Telomere-associated protein RIF1 - Mus musculus (Mouse)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Telomere-associated protein RIF1

Alternative name(s):
Rap1-interacting factor 1 homolog
Short name=mRif1

Gene names

Name:

Rif1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2419 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for checkpoint mediated arrest of cell cycle progression in response to DNA damage during S-phase (the intra-S-phase checkpoint). This checkpoint requires activation of at least 2 parallel pathways by the ATM kinase: one involves the MRN (MRE11A-RAD50-NBS1) complex, while the second requires CHEK2. RIF1 seems to act independently of both these pathways. Seems to play no role in either the G1/S or G2/M DNA damage checkpoints By similarity.
Subunit structure	A fraction of the protein may interact with TRF2.
Subcellular location	Nucleus. Chromosome › telomere. Cytoplasm › cytoskeleton › spindle By similarity. Note: Exhibits ATM- and TP53BP1-dependent localization to uncapped or aberrant telomeres and to DNA double strand breaks (DSBs). Localizes to microtubules of the midzone of the mitotic spindle during anaphase, and to condensed chromosomes in telophase By similarity. While the majority of the protein appears nuclear and distinct from normal telomere structures, a small fraction may bind to telomeres in embryonic stem cells. Ref.1
Tissue specificity	Expressed in Sertoli cells, prospermatagonia, early primary spermatocytes, and in oocytes at all stages of their growth. Expressed in embryonic stem (ES) and embryonic germ (EG) cells: expression is lost upon differentiation. Ref.1
Developmental stage	Found in the nucleus of germinal-vesicle (GV) stage oocytes prior to fertilization. Accumulates in the male and female pronucleus after fertilization. Expressed in the nuclei of all blastomeres from the two cell stage to the compacted morula stage, although absent from the polar body and inner cell mass (ICM). Found in the nuclei of polar and mural trophectoderm cells from E3.5, and at high levels in the epiblast from E5.5 to E7.5. Expressed by primitive germ cells (PGCs) in both male and female from E9.5 to E13.5, at which point expression declines. A low level is observed in Sertoli cells of the testis at E17.5. Ref.1
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR By similarity.
Sequence caution	The sequence BAB30843.1 differs from that shown. Reason: Erroneous initiation. The sequence BAC38846.1 differs from that shown. Reason: Chimeric cDNA. The sequence BAC40506.1 differs from that shown. Reason: Intron retention.

Ontologies

Keywords
Biological process	Cell cycle DNA damage
Cellular component	Chromosome Cytoplasm Cytoskeleton Nucleus Telomere
Coding sequence diversity	Alternative splicing
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW response to DNA damage stimulus Inferred from electronic annotation. Source: UniProtKB-KW stem cell maintenance Inferred from mutant phenotype PubMed 16518401. Source: MGI
Cellular_component	chromosome, telomeric region Inferred from direct assay Ref.1. Source: MGI cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW female pronucleus Inferred from direct assay Ref.1. Source: MGI male pronucleus Inferred from direct assay Ref.1. Source: MGI spindle Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Nanog	Q80Z64	5	EBI-2312621,EBI-2312517
Nr0b1	Q61066	2	EBI-2312621,EBI-2312665

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6PR54-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6PR54-2) The sequence of this isoform differs from the canonical sequence as follows: 2198-2223: Missing.

Isoform 3 (identifier: Q6PR54-3) The sequence of this isoform differs from the canonical sequence as follows: 167-167: I → ISHWFLHC
Note: May be due to a competing acceptor splice site. No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 2419

