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Protein

CCAAT/enhancer-binding protein epsilon

Gene

Cebpe

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers.By similarity

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: MGI
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI

GO - Biological processi

  1. cellular response to lipopolysaccharide Source: Ensembl
  2. cytokine biosynthetic process Source: MGI
  3. defense response to bacterium Source: MGI
  4. macrophage differentiation Source: MGI
  5. phagocytosis Source: MGI
  6. positive regulation of gene expression Source: MGI
  7. positive regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CCAAT/enhancer-binding protein epsilon
Short name:
C/EBP epsilon
Gene namesi
Name:Cebpe
Synonyms:Gm294
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:103572. Cebpe.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleoplasm Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 281281CCAAT/enhancer-binding protein epsilonPRO_0000076625Add
BLAST

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ6PZD9.

PTM databases

PhosphoSiteiQ6PZD9.

Expressioni

Gene expression databases

BgeeiQ6PZD9.
CleanExiMM_CEBPE.
ExpressionAtlasiQ6PZD9. baseline and differential.
GenevestigatoriQ6PZD9.

Interactioni

Subunit structurei

Binds DNA as a dimer and can form stable heterodimers with C/EBP delta.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068927.

Structurei

3D structure databases

ProteinModelPortaliQ6PZD9.
SMRiQ6PZD9. Positions 203-261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini204 – 26764bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni208 – 24538Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni246 – 26722Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. C/EBP subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG244516.
GeneTreeiENSGT00530000063192.
HOVERGENiHBG050879.
InParanoidiQ6PZD9.
KOiK10051.
OMAiPAGPLHK.
OrthoDBiEOG7R56TQ.
PhylomeDBiQ6PZD9.
TreeFamiTF105008.

Family and domain databases

InterProiIPR004827. bZIP.
IPR016468. CCAAT/enhancer-binding.
[Graphical view]
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
PIRSFiPIRSF005879. CCAAT/enhancer-binding. 1 hit.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PZD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHGTYYECE PRGGQQPLEF SGGRAGPGEL GDMCEHEASI DLSAYIESGE
60 70 80 90 100
EQLLSDLFAM KPTPEARSLK GPGAPSFPHY LPADPRPFAY PSHTFGPDRK
110 120 130 140 150
ALGPGIYSNP GSYDPRAVAV KEEPRGPEGN RGTSRGSYNP LQYQVAHCGQ
160 170 180 190 200
TAVHLPPTLA APGQPLRVLK APVAAAAPPC SPLLKAPSPA GPSHKGKKAV
210 220 230 240 250
NKDSLEYRLR RERNNIAVRK SRDKAKRRIM ETQQKVLEYM AENERLRNRV
260 270 280
DQLTQELDTL RNLFRQIPEA ASLIKGVGGC S
Length:281
Mass (Da):30,617
Last modified:July 5, 2004 - v1
Checksum:i864F3FABA54E939A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY570294 mRNA. Translation: AAS78198.1.
BC108953 mRNA. Translation: AAI08954.1.
CCDSiCCDS27100.1.
RefSeqiNP_997014.1. NM_207131.1.
UniGeneiMm.236223.

Genome annotation databases

EnsembliENSMUST00000064290; ENSMUSP00000068927; ENSMUSG00000052435.
GeneIDi110794.
KEGGimmu:110794.
UCSCiuc007twz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY570294 mRNA. Translation: AAS78198.1.
BC108953 mRNA. Translation: AAI08954.1.
CCDSiCCDS27100.1.
RefSeqiNP_997014.1. NM_207131.1.
UniGeneiMm.236223.

3D structure databases

ProteinModelPortaliQ6PZD9.
SMRiQ6PZD9. Positions 203-261.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000068927.

PTM databases

PhosphoSiteiQ6PZD9.

Proteomic databases

PRIDEiQ6PZD9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064290; ENSMUSP00000068927; ENSMUSG00000052435.
GeneIDi110794.
KEGGimmu:110794.
UCSCiuc007twz.1. mouse.

Organism-specific databases

CTDi1053.
MGIiMGI:103572. Cebpe.

Phylogenomic databases

eggNOGiNOG244516.
GeneTreeiENSGT00530000063192.
HOVERGENiHBG050879.
InParanoidiQ6PZD9.
KOiK10051.
OMAiPAGPLHK.
OrthoDBiEOG7R56TQ.
PhylomeDBiQ6PZD9.
TreeFamiTF105008.

Miscellaneous databases

NextBioi364671.
PROiQ6PZD9.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PZD9.
CleanExiMM_CEBPE.
ExpressionAtlasiQ6PZD9. baseline and differential.
GenevestigatoriQ6PZD9.

Family and domain databases

InterProiIPR004827. bZIP.
IPR016468. CCAAT/enhancer-binding.
[Graphical view]
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
PIRSFiPIRSF005879. CCAAT/enhancer-binding. 1 hit.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the macrophage differentiation induced by mutated G-CSF receptors."
    Zhuang D., Zhang P., Dong F.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Spleen.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiCEBPE_MOUSE
AccessioniPrimary (citable) accession number: Q6PZD9
Secondary accession number(s): Q32MW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: July 5, 2004
Last modified: March 4, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.