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Protein

Keratin, type I cytoskeletal 14

Gene

KRT14

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.By similarity

GO - Molecular functioni

GO - Biological processi

  • epithelial cell differentiation Source: UniProtKB
  • intermediate filament bundle assembly Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 14
Alternative name(s):
Cytokeratin-14
Short name:
CK-14
Keratin-14
Short name:
K14
Gene namesi
Name:KRT14
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Expressed in both as a filamentous pattern.By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • keratin filament Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Intermediate filament, Keratin, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 467467Keratin, type I cytoskeletal 14PRO_0000063656Add
BLAST

Proteomic databases

PaxDbiQ6PVZ1.
PRIDEiQ6PVZ1.

Expressioni

Tissue specificityi

Expressed in epidermis.1 Publication

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. keratin-14 associates with keratin-5. Interacts with TRADD and with keratin filaments. Associates with other type I keratins (By similarity).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006090.

Structurei

3D structure databases

ProteinModelPortaliQ6PVZ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 108108HeadBy similarityAdd
BLAST
Regioni109 – 416308RodBy similarityAdd
BLAST
Regioni109 – 14436Coil 1ABy similarityAdd
BLAST
Regioni145 – 16218Linker 1By similarityAdd
BLAST
Regioni163 – 25492Coil 1BBy similarityAdd
BLAST
Regioni255 – 27723Linker 12By similarityAdd
BLAST
Regioni278 – 416139Coil 2By similarityAdd
BLAST
Regioni417 – 46751TailBy similarityAdd
BLAST
Regioni419 – 46749Interaction with Type I keratins and keratin filamentsBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ6PVZ1.
KOiK07604.
PhylomeDBiQ6PVZ1.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PVZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTVRQFSS STSLKGLGGG SSRLSCGRAA GYQAPSVHGG SSSYSVSSRI
60 70 80 90 100
VSGLGAGYGG GYCSSVGGGL GGGFGASYGA GYGAGFGGGF GAGFGGGFGG
110 120 130 140 150
GDGILPAGEK ETMQNLNDRL AAYLDKVRAL EEANTDLEVK IREWYKKQGP
160 170 180 190 200
GPERDYSPYY RTIEELRSKI LAATVENANI VLQIDNARLA ADDFRTKFET
210 220 230 240 250
EQALRLSVEA DINGLRRVLD ELTLSRADLE MQIENLKEEL AYLKKNHEEE
260 270 280 290 300
MNALRGQVGG EISVEMDAAP GIDLTKILAE MREQYESLAE KNRRDAEQWF
310 320 330 340 350
FSKTEELNRE VAVNTEQLQS GKTEITELRR TIQSLEIDLQ SQLSTKAALE
360 370 380 390 400
GTLADTEARY GTQLAQLQAL ITSVEEQLAE LRCDMERQNH EYRVLLDVKC
410 420 430 440 450
RLEQEIATYR RLLEGEDAHI SSQYSSAMSS HSGRDAITTS RQVRTIVEEV
460
QDGKVVSSRE QMALTTR
Length:467
Mass (Da):50,986
Last modified:July 5, 2004 - v1
Checksum:iAA9E3E3046E5D3B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY574987 mRNA. Translation: AAS92202.1.
RefSeqiNP_001001311.2. NM_001001311.2.
UniGeneiGga.16196.

Genome annotation databases

GeneIDi408039.
KEGGigga:408039.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY574987 mRNA. Translation: AAS92202.1.
RefSeqiNP_001001311.2. NM_001001311.2.
UniGeneiGga.16196.

3D structure databases

ProteinModelPortaliQ6PVZ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006090.

Proteomic databases

PaxDbiQ6PVZ1.
PRIDEiQ6PVZ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi408039.
KEGGigga:408039.

Organism-specific databases

CTDi3861.

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ6PVZ1.
KOiK07604.
PhylomeDBiQ6PVZ1.

Miscellaneous databases

NextBioi20818650.
PROiQ6PVZ1.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Serial cultivation of chicken keratinocytes, a composite cell type that accumulates lipids and synthesizes a novel beta-keratin."
    Vanhoutteghem A., Londero T., Ghinea N., Djian P.
    Differentiation 72:123-137(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Keratinocyte1 Publication.

Entry informationi

Entry nameiK1C14_CHICK
AccessioniPrimary (citable) accession number: Q6PVZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.