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Q6PXP3

- GTR7_HUMAN

UniProt

Q6PXP3 - GTR7_HUMAN

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Protein

Solute carrier family 2, facilitated glucose transporter member 7

Gene

SLC2A7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

High-affinity transporter for glucose and fructose Does not transport galactose, 2-deoxy-d-glucose and xylose.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei331 – 3311MonosaccharideBy similarity

GO - Molecular functioni

  1. substrate-specific transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. carbohydrate transport Source: UniProtKB-KW
  2. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiREACT_19281. Class II GLUTs.

Protein family/group databases

TCDBi2.A.1.1.37. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 7
Alternative name(s):
Glucose transporter type 7
Short name:
GLUT-7
Gene namesi
Name:SLC2A7
Synonyms:GLUT7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:13445. SLC2A7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei22 – 4221HelicalSequence AnalysisAdd
BLAST
Topological domaini43 – 7836ExtracellularSequence AnalysisAdd
BLAST
Transmembranei79 – 9921HelicalSequence AnalysisAdd
BLAST
Topological domaini100 – 1078CytoplasmicSequence Analysis
Transmembranei108 – 12821HelicalSequence AnalysisAdd
BLAST
Topological domaini129 – 13810ExtracellularSequence Analysis
Transmembranei139 – 15921HelicalSequence AnalysisAdd
BLAST
Topological domaini160 – 17213CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei173 – 19321HelicalSequence AnalysisAdd
BLAST
Topological domaini194 – 1985ExtracellularSequence Analysis
Transmembranei199 – 21921HelicalSequence AnalysisAdd
BLAST
Topological domaini220 – 28162CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei282 – 30221HelicalSequence AnalysisAdd
BLAST
Topological domaini303 – 32119ExtracellularSequence AnalysisAdd
BLAST
Transmembranei322 – 34221HelicalSequence AnalysisAdd
BLAST
Topological domaini343 – 3508CytoplasmicSequence Analysis
Transmembranei351 – 37121HelicalSequence AnalysisAdd
BLAST
Topological domaini372 – 3798ExtracellularSequence Analysis
Transmembranei380 – 40021HelicalSequence AnalysisAdd
BLAST
Topological domaini401 – 41515CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei416 – 43621HelicalSequence AnalysisAdd
BLAST
Topological domaini437 – 4459ExtracellularSequence Analysis
Transmembranei446 – 46621HelicalSequence AnalysisAdd
BLAST
Topological domaini467 – 51246CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37770.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Solute carrier family 2, facilitated glucose transporter member 7PRO_0000317274Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6PXP3.
PRIDEiQ6PXP3.

PTM databases

PhosphoSiteiQ6PXP3.

Expressioni

Tissue specificityi

Expressed in small intestine and colon. Weakly expressed in testis and prostate.1 Publication

Gene expression databases

BgeeiQ6PXP3.
CleanExiHS_SLC2A7.
GenevestigatoriQ6PXP3.

Organism-specific databases

HPAiHPA039931.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YG7model-A1-512[»]
ProteinModelPortaliQ6PXP3.
SMRiQ6PXP3. Positions 23-469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni294 – 3007Monosaccharide bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiQ6PXP3.
KOiK12201.
OMAiYDFYAYT.
OrthoDBiEOG7QVM2R.
PhylomeDBiQ6PXP3.
TreeFamiTF313762.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PXP3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MENKEAGTPP PIPSREGRLQ PTLLLATLSA AFGSAFQYGY NLSVVNTPHK
60 70 80 90 100
VFKSFYNETY FERHATFMDG KLMLLLWSCT VSMFPLGGLL GSLLVGLLVD
110 120 130 140 150
SCGRKGTLLI NNIFAIIPAI LMGVSKVAKA FELIVFSRVV LGVCAGISYS
160 170 180 190 200
ALPMYLGELA PKNLRGMVGT MTEVFVIVGV FLAQIFSLQA ILGNPAGWPV
210 220 230 240 250
LLALTGVPAL LQLLTLPFFP ESPRYSLIQK GDEATARQAL RRLRGHTDME
260 270 280 290 300
AELEDMRAEA RAERAEGHLS VLHLCALRSL RWQLLSIIVL MAGQQLSGIN
310 320 330 340 350
AINYYADTIY TSAGVEAAHS QYVTVGSGVV NIVMTITSAV LVERLGRRHL
360 370 380 390 400
LLAGYGICGS ACLVLTVVLL FQNRVPELSY LGIICVFAYI AGHSIGPSPV
410 420 430 440 450
PSVVRTEIFL QSSRRAAFMV DGAVHWLTNF IIGFLFPSIQ EAIGAYSFII
460 470 480 490 500
FAGICLLTAI YIYVVIPETK GKTFVEINRI FAKRNRVKLP EEKEETIDAG
510
PPTASPAKET SF
Length:512
Mass (Da):55,728
Last modified:May 1, 2007 - v2
Checksum:iDCA09E35AB720382
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti135 – 1351V → I.
Corresponds to variant rs34545462 [ dbSNP | Ensembl ].
VAR_052504
Natural varianti261 – 2611R → Q.
Corresponds to variant rs12402973 [ dbSNP | Ensembl ].
VAR_061879

