ID   Q6PUJ7_HUMAN            Unreviewed;       272 AA.
AC   Q6PUJ7;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 79.
DE   RecName: Full=Prohibitin {ECO:0000256|RuleBase:RU366048};
GN   Name=HEL-215 {ECO:0000313|EMBL:ACI46033.1};
GN   Synonyms=HEL-S-54e {ECO:0000313|EMBL:ACS44653.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAS88903.1};
RN   [1] {ECO:0000313|EMBL:AAS88903.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Wang K., Wang R.;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACI46033.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Li J., Wang H., Liu J., Liu F.;
RL   Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:ACS44653.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Li J.;
RT   "Human epididymis sequences.";
RL   Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC       Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004273,
CC       ECO:0000256|RuleBase:RU366048}.
CC   -!- SIMILARITY: Belongs to the prohibitin family.
CC       {ECO:0000256|ARBA:ARBA00009658, ECO:0000256|RuleBase:RU366048}.
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DR   EMBL; AY577780; AAS88903.1; -; mRNA.
DR   EMBL; FJ224341; ACI46033.1; -; mRNA.
DR   EMBL; FJ460516; ACS44653.1; -; mRNA.
DR   AlphaFoldDB; Q6PUJ7; -.
DR   SMR; Q6PUJ7; -.
DR   IntAct; Q6PUJ7; 4.
DR   ChiTaRS; PHB; human.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd03401; SPFH_prohibitin; 1.
DR   Gene3D; 3.30.479.30; Band 7 domain; 1.
DR   InterPro; IPR001107; Band_7.
DR   InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR   InterPro; IPR000163; Prohibitin.
DR   PANTHER; PTHR23222; PROHIBITIN; 1.
DR   PANTHER; PTHR23222:SF0; PROHIBITIN 1; 1.
DR   Pfam; PF01145; Band_7; 1.
DR   PRINTS; PR00679; PROHIBITIN.
DR   SMART; SM00244; PHB; 1.
DR   SUPFAM; SSF117892; Band 7/SPFH domain; 1.
PE   2: Evidence at transcript level;
KW   Membrane {ECO:0000256|RuleBase:RU366048};
KW   Mitochondrion {ECO:0000256|RuleBase:RU366048};
KW   Mitochondrion inner membrane {ECO:0000256|RuleBase:RU366048}.
FT   DOMAIN          26..187
FT                   /note="Band 7"
FT                   /evidence="ECO:0000259|SMART:SM00244"
SQ   SEQUENCE   272 AA;  29820 MW;  995C00BA6A3CB122 CRC64;
     MAAKVFESIG KFGLALAVAG GVVNSALYNV DAGHRAVIFD RFRGVQDIVV GEGTHFLIPW
     VQKLIIFDCR SRPRNVPVIT GSKDLQNVNI TLRILFRPVA SQLPRIFTSI GEDYDERVLP
     SITTEILKSV VARFDAGELI TQRELVSRQV SDDLTERAAT FGLILDDVSL THLTFGKEFT
     EAVEAKQVAQ QEAERARFVV EKAEQQKKAA IISAEGDSKA AELIANSLAT AGDGLIELRK
     LEAAEDIAYQ LSRSRNITYL PAGQSVLLQL PQ
//