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Protein

Hydroxysteroid 11-beta-dehydrogenase 1-like protein

Gene

hsd11b1l

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei169SubstrateBy similarity1
Active sitei182Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 66NADPBy similarityAdd BLAST27
Nucleotide bindingi91 – 92NADPBy similarity2
Nucleotide bindingi118 – 120NADPBy similarity3
Nucleotide bindingi182 – 186NADPBy similarity5
Nucleotide bindingi215 – 221NADPBy similarity7

GO - Molecular functioni

  • steroid dehydrogenase activity Source: ZFIN

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxysteroid 11-beta-dehydrogenase 1-like protein (EC:1.1.1.-)
Alternative name(s):
11-beta-hydroxysteroid dehydrogenase type 3
Short name:
11-DH3
Short name:
11-beta-HSD3
Gene namesi
Name:hsd11b1l
Synonyms:hsd11b3, hsd3
ORF Names:si:dkey-78l4.15, zgc:56373
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 22

Organism-specific databases

ZFINiZDB-GENE-040426-1002 hsd11b1la

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000031681923 – 287Hydroxysteroid 11-beta-dehydrogenase 1-like proteinAdd BLAST265

Proteomic databases

PaxDbiQ6PUF3
PRIDEiQ6PUF3

Expressioni

Gene expression databases

BgeeiENSDARG00000071377
ExpressionAtlasiQ6PUF3 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000061738

Structurei

3D structure databases

ProteinModelPortaliQ6PUF3
SMRiQ6PUF3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1205 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00880000138008
HOGENOMiHOG000010276
HOVERGENiHBG005481
InParanoidiQ6PUF3
OMAiLRGWLPH
OrthoDBiEOG091G0E15
PhylomeDBiQ6PUF3
TreeFamiTF329114

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6PUF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLYAKLLLC SICVAFIAVR WSAPSFNEES LKGARVLVTG ASTGIGEQLA
60 70 80 90 100
YHYARLGAQI VITARRGNVL EQVVSKCREM GAQKAFYIPA DMANPSDADL
110 120 130 140 150
VVKYAIEQLG GLDYLVLNHI GPSPYQMWDG DVQHTRWLLE VNFLSYLQMA
160 170 180 190 200
QKALPTLEKS KGSIVVVSSL LGKICGPFAL PYASTKFALN GFFGGLQNEL
210 220 230 240 250
AMQKSNVSIT ICILGLIDTD SAMEKIKGYI NMTAYPSHEA ALQIIQAGAT
260 270 280
RQSESFYPWY TFYATLFRDW FPYLRDKVIQ NSYTYNP
Length:287
Mass (Da):31,918
Last modified:July 5, 2004 - v1
Checksum:iCC74BDD6D41C2CA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY578180 mRNA Translation: AAS89256.1
BX936298 Genomic DNA Translation: CAK11206.1
BC071452 mRNA Translation: AAH71452.1
BC153593 mRNA Translation: AAI53594.1
RefSeqiNP_001099077.1, NM_001105607.1
NP_956617.2, NM_200323.2
UniGeneiDr.120175
Dr.78218

Genome annotation databases

EnsembliENSDART00000061739; ENSDARP00000061738; ENSDARG00000071377
GeneIDi100006793
393293
KEGGidre:100006793
dre:393293

Similar proteinsi

Entry informationi

Entry nameiDHI1L_DANRE
AccessioniPrimary (citable) accession number: Q6PUF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health