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Q6PXP3 (GTR7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 2, facilitated glucose transporter member 7
Alternative name(s):
Glucose transporter type 7
Short name=GLUT-7
Gene names
Name:SLC2A7
Synonyms:GLUT7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length512 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

High-affinity transporter for glucose and fructose Does not transport galactose, 2-deoxy-d-glucose and xylose. Ref.1

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in small intestine and colon. Weakly expressed in testis and prostate. Ref.1

Sequence similarities

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]

Ontologies

Keywords
   Biological processSugar transport
Transport
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbohydrate transport

Inferred from electronic annotation. Source: UniProtKB-KW

transmembrane transport

Traceable author statement. Source: Reactome

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionsubstrate-specific transmembrane transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 512512Solute carrier family 2, facilitated glucose transporter member 7
PRO_0000317274

Regions

Topological domain1 – 2121Cytoplasmic Potential
Transmembrane22 – 4221Helical; Potential
Topological domain43 – 7836Extracellular Potential
Transmembrane79 – 9921Helical; Potential
Topological domain100 – 1078Cytoplasmic Potential
Transmembrane108 – 12821Helical; Potential
Topological domain129 – 13810Extracellular Potential
Transmembrane139 – 15921Helical; Potential
Topological domain160 – 17213Cytoplasmic Potential
Transmembrane173 – 19321Helical; Potential
Topological domain194 – 1985Extracellular Potential
Transmembrane199 – 21921Helical; Potential
Topological domain220 – 28162Cytoplasmic Potential
Transmembrane282 – 30221Helical; Potential
Topological domain303 – 32119Extracellular Potential
Transmembrane322 – 34221Helical; Potential
Topological domain343 – 3508Cytoplasmic Potential
Transmembrane351 – 37121Helical; Potential
Topological domain372 – 3798Extracellular Potential
Transmembrane380 – 40021Helical; Potential
Topological domain401 – 41515Cytoplasmic Potential
Transmembrane416 – 43621Helical; Potential
Topological domain437 – 4459Extracellular Potential
Transmembrane446 – 46621Helical; Potential
Topological domain467 – 51246Cytoplasmic Potential

Amino acid modifications

Glycosylation571N-linked (GlcNAc...) Potential

Natural variations

Natural variant1351V → I.
Corresponds to variant rs34545462 [ dbSNP | Ensembl ].
VAR_052504
Natural variant2611R → Q.
Corresponds to variant rs12402973 [ dbSNP | Ensembl ].
VAR_061879

Sequences

Sequence LengthMass (Da)Tools
Q6PXP3 [UniParc].

Last modified May 1, 2007. Version 2.
Checksum: DCA09E35AB720382

FASTA51255,728
        10         20         30         40         50         60 
MENKEAGTPP PIPSREGRLQ PTLLLATLSA AFGSAFQYGY NLSVVNTPHK VFKSFYNETY 

        70         80         90        100        110        120 
FERHATFMDG KLMLLLWSCT VSMFPLGGLL GSLLVGLLVD SCGRKGTLLI NNIFAIIPAI 

       130        140        150        160        170        180 
LMGVSKVAKA FELIVFSRVV LGVCAGISYS ALPMYLGELA PKNLRGMVGT MTEVFVIVGV 

       190        200        210        220        230        240 
FLAQIFSLQA ILGNPAGWPV LLALTGVPAL LQLLTLPFFP ESPRYSLIQK GDEATARQAL 

       250        260        270        280        290        300 
RRLRGHTDME AELEDMRAEA RAERAEGHLS VLHLCALRSL RWQLLSIIVL MAGQQLSGIN 

       310        320        330        340        350        360 
AINYYADTIY TSAGVEAAHS QYVTVGSGVV NIVMTITSAV LVERLGRRHL LLAGYGICGS 

       370        380        390        400        410        420 
ACLVLTVVLL FQNRVPELSY LGIICVFAYI AGHSIGPSPV PSVVRTEIFL QSSRRAAFMV 

       430        440        450        460        470        480 
DGAVHWLTNF IIGFLFPSIQ EAIGAYSFII FAGICLLTAI YIYVVIPETK GKTFVEINRI 

       490        500        510 
FAKRNRVKLP EEKEETIDAG PPTASPAKET SF 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and functional characterization of the human GLUT7 isoform SLC2A7 from the small intestine."
Li Q., Manolescu A.R., Ritzel M., Yao S., Slugoski M., Young J.D., Chen X.-Z., Cheeseman C.I.
Am. J. Physiol. 287:G236-G242(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY571960 mRNA. Translation: AAS78590.2.
AL158048 Genomic DNA. Translation: CAI23459.3.
CH471130 Genomic DNA. Translation: EAW71607.1.
RefSeqNP_997303.2. NM_207420.2.
UniGeneHs.531239.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1YG7model-A1-512[»]
ProteinModelPortalQ6PXP3.
SMRQ6PXP3. Positions 9-471.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

TCDB2.A.1.1.37. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteQ6PXP3.

Polymorphism databases

DMDM167008866.

Proteomic databases

PaxDbQ6PXP3.
PRIDEQ6PXP3.

Protocols and materials databases

DNASU155184.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000400906; ENSP00000383698; ENSG00000197241.
GeneID155184.
KEGGhsa:155184.
UCSCuc009vmo.1. human.

Organism-specific databases

CTD155184.
GeneCardsGC01M009063.
HGNCHGNC:13445. SLC2A7.
HPAHPA039931.
MIM610371. gene.
neXtProtNX_Q6PXP3.
PharmGKBPA37770.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0477.
HOGENOMHOG000202871.
HOVERGENHBG014816.
KOK12201.
OMAYDFYAYT.
OrthoDBEOG7QVM2R.
PhylomeDBQ6PXP3.
TreeFamTF313762.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

BgeeQ6PXP3.
CleanExHS_SLC2A7.
GenevestigatorQ6PXP3.

Family and domain databases

InterProIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSPR00171. SUGRTRNSPORT.
SUPFAMSSF103473. SSF103473. 1 hit.
TIGRFAMsTIGR00879. SP. 1 hit.
PROSITEPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSLC2A7.
GenomeRNAi155184.
NextBio87385.
PROQ6PXP3.
SOURCESearch...

Entry information

Entry nameGTR7_HUMAN
AccessionPrimary (citable) accession number: Q6PXP3
Secondary accession number(s): A2A333
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 2007
Last modified: April 16, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM