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Q6PZE0

- MUC19_MOUSE

UniProt

Q6PZE0 - MUC19_MOUSE

Protein

Mucin-19

Gene

Muc19

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 2 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    May function in ocular mucus homeostasis.By similarity

    GO - Biological processi

    1. cell differentiation involved in salivary gland development Source: MGI
    2. hematopoietic progenitor cell differentiation Source: MGI
    3. negative regulation of inflammatory response Source: MGI

    Enzyme and pathway databases

    ReactomeiREACT_198517. O-linked glycosylation of mucins.
    REACT_198575. Termination of O-glycan biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mucin-19
    Short name:
    MUC-19
    Alternative name(s):
    Gel-forming secreted mucin-19
    Sublingual apomucin
    Gene namesi
    Name:Muc19
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:2676278. Muc19.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 75247504Mucin-19PRO_5000093121Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi? ↔ 7518By similarity
    Disulfide bondi79 ↔ 87By similarity
    Disulfide bondi7435 ↔ 7482By similarity
    Disulfide bondi7449 ↔ 7496By similarity
    Disulfide bondi7458 ↔ 7512By similarity
    Disulfide bondi7462 ↔ 7514By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiQ6PZE0.
    PRIDEiQ6PZE0.

    PTM databases

    PhosphoSiteiQ6PZE0.

    Expressioni

    Tissue specificityi

    Specifically expressed in sublingual salivary glands. Expressed by mucous cells of the submandibular gland and submucosal gland of the trachea. Expression is altered in sld (sublingual gland differentiation arrest) mutants.3 Publications

    Gene expression databases

    BgeeiQ6PZE0.
    CleanExiMM_MUC19.
    GenevestigatoriQ6PZE0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PZE0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini56 – 257202VWFD 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini298 – 35356TILAdd
    BLAST
    Domaini392 – 600209VWFD 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini852 – 1062211VWFD 3PROSITE-ProRule annotationAdd
    BLAST
    Repeati1321 – 14831631Add
    BLAST
    Repeati1484 – 16461632Add
    BLAST
    Repeati1647 – 18091633Add
    BLAST
    Repeati1810 – 19721634Add
    BLAST
    Repeati1973 – 21351635Add
    BLAST
    Repeati2136 – 22981636Add
    BLAST
    Repeati2299 – 24611637Add
    BLAST
    Repeati2462 – 26241638Add
    BLAST
    Repeati2625 – 27871639Add
    BLAST
    Repeati2788 – 295016310Add
    BLAST
    Repeati2951 – 311316311Add
    BLAST
    Repeati3114 – 327616312Add
    BLAST
    Repeati3277 – 343916313Add
    BLAST
    Repeati3440 – 360216314Add
    BLAST
    Repeati3603 – 376516315Add
    BLAST
    Repeati3766 – 392816316Add
    BLAST
    Repeati3929 – 409116317Add
    BLAST
    Repeati4092 – 425416318Add
    BLAST
    Repeati4255 – 441716319Add
    BLAST
    Repeati4418 – 458016320Add
    BLAST
    Repeati4581 – 474316321Add
    BLAST
    Repeati4744 – 490616322Add
    BLAST
    Repeati4907 – 506916323Add
    BLAST
    Repeati5070 – 523216324Add
    BLAST
    Repeati5233 – 539516325Add
    BLAST
    Repeati5396 – 555816326Add
    BLAST
    Repeati5559 – 572116327Add
    BLAST
    Repeati5722 – 588416328Add
    BLAST
    Repeati5885 – 604716329Add
    BLAST
    Repeati6048 – 621016330Add
    BLAST
    Repeati6211 – 637316331Add
    BLAST
    Repeati6374 – 653616332Add
    BLAST
    Repeati6537 – 669916333Add
    BLAST
    Repeati6700 – 686216334Add
    BLAST
    Repeati6863 – 702516335Add
    BLAST
    Repeati7026 – 718816336Add
    BLAST
    Domaini7302 – 736867VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini7370 – 743263VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini7435 – 751985CTCKPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1321 – 71885868Approximate repeatsAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1216 – 72856070Thr-richAdd
    BLAST
    Compositional biasi1238 – 72496012Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
    Contains 2 VWFC domains.PROSITE-ProRule annotation
    Contains 3 VWFD domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    InParanoidiQ6PZE0.