2419

Telomere-associated protein RIF1

PRO_0000097334

Regions

Region

1882 – 2419

538

Interaction with condensed chromosomes in telophase By similarity

Amino acid modifications

Modified residue

7

1

Phosphoserine By similarity

Modified residue

401

1

Phosphoserine By similarity

Modified residue

403

1

Phosphotyrosine By similarity

Modified residue

779

1

Phosphoserine By similarity

Modified residue

976

1

Phosphoserine By similarity

Modified residue

1044

1

Phosphothreonine By similarity

Modified residue

1153

1

Phosphoserine By similarity

Modified residue

1231

1

Phosphoserine By similarity

Modified residue

1233

1

Phosphoserine By similarity

Modified residue

1269

1

N6-acetyllysine By similarity

Modified residue

1407

1

Phosphoserine By similarity

Modified residue

1439

1

Phosphoserine By similarity

Modified residue

1498

1

Phosphoserine By similarity

Modified residue

1504

1

Phosphothreonine By similarity

Modified residue

1528

1

Phosphoserine By similarity

Modified residue

1538

1

Phosphoserine By similarity

Modified residue

1540

1

Phosphoserine By similarity

Modified residue

1562

1

Phosphoserine By similarity

Modified residue

1565

1

Phosphoserine By similarity

Modified residue

1780

1

Phosphothreonine By similarity

Modified residue

1784

1

Phosphoserine By similarity

Modified residue

1842

1

Phosphoserine By similarity

Modified residue

1931

1

Phosphoserine By similarity

Modified residue

2094

1

Phosphoserine By similarity

Modified residue

2109

1

Phosphoserine By similarity

Modified residue

2111

1

Phosphoserine By similarity

Modified residue

2121

1

Phosphoserine By similarity

Modified residue

2125

1

Phosphoserine By similarity

Modified residue

2138

1

Phosphoserine By similarity

Modified residue

2144

1

Phosphoserine By similarity

Modified residue

2153

1

Phosphoserine By similarity

Modified residue

2191

1

Phosphoserine By similarity

Modified residue

2208

1

Phosphoserine By similarity

Modified residue

2213

1

Phosphoserine By similarity

Modified residue

2287

1

Phosphoserine By similarity

Modified residue

2341

1

Phosphoserine By similarity

Modified residue

2413

1

Phosphoserine By similarity

Modified residue

2419

1

Phosphoserine By similarity

Natural variations

Alternative sequence

167

1

I → ISHWFLHC in isoform 3.

VSP_014432

Alternative sequence

2198 – 2223

26

Missing in isoform 2.

