Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Transducin-like enhancer of split 3 splice variant 1

Gene

TLE3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ6PRX3.

Names & Taxonomyi

Protein namesi
Submitted name:
Transducin-like enhancer of split 3 splice variant 1Imported
Gene namesi
Name:TLE3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ6PRX3.
PeptideAtlasiQ6PRX3.
PRIDEiQ6PRX3.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000452871.

Structurei

3D structure databases

ProteinModelPortaliQ6PRX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini474 – 647174WD_REPEATS_REGIONInterPro annotationAdd
BLAST
Domaini688 – 76477WD_REPEATS_REGIONInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili26 – 6035Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis, RepeatUniRule annotation

Phylogenomic databases

eggNOGiKOG0639. Eukaryota.
ENOG410XPX3. LUCA.
HOGENOMiHOG000293211.
HOVERGENiHBG004689.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR005617. Groucho/TLE_N.
IPR009146. Groucho_enhance.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF03920. TLE_N. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR01850. GROUCHOFAMLY.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PRX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYPQGRHPAP HQPGQPGFKF TVAESCDRIK DEFQFLQAQY HSLKVEYDKL
60 70 80 90 100
ANEKTEMQRH YVMYYEMSYG LNIEMHKQTE IAKRLNTILA QIMPFLSQEH
110 120 130 140 150
QQQVAQAVER AKQVTMTELN AIIGQQQLQA QHLSHATHGP PVQLPPHPSG
160 170 180 190 200
LQPPGIPPVT GSSSGLLALG ALGSQAHLTV KDEKNHHELD HRERESSANN
210 220 230 240 250
SVSPSESLRA SEKHRGSADY SMEAKKRKAE EKDSLSRYDS DGDKSDDLVV
260 270 280 290 300
DVSNEDPATP RVSPAHSPPE NGLVKARSLK KDAPTSPASV ASSSSAPSSK
310 320 330 340 350
TKDLGHNDKS STPGLKSNTP TPRNDAPTPG TSTTPGLRSM PGKPPGMDPI
360 370 380 390 400
ASALRTPISI TSSYAAPFAM MSHHEMNGSL TSPGAYAGLH NIPPQMSAAA
410 420 430 440 450
AAAAAAYGRS PMVGFDPHPP MRATGLPSSL ASIPGGKPAY SFHVSADGQM
460 470 480 490 500
QPVPFPHDAL AGPGIPRHAR QINTLSHGEV VCAVTISNPT RHVYTGGKGC
510 520 530 540 550
VKIWDISQPG SKSPISQLDC LNRDNYIRSC KLLPDGRTLI VGGEASTLTI
560 570 580 590 600
WDLASPTPRI KAELTSSAPA CYALAISPDA KVCFSCRSDG NIAVWDLHNQ
610 620 630 640 650
TLVRQFQGHT DGASCIDISH DGTKLWTGGL DNTVRSWDLR EGRQLQQHDF
660 670 680 690 700
TSQIFSLGYC PTGEWLAVGM ESSNVEVLHH TKPDKYQLHL HESCVLSLKF
710 720 730 740 750
AYCGKWFVST GKDNLLNAWR TPYGASIFQS KESSSVLSCD ISADDKYIVT
760
GSGDKKATVY EVIY
Length:764
Mass (Da):82,661
Last modified:July 5, 2004 - v1
Checksum:iD8D48782C7EB80C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY583459 mRNA. Translation: AAS90945.1.
RefSeqiNP_001269908.1. NM_001282979.1.
UniGeneiHs.287362.

Genome annotation databases

GeneIDi7090.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY583459 mRNA. Translation: AAS90945.1.
RefSeqiNP_001269908.1. NM_001282979.1.
UniGeneiHs.287362.

3D structure databases

ProteinModelPortaliQ6PRX3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000452871.

Proteomic databases

PaxDbiQ6PRX3.
PeptideAtlasiQ6PRX3.
PRIDEiQ6PRX3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi7090.

Organism-specific databases

CTDi7090.

Phylogenomic databases

eggNOGiKOG0639. Eukaryota.
ENOG410XPX3. LUCA.
HOGENOMiHOG000293211.
HOVERGENiHBG004689.

Enzyme and pathway databases

SignaLinkiQ6PRX3.

Miscellaneous databases

ChiTaRSiTLE3. human.
GenomeRNAii7090.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR005617. Groucho/TLE_N.
IPR009146. Groucho_enhance.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF03920. TLE_N. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR01850. GROUCHOFAMLY.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of new splice variants of the human transducin-like enhancer of split 3 gene."
    Zhu X., Huang P.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ6PRX3_HUMAN
AccessioniPrimary (citable) accession number: Q6PRX3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.