    Family and domain databases

    InterProiIPR006207. Cys_knot_C.
    IPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    [Graphical view]
    PfamiPF08742. C8. 3 hits.
    PF01826. TIL. 1 hit.
    PF00094. VWD. 3 hits.
    [Graphical view]
    SMARTiSM00832. C8. 2 hits.
    SM00041. CT. 1 hit.
    SM00214. VWC. 2 hits.
    SM00216. VWD. 3 hits.
    [Graphical view]
    SUPFAMiSSF57567. SSF57567. 3 hits.
    PROSITEiPS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    PS51233. VWFD. 3 hits.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Note: Isoform 1 and isoform 2-6 share the first 17 amino acid residues that correspond to the signal sequence.

    Isoform 1 (identifier: Q6PZE0-1) [UniParc]FASTAAdd to Basket

    Also known as: Mucin-19

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MKLILLYLAV VLCFVGKGAA RSPTTTRTPT PSTSEKASHV PEATPTYSEA     50
    NEVAGEATMW GKDKYKALNG HIFSFESECT FTFCRDCAEP GGDFNIEIKK 100
    HKNGDIEEIK ALIDDVEILV VRNSISVNEE RVKVPFSNKM IHIKKQGNHY 150
    SLKTRRRILS LKWSKDKLSL ILYSHYTTCG LCGNFDSVPG DDVNEHIASS 200
    KISNDCPSPL SRSNEVCEDG VQYCDKIIET YFEKCSKVSP LSREYKNVCA 250
    DEYCRKGGGK QTTCDTYSEL ARLCAYDGPG DYEHWRDDSA VVCAKEQCPG 300
    KHIYKECGPS NPPTCSNVAP FQDSECVSGC TCPEGYLLDD IGEKGKCVLK 350
    EKCPCESNGK VYKPGKVREG PCGSRCTCQE AKWSCTEARC PGICKVEGSS 400
    FTTFDDNKFS HPGDCHFLAV HNDEISISVE IHPCGNGQTG SCLTSVMVLQ 450
    NSSSSSNRYV FNRDGTVTKD GVIIKGYYYS DDVQIFNSSS SYMQAEILSH 500
    IKLQIQLAPR MQLYVSLAPN TSTDTVGLCG SFNNKAEDDF MSSQNILEST 550
    AQAFANSWEM MPCSEGSPSS CVSIETEKFA ESNCEILLSS SGPFAACHQT 600
    VNPKFYHEEC KKYTCSCENG QDCLCTVLGN YVKACAEKEI YLVGWRDGLC 650
    EVSCPSGLVF NYKVKTCNSS CRSLSARDRS CDIEDIPVDG CTCPDGMYQN 700
    NEGNCVQKSE CDCYVNDEIV QPGKSILIDD NKCVCQDGVL HCQTPLDLTL 750
    QNCSRGAEYI DCKDPKAQRR TERTCATRNI PDFEGDLPCK RGCYCPVGMV 800
    RNSKGICIHP DDCPCSFGDR EYEQGSVTSV GCNECTCIKG SWNCTQNECQ 850
    STCHVYGEGH FRTFDGESYS FDGLCQYTFL EDYCGQENGT FRILIESVPC 900
    CENGLTCSRK VIVTFQDQNI ILQDGKVTAV QTAESTDCRE RSANLYSIHT 950
    VGLYLIVKLL NGIILIWDKY TKVSVILDPS WQNKVCGLCG NNNGDLKDDF 1000
    TTRHSSVAAG ALEFANSWKT SQECSDTVTQ SFPCDSNPYC KAWAEKRCEI 1050
    LRDDTFRDCH SKVDPTTYYD ACIEEACSCD MEGKYLGFCT AVAMYAEACN 1100
    AAGVCVSWRK PNLCPVYCDY YNAPGECSWH YEPCGTVTAK TCKDQVIGQK 1150
    FSSLLEGCYA KCPENAPYLD ENTMKCVQLS ECSCFYNDVI PAGGAVVDDC 1200
    GRTCSCSAGE LECSETPPNS TTTTTATTAA VSTATTTSVL STSAAATRAS 1250
    SSTSGSVETS VPATTSTSKA QAHITTASST ETSALNSTAV YPKATTREGL 1300
    LSSSGPGAFV AERPDNTPRP AVSTTSAGST SARAATTSPG GSSGSSAPAS 1350
    STSGRAATTT STSAATTTTT TTATTVGSAG SSAPTASSTA AGSGLREAAN 1400
    ATSAPASTSG QPGASTGSSG TSSSVSSTAA ATTAGTTTAA SNETSAPAST 1450