VSP_014433

Experimental info

Sequence conflict

211

1

M → V in AAR87833. Ref.1

Sequence conflict

548

1

M → V in AAR87833. Ref.1

Sequence conflict

586

1

F → L in AAR87833. Ref.1

Sequence conflict

586

1

F → L in BAC40506. Ref.3

Sequence conflict

592

1

E → G in AAR87833. Ref.1

Sequence conflict

592

1

E → G in BAC40506. Ref.3

Sequence conflict

596

1

E → G in AAR87833. Ref.1

Sequence conflict

596

1

E → G in BAC40506. Ref.3

Sequence conflict

717

1

S → A in AAR87833. Ref.1

Sequence conflict

717

1

S → A in BAC40506. Ref.3

Sequence conflict

743

1

V → A in AAR87833. Ref.1

Sequence conflict

743

1

V → A in BAC40506. Ref.3

Sequence conflict

802

1

K → E in BAC40506. Ref.3

Sequence conflict

959

1

I → S in AAR87833. Ref.1

Sequence conflict

959

1

I → S in BAC40506. Ref.3

Sequence conflict

1066

1

K → R in BAB30843. Ref.3

Sequence conflict

1122

1

M → T in AAR87833. Ref.1

Sequence conflict

1179

1

L → M in AAR87833. Ref.1

Sequence conflict

1238

1

I → M in AAR87833. Ref.1

Sequence conflict

1527

1

A → R in BAB30843. Ref.3

Sequence conflict

1584

1

A → S in AAR87833. Ref.1

Sequence conflict

1671

1

N → T in AAR87833. Ref.1

Sequence conflict

1772

1

V → L in AAR87833. Ref.1

Sequence conflict

1798

1

P → S in AAR87833. Ref.1

Sequence conflict

1897

1

V → I in AAR87833. Ref.1

Sequence conflict

1918

1

E → D in AAR87833. Ref.1

Sequence conflict

1997

1

L → F in AAR87833. Ref.1

Sequence conflict

2018

1

F → L in AAR87833. Ref.1

Sequence conflict

2024

1

M → T in AAR87833. Ref.1

Sequence conflict

2052

1

N → K in AAR87833. Ref.1

Sequence conflict

2114

1

Missing in AAR87833. Ref.1

Sequence conflict

2394

1

E → G in AAR87833. Ref.1

Sequences

Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified July 5, 2005. Version 2. Checksum: 016A1A4CEF25B8F9 Show »	FASTA	2,419	266,228
10 20 30 40 50 60 MTAPGRSPLE PLLETWEDPS VPPGEQTDAY LTLTSRMTGE EGKEVIAEIE KNLSRLYTVL 70 80 90 100 110 120 KAHISSQNSE LSSAALQALG FCLYNPRITS GLSEANIQEL LLTLNGIIKS SDKNVCTRAL 130 140 150 160 170 180 WVISKQTFPA ELVSKMVSSI IDSLEVILSK GEIHSAVVDF EALNVIIRLI EQAPVQMGEE 190 200 210 220 230 240 SVRWAKLVIP LVVHSAQKVH LRGATALEMG MPLLLQKQQE IALITEHLMT TKLISELQKL 250 260 270 280 290 300 FKNKNETYVL KLWPLFVKLL GKTLHRSGSF INSLLQLEEL GFRSGTPMIK KIAFIAWKSL 310 320 330 340 350 360 IDNFALNPDI LCSAKRLKLL MQPLSSIHVR TETLALTKLE VWWYLLMRLG PQLPANFEQV 370 380 390 400 410 420 CVPLIQSTIS VDSIPSPQGN SSRGSASPGL SPLTPGHKGA SPYGSPRGNL SSNTGGMAAI 430 440 450 460 470 480 PSIQLLGLEM MLHFLLGPEV LSFAKQHKIV LSLEPLEHPL ISSPSFFSKY AHTLITAVHD 490 500 510 520 530 540 