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Protein

Alpha-conotoxin-like Qc1.1b

Gene
N/A
Organism
Conus quercinus (Oak cone)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin-like Qc1.1b
Alternative name(s):
Qc1.3
OrganismiConus quercinus (Oak cone)
Taxonomic identifieri101313 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri551. Qc1.1b precursor.
554. Qc1.1b precursor.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000037744922 – 46By similarityAdd BLAST25
PeptideiPRO_000037745047 – 67Alpha-conotoxin-like Qc1.1bAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 55By similarity
Disulfide bondi50 ↔ 63By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

ProteinModelPortaliQ6PPB3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is I (CC-C-C). Alpha4/7 pattern.

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR009958. Conotoxin_a-typ.
PfamiView protein in Pfam
PF07365. Toxin_8. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6PPB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMRMMFTMF LLVVLAITVV SFTSDHASDG RNTAANDKAS KLMALRNECC
60
DNPPCKSSNP DLCDWRS
Length:67
Mass (Da):7,417
Last modified:July 5, 2004 - v1
Checksum:iD3D776AA38BBBCCD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY588972 mRNA. Translation: AAS99932.1.
DQ311061 mRNA. Translation: ABD33853.1.
DQ311064 Genomic DNA. Translation: ABD33856.1.

Similar proteinsi

Entry informationi

Entry nameiCA11B_CONQU
AccessioniPrimary (citable) accession number: Q6PPB3
Secondary accession number(s): A1X8C4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families