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY571960 mRNA. Translation: AAS78590.2.
AL158048 Genomic DNA. Translation: CAI23459.3.
CH471130 Genomic DNA. Translation: EAW71607.1.
CCDSiCCDS98.2.
RefSeqiNP_997303.2. NM_207420.2.
UniGeneiHs.531239.

Genome annotation databases

EnsembliENST00000400906; ENSP00000383698; ENSG00000197241.
GeneIDi155184.
KEGGihsa:155184.
UCSCiuc009vmo.1. human.

Polymorphism databases

DMDMi167008866.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY571960 mRNA. Translation: AAS78590.2 .
AL158048 Genomic DNA. Translation: CAI23459.3 .
CH471130 Genomic DNA. Translation: EAW71607.1 .
CCDSi CCDS98.2.
RefSeqi NP_997303.2. NM_207420.2.
UniGenei Hs.531239.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1YG7 model - A 1-512 [» ]
ProteinModelPortali Q6PXP3.
SMRi Q6PXP3. Positions 23-469.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

TCDBi 2.A.1.1.37. the major facilitator superfamily (mfs).

PTM databases

PhosphoSitei Q6PXP3.

Polymorphism databases

DMDMi 167008866.

Proteomic databases

PaxDbi Q6PXP3.
PRIDEi Q6PXP3.

Protocols and materials databases

DNASUi 155184.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000400906 ; ENSP00000383698 ; ENSG00000197241 .
GeneIDi 155184.
KEGGi hsa:155184.
UCSCi uc009vmo.1. human.

Organism-specific databases

CTDi 155184.
GeneCardsi GC01M009063.
HGNCi HGNC:13445. SLC2A7.
HPAi HPA039931.
MIMi 610371. gene.
neXtProti NX_Q6PXP3.
PharmGKBi PA37770.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00760000119022.
HOGENOMi HOG000202871.
HOVERGENi HBG014816.
InParanoidi Q6PXP3.
KOi K12201.
OMAi YDFYAYT.
OrthoDBi EOG7QVM2R.
PhylomeDBi Q6PXP3.
TreeFami TF313762.

Enzyme and pathway databases

Reactomei REACT_19281. Class II GLUTs.

Miscellaneous databases

GeneWikii SLC2A7.
GenomeRNAii 155184.
NextBioi 87385.
PROi Q6PXP3.
SOURCEi Search...

Gene expression databases

Bgeei Q6PXP3.
CleanExi HS_SLC2A7.
Genevestigatori Q6PXP3.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view ]
Pfami PF00083. Sugar_tr. 1 hit.
[Graphical view ]
PRINTSi PR00171. SUGRTRNSPORT.
SUPFAMi SSF103473. SSF103473. 1 hit.
TIGRFAMsi TIGR00879. SP. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional characterization of the human GLUT7 isoform SLC2A7 from the small intestine."
    Li Q., Manolescu A.R., Ritzel M., Yao S., Slugoski M., Young J.D., Chen X.-Z., Cheeseman C.I.
    Am. J. Physiol. 287:G236-G242(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiGTR7_HUMAN
AccessioniPrimary (citable) accession number: Q6PXP3
Secondary accession number(s): A2A333
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 2007
Last modified: October 29, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3