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Q6PUV4

- CPLX2_HUMAN

UniProt

Q6PUV4 - CPLX2_HUMAN

Protein

Complexin-2

Gene

CPLX2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in synaptic vesicle exocytosis. Also involved in mast cell exocytosis By similarity.By similarity

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. mast cell degranulation Source: UniProtKB-KW
    3. nervous system development Source: UniProtKB-KW
    4. positive regulation of synaptic plasticity Source: UniProtKB
    5. synaptic vesicle exocytosis Source: Ensembl
    6. vesicle docking involved in exocytosis Source: ProtInc

    Keywords - Biological processi

    Differentiation, Exocytosis, Mast cell degranulation, Neurogenesis, Neurotransmitter transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Complexin-2
    Alternative name(s):
    Complexin II
    Short name:
    CPX II
    Synaphin-1
    Gene namesi
    Name:CPLX2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:2310. CPLX2.

    Subcellular locationi

    Cytoplasmcytosol
    Note: Enriched at synaptic-releasing sites in mature neurons.By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB-SubCell
    2. dendrite Source: Ensembl
    3. mast cell granule Source: GOC
    4. neuronal cell body Source: Ensembl
    5. synapse Source: Ensembl
    6. synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26827.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 134134Complexin-2PRO_0000144875Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei93 – 931PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6PUV4.
    PaxDbiQ6PUV4.
    PeptideAtlasiQ6PUV4.
    PRIDEiQ6PUV4.

    PTM databases

    PhosphoSiteiQ6PUV4.

    Expressioni

    Tissue specificityi

    Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia.5 Publications

    Gene expression databases

    ArrayExpressiQ6PUV4.
    BgeeiQ6PUV4.
    CleanExiHS_CPLX2.
    GenevestigatoriQ6PUV4.

    Interactioni

    Subunit structurei

    Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.By similarity

    Protein-protein interaction databases

    BioGridi116027. 2 interactions.
    IntActiQ6PUV4. 2 interactions.
    STRINGi9606.ENSP00000352544.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PUV4.
    SMRiQ6PUV4. Positions 32-72.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni41 – 9757Interaction with the SNARE complexBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili28 – 8457Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the complexin/synaphin family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG85303.
    HOVERGENiHBG062792.
    InParanoidiQ6PUV4.
    KOiK15294.
    OMAiHARMESD.
    OrthoDBiEOG71G9XG.
    PhylomeDBiQ6PUV4.
    TreeFamiTF315172.

    Family and domain databases

    InterProiIPR008849. Synaphin.
    [Graphical view]
    PANTHERiPTHR16705. PTHR16705. 1 hit.
    PfamiPF05835. Synaphin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6PUV4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFVMKQALG GATKDMGKML GGEEEKDPDA QKKEEERQEA LRQQEEERKA    50
    KHARMEAERE KVRQQIRDKY GLKKKEEKEA EEKAALEQPC EGSLTRPKKA 100
    IPAGCGDEEE EEEESILDTV LKYLPGPLQD MFKK 134
    Length:134
    Mass (Da):15,394
    Last modified:August 16, 2004 - v2
    Checksum:i7791812FD4194AC5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U35100 mRNA. Translation: AAC50229.1.
    AK314177 mRNA. Translation: BAG36859.1.
    BC093706 mRNA. Translation: AAH93706.1.
    BC112287 mRNA. Translation: AAI12288.1.
    AY576870 mRNA. Translation: AAS93622.1.
    BN000499 mRNA. Translation: CAG26663.1.
    BN000500 mRNA. Translation: CAG26664.1.
    CCDSiCCDS4396.1.
    PIRiE57233.
    RefSeqiNP_001008221.1. NM_001008220.1.
    NP_006641.1. NM_006650.3.
    XP_005265855.1. XM_005265798.1.
    XP_005265856.1. XM_005265799.1.
    UniGeneiHs.193235.

    Genome annotation databases

    EnsembliENST00000359546; ENSP00000352544; ENSG00000145920.
    ENST00000393745; ENSP00000377346; ENSG00000145920.
    ENST00000515094; ENSP00000421825; ENSG00000145920.
    GeneIDi10814.
    KEGGihsa:10814.
    UCSCiuc003mde.1. human.

