSAGSTSAR AATTSPGGSS GSSAPASSTS GRAATTTSTA TTTTTTTTTA 6100
TTVGSAGSSA PTASSTAAGS GLREAANATS APASTSGQPG ASTGSSGTSS 6150
SVSSTAAATT AGTTTAASNE TSAPASTAGP TSSATTAAPA SSSASSATTP 6200
AETAGSTTGP AVSTTSAGST SARAATTSPG GSSGSSAPAS STSGRAATTT 6250
STATTTTTTT TTATTVGSAG SSAPTASSTA AGSGLREAAN ATSAPASTSG 6300
QPGASTGSSG TSSSVSSTAA ATTAGTTTAA SNETSAPAST AGPTSSATTA 6350
APASSSASSA TTPAETAGST TGPAVSTTSA GSTSARAATT SPGGSSGSSA 6400
PASSTSGRAA TTTSTATTTT TTTTTATTVG SAGSSAPTAS STAAGSGLRE 6450
AANATSAPAS TSGQPGASTG SSGTSSSVSS TAAATTAGTT TAASNETSAP 6500
ASTAGPTSSA TTAAPASSSA SSATTPAETA GSTTGPAVST TSAGSTSARA 6550
ATTSPGGSSG SSAPASSTSG RAATTTSTAT TTTTTTTTAT TVGSAGSSAP 6600
TASSTAAGSG LREAANATSA PASTSGQPGA STGSSGTSSS VSSTAAATTA 6650
GTTTAASNET SAPASTAGPT SSATTAAPAS SSASSATTPA ETAGSTTGPA 6700
VSTTSAGSTS ARAATTSPGG SSGSSAPASS TSGRAATTTS TATTTTTTTT 6750
TATTVGSAGS SAPTASSTAA GSGLREAANA TSAPASTSGQ PGASTGSSGT 6800
SSSVSSTAAA TTAGTTTAAS NETSAPASTA GPTSSATTAA PASSSASSAT 6850
TPAETAGSTT GPAVSTTSAG STSARAATTS PGGSSGSSAP ASSTSGRAAT 6900
TTSTATTTTT TTTTATTVGS AGSSAPTASS TAAGSGLREA ANATSAPAST 6950
SGQPGASTGS SGTSSSVSST AAATTAGTTT AASNETSAPA STAGPTSSAT 7000
TAAPASSSAS SATTPAETAG STTGPAVSTT SAGSTSARAA TTSPGGSSGS 7050
SAPASSTSGR AATTTSTATT TTTTTTTATT VGSAGSSAPT ASSTAAGSGL 7100
REAANATSAP VSTSGQPGAS TGSSGTSSSV SSTAAATTAG TTTAASNETS 7150
APASTAGPTS SATTAAPASS SASSATTPAE TAGSTTGPAV STTSAGSTSA 7200
RAATTSPGGS SGSSSLAIST MSVSSSSFIS PSGHPVPSTA SVAFLSSPSV 7250
IKTGGTTGTT AKSNETTGRT TSMPASTSVA PGVTTSPNIS QPECPDSLPP 7300
TPVCHGPLGE EKSPGDVWIS NCHQCTCTEK QAVDCKPKEC PSPPTCKDGE 7350
KLMKFKSNDS CCEIGHCEPR TCLFNNTDYA IGSSFDDPSN PCLSYTCNPT 7400
GLVAVVQDCP KQTWCAEEER IYDSNKCCYK CKNDCRTTPV NVTVKYNGCR 7450
KRVEMARCIG ECKRSVKYNY ETFQLENSCS CCREENYEFR DIALECSDGS 7500
TIPYRYRHTT TCSCRDQCEQ SKAS 7524
Length:7,524
Mass (Da):693,499
Last modified:October 25, 2004 - v2
Checksum:iB99A4519CE1EF6D4
GO
Isoform 2 (identifier: Q6JHY2-1) [UniParc]FASTAAdd to Basket

Also known as: Smgc

The sequence of this isoform can be found in the external entry Q6JHY2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:733
Mass (Da):74,383
GO
Isoform 3 (identifier: Q6JHY2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry Q6JHY2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: No experimental confirmation available.

Length:700
Mass (Da):70,835
GO
Isoform 4 (identifier: Q6JHY2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry Q6JHY2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: No experimental confirmation available.

