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Protein

XK-related protein 2

Gene

XKRX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-33264-MONOMER.

Protein family/group databases

TCDBi2.A.112.1.6. 2.a.112. the kx blood-group antigen (kxa) family.

Names & Taxonomyi

Protein namesi
Recommended name:
XK-related protein 2
Alternative name(s):
Membrane protein XPLAC
X Kell blood group-related, X-linked
Gene namesi
Name:XKRX
Synonyms:XKR2, XPLAC, XRG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:29845. XKRX.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Transmembranei357 – 377HelicalSequence analysisAdd BLAST21
Transmembranei382 – 402HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000182489.
PharmGKBiPA134962569.

Polymorphism and mutation databases

BioMutaiXKRX.
DMDMi77417617.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001907721 – 449XK-related protein 2Add BLAST449

Proteomic databases

PaxDbiQ6PP77.
PRIDEiQ6PP77.

PTM databases

iPTMnetiQ6PP77.
PhosphoSitePlusiQ6PP77.

Expressioni

Tissue specificityi

Expressed predominantly in the placenta, in syncytiotrophoblasts. Moderate levels in the adrenal gland, low levels in the trachea and very low levels in the bone marrow.1 Publication

Gene expression databases

BgeeiENSG00000182489.
CleanExiHS_XKRX.
ExpressionAtlasiQ6PP77. baseline and differential.
GenevisibleiQ6PP77. HS.

Interactioni

Protein-protein interaction databases

BioGridi135464. 8 interactors.
IntActiQ6PP77. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ6PP77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the XK family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ21. Eukaryota.
ENOG4110US3. LUCA.
GeneTreeiENSGT00390000003231.
HOGENOMiHOG000118070.
HOVERGENiHBG055838.
InParanoidiQ6PP77.
OMAiGQEEPYV.
OrthoDBiEOG091G07Y7.
PhylomeDBiQ6PP77.
TreeFamiTF331465.

Family and domain databases

InterProiIPR018629. XK_rel.
[Graphical view]
PfamiPF09815. XK-related. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PP77-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDRVYEIPEE PNVDPVSSLE EDVIRGANPR FTFPFSILFS TFLYCGEAAS
60 70 80 90 100
ALYMVRIYRK NSETYWMTYT FSFFMFSSIM VQLTLIFVHR DLAKDKPLSL
110 120 130 140 150
FMHLILLGPV IRCLEAMIKY LTLWKKEEQE EPYVSLTRKK MLIDGEEVLI
160 170 180 190 200
EWEVGHSIRT LAMHRNAYKR MSQIQAFLGS VPQLTYQLYV SLISAEVPLG
210 220 230 240 250
RVVLMVFSLV SVTYGATLCN MLAIQIKYDD YKIRLGPLEV LCITIWRTLE
260 270 280 290 300
ITSRLLILVL FSATLKLKAV PFLVLNFLII LFEPWIKFWR SGAQMPNNIE
310 320 330 340 350
KNFSRVGTLV VLISVTILYA GINFSCWSAL QLRLADRDLV DKGQNWGHMG
360 370 380 390 400
LHYSVRLVEN VIMVLVFKFF GVKVLLNYCH SLIALQLIIA YLISIGFMLL
410 420 430 440
FFQYLHPLRS LFTHNVVDYL HCVCCHQHPR TRVENSEPPF ETEARQSVV
Length:449
Mass (Da):52,052
Last modified:October 11, 2005 - v2
Checksum:i29DB15BC41796730
GO
Isoform 2 (identifier: Q6PP77-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-204: Missing.

Show »
Length:245
Mass (Da):28,242
Checksum:iB75209D4DE8BE985
GO

Sequence cautioni

The sequence AAI37011 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI37012 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAT00456 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAT07088 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti340V → A in BAG59304 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0375201 – 204Missing in isoform 2. 1 PublicationAdd BLAST204

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY589511 mRNA. Translation: AAT00456.1. Different initiation.
AY534239 mRNA. Translation: AAT07088.1. Different initiation.
AK296711 mRNA. Translation: BAG59304.1.
Z73417 Genomic DNA. Translation: CAI41970.1.
BC137010 mRNA. Translation: AAI37011.1. Different initiation.
BC137011 mRNA. Translation: AAI37012.1. Different initiation.
CCDSiCCDS14476.2. [Q6PP77-1]
RefSeqiNP_997724.2. NM_212559.2. [Q6PP77-1]
XP_005262187.1. XM_005262130.2. [Q6PP77-2]
XP_016885006.1. XM_017029517.1. [Q6PP77-2]
UniGeneiHs.364911.
Hs.745071.

Genome annotation databases

EnsembliENST00000372956; ENSP00000362047; ENSG00000182489. [Q6PP77-1]
GeneIDi402415.
KEGGihsa:402415.
UCSCiuc004egn.3. human. [Q6PP77-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY589511 mRNA. Translation: AAT00456.1. Different initiation.
AY534239 mRNA. Translation: AAT07088.1. Different initiation.
AK296711 mRNA. Translation: BAG59304.1.
Z73417 Genomic DNA. Translation: CAI41970.1.
BC137010 mRNA. Translation: AAI37011.1. Different initiation.
BC137011 mRNA. Translation: AAI37012.1. Different initiation.
CCDSiCCDS14476.2. [Q6PP77-1]
RefSeqiNP_997724.2. NM_212559.2. [Q6PP77-1]
XP_005262187.1. XM_005262130.2. [Q6PP77-2]
XP_016885006.1. XM_017029517.1. [Q6PP77-2]
UniGeneiHs.364911.
Hs.745071.

3D structure databases

ProteinModelPortaliQ6PP77.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi135464. 8 interactors.
IntActiQ6PP77. 1 interactor.

Protein family/group databases

TCDBi2.A.112.1.6. 2.a.112. the kx blood-group antigen (kxa) family.

PTM databases

iPTMnetiQ6PP77.
PhosphoSitePlusiQ6PP77.

Polymorphism and mutation databases

BioMutaiXKRX.
DMDMi77417617.

Proteomic databases

PaxDbiQ6PP77.
PRIDEiQ6PP77.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372956; ENSP00000362047; ENSG00000182489. [Q6PP77-1]
GeneIDi402415.
KEGGihsa:402415.
UCSCiuc004egn.3. human. [Q6PP77-1]

Organism-specific databases

CTDi402415.
GeneCardsiXKRX.
HGNCiHGNC:29845. XKRX.
MIMi300684. gene.
neXtProtiNX_Q6PP77.
OpenTargetsiENSG00000182489.
PharmGKBiPA134962569.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ21. Eukaryota.
ENOG4110US3. LUCA.
GeneTreeiENSGT00390000003231.
HOGENOMiHOG000118070.
HOVERGENiHBG055838.
InParanoidiQ6PP77.
OMAiGQEEPYV.
OrthoDBiEOG091G07Y7.
PhylomeDBiQ6PP77.
TreeFamiTF331465.

Enzyme and pathway databases

BioCyciZFISH:G66-33264-MONOMER.

Miscellaneous databases

GenomeRNAii402415.
PROiQ6PP77.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182489.
CleanExiHS_XKRX.
ExpressionAtlasiQ6PP77. baseline and differential.
GenevisibleiQ6PP77. HS.

Family and domain databases

InterProiIPR018629. XK_rel.
[Graphical view]
PfamiPF09815. XK-related. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXKR2_HUMAN
AccessioniPrimary (citable) accession number: Q6PP77
Secondary accession number(s): B2RNN6, B4DKU2, Q5H9J6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.