Q6PUF3 (DHI1L_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hydroxysteroid 11-beta-dehydrogenase 1-like protein
EC=1.1.1.-

Alternative name(s):
11-beta-hydroxysteroid dehydrogenase type 3
Short name=11-DH3
Short name=11-beta-HSD3

Gene names

Name:	hsd11b1l
Synonyms:	hsd11b3, hsd3
ORF Names:	si:dkey-78l4.15, zgc:56373

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	287 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	steroid dehydrogenase activity Inferred from sequence or structural similarity PubMed 15358559. Source: ZFIN
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 287	265	Hydroxysteroid 11-beta-dehydrogenase 1-like protein		PRO_0000316819
Regions
	Nucleotide binding	40 – 66	27	NADP By similarity
	Nucleotide binding	91 – 92	2	NADP By similarity
	Nucleotide binding	118 – 120	3	NADP By similarity
	Nucleotide binding	182 – 186	5	NADP By similarity
	Nucleotide binding	215 – 221	7	NADP By similarity
Sites
	Active site	182	1	Proton acceptor By similarity
	Binding site	169	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6PUF3 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: CC74BDD6D41C2CA8	FASTA	287	31,918
	10 20 30 40 50 60 MKLYAKLLLC SICVAFIAVR WSAPSFNEES LKGARVLVTG ASTGIGEQLA YHYARLGAQI 70 80 90 100 110 120 VITARRGNVL EQVVSKCREM GAQKAFYIPA DMANPSDADL VVKYAIEQLG GLDYLVLNHI 130 140 150 160 170 180 GPSPYQMWDG DVQHTRWLLE VNFLSYLQMA QKALPTLEKS KGSIVVVSSL LGKICGPFAL 190 200 210 220 230 240 PYASTKFALN GFFGGLQNEL AMQKSNVSIT ICILGLIDTD SAMEKIKGYI NMTAYPSHEA 250 260 270 280 ALQIIQAGAT RQSESFYPWY TFYATLFRDW FPYLRDKVIQ NSYTYNP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Huang C.Q., Zhou J.L., Wu S.L. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	The Danio rerio sequencing project at the Sanger Institute Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuebingen.
[3]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY578180 mRNA. Translation: AAS89256.1. BX936298 Genomic DNA. Translation: CAK11206.1. BC071452 mRNA. Translation: AAH71452.1. BC153593 mRNA. Translation: AAI53594.1.
IPI	IPI00994585.
RefSeq	NP_001099077.1. NM_001105607.1. NP_956617.2. NM_200323.2.
UniGene	Dr.120175. Dr.78218.
3D structure databases
ProteinModelPortal	Q6PUF3.
ModBase	Search...
Protein-protein interaction databases
STRING	7955.ENSDARP00000061738.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000061739; ENSDARP00000061738; ENSDARG00000071377.
GeneID	100006793. 393293.
KEGG	dre:100006793. dre:393293.
Organism-specific databases
CTD	393293.
ZFIN	ZDB-GENE-040426-1002. hsd11b3a.
Phylogenomic databases
eggNOG	COG4221.
GeneTree	ENSGT00650000093378.
HOGENOM	HOG000010276.
HOVERGEN	HBG005481.
InParanoid	Q6PUF3.
OMA	PSPFSMW.
OrthoDB	EOG405S1K.
Gene expression databases
ArrayExpress	Q6PUF3.
Bgee	Q6PUF3.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20787272.

Entry information

Entry name

DHI1L_DANRE

Accession

Primary (citable) accession number: Q6PUF3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	July 5, 2004
Last modified:	May 29, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program