    Polymorphism databases

    DMDMi51316998.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U35100 mRNA. Translation: AAC50229.1 .
    AK314177 mRNA. Translation: BAG36859.1 .
    BC093706 mRNA. Translation: AAH93706.1 .
    BC112287 mRNA. Translation: AAI12288.1 .
    AY576870 mRNA. Translation: AAS93622.1 .
    BN000499 mRNA. Translation: CAG26663.1 .
    BN000500 mRNA. Translation: CAG26664.1 .
    CCDSi CCDS4396.1.
    PIRi E57233.
    RefSeqi NP_001008221.1. NM_001008220.1.
    NP_006641.1. NM_006650.3.
    XP_005265855.1. XM_005265798.1.
    XP_005265856.1. XM_005265799.1.
    UniGenei Hs.193235.

    3D structure databases

    ProteinModelPortali Q6PUV4.
    SMRi Q6PUV4. Positions 32-72.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116027. 2 interactions.
    IntActi Q6PUV4. 2 interactions.
    STRINGi 9606.ENSP00000352544.

    PTM databases

    PhosphoSitei Q6PUV4.

    Polymorphism databases

    DMDMi 51316998.

    Proteomic databases

    MaxQBi Q6PUV4.
    PaxDbi Q6PUV4.
    PeptideAtlasi Q6PUV4.
    PRIDEi Q6PUV4.

    Protocols and materials databases

    DNASUi 10814.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000359546 ; ENSP00000352544 ; ENSG00000145920 .
    ENST00000393745 ; ENSP00000377346 ; ENSG00000145920 .
    ENST00000515094 ; ENSP00000421825 ; ENSG00000145920 .
    GeneIDi 10814.
    KEGGi hsa:10814.
    UCSCi uc003mde.1. human.

    Organism-specific databases

    CTDi 10814.
    GeneCardsi GC05P175156.
    HGNCi HGNC:2310. CPLX2.
    MIMi 605033. gene.
    neXtProti NX_Q6PUV4.
    PharmGKBi PA26827.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG85303.
    HOVERGENi HBG062792.
    InParanoidi Q6PUV4.
    KOi K15294.
    OMAi HARMESD.
    OrthoDBi EOG71G9XG.
    PhylomeDBi Q6PUV4.
    TreeFami TF315172.

    Miscellaneous databases

    ChiTaRSi CPLX2. human.
    GeneWikii CPLX2.
    GenomeRNAii 10814.
    NextBioi 20805633.
    PROi Q6PUV4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6PUV4.
    Bgeei Q6PUV4.
    CleanExi HS_CPLX2.
    Genevestigatori Q6PUV4.

    Family and domain databases

    InterProi IPR008849. Synaphin.
    [Graphical view ]
    PANTHERi PTHR16705. PTHR16705. 1 hit.
    Pfami PF05835. Synaphin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complexins: cytosolic proteins that regulate SNAP receptor function."
      McMahon H.T., Missler M., Li C., Suedhof T.C.
      Cell 83:111-119(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cerebellum.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "Structural organization of the human complexin 2 gene (CPLX2) and aspects of its functional activity."
      Raevskaya N.M., Dergunova L.V., Vladychenskaya I.P., Stavchansky V.V., Oborina M.V., Poltaraus A.B., Limborska S.A.
      Gene 359:127-137(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-114, TISSUE SPECIFICITY.
      Tissue: Cerebellum.
    5. "Preferential involvement of excitatory neurons in medial temporal lobe in schizophrenia."
      Harrison P.J., Eastwood S.L.
      Lancet 352:1669-1673(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    6. "Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the complexins."
      Eastwood S.L., Harrison P.J.
      Brain Res. Bull. 55:569-578(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    7. "Cerebellar synaptic protein expression in schizophrenia."
      Eastwood S.L., Cotter D., Harrison P.J.
      Neuroscience 105:219-229(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    8. "Early changes in Huntington's disease patient brains involve alterations in cytoskeletal and synaptic elements."
      DiProspero N.A., Chen E.-Y., Charles V., Plomann M., Kordower J.H., Tagle D.A.
      J. Neurocytol. 33:517-533(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiCPLX2_HUMAN
    AccessioniPrimary (citable) accession number: Q6PUV4
    Secondary accession number(s): B2RAG2
    , O09056, Q13329, Q28184, Q52M15, Q64386
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3