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Q6PUV4 (CPLX2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Complexin-2
Alternative name(s):
Complexin II
Short name=CPX II
Synaphin-1
Gene names
Name:CPLX2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length134 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in synaptic vesicle exocytosis. Also involved in mast cell exocytosis By similarity.

Subunit structure

Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A By similarity.

Subcellular location

Cytoplasmcytosol. Note: Enriched at synaptic-releasing sites in mature neurons By similarity.

Tissue specificity

Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia. Ref.4 Ref.5 Ref.6 Ref.7 Ref.8

Sequence similarities

Belongs to the complexin/synaphin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 134134Complexin-2
PRO_0000144875

Regions

Region41 – 9757Interaction with the SNARE complex By similarity
Coiled coil28 – 8457 Potential

Amino acid modifications

Modified residue931Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6PUV4 [UniParc].

Last modified August 16, 2004. Version 2.
Checksum: 7791812FD4194AC5

FASTA13415,394
        10         20         30         40         50         60 
MDFVMKQALG GATKDMGKML GGEEEKDPDA QKKEEERQEA LRQQEEERKA KHARMEAERE 

        70         80         90        100        110        120 
KVRQQIRDKY GLKKKEEKEA EEKAALEQPC EGSLTRPKKA IPAGCGDEEE EEEESILDTV 

       130 
LKYLPGPLQD MFKK 

« Hide

References

« Hide 'large scale' references
[1]"Complexins: cytosolic proteins that regulate SNAP receptor function."
McMahon H.T., Missler M., Li C., Suedhof T.C.
Cell 83:111-119(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Cerebellum.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Structural organization of the human complexin 2 gene (CPLX2) and aspects of its functional activity."
Raevskaya N.M., Dergunova L.V., Vladychenskaya I.P., Stavchansky V.V., Oborina M.V., Poltaraus A.B., Limborska S.A.
Gene 359:127-137(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-114, TISSUE SPECIFICITY.
Tissue: Cerebellum.
[5]"Preferential involvement of excitatory neurons in medial temporal lobe in schizophrenia."
Harrison P.J., Eastwood S.L.
Lancet 352:1669-1673(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[6]"Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the complexins."
Eastwood S.L., Harrison P.J.
Brain Res. Bull. 55:569-578(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[7]"Cerebellar synaptic protein expression in schizophrenia."
Eastwood S.L., Cotter D., Harrison P.J.
Neuroscience 105:219-229(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[8]"Early changes in Huntington's disease patient brains involve alterations in cytoskeletal and synaptic elements."
DiProspero N.A., Chen E.-Y., Charles V., Plomann M., Kordower J.H., Tagle D.A.
J. Neurocytol. 33:517-533(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U35100 mRNA. Translation: AAC50229.1.
AK314177 mRNA. Translation: BAG36859.1.
BC093706 mRNA. Translation: AAH93706.1.
BC112287 mRNA. Translation: AAI12288.1.
AY576870 mRNA. Translation: AAS93622.1.
BN000499 mRNA. Translation: CAG26663.1.
BN000500 mRNA. Translation: CAG26664.1.
CCDSCCDS4396.1.
PIRE57233.
RefSeqNP_001008221.1. NM_001008220.1.
NP_006641.1. NM_006650.3.
XP_005265855.1. XM_005265798.1.
XP_005265856.1. XM_005265799.1.
UniGeneHs.193235.

3D structure databases

ProteinModelPortalQ6PUV4.
SMRQ6PUV4. Positions 32-72.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116027. 2 interactions.
IntActQ6PUV4. 2 interactions.
STRING9606.ENSP00000352544.

PTM databases

PhosphoSiteQ6PUV4.

Polymorphism databases

DMDM51316998.

Proteomic databases

MaxQBQ6PUV4.
PaxDbQ6PUV4.
PeptideAtlasQ6PUV4.
PRIDEQ6PUV4.

Protocols and materials databases

DNASU10814.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000359546; ENSP00000352544; ENSG00000145920.
ENST00000393745; ENSP00000377346; ENSG00000145920.
ENST00000515094; ENSP00000421825; ENSG00000145920.
GeneID10814.
KEGGhsa:10814.
UCSCuc003mde.1. human.

Organism-specific databases

CTD10814.
GeneCardsGC05P175156.
HGNCHGNC:2310. CPLX2.
MIM605033. gene.
neXtProtNX_Q6PUV4.
PharmGKBPA26827.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG85303.
HOVERGENHBG062792.
InParanoidQ6PUV4.
KOK15294.
OMAHARMESD.
OrthoDBEOG71G9XG.
PhylomeDBQ6PUV4.
TreeFamTF315172.

Gene expression databases

ArrayExpressQ6PUV4.
BgeeQ6PUV4.
CleanExHS_CPLX2.
GenevestigatorQ6PUV4.

Family and domain databases

InterProIPR008849. Synaphin.
[Graphical view]
PANTHERPTHR16705. PTHR16705. 1 hit.
PfamPF05835. Synaphin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCPLX2. human.
GeneWikiCPLX2.
GenomeRNAi10814.
NextBio20805633.
PROQ6PUV4.
SOURCESearch...

Entry information

Entry nameCPLX2_HUMAN
AccessionPrimary (citable) accession number: Q6PUV4
Secondary accession number(s): B2RAG2 expand/collapse secondary AC list , O09056, Q13329, Q28184, Q52M15, Q64386
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: July 9, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM