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Protein

Complexin-2

Gene

CPLX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation, Exocytosis, Mast cell degranulation, Neurogenesis, Neurotransmitter transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145925-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Complexin-2
Alternative name(s):
Complexin II
Short name:
CPX II
Synaphin-1
Gene namesi
Name:CPLX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:2310. CPLX2.

Subcellular locationi

  • Cytoplasmcytosol

  • Note: Enriched at synaptic-releasing sites in mature neurons.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi10814.
OpenTargetsiENSG00000145920.
PharmGKBiPA26827.

Polymorphism and mutation databases

BioMutaiCPLX2.
DMDMi51316998.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001448751 – 134Complexin-2Add BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei93PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PUV4.
MaxQBiQ6PUV4.
PaxDbiQ6PUV4.
PeptideAtlasiQ6PUV4.
PRIDEiQ6PUV4.
TopDownProteomicsiQ6PUV4.

PTM databases

iPTMnetiQ6PUV4.
PhosphoSitePlusiQ6PUV4.

Expressioni

Tissue specificityi

Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia.5 Publications

Gene expression databases

BgeeiENSG00000145920.
CleanExiHS_CPLX2.
ExpressionAtlasiQ6PUV4. baseline and differential.
GenevisibleiQ6PUV4. HS.

Interactioni

Subunit structurei

Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.By similarity

Protein-protein interaction databases

BioGridi116027. 8 interactors.
IntActiQ6PUV4. 2 interactors.
STRINGi9606.ENSP00000352544.

Structurei

3D structure databases

ProteinModelPortaliQ6PUV4.
SMRiQ6PUV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 97Interaction with the SNARE complexBy similarityAdd BLAST57

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili28 – 84Sequence analysisAdd BLAST57

Sequence similaritiesi

Belongs to the complexin/synaphin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IWGS. Eukaryota.
ENOG4111MX0. LUCA.
GeneTreeiENSGT00490000043416.
HOVERGENiHBG062792.
InParanoidiQ6PUV4.
KOiK15294.
OMAiAMEQPCE.
PhylomeDBiQ6PUV4.
TreeFamiTF315172.

Family and domain databases

InterProiIPR008849. Synaphin.
[Graphical view]
PANTHERiPTHR16705. PTHR16705. 1 hit.
PfamiPF05835. Synaphin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PUV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFVMKQALG GATKDMGKML GGEEEKDPDA QKKEEERQEA LRQQEEERKA
60 70 80 90 100
KHARMEAERE KVRQQIRDKY GLKKKEEKEA EEKAALEQPC EGSLTRPKKA
110 120 130
IPAGCGDEEE EEEESILDTV LKYLPGPLQD MFKK
Length:134
Mass (Da):15,394
Last modified:August 16, 2004 - v2
Checksum:i7791812FD4194AC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35100 mRNA. Translation: AAC50229.1.
AK314177 mRNA. Translation: BAG36859.1.
BC093706 mRNA. Translation: AAH93706.1.
BC112287 mRNA. Translation: AAI12288.1.
AY576870 mRNA. Translation: AAS93622.1.
BN000499 mRNA. Translation: CAG26663.1.
BN000500 mRNA. Translation: CAG26664.1.
CCDSiCCDS4396.1.
PIRiE57233.
RefSeqiNP_001008221.1. NM_001008220.1.
NP_006641.1. NM_006650.3.
XP_005265855.1. XM_005265798.1.
XP_005265856.1. XM_005265799.1.
XP_011532721.1. XM_011534419.1.
XP_016864453.1. XM_017008964.1.
UniGeneiHs.193235.

Genome annotation databases

EnsembliENST00000359546; ENSP00000352544; ENSG00000145920.
ENST00000393745; ENSP00000377346; ENSG00000145920.
ENST00000515094; ENSP00000421825; ENSG00000145920.
GeneIDi10814.
KEGGihsa:10814.
UCSCiuc003mde.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35100 mRNA. Translation: AAC50229.1.
AK314177 mRNA. Translation: BAG36859.1.
BC093706 mRNA. Translation: AAH93706.1.
BC112287 mRNA. Translation: AAI12288.1.
AY576870 mRNA. Translation: AAS93622.1.
BN000499 mRNA. Translation: CAG26663.1.
BN000500 mRNA. Translation: CAG26664.1.
CCDSiCCDS4396.1.
PIRiE57233.
RefSeqiNP_001008221.1. NM_001008220.1.
NP_006641.1. NM_006650.3.
XP_005265855.1. XM_005265798.1.
XP_005265856.1. XM_005265799.1.
XP_011532721.1. XM_011534419.1.
XP_016864453.1. XM_017008964.1.
UniGeneiHs.193235.

3D structure databases

ProteinModelPortaliQ6PUV4.
SMRiQ6PUV4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116027. 8 interactors.
IntActiQ6PUV4. 2 interactors.
STRINGi9606.ENSP00000352544.

PTM databases

iPTMnetiQ6PUV4.
PhosphoSitePlusiQ6PUV4.

Polymorphism and mutation databases

BioMutaiCPLX2.
DMDMi51316998.

Proteomic databases

EPDiQ6PUV4.
MaxQBiQ6PUV4.
PaxDbiQ6PUV4.
PeptideAtlasiQ6PUV4.
PRIDEiQ6PUV4.
TopDownProteomicsiQ6PUV4.

Protocols and materials databases

DNASUi10814.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359546; ENSP00000352544; ENSG00000145920.
ENST00000393745; ENSP00000377346; ENSG00000145920.
ENST00000515094; ENSP00000421825; ENSG00000145920.
GeneIDi10814.
KEGGihsa:10814.
UCSCiuc003mde.2. human.

Organism-specific databases

CTDi10814.
DisGeNETi10814.
GeneCardsiCPLX2.
HGNCiHGNC:2310. CPLX2.
MIMi605033. gene.
neXtProtiNX_Q6PUV4.
OpenTargetsiENSG00000145920.
PharmGKBiPA26827.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWGS. Eukaryota.
ENOG4111MX0. LUCA.
GeneTreeiENSGT00490000043416.
HOVERGENiHBG062792.
InParanoidiQ6PUV4.
KOiK15294.
OMAiAMEQPCE.
PhylomeDBiQ6PUV4.
TreeFamiTF315172.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145925-MONOMER.

Miscellaneous databases

ChiTaRSiCPLX2. human.
GeneWikiiCPLX2.
GenomeRNAii10814.
PROiQ6PUV4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145920.
CleanExiHS_CPLX2.
ExpressionAtlasiQ6PUV4. baseline and differential.
GenevisibleiQ6PUV4. HS.

Family and domain databases

InterProiIPR008849. Synaphin.
[Graphical view]
PANTHERiPTHR16705. PTHR16705. 1 hit.
PfamiPF05835. Synaphin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCPLX2_HUMAN
AccessioniPrimary (citable) accession number: Q6PUV4
Secondary accession number(s): B2RAG2
, O09056, Q13329, Q28184, Q52M15, Q64386
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 2, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.