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Q6PXP3

- GTR7_HUMAN

UniProt

Q6PXP3 - GTR7_HUMAN

Protein

Solute carrier family 2, facilitated glucose transporter member 7

Gene

SLC2A7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (01 May 2007)
      Previous versions | rss
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    Functioni

    High-affinity transporter for glucose and fructose Does not transport galactose, 2-deoxy-d-glucose and xylose.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei331 – 3311MonosaccharideBy similarity

    GO - Molecular functioni

    1. substrate-specific transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. carbohydrate transport Source: UniProtKB-KW
    2. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Sugar transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_19281. Class II GLUTs.

    Protein family/group databases

    TCDBi2.A.1.1.37. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 7
    Alternative name(s):
    Glucose transporter type 7
    Short name:
    GLUT-7
    Gene namesi
    Name:SLC2A7
    Synonyms:GLUT7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:13445. SLC2A7.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37770.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 512512Solute carrier family 2, facilitated glucose transporter member 7PRO_0000317274Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi57 – 571N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ6PXP3.
    PRIDEiQ6PXP3.

    PTM databases

    PhosphoSiteiQ6PXP3.

    Expressioni

    Tissue specificityi

    Expressed in small intestine and colon. Weakly expressed in testis and prostate.1 Publication

    Gene expression databases

    BgeeiQ6PXP3.
    CleanExiHS_SLC2A7.
    GenevestigatoriQ6PXP3.

    Organism-specific databases

    HPAiHPA039931.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1YG7model-A1-512[»]
    ProteinModelPortaliQ6PXP3.
    SMRiQ6PXP3. Positions 81-471.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2121CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini43 – 7836ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini100 – 1078CytoplasmicSequence Analysis
    Topological domaini129 – 13810ExtracellularSequence Analysis
    Topological domaini160 – 17213CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini194 – 1985ExtracellularSequence Analysis
    Topological domaini220 – 28162CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini303 – 32119ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini343 – 3508CytoplasmicSequence Analysis
    Topological domaini372 – 3798ExtracellularSequence Analysis
    Topological domaini401 – 41515CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini437 – 4459ExtracellularSequence Analysis
    Topological domaini467 – 51246CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei22 – 4221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei79 – 9921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei108 – 12821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei139 – 15921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei173 – 19321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei199 – 21921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei282 – 30221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei322 – 34221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei351 – 37121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei380 – 40021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei416 – 43621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei446 – 46621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni294 – 3007Monosaccharide bindingBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    HOGENOMiHOG000202871.
    HOVERGENiHBG014816.
    KOiK12201.
    OMAiYDFYAYT.
    OrthoDBiEOG7QVM2R.
    PhylomeDBiQ6PXP3.
    TreeFamiTF313762.

    Family and domain databases

    InterProiIPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    PRINTSiPR00171. SUGRTRNSPORT.
    SUPFAMiSSF103473. SSF103473. 1 hit.
    TIGRFAMsiTIGR00879. SP. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6PXP3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENKEAGTPP PIPSREGRLQ PTLLLATLSA AFGSAFQYGY NLSVVNTPHK    50
    VFKSFYNETY FERHATFMDG KLMLLLWSCT VSMFPLGGLL GSLLVGLLVD 100
    SCGRKGTLLI NNIFAIIPAI LMGVSKVAKA FELIVFSRVV LGVCAGISYS 150
    ALPMYLGELA PKNLRGMVGT MTEVFVIVGV FLAQIFSLQA ILGNPAGWPV 200
    LLALTGVPAL LQLLTLPFFP ESPRYSLIQK GDEATARQAL RRLRGHTDME 250
    AELEDMRAEA RAERAEGHLS VLHLCALRSL RWQLLSIIVL MAGQQLSGIN 300
    AINYYADTIY TSAGVEAAHS QYVTVGSGVV NIVMTITSAV LVERLGRRHL 350
    LLAGYGICGS ACLVLTVVLL FQNRVPELSY LGIICVFAYI AGHSIGPSPV 400
    PSVVRTEIFL QSSRRAAFMV DGAVHWLTNF IIGFLFPSIQ EAIGAYSFII 450
    FAGICLLTAI YIYVVIPETK GKTFVEINRI FAKRNRVKLP EEKEETIDAG 500
    PPTASPAKET SF 512
    Length:512
    Mass (Da):55,728
    Last modified:May 1, 2007 - v2
    Checksum:iDCA09E35AB720382
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti135 – 1351V → I.
    Corresponds to variant rs34545462 [ dbSNP | Ensembl ].
    VAR_052504
    Natural varianti261 – 2611R → Q.
    Corresponds to variant rs12402973 [ dbSNP | Ensembl ].
    VAR_061879