Length:341
Mass (Da):34,128
GO
Isoform 5 (identifier: Q6JHY2-4) [UniParc]FASTAAdd to Basket

Also known as: t-Smgc

The sequence of this isoform can be found in the external entry Q6JHY2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:128
Mass (Da):12,633
GO
Isoform 6 (identifier: Q6JHY2-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry Q6JHY2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:431
Mass (Da):43,160
GO

Sequence cautioni

The sequence AAO49800.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7111 – 71111V → A in AAO49800. 1 Publication
Sequence conflicti7178 – 71781P → L in AAO38851. 1 Publication
Sequence conflicti7178 – 71781P → L in AAO49800. 1 Publication
Sequence conflicti7293 – 72931E → V in AAO38851. 1 Publication
Sequence conflicti7293 – 72931E → V in AAO49800. 1 Publication
Sequence conflicti7293 – 72931E → V in AAH61502. 1 Publication
Sequence conflicti7333 – 73331V → L in AAO38851. 1 Publication
Sequence conflicti7333 – 73331V → L in AAH61502. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY570293 mRNA. Translation: AAS77382.2.
EU089955 mRNA. Translation: ABU50842.1.
EU089956 mRNA. Translation: ABU50843.1.
EU089957 mRNA. Translation: ABU50844.1.
EU089959 mRNA. Translation: ABU50846.1.
AY172172 mRNA. Translation: AAO38851.1.
AY193891 mRNA. Translation: AAO49800.1. Sequence problems.
BC061502 mRNA. Translation: AAH61502.1.
RefSeqiNP_997126.2. NM_207243.2. [Q6PZE0-1]
UniGeneiMm.486225.

Genome annotation databases

GeneIDi239611.
KEGGimmu:239611.
UCSCiuc007xie.1. mouse. [Q6PZE0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Mucin database

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY570293 mRNA. Translation: AAS77382.2 .
EU089955 mRNA. Translation: ABU50842.1 .
EU089956 mRNA. Translation: ABU50843.1 .
EU089957 mRNA. Translation: ABU50844.1 .
EU089959 mRNA. Translation: ABU50846.1 .
AY172172 mRNA. Translation: AAO38851.1 .
AY193891 mRNA. Translation: AAO49800.1 . Sequence problems.
BC061502 mRNA. Translation: AAH61502.1 .
RefSeqi NP_997126.2. NM_207243.2. [Q6PZE0-1 ]
UniGenei Mm.486225.

3D structure databases

ProteinModelPortali Q6PZE0.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q6PZE0.

Proteomic databases

MaxQBi Q6PZE0.
PRIDEi Q6PZE0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 239611.
KEGGi mmu:239611.
UCSCi uc007xie.1. mouse. [Q6PZE0-1 ]

Organism-specific databases

CTDi 283463.
MGIi MGI:2676278. Muc19.

Phylogenomic databases

eggNOGi NOG12793.
InParanoidi Q6PZE0.

Enzyme and pathway databases

Reactomei REACT_198517. O-linked glycosylation of mucins.
REACT_198575. Termination of O-glycan biosynthesis.

Miscellaneous databases

NextBioi 384199.
SOURCEi Search...

Gene expression databases

Bgeei Q6PZE0.
CleanExi MM_MUC19.
Genevestigatori Q6PZE0.

Family and domain databases

InterProi IPR006207. Cys_knot_C.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view ]
Pfami PF08742. C8. 3 hits.
PF01826. TIL. 1 hit.
PF00094. VWD. 3 hits.
[Graphical view ]
SMARTi SM00832. C8. 2 hits.
SM00041. CT. 1 hit.
SM00214. VWC. 2 hits.
SM00216. VWD. 3 hits.
[Graphical view ]
SUPFAMi SSF57567. SSF57567. 3 hits.
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
PS51233. VWFD. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The gene encoding mouse Muc19: cDNA, genomic organization and relationship to Smgc."
    Culp D.J., Latchney L.R., Fallon M.A., Denny P.A., Denny P.C., Couwenhoven R.I., Chuang S.
    Physiol. Genomics 19:303-318(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: NFS.
    Tissue: Sublingual gland.
  2. "The sld mutation is specific for sublingual salivary mucous cells and disrupts apomucin gene expression."
    Fallon M.A., Latchney L.R., Hand A.R., Johar A., Denny P.A., Georgel P.T., Denny P.C., Culp D.J.
    Physiol. Genomics 14:95-106(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6711-7524, TISSUE SPECIFICITY.
    Strain: Swiss Webster.
    Tissue: Sublingual gland.
  3. "Genome-wide search and identification of a novel gel-forming mucin MUC19/Muc19 in glandular tissues."
    Chen Y., Zhao Y.H., Kalaslavadi T.B., Hamati E., Nehrke K., Le A.D., Ann D.K., Wu R.
    Am. J. Respir. Cell Mol. Biol. 30:155-165(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6918-7524, TISSUE SPECIFICITY.
    Strain: C57BL/6 X DBA/2.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7276-7524.
    Strain: FVB/N.
    Tissue: Salivary gland.

Entry informationi

Entry nameiMUC19_MOUSE
AccessioniPrimary (citable) accession number: Q6PZE0
Secondary accession number(s): A7UN62
, A7UN63, A7UN64, A7UN66, Q6P7U5, Q6Y0X6, Q80UR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: October 25, 2004
Last modified: September 3, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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