SFVSVGKDAS DAVVSAIWKE LISLVKSVTE AGNRKEKSGS EVLTLLLKSL ENIVKSEVFP 550 560 570 580 590 600 VSKTLVLMEI TVKGLPPKVL GSPAYQVANM DILNGTPALF LIQLIFNNNL LECGVEDEKF 610 620 630 640 650 660 FLNLETLVGC VLSGPTSPLA FSDSVLTVIN QNAKQLVNKE HLWRMWSMIV SPLTDVIHQT 670 680 690 700 710 720 NEVNQGDALE HNFSAIYGAL TLPINHIFSA QTFPTGTMKA LLKTWSELYR AFTRCASLVA 730 740 750 760 770 780 TAEENLCCEE LSSKIMCSLE DEVLSDLLFL DRISHIIIVM VDCIDFSPYN KKYQPKIKSP 790 800 810 820 830 840 QRSSDWSRKK KEPLGKLASL FKLIVKVIDT FHTLSLKETF SDTLLAIGNS IISMLSNVFG 850 860 870 880 890 900 HISLPSMIRE IFATFTRPLA LLYENSKLDE APKVYTSLNN KLEKLLGEIV ACLQFSYLGA 910 920 930 940 950 960 YDSELLEHLS PLLCVIFLHK NKQIRKQSAL LWNATFAKAT ALVYPEELKP ILRQAKQKIL 970 980 990 1000 1010 1020 LLLPGLENVE MMDESSEPYS ESTENSQLNV KISGMERKSS GKRDSILAHT KDKKKKVKLS 1030 1040 1050 1060 1070 1080 AKLKLESSSP KIKSGKLLEE EKSTDFVFIP PEGKETKARV LTEHQKEVLK TKRCDIPALY 1090 1100 1110 1120 1130 1140 NNLDASQDTL FSAQFSQEES MESLTLTEKP KEDAKIIKEE QMESTIFIHQ DAPENCGIDE 1150 1160 1170 1180 1190 1200 HSENASLPNC GGSVAETNPE TLITGFDARK EVLISSKILS AESSSSTETS VVSSSSVSNA 1210 1220 1230 1240 1250 1260 TFSGTPPQPT SRRQTFITLE KFDGSETRPF SPSPLNNISS TVTVRNNQDN TTNTDMPPKA 1270 1280 1290 1300 1310 1320 RKREVTNSKS DSENLANAGK KSSRRWSKAE QSVTKKSKPS LTSEQEEHSS ENNSPDLLSP 1330 1340 1350 1360 1370 1380 TEHVSENDDH PSEATLEHKD GDPKPAVENA SLEDLTTEEK NVGINMESKE STASVVARTE 1390 1400 1410 1420 1430 1440 QIVNEDSQAA ALAPNPKTLR RSSRRRSEAV DSCSDSQERE SGQQKKERRK EEEKIISKSP 1450 1460 1470 1480 1490 1500 LRIKDDKLPT QKLTDESPIQ ENLTEKGNTL PERTSGEPSV NAEIDQNRRK PDLENVSSEG 1510 1520 1530 1540 1550 1560 GGGTLDNLDK SSEKPLRGRT RYQTRRASQG LISAVENSES DSSEAKEEVS RKKRSGKWKN 1570 1580 1590 1600 1610 1620 RSSDSVDIEE QEEKKAEEEV MKTANQTLDG QAVPDVDVNA AAQVCEKSTN NNRVILQDSA 1630 1640 1650 1660 1670 1680 GPADSLQAPP KGEEKSKINK CVDSSFVSLP VPESNLRTRN ASKRLLYKQD NDSNVRVSDS 1690 1700 1710 1720 1730 1740 SLSPEKFTQV ECQHKRSRRV RRSKSCDCCG EKSQSQEKSF IGLKNTESYA IKSVEKKKTD 1750 1760 1770 1780 1790 1800 LQVPETAPET REARDHAETK LAGEEPLVNF HVGLKEENCT TGDSVKSEAE LQEASLPPEI 1810 1820 1830 1840 1850 1860 VTVKEKTYDT DASEAVSEIQ GPCSENHSPA EDPGLSECKD ISQKQLSENG ELDISDVGKA 1870 1880 1890 1900 1910 1920 CKVIAGSSPE GVETMELNVR NDAFVAADSE KSTQMDVSVD VATEEDNKKD ECEAVTTEVN 1930 1940 1950 1960 1970 1980 VEGVATEDFN SGMDLSDTPI PVSKDVETEH AASGEIEGES NESDSGSCEE MNKEMGSHKA 1990 2000 2010 2020 2030 2040 QMSTEIDSAR VKETDILASA SKSEEALIGR LDVNTQSFVS DIEMSSGERT VNCKTETSIE 2050 2060 2070 2080 2090 2100 LNKLDEAKLS GNEATVGNDT LQEVCFTSEK VEKLPQCLLV QVASELGAES NTTSPEKLEL 2110 2120 2130 2140 2150 2160 DSFGSVNESP SGMQQARCVW SPLASPSTSI LKRGLKRSQE DEISPVNKIR RVSFADPIYQ 2170 2180 2190 2200 2210 2220 AGLADDIDRR CSVVRSHSSN SSPIIKSVKT SPTSHSKHNT TSAKGFLSPG SQSSKFKSPK 2230 2240 2250 2260 2270 2280 KCLITEMAQE SMLSPTESVY PALVNCAASV DIILPQITSN MWARGLGQLI RAKNIKTIGD 2290 2300 2310 2320 2330 2340 LSTLTASEIK TLPIRSPKVF NVKKALRVYH EQQMKSRGLE EIPIFDISEK AVNGVESRTV 2350 2360 2370 2380 2390 2400 STDEERFASD LIEPVTLDTP LSKNLVAQIS ALALQLDSED LYSYTGSQLF EMHEKLGTMA 2410 NSIIRNLQSR WRSPAHENS « Hide
