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Protein

Alpha-conotoxin-like

Gene
N/A
Organism
Conus quercinus (Oak cone)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxinUniRule annotation, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin-likeUniRule annotation
OrganismiConus quercinus (Oak cone)Imported
Taxonomic identifieri101313 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConusLividoconus

Organism-specific databases

ConoServeri125. Qc1.4 precursor.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500427807322 – 66Alpha-conotoxin-likeSequence analysisAdd BLAST45

Structurei

3D structure databases

ProteinModelPortaliQ6PPB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the conotoxin A superfamily.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Family and domain databases

InterProiView protein in InterPro
IPR009958. Conotoxin_a-typ.
IPR018072. Conotoxin_a-typ_CS.
PfamiView protein in Pfam
PF07365. Toxin_8. 1 hit.
PROSITEiView protein in PROSITE
PS60014. ALPHA_CONOTOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6PPB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMRMMFTVF LLVVLATTVT SDRVSNGRKA AAKLKAPALM ELSVRQGCCS
60
DPACAVSNPD ICGGGR
Length:66
Mass (Da):6,905
Last modified:July 5, 2004 - v1
Checksum:iC49786F54DFF8652
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY588973 mRNA. Translation: AAS99933.1.

Similar proteinsi

Entry informationi

Entry nameiQ6PPB2_CONQU
AccessioniPrimary (citable) accession number: Q6PPB2
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)