    AGPTSSATTA APASSSASSA TTPAETAGST TGPAVSTTSA GSTSARAATT 1500
    SPGGSSGSSA PASSTSGRAA TTTSTATTTT TTTTTATTVG SAGSSAPTAS 1550
    STAAGSGLRE AANATSAPAS TSGQPGASTG SSGTSSSVSS TAAATTAGTT 1600
    TAASNETSAP ASTAGPTSSA TTAAPASSSA SSATTPAETA GSTTGPAVST 1650
    TSAGSTSARA ATTSPGGSSG SSAPASSTSG RAATTTSTAT TTTTTTTTAT 1700
    TVGSAGSSAP TASSTAAGSG LREAANATSA PASTSGQPGA STGSSGTSSS 1750
    VSSTAAATTA GTTTAASNET SAPASTAGPT SSATTAAPAS SSASSATTPA 1800
    ETAGSTTGPA VSTTSAGSTS ARAATTSPGG SSGSSAPASS TSGRAATTTS 1850
    TATTTTTTTT TATTVGSAGS SAPTASSTAA GSGLREAANA TSAPASTSGQ 1900
    PGASTGSSGT SSSVSSTAAA TTAGTTTAAS NETSAPASTA GPTSSATTAA 1950
    PASSSASSAT TPAETAGSTT GPAVSTTSAG STSARAATTS PGGSSGSSAP 2000
    ASSTSGRAAT TTSTATTTTT TTTTATTVGS AGSSAPTASS TAAGSGLREA 2050
    ANATSAPAST SGQPGASTGS SGTSSSVSST AAATTAGTTT AASNETSAPA 2100
    STAGPTSSAT TAAPASSSAS SATTPAETAG STTGPAVSTT SAGSTSARAA 2150
    TTSPGGSSGS SAPASSTSGR AATTTSTATT TTTTTTTATT VGSAGSSAPT 2200
    ASSTAAGSGL REAANATSAP ASTSGQPGAS TGSSGTSSSV SSTAAATTAG 2250
    TTTAASNETS APASTAGPTS SATTAAPASS SASSATTPAE TAGSTTGPAV 2300
    STTSAGSTSA RAATTSPGGS SGSSAPASST SGRAATTTST ATTTTTTTTT 2350
    ATTVGSAGSS APTASSTAAG SGLREAANAT SAPASTSGQP GASTGSSGTS 2400
    SSVSSTAAAT TAGTTTAASN ETSAPASTAG PTSSATTAAP ASSSASSATT 2450
    PAETAGSTTG PAVSTTSAGS TSARAATTSP GGSSGSSAPA SSTSGRAATT 2500
    TSTATTTTTT TTTATTVGSA GSSAPTASST AAGSGLREAA NATSAPASTS 2550
    GQPGASTGSS GTSSSVSSTA AATTAGTTTA ASNETSAPAS TAGPTSSATT 2600
    AAPASSSASS ATTPAETAGS TTGPAVSTTS AGSTSARAAT TSPGGSSGSS 2650
    APASSTSGRA ATTTSTATTT TTTTTTATTV GSAGSSAPTA SSTAAGSGLR 2700
    EAANATSAPA STSGQPGAST GSSGTSSSVS STAAATTAGT TTAASNETSA 2750
    PASTAGPTSS ATTAAPASSS ASSATTPAET AGSTTGPAVS TTSAGSTSAR 2800
    AATTSPGGSS GSSAPASSTS GRAATTTSTA TTTTTTTTTA TTVGSAGSSA 2850
    PTASSTAAGS GLREAANATS APASTSGQPG ASTGSSGTSS SVSSTAAATT 2900
    AGTTTAASNE TSAPASTAGP TSSATTAAPA SSSASSATTP AETAGSTTGP 2950
    AVSTTSAGST SARAATTSPG GSSGSSAPAS STSGRAATTT STATTTTTTT 3000
    TTATTVGSAG SSAPTASSTA AGSGLREAAN ATSAPASTSG QPGASTGSSG 3050
    TSSSVSSTAA ATTAGTTTAA SNETSAPAST AGPTSSATTA APASSSASSA 3100
    TTPAETAGST TGPAVSTTSA GSTSARAATT SPGGSSGSSA PASSTSGRAA 3150
    TTTSTATTTT TTTTTATTVG SAGSSAPTAS STAAGSGLRE AANATSAPAS 3200
    TSGQPGASTG SSGTSSSVSS TAAATTAGTT TAASNETSAP ASTAGPTSSA 3250
    TTAAPASSSA SSATTPAETA GSTTGPAVST TSAGSTSARA ATTSPGGSSG 3300
    SSAPASSTSG RAATTTSTAT TTTTTTTTAT TVGSAGSSAP TASSTAAGSG 3350
    LREAANATSA PASTSGQPGA STGSSGTSSS VSSTAAATTA GTTTAASNET 3400
    SAPASTAGPT SSATTAAPAS SSASSATTPA ETAGSTTGPA VSTTSAGSTS 3450
    ARAATTSPGG SSGSSAPASS TSGRAATTTS TATTTTTTTT TATTVGSAGS 3500