Isoform 2 [UniParc]. Checksum: 97A1207A4F3AD637 Show »	FASTA	2,393	263,480
10 20 30 40 50 60 MTAPGRSPLE PLLETWEDPS VPPGEQTDAY LTLTSRMTGE EGKEVIAEIE KNLSRLYTVL 70 80 90 100 110 120 KAHISSQNSE LSSAALQALG FCLYNPRITS GLSEANIQEL LLTLNGIIKS SDKNVCTRAL 130 140 150 160 170 180 WVISKQTFPA ELVSKMVSSI IDSLEVILSK GEIHSAVVDF EALNVIIRLI EQAPVQMGEE 190 200 210 220 230 240 SVRWAKLVIP LVVHSAQKVH LRGATALEMG MPLLLQKQQE IALITEHLMT TKLISELQKL 250 260 270 280 290 300 FKNKNETYVL KLWPLFVKLL GKTLHRSGSF INSLLQLEEL GFRSGTPMIK KIAFIAWKSL 310 320 330 340 350 360 IDNFALNPDI LCSAKRLKLL MQPLSSIHVR TETLALTKLE VWWYLLMRLG PQLPANFEQV 370 380 390 400 410 420 CVPLIQSTIS VDSIPSPQGN SSRGSASPGL SPLTPGHKGA SPYGSPRGNL SSNTGGMAAI 430 440 450 460 470 480 PSIQLLGLEM MLHFLLGPEV LSFAKQHKIV LSLEPLEHPL ISSPSFFSKY AHTLITAVHD 490 500 510 520 530 540 SFVSVGKDAS DAVVSAIWKE LISLVKSVTE AGNRKEKSGS EVLTLLLKSL ENIVKSEVFP 550 560 570 580 590 600 VSKTLVLMEI TVKGLPPKVL GSPAYQVANM DILNGTPALF LIQLIFNNNL LECGVEDEKF 610 620 630 640 650 660 FLNLETLVGC VLSGPTSPLA FSDSVLTVIN QNAKQLVNKE HLWRMWSMIV SPLTDVIHQT 670 680 690 700 710 720 NEVNQGDALE HNFSAIYGAL TLPINHIFSA QTFPTGTMKA LLKTWSELYR AFTRCASLVA 730 740 750 760 770 780 TAEENLCCEE LSSKIMCSLE DEVLSDLLFL DRISHIIIVM VDCIDFSPYN KKYQPKIKSP 790 800 810 820 830 840 QRSSDWSRKK KEPLGKLASL FKLIVKVIDT FHTLSLKETF SDTLLAIGNS IISMLSNVFG 850 860 870 880 890 900 HISLPSMIRE IFATFTRPLA LLYENSKLDE APKVYTSLNN KLEKLLGEIV ACLQFSYLGA 910 920 930 940 950 960 YDSELLEHLS PLLCVIFLHK NKQIRKQSAL LWNATFAKAT ALVYPEELKP ILRQAKQKIL 970 980 990 1000 1010 1020 LLLPGLENVE MMDESSEPYS ESTENSQLNV KISGMERKSS GKRDSILAHT KDKKKKVKLS 1030 1040 1050 1060 1070 1080 AKLKLESSSP KIKSGKLLEE EKSTDFVFIP PEGKETKARV LTEHQKEVLK TKRCDIPALY 1090 1100 1110 1120 1130 1140 NNLDASQDTL FSAQFSQEES MESLTLTEKP KEDAKIIKEE QMESTIFIHQ DAPENCGIDE 1150 1160 1170 1180 1190 1200 HSENASLPNC GGSVAETNPE TLITGFDARK EVLISSKILS AESSSSTETS VVSSSSVSNA 1210 1220 1230 1240 1250 1260 TFSGTPPQPT SRRQTFITLE KFDGSETRPF SPSPLNNISS TVTVRNNQDN TTNTDMPPKA 1270 1280 1290 1300 1310 1320 RKREVTNSKS DSENLANAGK KSSRRWSKAE QSVTKKSKPS LTSEQEEHSS ENNSPDLLSP 1330 1340 1350 1360 1370 1380 TEHVSENDDH PSEATLEHKD GDPKPAVENA SLEDLTTEEK NVGINMESKE STASVVARTE 1390 1400 1410 1420 1430 1440 QIVNEDSQAA ALAPNPKTLR RSSRRRSEAV DSCSDSQERE