Unreviewed, UniProtKB/TrEMBL Q6PSM0 (Q6PSM0_RAT)

Names and origin

Protein names

Submitted name:
    Multidrug resistance protein 1a EMBL AAS91649.1

Gene names

Name:	Abcb1a RGD 619951
Synonyms:	Mdr1a EMBL AAS91649.1

Organism

Rattus norvegicus (Rat) EMBL AAS91649.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1272 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Belongs to the ABC transporter superfamily.

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000684V4 Nucleotide-binding
Gene Ontology (GO)
Biological process	drug transport Inferred from electronic annotation. Source: Compara response to cadmium ion Inferred from expression pattern. Source: RGD transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: InterPro intercellular canaliculus Inferred from electronic annotation. Source: Compara
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
HAX1	O00165	1	EBI-930055,EBI-357001	From a different organism.
Hax1	Q7TSE9	1	EBI-930055,EBI-930005

Sequences

	Sequence		Length	Mass (Da)
	Q6PSM0-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 754F9496700083E5	FASTA	1,272	140,284
	10 20 30 40 50 60 MELEEDLNGR ADKNFSKMGK KSKKEKKEKK PAVSVLTMFR YAGWLDRFYM LLGTLAAIIH 70 80 90 100 110 120 GIALPLMMLV FGDMTDSFAN VGNNRSMSFY NATDIYAKLK DEMTTYAYYY TGIGAGVLIV 130 140 150 160 170 180 AYIQVSLWCL AAGRQIHKIR QKFFHAIMNQ EIGWFDVHDV GELNTRLTDD VSKINEGIGD 190 200 210 220 230 240 KIGMFFQAMA TFFGGFIIGF TRGWKLTLVI LAISPVLGLS AGIWAKILSS FTDKELQAYA 250 260 270 280 290 300 KAGAVAEEVL AAIRTVIAFG GQKKELERYN NNLEEAKRLG IKKAITANIS MGAAFLLIYA 310 320 330 340 350 360 SYALAFWYGT SLVISKEYTI GQVLTVFFSV LIGAFSVGQA SPNIEAFANA RGAAYEVFSI 370 380 390 400 410 420 IDNKPSIDSF SKSGHKPDNI QGNLEFKNIH FSYPSRKDVQ ILKGLNLKVK SGQTVALVGN 430 440 450 460 470 480 SGCGKSTTVQ LLQRLYDPIE GEVSIDGQDI RTINVRYLRE IIGVVSQEPV LFATTIAENI 490 500 510 520 530 540 RYGRENVTMD EIEKAVKEAN AYDFIMKLPH KFDTLVGERG AQLSGGQKQR IAIARALVRN 550 560 570 580 590 600 PKILLLDEAT SALDTESEAV VQAALDKARE GRTTIVIAHR LSTVRNADVI AGFDGGVIVE 610 620 630 640 650 660 QGNHDELMRE KGIYFKLVMT QTAGNEIELG NEACESKDGI DNVDMSSKDS GSSLIRRRST 670 680 690 700 710 720 RKSIRGPHDQ DGELSTKEAL DDDVPPASFW RILKLNSTEW PYFVVGVFCA IINGGLQPAF 730 740 750 760 770 780 SIIFSKVVGV FTKNDTPEIQ RQNSNLFSLL FLILGIISFI TFFLQGFTFG KAGEILTKRL 790 800 810 820 830 840 RYMVFKSMLR QDISWFDDPK NTTGALTTRL ANDAAQVKGA TGSRLAVITQ NIANLGTGII 850 860 870 880 890 900 ISLIYGWQLT LLLLAIVPII AIAGVVEMKM LSGQALKDKK ELEGSGKIAT EAIENFRTVV 910 920 930 940 950 960 SLTREQKFET MYAQSLQIPY RNALKKAHVF GITFSFTQAM MYFSYAACFR FGAYLVAREL 970 980 990 1000 1010 1020 MTFENVLLVF SAIVFGAMAV GQVSSFAPDY AKAKVSASHI IRIIEKIPEI DSYSTEGLKP 1030 1040 1050 1060 1070 1080 NMLEGNVKFN GVMFNYPTRP NIPVLQGLSL EGKKGQTLAL VGSSGCGKST VVQLLERFYD 1090 1100 1110 1120 1130 1140 PMAGTVFLDG KEIKQLNVQW LRAHLGIVSQ EPILFDCSIA ENIAYGDNSR VVSHEEIVKA 1150 1160 1170 1180 1190 1200 AKEANIHQFI DSLPEKYNTR VGDKGTQLSG GQKQRIAIAR ALVRQPHILL LDEATSALDT 1210 1220 1230 1240 1250 1260 ESEKVVQEAL DKAREGRTCI VIAHRLSTIQ NADLIVVIQN GQVKEHGTHQ QLLAQKGIYF 1270 SMVSVQAGAK RS

References

[1]

"Development and characterization of LLC-PK1 cells containing Sprague-Dawley rat Abcb1a (Mdr1a): comparison of rat P-glycoprotein transport to human and mouse." Booth-Genthe C.L., Louie S.W., Carlini E.J., Li B., Leake B.F., Eisenhandler R., Hochman J.H., Mei Q., Kim R.B., Rushmore T.H., Yamazaki M. J. Pharmacol. Toxicol. Methods 54:78-89(2006) [PubMed: 16545584] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Sprague-Dawley EMBL AAS91649.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY582535 mRNA. Translation: AAS91649.1.
IPI	IPI00470287.
UniGene	Rn.154810
3D structure databases
SMR	Q6PSM0. Positions 45-622, 690-1267.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6PSM0. 2 interactions.
STRING	Q6PSM0.
Genome annotation databases
Ensembl	ENSRNOT00000011166; ENSRNOP00000011166; ENSRNOG00000008012; Rattus norvegicus. [Genome view]
Phylogenomic databases
eggNOG	roNOG07605.
HOVERGEN	Q6PSM0.
InParanoid	Q6PSM0.
Gene expression databases
ArrayExpress	Q6PSM0.
Genevestigator	Q6PSM0.
Family and domain databases
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR001140. ABC_transptr_TM_dom. IPR011527. ABC_transptrTM_dom_typ1. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF00664. ABC_membrane. 2 hits. PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS50929. ABC_TM1F. 2 hits. PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q6PSM0_RAT

Accession

Primary (citable) accession number: Q6PSM0

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	February 9, 2010
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)