    SAPTASSTAA GSGLREAANA TSAPASTSGQ PGASTGSSGT SSSVSSTAAA 3550
    TTAGTTTAAS NETSAPASTA GPTSSATTAA PASSSASSAT TPAETAGSTT 3600
    GPAVSTTSAG STSARAATTS PGGSSGSSAP ASSTSGRAAT TTSTATTTTT 3650
    TTTTATTVGS AGSSAPTASS TAAGSGLREA ANATSAPAST SGQPGASTGS 3700
    SGTSSSVSST AAATTAGTTT AASNETSAPA STAGPTSSAT TAAPASSSAS 3750
    SATTPAETAG STTGPAVSTT SAGSTSARAA TTSPGGSSGS SAPASSTSGR 3800
    AATTTSTATT TTTTTTTATT VGSAGSSAPT ASSTAAGSGL REAANATSAP 3850
    ASTSGQPGAS TGSSGTSSSV SSTAAATTAG TTTAASNETS APASTAGPTS 3900
    SATTAAPASS SASSATTPAE TAGSTTGPAV STTSAGSTSA RAATTSPGGS 3950
    SGSSAPASST SGRAATTTST ATTTTTTTTT ATTVGSAGSS APTASSTAAG 4000
    SGLREAANAT SAPASTSGQP GASTGSSGTS SSVSSTAAAT TAGTTTAASN 4050
    ETSAPASTAG PTSSATTAAP ASSSASSATT PAETAGSTTG PAVSTTSAGS 4100
    TSARAATTSP GGSSGSSAPA SSTSGRAATT TSTATTTTTT TTTATTVGSA 4150
    GSSAPTASST AAGSGLREAA NATSAPASTS GQPGASTGSS GTSSSVSSTA 4200
    AATTAGTTTA ASNETSAPAS TAGPTSSATT AAPASSSASS ATTPAETAGS 4250
    TTGPAVSTTS AGSTSARAAT TSPGGSSGSS APASSTSGRA ATTTSTATTT 4300
    TTTTTTATTV GSAGSSAPTA SSTAAGSGLR EAANATSAPA STSGQPGAST 4350
    GSSGTSSSVS STAAATTAGT TTAASNETSA PASTAGPTSS ATTAAPASSS 4400
    ASSATTPAET AGSTTGPAVS TTSAGSTSAR AATTSPGGSS GSSAPASSTS 4450
    GRAATTTSTA TTTTTTTTTA TTVGSAGSSA PTASSTAAGS GLREAANATS 4500
    APASTSGQPG ASTGSSGTSS SVSSTAAATT AGTTTAASNE TSAPASTAGP 4550
    TSSATTAAPA SSSASSATTP AETAGSTTGP AVSTTSAGST SARAATTSPG 4600
    GSSGSSAPAS STSGRAATTT STATTTTTTT TTATTVGSAG SSAPTASSTA 4650
    AGSGLREAAN ATSAPASTSG QPGASTGSSG TSSSVSSTAA ATTAGTTTAA 4700
    SNETSAPAST AGPTSSATTA APASSSASSA TTPAETAGST TGPAVSTTSA 4750
    GSTSARAATT SPGGSSGSSA PASSTSGRAA TTTSTATTTT TTTTTATTVG 4800
    SAGSSAPTAS STAAGSGLRE AANATSAPAS TSGQPGASTG SSGTSSSVSS 4850
    TAAATTAGTT TAASNETSAP ASTAGPTSSA TTAAPASSSA SSATTPAETA 4900
    GSTTGPAVST TSAGSTSARA ATTSPGGSSG SSAPASSTSG RAATTTSTAT 4950
    TTTTTTTTAT TVGSAGSSAP TASSTAAGSG LREAANATSA PASTSGQPGA 5000
    STGSSGTSSS VSSTAAATTA GTTTAASNET SAPASTAGPT SSATTAAPAS 5050
    SSASSATTPA ETAGSTTGPA VSTTSAGSTS ARAATTSPGG SSGSSAPASS 5100
    TSGRAATTTS TATTTTTTTT TATTVGSAGS SAPTASSTAA GSGLREAANA 5150
    TSAPASTSGQ PGASTGSSGT SSSVSSTAAA TTAGTTTAAS NETSAPASTA 5200
    GPTSSATTAA PASSSASSAT TPAETAGSTT GPAVSTTSAG STSARAATTS 5250
    PGGSSGSSAP ASSTSGRAAT TTSTATTTTT TTTTATTVGS AGSSAPTASS 5300
    TAAGSGLREA ANATSAPAST SGQPGASTGS SGTSSSVSST AAATTAGTTT 5350
    AASNETSAPA STAGPTSSAT TAAPASSSAS SATTPAETAG STTGPAVSTT 5400
    SAGSTSARAA TTSPGGSSGS SAPASSTSGR AATTTSTATT TTTTTTTATT 5450
    VGSAGSSAPT ASSTAAGSGL REAANATSAP ASTSGQPGAS TGSSGTSSSV 5500
    SSTAAATTAG TTTAASNETS APASTAGPTS SATTAAPASS SASSATTPAE 5550
    TAGSTTGPAV STTSAGSTSA RAATTSPGGS SGSSAPASST SGRAATTTST 5600