SGQQKKERRK EEEKIISKSP 1450 1460 1470 1480 1490 1500 LRIKDDKLPT QKLTDESPIQ ENLTEKGNTL PERTSGEPSV NAEIDQNRRK PDLENVSSEG 1510 1520 1530 1540 1550 1560 GGGTLDNLDK SSEKPLRGRT RYQTRRASQG LISAVENSES DSSEAKEEVS RKKRSGKWKN 1570 1580 1590 1600 1610 1620 RSSDSVDIEE QEEKKAEEEV MKTANQTLDG QAVPDVDVNA AAQVCEKSTN NNRVILQDSA 1630 1640 1650 1660 1670 1680 GPADSLQAPP KGEEKSKINK CVDSSFVSLP VPESNLRTRN ASKRLLYKQD NDSNVRVSDS 1690 1700 1710 1720 1730 1740 SLSPEKFTQV ECQHKRSRRV RRSKSCDCCG EKSQSQEKSF IGLKNTESYA IKSVEKKKTD 1750 1760 1770 1780 1790 1800 LQVPETAPET REARDHAETK LAGEEPLVNF HVGLKEENCT TGDSVKSEAE LQEASLPPEI 1810 1820 1830 1840 1850 1860 VTVKEKTYDT DASEAVSEIQ GPCSENHSPA EDPGLSECKD ISQKQLSENG ELDISDVGKA 1870 1880 1890 1900 1910 1920 CKVIAGSSPE GVETMELNVR NDAFVAADSE KSTQMDVSVD VATEEDNKKD ECEAVTTEVN 1930 1940 1950 1960 1970 1980 VEGVATEDFN SGMDLSDTPI PVSKDVETEH AASGEIEGES NESDSGSCEE MNKEMGSHKA 1990 2000 2010 2020 2030 2040 QMSTEIDSAR VKETDILASA SKSEEALIGR LDVNTQSFVS DIEMSSGERT VNCKTETSIE 2050 2060 2070 2080 2090 2100 LNKLDEAKLS GNEATVGNDT LQEVCFTSEK VEKLPQCLLV QVASELGAES NTTSPEKLEL 2110 2120 2130 2140 2150 2160 DSFGSVNESP SGMQQARCVW SPLASPSTSI LKRGLKRSQE DEISPVNKIR RVSFADPIYQ 2170 2180 2190 2200 2210 2220 AGLADDIDRR CSVVRSHSSN SSPIIKSVKT SPTSHSKITE MAQESMLSPT ESVYPALVNC 2230 2240 2250 2260 2270 2280 AASVDIILPQ ITSNMWARGL GQLIRAKNIK TIGDLSTLTA SEIKTLPIRS PKVFNVKKAL 2290 2300 2310 2320 2330 2340 RVYHEQQMKS RGLEEIPIFD ISEKAVNGVE SRTVSTDEER FASDLIEPVT LDTPLSKNLV 2350 2360 2370 2380 2390 AQISALALQL DSEDLYSYTG SQLFEMHEKL GTMANSIIRN LQSRWRSPAH ENS « Hide
Isoform 3 [UniParc]. Checksum: 72C0C38EBD54A556 Show »	FASTA	2,426	267,139
10 20 30 40 50 60 MTAPGRSPLE PLLETWEDPS VPPGEQTDAY LTLTSRMTGE EGKEVIAEIE KNLSRLYTVL 70 80 90 100 110 120 KAHISSQNSE LSSAALQALG FCLYNPRITS GLSEANIQEL LLTLNGIIKS SDKNVCTRAL 130 140 150 160 170 180 WVISKQTFPA ELVSKMVSSI IDSLEVILSK GEIHSAVVDF EALNVIISHW FLHCRLIEQA 190 200 210 220 230 240 PVQMGEESVR WAKLVIPLVV HSAQKVHLRG ATALEMGMPL LLQKQQEIAL ITEHLMTTKL 250 260 270 280 290 300 ISELQKLFKN KNETYVLKLW PLFVKLLGKT LHRSGSFINS LLQLEELGFR SGTPMIKKIA 310 320 330 340 350 360 FIAWKSLIDN FALNPDILCS AKRLKLLMQP LSSIHVRTET LALTKLEVWW YLLMRLGPQL 370 380 390 400 410 420 PANFEQVCVP LIQSTISVDS IPSPQGNSSR GSASPGLSPL TPGHKGASPY GSPRGNLSSN 430 440 450 460 470 480 TGGMAAIPSI QLLGLEMMLH FLLGPEVLSF AKQHKIVLSL EPLEHPLISS PSFFSKYAHT 490 500 510 520 530 540 LITAVHDSFV SVGKDASDAV VSAIWKELIS LVKSVTEAGN RKEKSGSEVL TLLLKSLENI 550 560 570 580 590 600 VKSEVFPVSK TLVLMEITVK GLPPKVLGSP AYQVANMDIL NGTPALFLIQ LIFNNNLLEC 610 620 630 640 650 660 GVEDEKFFLN LETLVGCVLS GPTSPLAFSD SVLTVINQNA KQLVNKEHLW RMWSMIVSPL 670 680 690 700 710 720 