Q6PXP3 (GTR7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier family 2, facilitated glucose transporter member 7

Alternative name(s):
Glucose transporter type 7
Short name=GLUT-7

Gene names

Name:	SLC2A7
Synonyms:	GLUT7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	512 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	High-affinity transporter for glucose and fructose Does not transport galactose, 2-deoxy-d-glucose and xylose. Ref.1
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in small intestine and colon. Weakly expressed in testis and prostate. Ref.1
Sequence similarities	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]

Ontologies

Keywords
Biological process	Sugar transport Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carbohydrate transport Inferred from electronic annotation. Source: UniProtKB-KW transmembrane transport Traceable author statement. Source: Reactome
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	substrate-specific transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 512	512	Solute carrier family 2, facilitated glucose transporter member 7		PRO_0000317274
Regions
	Topological domain	1 – 21	21	Cytoplasmic Potential
	Transmembrane	22 – 42	21	Helical; Potential
	Topological domain	43 – 78	36	Extracellular Potential
	Transmembrane	79 – 99	21	Helical; Potential
	Topological domain	100 – 107	8	Cytoplasmic Potential
	Transmembrane	108 – 128	21	Helical; Potential
	Topological domain	129 – 138	10	Extracellular Potential
	Transmembrane	139 – 159	21	Helical; Potential
	Topological domain	160 – 172	13	Cytoplasmic Potential
	Transmembrane	173 – 193	21	Helical; Potential
	Topological domain	194 – 198	5	Extracellular Potential
	Transmembrane	199 – 219	21	Helical; Potential
	Topological domain	220 – 281	62	Cytoplasmic Potential
	Transmembrane	282 – 302	21	Helical; Potential
	Topological domain	303 – 321	19	Extracellular Potential
	Transmembrane	322 – 342	21	Helical; Potential
	Topological domain	343 – 350	8	Cytoplasmic Potential
	Transmembrane	351 – 371	21	Helical; Potential
	Topological domain	372 – 379	8	Extracellular Potential
	Transmembrane	380 – 400	21	Helical; Potential
	Topological domain	401 – 415	15	Cytoplasmic Potential
	Transmembrane	416 – 436	21	Helical; Potential
	Topological domain	437 – 445	9	Extracellular Potential
	Transmembrane	446 – 466	21	Helical; Potential
	Topological domain	467 – 512	46	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	57	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	135	1	V → I. Corresponds to variant rs34545462 [ dbSNP | Ensembl ].		VAR_052504
	Natural variant	261	1	R → Q. Corresponds to variant rs12402973 [ dbSNP | Ensembl ].		VAR_061879

Sequences

	Sequence		Length	Mass (Da)
	Q6PXP3 [UniParc]. Last modified May 1, 2007. Version 2. Checksum: DCA09E35AB720382	FASTA	512	55,728
	10 20 30 40 50 60 MENKEAGTPP PIPSREGRLQ PTLLLATLSA AFGSAFQYGY NLSVVNTPHK VFKSFYNETY 70 80 90 100 110 120 FERHATFMDG KLMLLLWSCT VSMFPLGGLL GSLLVGLLVD SCGRKGTLLI NNIFAIIPAI 130 140 150 160 170 180 LMGVSKVAKA FELIVFSRVV LGVCAGISYS ALPMYLGELA PKNLRGMVGT MTEVFVIVGV 190 200 210 220 230 240 FLAQIFSLQA ILGNPAGWPV LLALTGVPAL LQLLTLPFFP ESPRYSLIQK GDEATARQAL 250 260 270 280 290 300 RRLRGHTDME AELEDMRAEA RAERAEGHLS VLHLCALRSL RWQLLSIIVL MAGQQLSGIN 310 320 330 340 350 360 AINYYADTIY TSAGVEAAHS QYVTVGSGVV NIVMTITSAV LVERLGRRHL LLAGYGICGS 370 380 390 400 410 420 ACLVLTVVLL FQNRVPELSY LGIICVFAYI AGHSIGPSPV PSVVRTEIFL QSSRRAAFMV 430 440 450 460 470 480 DGAVHWLTNF IIGFLFPSIQ EAIGAYSFII FAGICLLTAI YIYVVIPETK GKTFVEINRI 490 500 510 FAKRNRVKLP EEKEETIDAG PPTASPAKET SF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and functional characterization of the human GLUT7 isoform SLC2A7 from the small intestine." Li Q., Manolescu A.R., Ritzel M., Yao S., Slugoski M., Young J.D., Chen X.-Z., Cheeseman C.I. Am. J. Physiol. 287:G236-G242(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY571960 mRNA. Translation: AAS78590.2.
AL158048 Genomic DNA. Translation: CAI23459.3.
CH471130 Genomic DNA. Translation: EAW71607.1.

IPI

IPI00057815.

RefSeq

NP_997303.2. NM_207420.2.

UniGene

Hs.531239.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1YG7	model	-	A	1-512	[»]

ProteinModelPortal

Q6PXP3.

ModBase

Search...

Protein family/group databases

TCDB

2.A.1.1.37. major facilitator superfamily (MFS).

PTM databases

PhosphoSite

Q6PXP3.

Polymorphism databases

DMDM

167008866.

Proteomic databases

PaxDb

Q6PXP3.

PRIDE

Q6PXP3.

Protocols and materials databases

DNASU

155184.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000400906; ENSP00000383698; ENSG00000197241.

GeneID

155184.

KEGG

hsa:155184.

UCSC

uc009vmo.1. human.

Organism-specific databases

CTD

155184.

GeneCards

GC01M009063.

HGNC

HGNC:13445. SLC2A7.

HPA

HPA039931.

MIM

610371. gene.

neXtProt

NX_Q6PXP3.

PharmGKB

PA37770.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG0477.

HOGENOM

HOG000202871.

HOVERGEN

HBG014816.

KO

K12201.

OMA

HPRAVAT.

OrthoDB

EOG42Z4Q3.

Enzyme and pathway databases

Reactome

REACT_15518. Transmembrane transport of small molecules.

Gene expression databases

Bgee

Q6PXP3.

CleanEx

HS_SLC2A7.

Genevestigator

Q6PXP3.

Family and domain databases

InterPro

IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]

Pfam

PF00083. Sugar_tr. 1 hit.
[Graphical view]

PRINTS

PR00171. SUGRTRNSPORT.

SUPFAM

SSF103473. MFS_gen_substrate_transporter. 1 hit.

TIGRFAMs

TIGR00879. SP. 1 hit.

PROSITE

PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

155184.

NextBio

87385.

SOURCE

Search...

Entry information

Entry name

GTR7_HUMAN

Accession

Primary (citable) accession number: Q6PXP3
Secondary accession number(s): A2A333

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	May 1, 2007
Last modified:	April 3, 2013
This is version 83 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.