    ATTTTTTTTT ATTVGSAGSS APTASSTAAG SGLREAANAT SAPASTSGQP 5650
    GASTGSSGTS SSVSSTAAAT TAGTTTAASN ETSAPASTAG PTSSATTAAP 5700
    ASSSASSATT PAETAGSTTG PAVSTTSAGS TSARAATTSP GGSSGSSAPA 5750
    SSTSGRAATT TSTATTTTTT TTTATTVGSA GSSAPTASST AAGSGLREAA 5800
    NATSAPASTS GQPGASTGSS GTSSSVSSTA AATTAGTTTA ASNETSAPAS 5850
    TAGPTSSATT AAPASSSASS ATTPAETAGS TTGPAVSTTS AGSTSARAAT 5900
    TSPGGSSGSS APASSTSGRA ATTTSTATTT TTTTTTATTV GSAGSSAPTA 5950
    SSTAAGSGLR EAANATSAPA STSGQPGAST GSSGTSSSVS STAAATTAGT 6000
    TTAASNETSA PASTAGPTSS ATTAAPASSS ASSATTPAET AGSTTGPAVS 6050
    TTSAGSTSAR AATTSPGGSS GSSAPASSTS GRAATTTSTA TTTTTTTTTA 6100
    TTVGSAGSSA PTASSTAAGS GLREAANATS APASTSGQPG ASTGSSGTSS 6150
    SVSSTAAATT AGTTTAASNE TSAPASTAGP TSSATTAAPA SSSASSATTP 6200
    AETAGSTTGP AVSTTSAGST SARAATTSPG GSSGSSAPAS STSGRAATTT 6250
    STATTTTTTT TTATTVGSAG SSAPTASSTA AGSGLREAAN ATSAPASTSG 6300
    QPGASTGSSG TSSSVSSTAA ATTAGTTTAA SNETSAPAST AGPTSSATTA 6350
    APASSSASSA TTPAETAGST TGPAVSTTSA GSTSARAATT SPGGSSGSSA 6400
    PASSTSGRAA TTTSTATTTT TTTTTATTVG SAGSSAPTAS STAAGSGLRE 6450
    AANATSAPAS TSGQPGASTG SSGTSSSVSS TAAATTAGTT TAASNETSAP 6500
    ASTAGPTSSA TTAAPASSSA SSATTPAETA GSTTGPAVST TSAGSTSARA 6550
    ATTSPGGSSG SSAPASSTSG RAATTTSTAT TTTTTTTTAT TVGSAGSSAP 6600
    TASSTAAGSG LREAANATSA PASTSGQPGA STGSSGTSSS VSSTAAATTA 6650
    GTTTAASNET SAPASTAGPT SSATTAAPAS SSASSATTPA ETAGSTTGPA 6700
    VSTTSAGSTS ARAATTSPGG SSGSSAPASS TSGRAATTTS TATTTTTTTT 6750
    TATTVGSAGS SAPTASSTAA GSGLREAANA TSAPASTSGQ PGASTGSSGT 6800
    SSSVSSTAAA TTAGTTTAAS NETSAPASTA GPTSSATTAA PASSSASSAT 6850
    TPAETAGSTT GPAVSTTSAG STSARAATTS PGGSSGSSAP ASSTSGRAAT 6900
    TTSTATTTTT TTTTATTVGS AGSSAPTASS TAAGSGLREA ANATSAPAST 6950
    SGQPGASTGS SGTSSSVSST AAATTAGTTT AASNETSAPA STAGPTSSAT 7000
    TAAPASSSAS SATTPAETAG STTGPAVSTT SAGSTSARAA TTSPGGSSGS 7050
    SAPASSTSGR AATTTSTATT TTTTTTTATT VGSAGSSAPT ASSTAAGSGL 7100
    REAANATSAP VSTSGQPGAS TGSSGTSSSV SSTAAATTAG TTTAASNETS 7150
    APASTAGPTS SATTAAPASS SASSATTPAE TAGSTTGPAV STTSAGSTSA 7200
    RAATTSPGGS SGSSSLAIST MSVSSSSFIS PSGHPVPSTA SVAFLSSPSV 7250
    IKTGGTTGTT AKSNETTGRT TSMPASTSVA PGVTTSPNIS QPECPDSLPP 7300
    TPVCHGPLGE EKSPGDVWIS NCHQCTCTEK QAVDCKPKEC PSPPTCKDGE 7350
    KLMKFKSNDS CCEIGHCEPR TCLFNNTDYA IGSSFDDPSN PCLSYTCNPT 7400
    GLVAVVQDCP KQTWCAEEER IYDSNKCCYK CKNDCRTTPV NVTVKYNGCR 7450
    KRVEMARCIG ECKRSVKYNY ETFQLENSCS CCREENYEFR DIALECSDGS 7500
    TIPYRYRHTT TCSCRDQCEQ SKAS 7524
    Length:7,524
    Mass (Da):693,499
    Last modified:October 25, 2004 - v2
    Checksum:iB99A4519CE1EF6D4
    GO
    Isoform 2 (identifier: Q6JHY2-1) [UniParc]FASTAAdd to Basket