TDVIHQTNEV NQGDALEHNF SAIYGALTLP INHIFSAQTF PTGTMKALLK TWSELYRAFT 730 740 750 760 770 780 RCASLVATAE ENLCCEELSS KIMCSLEDEV LSDLLFLDRI SHIIIVMVDC IDFSPYNKKY 790 800 810 820 830 840 QPKIKSPQRS SDWSRKKKEP LGKLASLFKL IVKVIDTFHT LSLKETFSDT LLAIGNSIIS 850 860 870 880 890 900 MLSNVFGHIS LPSMIREIFA TFTRPLALLY ENSKLDEAPK VYTSLNNKLE KLLGEIVACL 910 920 930 940 950 960 QFSYLGAYDS ELLEHLSPLL CVIFLHKNKQ IRKQSALLWN ATFAKATALV YPEELKPILR 970 980 990 1000 1010 1020 QAKQKILLLL PGLENVEMMD ESSEPYSEST ENSQLNVKIS GMERKSSGKR DSILAHTKDK 1030 1040 1050 1060 1070 1080 KKKVKLSAKL KLESSSPKIK SGKLLEEEKS TDFVFIPPEG KETKARVLTE HQKEVLKTKR 1090 1100 1110 1120 1130 1140 CDIPALYNNL DASQDTLFSA QFSQEESMES LTLTEKPKED AKIIKEEQME STIFIHQDAP 1150 1160 1170 1180 1190 1200 ENCGIDEHSE NASLPNCGGS VAETNPETLI TGFDARKEVL ISSKILSAES SSSTETSVVS 1210 1220 1230 1240 1250 1260 SSSVSNATFS GTPPQPTSRR QTFITLEKFD GSETRPFSPS PLNNISSTVT VRNNQDNTTN 1270 1280 1290 1300 1310 1320 TDMPPKARKR EVTNSKSDSE NLANAGKKSS RRWSKAEQSV TKKSKPSLTS EQEEHSSENN 1330 1340 1350 1360 1370 1380 SPDLLSPTEH VSENDDHPSE ATLEHKDGDP KPAVENASLE DLTTEEKNVG INMESKESTA 1390 1400 1410 1420 1430 1440 SVVARTEQIV NEDSQAAALA PNPKTLRRSS RRRSEAVDSC SDSQERESGQ QKKERRKEEE 1450 1460 1470 1480 1490 1500 KIISKSPLRI KDDKLPTQKL TDESPIQENL TEKGNTLPER TSGEPSVNAE IDQNRRKPDL 1510 1520 1530 1540 1550 1560 ENVSSEGGGG TLDNLDKSSE KPLRGRTRYQ TRRASQGLIS AVENSESDSS EAKEEVSRKK 1570 1580 1590 1600 1610 1620 RSGKWKNRSS DSVDIEEQEE KKAEEEVMKT ANQTLDGQAV PDVDVNAAAQ VCEKSTNNNR 1630 1640 1650 1660 1670 1680 VILQDSAGPA DSLQAPPKGE EKSKINKCVD SSFVSLPVPE SNLRTRNASK RLLYKQDNDS 1690 1700 1710 1720 1730 1740 NVRVSDSSLS PEKFTQVECQ HKRSRRVRRS KSCDCCGEKS QSQEKSFIGL KNTESYAIKS 1750 1760 1770 1780 1790 1800 VEKKKTDLQV PETAPETREA RDHAETKLAG EEPLVNFHVG LKEENCTTGD SVKSEAELQE 1810 1820 1830 1840 1850 1860 ASLPPEIVTV KEKTYDTDAS EAVSEIQGPC SENHSPAEDP GLSECKDISQ KQLSENGELD 1870 1880 1890 1900 1910 1920 ISDVGKACKV IAGSSPEGVE TMELNVRNDA FVAADSEKST QMDVSVDVAT EEDNKKDECE 1930 1940 1950 1960 1970 1980 AVTTEVNVEG VATEDFNSGM DLSDTPIPVS KDVETEHAAS GEIEGESNES DSGSCEEMNK 1990 2000 2010 2020 2030 2040 EMGSHKAQMS TEIDSARVKE TDILASASKS EEALIGRLDV NTQSFVSDIE MSSGERTVNC 2050 2060 2070 2080 2090 2100 KTETSIELNK LDEAKLSGNE ATVGNDTLQE VCFTSEKVEK LPQCLLVQVA SELGAESNTT 2110 2120 2130 2140 2150 2160 SPEKLELDSF GSVNESPSGM QQARCVWSPL ASPSTSILKR GLKRSQEDEI SPVNKIRRVS 2170 2180 2190 2200 2210 2220 FADPIYQAGL ADDIDRRCSV VRSHSSNSSP IIKSVKTSPT SHSKHNTTSA KGFLSPGSQS 2230 2240 2250 2260 2270 2280 SKFKSPKKCL ITEMAQESML SPTESVYPAL VNCAASVDII LPQITSNMWA RGLGQLIRAK 2290 2300 2310 2320 2330 2340 NIKTIGDLST LTASEIKTLP IRSPKVFNVK KALRVYHEQQ MKSRGLEEIP IFDISEKAVN 2350 