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Protein

Hydroxysteroid 11-beta-dehydrogenase 1-like protein

Gene

hsd11b1l

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei169 – 1691SubstrateBy similarity
Active sitei182 – 1821Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi40 – 6627NADPBy similarityAdd
BLAST
Nucleotide bindingi91 – 922NADPBy similarity
Nucleotide bindingi118 – 1203NADPBy similarity
Nucleotide bindingi182 – 1865NADPBy similarity
Nucleotide bindingi215 – 2217NADPBy similarity

GO - Molecular functioni

  • steroid dehydrogenase activity Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxysteroid 11-beta-dehydrogenase 1-like protein (EC:1.1.1.-)
Alternative name(s):
11-beta-hydroxysteroid dehydrogenase type 3
Short name:
11-DH3
Short name:
11-beta-HSD3
Gene namesi
Name:hsd11b1l
Synonyms:hsd11b3, hsd3
ORF Names:si:dkey-78l4.15, zgc:56373
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 22

Organism-specific databases

ZFINiZDB-GENE-040426-1002. hsd11b1la.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 287265Hydroxysteroid 11-beta-dehydrogenase 1-like proteinPRO_0000316819Add
BLAST

Proteomic databases

PaxDbiQ6PUF3.

Expressioni

Gene expression databases

BgeeiENSDARG00000071377.
ExpressionAtlasiQ6PUF3. differential.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000061738.

Structurei

3D structure databases

ProteinModelPortaliQ6PUF3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1205. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00840000129712.
HOGENOMiHOG000010276.
HOVERGENiHBG005481.
InParanoidiQ6PUF3.
OMAiLRGWLPH.
OrthoDBiEOG091G0E15.
PhylomeDBiQ6PUF3.
TreeFamiTF329114.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6PUF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLYAKLLLC SICVAFIAVR WSAPSFNEES LKGARVLVTG ASTGIGEQLA
60 70 80 90 100
YHYARLGAQI VITARRGNVL EQVVSKCREM GAQKAFYIPA DMANPSDADL
110 120 130 140 150
VVKYAIEQLG GLDYLVLNHI GPSPYQMWDG DVQHTRWLLE VNFLSYLQMA
160 170 180 190 200
QKALPTLEKS KGSIVVVSSL LGKICGPFAL PYASTKFALN GFFGGLQNEL
210 220 230 240 250
AMQKSNVSIT ICILGLIDTD SAMEKIKGYI NMTAYPSHEA ALQIIQAGAT
260 270 280
RQSESFYPWY TFYATLFRDW FPYLRDKVIQ NSYTYNP
Length:287
Mass (Da):31,918
Last modified:July 5, 2004 - v1
Checksum:iCC74BDD6D41C2CA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY578180 mRNA. Translation: AAS89256.1.
BX936298 Genomic DNA. Translation: CAK11206.1.
BC071452 mRNA. Translation: AAH71452.1.
BC153593 mRNA. Translation: AAI53594.1.
RefSeqiNP_001099077.1. NM_001105607.1.
NP_956617.2. NM_200323.2.
UniGeneiDr.120175.
Dr.78218.

Genome annotation databases

EnsembliENSDART00000061739; ENSDARP00000061738; ENSDARG00000071377.
GeneIDi100006793.
393293.
KEGGidre:100006793.
dre:393293.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY578180 mRNA. Translation: AAS89256.1.
BX936298 Genomic DNA. Translation: CAK11206.1.
BC071452 mRNA. Translation: AAH71452.1.
BC153593 mRNA. Translation: AAI53594.1.
RefSeqiNP_001099077.1. NM_001105607.1.
NP_956617.2. NM_200323.2.
UniGeneiDr.120175.
Dr.78218.

3D structure databases

ProteinModelPortaliQ6PUF3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000061738.

Proteomic databases

PaxDbiQ6PUF3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000061739; ENSDARP00000061738; ENSDARG00000071377.
GeneIDi100006793.
393293.
KEGGidre:100006793.
dre:393293.

Organism-specific databases

CTDi393293.
ZFINiZDB-GENE-040426-1002. hsd11b1la.

Phylogenomic databases

eggNOGiKOG1205. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00840000129712.
HOGENOMiHOG000010276.
HOVERGENiHBG005481.
InParanoidiQ6PUF3.
OMAiLRGWLPH.
OrthoDBiEOG091G0E15.
PhylomeDBiQ6PUF3.
TreeFamiTF329114.

Miscellaneous databases

PROiQ6PUF3.

Gene expression databases

BgeeiENSDARG00000071377.
ExpressionAtlasiQ6PUF3. differential.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDHI1L_DANRE
AccessioniPrimary (citable) accession number: Q6PUF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.