    Also known as: Smgc

    The sequence of this isoform can be found in the external entry Q6JHY2.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:733
    Mass (Da):74,383
    GO
    Isoform 3 (identifier: Q6JHY2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry Q6JHY2.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

    Note: No experimental confirmation available.

    Length:700
    Mass (Da):70,835
    GO
    Isoform 4 (identifier: Q6JHY2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry Q6JHY2.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

    Note: No experimental confirmation available.

    Length:341
    Mass (Da):34,128
    GO
    Isoform 5 (identifier: Q6JHY2-4) [UniParc]FASTAAdd to Basket

    Also known as: t-Smgc

    The sequence of this isoform can be found in the external entry Q6JHY2.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:128
    Mass (Da):12,633
    GO
    Isoform 6 (identifier: Q6JHY2-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry Q6JHY2.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:431
    Mass (Da):43,160
    GO

    Sequence cautioni

    The sequence AAO49800.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7111 – 71111V → A in AAO49800. (PubMed:12882755)Curated
    Sequence conflicti7178 – 71781P → L in AAO38851. (PubMed:12847143)Curated
    Sequence conflicti7178 – 71781P → L in AAO49800. (PubMed:12882755)Curated
    Sequence conflicti7293 – 72931E → V in AAO38851. (PubMed:12847143)Curated
    Sequence conflicti7293 – 72931E → V in AAO49800. (PubMed:12882755)Curated
    Sequence conflicti7293 – 72931E → V in AAH61502. (PubMed:15489334)Curated
    Sequence conflicti7333 – 73331V → L in AAO38851. (PubMed:12847143)Curated
    Sequence conflicti7333 – 73331V → L in AAH61502. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY570293 mRNA. Translation: AAS77382.2.
    EU089955 mRNA. Translation: ABU50842.1.
    EU089956 mRNA. Translation: ABU50843.1.
    EU089957 mRNA. Translation: ABU50844.1.
    EU089959 mRNA. Translation: ABU50846.1.
    AY172172 mRNA. Translation: AAO38851.1.
    AY193891 mRNA. Translation: AAO49800.1. Sequence problems.
    BC061502 mRNA. Translation: AAH61502.1.
    RefSeqiNP_997126.2. NM_207243.2. [Q6PZE0-1]
    UniGeneiMm.486225.