2360 2370 2380 2390 2400 GVESRTVSTD EERFASDLIE PVTLDTPLSK NLVAQISALA LQLDSEDLYS YTGSQLFEMH 2410 2420 EKLGTMANSI IRNLQSRWRS PAHENS « Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterisation of mRif1: a mouse telomere-associated protein highly expressed in germ cells and embryo-derived pluripotent stem cells." Adams I.R., McLaren A. Dev. Dyn. 229:733-744(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH TRF2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Strain: 129/Sv.
[2]	"ATM-mediated S-phase checkpoint function for hRif1." Silvermann J., Takai H., Buonomo S.B.C., Eisenhaber F., de Lange T. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 416-1011; 1061-1556 AND 1859-2419. Strain: C57BL/6J. Tissue: Liver and Thymus.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1860-2419. Strain: C57BL/6. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY428571 mRNA. Translation: AAR87833.2. AY585206 mRNA. Translation: AAS94124.1. AK017618 mRNA. Translation: BAB30843.1. Different initiation. AK083291 mRNA. Translation: BAC38846.1. Sequence problems. AK088688 mRNA. Translation: BAC40506.1. Sequence problems. BC055320 mRNA. Translation: AAH55320.1.
IPI	IPI00408125. IPI00421167. IPI00626173.
RefSeq	NP_780447.4. NM_175238.5.
UniGene	Mm.254530.
3D structure databases
ProteinModelPortal	Q6PR54.
SMR	Q6PR54. Positions 271-301.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-54907N.
IntAct	Q6PR54. 4 interactions.
PTM databases
PhosphoSite	Q6PR54.
Proteomic databases
PaxDb	Q6PR54.
PRIDE	Q6PR54.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000069794; ENSMUSP00000064155; ENSMUSG00000036202. ENSMUST00000112693; ENSMUSP00000108313; ENSMUSG00000036202.
GeneID	51869.
KEGG	mmu:51869.
UCSC	uc008jqr.1. mouse. uc008jqt.1. mouse.
Organism-specific databases
CTD	55183.
MGI	MGI:1098622. Rif1.
Phylogenomic databases
eggNOG	NOG87885.
GeneTree	ENSGT00390000012204.
HOGENOM	HOG000231777.
HOVERGEN	HBG080431.
InParanoid	Q6PR54.
KO	K11138.
OMA	PTESVYP.
OrthoDB	EOG4XWFWW.
Gene expression databases
ArrayExpress	Q6PR54.
Bgee	Q6PR54.
CleanEx	MM_RIF1.
Genevestigator	Q6PR54.
GermOnline	ENSMUSG00000036202. Mus musculus.
Family and domain databases
InterPro	IPR022031. Rif1_N. [Graphical view]
Pfam	PF12231. Rif1_N. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RIF1. mouse.
NextBio	308166.
SOURCE	Search...

Entry information

Entry name

RIF1_MOUSE

Accession

Primary (citable) accession number: Q6PR54
Secondary accession number(s): Q6T8D9

Q9CS77

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	July 5, 2005
Last modified:	May 1, 2013
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents