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Protein

Alpha-conotoxin Mr1.1

Gene
N/A
Organism
Conus marmoreus (Marble cone)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin inhibits rat alpha-7 and weakly alpha-6/alpha-3-beta-2 and alpha-3-beta-2 nAChR. In vivo, this toxin shows analgesic effect.1 Publication

Miscellaneous

Does not or very weakly inhibit mouse muscle alpha-1-beta-1-gamma-delta, and rat neuronal alpha-6/alpha-3-beta-4, alpha-3-beta-4, alpha-4-beta-4 and alpha-4-beta-2 nAChR.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin Mr1.11 Publication
OrganismiConus marmoreus (Marble cone)
Taxonomic identifieri42752 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri123. Mr1.1 precursor.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000024784722 – 48By similarityAdd BLAST27
PeptideiPRO_000024784849 – 64Alpha-conotoxin Mr1.1Add BLAST16

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 56By similarity
Disulfide bondi51 ↔ 64By similarity
Modified residuei64Cysteine amideBy similarity1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ6PTD1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is I (CC-C-C). Alpha4/7 pattern.Curated

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR009958. Conotoxin_a-typ.
PfamiView protein in Pfam
PF07365. Toxin_8. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6PTD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMRMMFTVF LLVVLATTVV SFTSDRASDG RKAAAKDKAS DLVALTVKGC
60
CSHPACSVNN PDICG
Length:65
Mass (Da):6,810
Last modified:July 5, 2004 - v1
Checksum:i31ECF5763F599134
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32K → N in ABD33869 (PubMed:17400270).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY580325 mRNA. Translation: AAS93428.1.
DQ311077 Genomic DNA. Translation: ABD33869.1.

Similar proteinsi

Entry informationi

Entry nameiCA11_CONMR
AccessioniPrimary (citable) accession number: Q6PTD1
Secondary accession number(s): A1X8D7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families