    Genome annotation databases

    GeneIDi239611.
    KEGGimmu:239611.
    UCSCiuc007xie.1. mouse. [Q6PZE0-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Mucin database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY570293 mRNA. Translation: AAS77382.2 .
    EU089955 mRNA. Translation: ABU50842.1 .
    EU089956 mRNA. Translation: ABU50843.1 .
    EU089957 mRNA. Translation: ABU50844.1 .
    EU089959 mRNA. Translation: ABU50846.1 .
    AY172172 mRNA. Translation: AAO38851.1 .
    AY193891 mRNA. Translation: AAO49800.1 . Sequence problems.
    BC061502 mRNA. Translation: AAH61502.1 .
    RefSeqi NP_997126.2. NM_207243.2. [Q6PZE0-1 ]
    UniGenei Mm.486225.

    3D structure databases

    ProteinModelPortali Q6PZE0.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q6PZE0.

    Proteomic databases

    MaxQBi Q6PZE0.
    PRIDEi Q6PZE0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 239611.
    KEGGi mmu:239611.
    UCSCi uc007xie.1. mouse. [Q6PZE0-1 ]

    Organism-specific databases

    CTDi 283463.
    MGIi MGI:2676278. Muc19.

    Phylogenomic databases

    eggNOGi NOG12793.
    InParanoidi Q6PZE0.

    Enzyme and pathway databases

    Reactomei REACT_198517. O-linked glycosylation of mucins.
    REACT_198575. Termination of O-glycan biosynthesis.

    Miscellaneous databases

    NextBioi 384199.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6PZE0.
    CleanExi MM_MUC19.
    Genevestigatori Q6PZE0.

    Family and domain databases

    InterProi IPR006207. Cys_knot_C.
    IPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    [Graphical view ]
    Pfami PF08742. C8. 3 hits.
    PF01826. TIL. 1 hit.
    PF00094. VWD. 3 hits.
    [Graphical view ]
    SMARTi SM00832. C8. 2 hits.
    SM00041. CT. 1 hit.
    SM00214. VWC. 2 hits.
    SM00216. VWD. 3 hits.
    [Graphical view ]
    SUPFAMi SSF57567. SSF57567. 3 hits.
    PROSITEi PS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    PS51233. VWFD. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The gene encoding mouse Muc19: cDNA, genomic organization and relationship to Smgc."
      Culp D.J., Latchney L.R., Fallon M.A., Denny P.A., Denny P.C., Couwenhoven R.I., Chuang S.
      Physiol. Genomics 19:303-318(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: NFS.
      Tissue: Sublingual gland.
    2. "The sld mutation is specific for sublingual salivary mucous cells and disrupts apomucin gene expression."
      Fallon M.A., Latchney L.R., Hand A.R., Johar A., Denny P.A., Georgel P.T., Denny P.C., Culp D.J.
      Physiol. Genomics 14:95-106(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6711-7524, TISSUE SPECIFICITY.
      Strain: Swiss Webster.
      Tissue: Sublingual gland.
    3. "Genome-wide search and identification of a novel gel-forming mucin MUC19/Muc19 in glandular tissues."
      Chen Y., Zhao Y.H., Kalaslavadi T.B., Hamati E., Nehrke K., Le A.D., Ann D.K., Wu R.
      Am. J. Respir. Cell Mol. Biol. 30:155-165(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6918-7524, TISSUE SPECIFICITY.
      Strain: C57BL/6 X DBA/2.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7276-7524.
      Strain: FVB/N.
      Tissue: Salivary gland.

    Entry informationi

    Entry nameiMUC19_MOUSE
    AccessioniPrimary (citable) accession number: Q6PZE0
    Secondary accession number(s): A7UN62
    , A7UN63, A7UN64, A7UN66, Q6P7U5, Q6Y0X6, Q80UR5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 75 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3