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Q6PZD9

- CEBPE_MOUSE

UniProt

Q6PZD9 - CEBPE_MOUSE

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Protein

CCAAT/enhancer-binding protein epsilon

Gene

Cebpe

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers.By similarity

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl

GO - Biological processi

  1. cellular response to lipopolysaccharide Source: Ensembl
  2. cytokine biosynthetic process Source: MGI
  3. defense response to bacterium Source: MGI
  4. macrophage differentiation Source: MGI
  5. phagocytosis Source: MGI
  6. positive regulation of gene expression Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CCAAT/enhancer-binding protein epsilon
Short name:
C/EBP epsilon
Gene namesi
Name:Cebpe
Synonyms:Gm294
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:103572. Cebpe.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 281281CCAAT/enhancer-binding protein epsilonPRO_0000076625Add
BLAST

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ6PZD9.

PTM databases

PhosphoSiteiQ6PZD9.

Expressioni

Gene expression databases

BgeeiQ6PZD9.
CleanExiMM_CEBPE.
ExpressionAtlasiQ6PZD9. baseline and differential.
GenevestigatoriQ6PZD9.

Interactioni

Subunit structurei

Binds DNA as a dimer and can form stable heterodimers with C/EBP delta.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068927.

Structurei

3D structure databases

ProteinModelPortaliQ6PZD9.
SMRiQ6PZD9. Positions 203-261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini204 – 26764bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni208 – 24538Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni246 – 26722Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. C/EBP subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG244516.
GeneTreeiENSGT00530000063192.
HOVERGENiHBG050879.
InParanoidiQ6PZD9.
KOiK10051.
OMAiPAGPLHK.
OrthoDBiEOG7R56TQ.
PhylomeDBiQ6PZD9.
TreeFamiTF105008.

Family and domain databases

InterProiIPR004827. bZIP.
IPR016468. CCAAT/enhancer-binding.
[Graphical view]
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
PIRSFiPIRSF005879. CCAAT/enhancer-binding. 1 hit.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PZD9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSHGTYYECE PRGGQQPLEF SGGRAGPGEL GDMCEHEASI DLSAYIESGE
60 70 80 90 100
EQLLSDLFAM KPTPEARSLK GPGAPSFPHY LPADPRPFAY PSHTFGPDRK
110 120 130 140 150
ALGPGIYSNP GSYDPRAVAV KEEPRGPEGN RGTSRGSYNP LQYQVAHCGQ
160 170 180 190 200
TAVHLPPTLA APGQPLRVLK APVAAAAPPC SPLLKAPSPA GPSHKGKKAV
210 220 230 240 250
NKDSLEYRLR RERNNIAVRK SRDKAKRRIM ETQQKVLEYM AENERLRNRV
260 270 280
DQLTQELDTL RNLFRQIPEA ASLIKGVGGC S
Length:281
Mass (Da):30,617
Last modified:July 5, 2004 - v1
Checksum:i864F3FABA54E939A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY570294 mRNA. Translation: AAS78198.1.
BC108953 mRNA. Translation: AAI08954.1.
CCDSiCCDS27100.1.
RefSeqiNP_997014.1. NM_207131.1.
UniGeneiMm.236223.

Genome annotation databases

EnsembliENSMUST00000064290; ENSMUSP00000068927; ENSMUSG00000052435.
GeneIDi110794.
KEGGimmu:110794.
UCSCiuc007twz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY570294 mRNA. Translation: AAS78198.1 .
BC108953 mRNA. Translation: AAI08954.1 .
CCDSi CCDS27100.1.
RefSeqi NP_997014.1. NM_207131.1.
UniGenei Mm.236223.

3D structure databases

ProteinModelPortali Q6PZD9.
SMRi Q6PZD9. Positions 203-261.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000068927.

PTM databases

PhosphoSitei Q6PZD9.

Proteomic databases

PRIDEi Q6PZD9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000064290 ; ENSMUSP00000068927 ; ENSMUSG00000052435 .
GeneIDi 110794.
KEGGi mmu:110794.
UCSCi uc007twz.1. mouse.

Organism-specific databases

CTDi 1053.
MGIi MGI:103572. Cebpe.

Phylogenomic databases

eggNOGi NOG244516.
GeneTreei ENSGT00530000063192.
HOVERGENi HBG050879.
InParanoidi Q6PZD9.
KOi K10051.
OMAi PAGPLHK.
OrthoDBi EOG7R56TQ.
PhylomeDBi Q6PZD9.
TreeFami TF105008.

Miscellaneous databases

NextBioi 364671.
PROi Q6PZD9.
SOURCEi Search...

Gene expression databases

Bgeei Q6PZD9.
CleanExi MM_CEBPE.
ExpressionAtlasi Q6PZD9. baseline and differential.
Genevestigatori Q6PZD9.

Family and domain databases

InterProi IPR004827. bZIP.
IPR016468. CCAAT/enhancer-binding.
[Graphical view ]
Pfami PF07716. bZIP_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF005879. CCAAT/enhancer-binding. 1 hit.
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
PROSITEi PS50217. BZIP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the macrophage differentiation induced by mutated G-CSF receptors."
    Zhuang D., Zhang P., Dong F.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Spleen.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiCEBPE_MOUSE
AccessioniPrimary (citable) accession number: Q6PZD9
Secondary accession number(s): Q32MW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3