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY571960 mRNA. Translation: AAS78590.2.
    AL158048 Genomic DNA. Translation: CAI23459.3.
    CH471130 Genomic DNA. Translation: EAW71607.1.
    CCDSiCCDS98.2.
    RefSeqiNP_997303.2. NM_207420.2.
    UniGeneiHs.531239.

    Genome annotation databases

    EnsembliENST00000400906; ENSP00000383698; ENSG00000197241.
    GeneIDi155184.
    KEGGihsa:155184.
    UCSCiuc009vmo.1. human.

    Polymorphism databases

    DMDMi167008866.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY571960 mRNA. Translation: AAS78590.2 .
    AL158048 Genomic DNA. Translation: CAI23459.3 .
    CH471130 Genomic DNA. Translation: EAW71607.1 .
    CCDSi CCDS98.2.
    RefSeqi NP_997303.2. NM_207420.2.
    UniGenei Hs.531239.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1YG7 model - A 1-512 [» ]
    ProteinModelPortali Q6PXP3.
    SMRi Q6PXP3. Positions 81-471.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 2.A.1.1.37. the major facilitator superfamily (mfs).

    PTM databases

    PhosphoSitei Q6PXP3.

    Polymorphism databases

    DMDMi 167008866.

    Proteomic databases

    PaxDbi Q6PXP3.
    PRIDEi Q6PXP3.

    Protocols and materials databases

    DNASUi 155184.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000400906 ; ENSP00000383698 ; ENSG00000197241 .
    GeneIDi 155184.
    KEGGi hsa:155184.
    UCSCi uc009vmo.1. human.

    Organism-specific databases

    CTDi 155184.
    GeneCardsi GC01M009063.
    HGNCi HGNC:13445. SLC2A7.
    HPAi HPA039931.
    MIMi 610371. gene.
    neXtProti NX_Q6PXP3.
    PharmGKBi PA37770.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0477.
    HOGENOMi HOG000202871.
    HOVERGENi HBG014816.
    KOi K12201.
    OMAi YDFYAYT.
    OrthoDBi EOG7QVM2R.
    PhylomeDBi Q6PXP3.
    TreeFami TF313762.

    Enzyme and pathway databases

    Reactomei REACT_19281. Class II GLUTs.

    Miscellaneous databases

    GeneWikii SLC2A7.
    GenomeRNAii 155184.
    NextBioi 87385.
    PROi Q6PXP3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6PXP3.
    CleanExi HS_SLC2A7.
    Genevestigatori Q6PXP3.

    Family and domain databases

    InterProi IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view ]
    Pfami PF00083. Sugar_tr. 1 hit.
    [Graphical view ]
    PRINTSi PR00171. SUGRTRNSPORT.
    SUPFAMi SSF103473. SSF103473. 1 hit.
    TIGRFAMsi TIGR00879. SP. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and functional characterization of the human GLUT7 isoform SLC2A7 from the small intestine."
      Li Q., Manolescu A.R., Ritzel M., Yao S., Slugoski M., Young J.D., Chen X.-Z., Cheeseman C.I.
      Am. J. Physiol. 287:G236-G242(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiGTR7_HUMAN
    AccessioniPrimary (citable) accession number: Q6PXP3
    Secondary accession number(s): A2A333
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3