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Protein

CCAAT/enhancer-binding protein epsilon

Gene

Cebpe

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers.By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to lipopolysaccharide Source: Ensembl
  • cytokine biosynthetic process Source: MGI
  • defense response to bacterium Source: MGI
  • macrophage differentiation Source: MGI
  • phagocytosis Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
CCAAT/enhancer-binding protein epsilon
Short name:
C/EBP epsilon
Gene namesi
Name:Cebpe
Synonyms:Gm294
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:103572. Cebpe.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000766251 – 281CCAAT/enhancer-binding protein epsilonAdd BLAST281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki121Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei181PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ6PZD9.
PaxDbiQ6PZD9.
PRIDEiQ6PZD9.

PTM databases

iPTMnetiQ6PZD9.
PhosphoSitePlusiQ6PZD9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000052435.
CleanExiMM_CEBPE.

Interactioni

Subunit structurei

Binds DNA as a dimer and can form stable heterodimers with C/EBP delta.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068927.

Structurei

3D structure databases

ProteinModelPortaliQ6PZD9.
SMRiQ6PZD9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini204 – 267bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni208 – 245Basic motifPROSITE-ProRule annotationAdd BLAST38
Regioni246 – 267Leucine-zipperPROSITE-ProRule annotationAdd BLAST22

Sequence similaritiesi

Belongs to the bZIP family. C/EBP subfamily.Curated

Phylogenomic databases

eggNOGiKOG3119. Eukaryota.
ENOG410YJ8G. LUCA.
GeneTreeiENSGT00530000063192.
HOVERGENiHBG050879.
InParanoidiQ6PZD9.
KOiK10051.
OMAiCDHEASI.
OrthoDBiEOG091G11FC.
PhylomeDBiQ6PZD9.
TreeFamiTF105008.

Family and domain databases

InterProiView protein in InterPro
IPR004827. bZIP.
IPR016468. C/EBP_chordates.
PfamiView protein in Pfam
PF07716. bZIP_2. 1 hit.
PIRSFiPIRSF005879. CCAAT/enhancer-binding. 1 hit.
SMARTiView protein in SMART
SM00338. BRLZ. 1 hit.
PROSITEiView protein in PROSITE
PS50217. BZIP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6PZD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHGTYYECE PRGGQQPLEF SGGRAGPGEL GDMCEHEASI DLSAYIESGE
60 70 80 90 100
EQLLSDLFAM KPTPEARSLK GPGAPSFPHY LPADPRPFAY PSHTFGPDRK
110 120 130 140 150
ALGPGIYSNP GSYDPRAVAV KEEPRGPEGN RGTSRGSYNP LQYQVAHCGQ
160 170 180 190 200
TAVHLPPTLA APGQPLRVLK APVAAAAPPC SPLLKAPSPA GPSHKGKKAV
210 220 230 240 250
NKDSLEYRLR RERNNIAVRK SRDKAKRRIM ETQQKVLEYM AENERLRNRV
260 270 280
DQLTQELDTL RNLFRQIPEA ASLIKGVGGC S
Length:281
Mass (Da):30,617
Last modified:July 5, 2004 - v1
Checksum:i864F3FABA54E939A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY570294 mRNA. Translation: AAS78198.1.
BC108953 mRNA. Translation: AAI08954.1.
CCDSiCCDS27100.1.
RefSeqiNP_997014.1. NM_207131.1.
UniGeneiMm.236223.

Genome annotation databases

EnsembliENSMUST00000064290; ENSMUSP00000068927; ENSMUSG00000052435.
GeneIDi110794.
KEGGimmu:110794.
UCSCiuc007twz.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiCEBPE_MOUSE
AccessioniPrimary (citable) accession number: Q6PZD9
Secondary accession number(s): Q32MW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: July 5, 2004
Last modified: August 30, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families