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Q6PZD9

- CEBPE_MOUSE

UniProt

Q6PZD9 - CEBPE_MOUSE

Protein

CCAAT/enhancer-binding protein epsilon

Gene

Cebpe

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers.By similarity

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. cellular response to lipopolysaccharide Source: Ensembl
    2. cytokine biosynthetic process Source: MGI
    3. defense response to bacterium Source: MGI
    4. macrophage differentiation Source: MGI
    5. phagocytosis Source: MGI
    6. positive regulation of gene expression Source: MGI
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CCAAT/enhancer-binding protein epsilon
    Short name:
    C/EBP epsilon
    Gene namesi
    Name:Cebpe
    Synonyms:Gm294
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:103572. Cebpe.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 281281CCAAT/enhancer-binding protein epsilonPRO_0000076625Add
    BLAST

    Post-translational modificationi

    Phosphorylated.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ6PZD9.

    PTM databases

    PhosphoSiteiQ6PZD9.

    Expressioni

    Gene expression databases

    BgeeiQ6PZD9.
    CleanExiMM_CEBPE.
    GenevestigatoriQ6PZD9.

    Interactioni

    Subunit structurei

    Binds DNA as a dimer and can form stable heterodimers with C/EBP delta.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000068927.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PZD9.
    SMRiQ6PZD9. Positions 203-261.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini204 – 26764bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni208 – 24538Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni246 – 26722Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the bZIP family. C/EBP subfamily.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG244516.
    GeneTreeiENSGT00530000063192.
    HOVERGENiHBG050879.
    InParanoidiQ32MW9.
    KOiK10051.
    OMAiPAGPLHK.
    OrthoDBiEOG7R56TQ.
    PhylomeDBiQ6PZD9.
    TreeFamiTF105008.

    Family and domain databases

    InterProiIPR004827. bZIP.
    IPR016468. CCAAT/enhancer-binding.
    [Graphical view]
    PfamiPF07716. bZIP_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005879. CCAAT/enhancer-binding. 1 hit.
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    PROSITEiPS50217. BZIP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6PZD9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHGTYYECE PRGGQQPLEF SGGRAGPGEL GDMCEHEASI DLSAYIESGE    50
    EQLLSDLFAM KPTPEARSLK GPGAPSFPHY LPADPRPFAY PSHTFGPDRK 100
    ALGPGIYSNP GSYDPRAVAV KEEPRGPEGN RGTSRGSYNP LQYQVAHCGQ 150
    TAVHLPPTLA APGQPLRVLK APVAAAAPPC SPLLKAPSPA GPSHKGKKAV 200
    NKDSLEYRLR RERNNIAVRK SRDKAKRRIM ETQQKVLEYM AENERLRNRV 250
    DQLTQELDTL RNLFRQIPEA ASLIKGVGGC S 281
    Length:281
    Mass (Da):30,617
    Last modified:July 5, 2004 - v1
    Checksum:i864F3FABA54E939A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY570294 mRNA. Translation: AAS78198.1.
    BC108953 mRNA. Translation: AAI08954.1.
    CCDSiCCDS27100.1.
    RefSeqiNP_997014.1. NM_207131.1.
    UniGeneiMm.236223.

    Genome annotation databases

    EnsembliENSMUST00000064290; ENSMUSP00000068927; ENSMUSG00000052435.
    GeneIDi110794.
    KEGGimmu:110794.
    UCSCiuc007twz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY570294 mRNA. Translation: AAS78198.1 .
    BC108953 mRNA. Translation: AAI08954.1 .
    CCDSi CCDS27100.1.
    RefSeqi NP_997014.1. NM_207131.1.
    UniGenei Mm.236223.

    3D structure databases

    ProteinModelPortali Q6PZD9.
    SMRi Q6PZD9. Positions 203-261.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000068927.

    PTM databases

    PhosphoSitei Q6PZD9.

    Proteomic databases

    PRIDEi Q6PZD9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000064290 ; ENSMUSP00000068927 ; ENSMUSG00000052435 .
    GeneIDi 110794.
    KEGGi mmu:110794.
    UCSCi uc007twz.1. mouse.

    Organism-specific databases

    CTDi 1053.
    MGIi MGI:103572. Cebpe.

    Phylogenomic databases

    eggNOGi NOG244516.
    GeneTreei ENSGT00530000063192.
    HOVERGENi HBG050879.
    InParanoidi Q32MW9.
    KOi K10051.
    OMAi PAGPLHK.
    OrthoDBi EOG7R56TQ.
    PhylomeDBi Q6PZD9.
    TreeFami TF105008.

    Miscellaneous databases

    NextBioi 364671.
    PROi Q6PZD9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6PZD9.
    CleanExi MM_CEBPE.
    Genevestigatori Q6PZD9.

    Family and domain databases

    InterProi IPR004827. bZIP.
    IPR016468. CCAAT/enhancer-binding.
    [Graphical view ]
    Pfami PF07716. bZIP_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005879. CCAAT/enhancer-binding. 1 hit.
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50217. BZIP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the macrophage differentiation induced by mutated G-CSF receptors."
      Zhuang D., Zhang P., Dong F.
      Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
      Tissue: Spleen.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiCEBPE_MOUSE
    AccessioniPrimary (citable) accession number: Q6PZD9
    Secondary accession number(s): Q32MW9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3