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Protein

Solute carrier family 2, facilitated glucose transporter member 7

Gene

SLC2A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

High-affinity transporter for glucose and fructose Does not transport galactose, 2-deoxy-d-glucose and xylose.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei331MonosaccharideBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciZFISH:G66-31784-MONOMER.
ReactomeiR-HSA-428776. Class II GLUTs.

Protein family/group databases

TCDBi2.A.1.1.37. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 7
Alternative name(s):
Glucose transporter type 7
Short name:
GLUT-7
Gene namesi
Name:SLC2A7
Synonyms:GLUT7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:13445. SLC2A7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21CytoplasmicSequence analysisAdd BLAST21
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Topological domaini43 – 78ExtracellularSequence analysisAdd BLAST36
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Topological domaini100 – 107CytoplasmicSequence analysis8
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Topological domaini129 – 138ExtracellularSequence analysis10
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Topological domaini160 – 172CytoplasmicSequence analysisAdd BLAST13
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 198ExtracellularSequence analysis5
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 281CytoplasmicSequence analysisAdd BLAST62
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21
Topological domaini303 – 321ExtracellularSequence analysisAdd BLAST19
Transmembranei322 – 342HelicalSequence analysisAdd BLAST21
Topological domaini343 – 350CytoplasmicSequence analysis8
Transmembranei351 – 371HelicalSequence analysisAdd BLAST21
Topological domaini372 – 379ExtracellularSequence analysis8
Transmembranei380 – 400HelicalSequence analysisAdd BLAST21
Topological domaini401 – 415CytoplasmicSequence analysisAdd BLAST15
Transmembranei416 – 436HelicalSequence analysisAdd BLAST21
Topological domaini437 – 445ExtracellularSequence analysis9
Transmembranei446 – 466HelicalSequence analysisAdd BLAST21
Topological domaini467 – 512CytoplasmicSequence analysisAdd BLAST46

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197241.
PharmGKBiPA37770.

Polymorphism and mutation databases

BioMutaiSLC2A7.
DMDMi167008866.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003172741 – 512Solute carrier family 2, facilitated glucose transporter member 7Add BLAST512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6PXP3.
PeptideAtlasiQ6PXP3.
PRIDEiQ6PXP3.

Expressioni

Tissue specificityi

Expressed in small intestine and colon. Weakly expressed in testis and prostate.1 Publication

Gene expression databases

BgeeiENSG00000197241.
CleanExiHS_SLC2A7.

Organism-specific databases

HPAiHPA039931.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000383698.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YG7model-A1-512[»]
ProteinModelPortaliQ6PXP3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni294 – 300Monosaccharide bindingBy similarity7

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiQ6PXP3.
KOiK12201.
OMAiHSHIHED.
OrthoDBiEOG091G0A9K.
PhylomeDBiQ6PXP3.
TreeFamiTF313762.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PXP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENKEAGTPP PIPSREGRLQ PTLLLATLSA AFGSAFQYGY NLSVVNTPHK
60 70 80 90 100
VFKSFYNETY FERHATFMDG KLMLLLWSCT VSMFPLGGLL GSLLVGLLVD
110 120 130 140 150
SCGRKGTLLI NNIFAIIPAI LMGVSKVAKA FELIVFSRVV LGVCAGISYS
160 170 180 190 200
ALPMYLGELA PKNLRGMVGT MTEVFVIVGV FLAQIFSLQA ILGNPAGWPV
210 220 230 240 250
LLALTGVPAL LQLLTLPFFP ESPRYSLIQK GDEATARQAL RRLRGHTDME
260 270 280 290 300
AELEDMRAEA RAERAEGHLS VLHLCALRSL RWQLLSIIVL MAGQQLSGIN
310 320 330 340 350
AINYYADTIY TSAGVEAAHS QYVTVGSGVV NIVMTITSAV LVERLGRRHL
360 370 380 390 400
LLAGYGICGS ACLVLTVVLL FQNRVPELSY LGIICVFAYI AGHSIGPSPV
410 420 430 440 450
PSVVRTEIFL QSSRRAAFMV DGAVHWLTNF IIGFLFPSIQ EAIGAYSFII
460 470 480 490 500
FAGICLLTAI YIYVVIPETK GKTFVEINRI FAKRNRVKLP EEKEETIDAG
510
PPTASPAKET SF
Length:512
Mass (Da):55,728
Last modified:May 1, 2007 - v2
Checksum:iDCA09E35AB720382
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052504135V → I.Corresponds to variant rs34545462dbSNPEnsembl.1
Natural variantiVAR_061879261R → Q.Corresponds to variant rs12402973dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY571960 mRNA. Translation: AAS78590.2.
AL158048 Genomic DNA. Translation: CAI23459.3.
CH471130 Genomic DNA. Translation: EAW71607.1.
CCDSiCCDS98.2.
RefSeqiNP_997303.2. NM_207420.2.
UniGeneiHs.531239.

Genome annotation databases

EnsembliENST00000400906; ENSP00000383698; ENSG00000197241.
GeneIDi155184.
KEGGihsa:155184.
UCSCiuc009vmo.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY571960 mRNA. Translation: AAS78590.2.
AL158048 Genomic DNA. Translation: CAI23459.3.
CH471130 Genomic DNA. Translation: EAW71607.1.
CCDSiCCDS98.2.
RefSeqiNP_997303.2. NM_207420.2.
UniGeneiHs.531239.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YG7model-A1-512[»]
ProteinModelPortaliQ6PXP3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000383698.

Protein family/group databases

TCDBi2.A.1.1.37. the major facilitator superfamily (mfs).

Polymorphism and mutation databases

BioMutaiSLC2A7.
DMDMi167008866.

Proteomic databases

PaxDbiQ6PXP3.
PeptideAtlasiQ6PXP3.
PRIDEiQ6PXP3.

Protocols and materials databases

DNASUi155184.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400906; ENSP00000383698; ENSG00000197241.
GeneIDi155184.
KEGGihsa:155184.
UCSCiuc009vmo.1. human.

Organism-specific databases

CTDi155184.
GeneCardsiSLC2A7.
HGNCiHGNC:13445. SLC2A7.
HPAiHPA039931.
MIMi610371. gene.
neXtProtiNX_Q6PXP3.
OpenTargetsiENSG00000197241.
PharmGKBiPA37770.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiQ6PXP3.
KOiK12201.
OMAiHSHIHED.
OrthoDBiEOG091G0A9K.
PhylomeDBiQ6PXP3.
TreeFamiTF313762.

Enzyme and pathway databases

BioCyciZFISH:G66-31784-MONOMER.
ReactomeiR-HSA-428776. Class II GLUTs.

Miscellaneous databases

GeneWikiiSLC2A7.
GenomeRNAii155184.
PROiQ6PXP3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197241.
CleanExiHS_SLC2A7.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGTR7_HUMAN
AccessioniPrimary (citable) accession number: Q6PXP3
Secondary accession number(s): A2A333
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 2007
Last modified: November 30, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.