Q6PP77 (XKR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
XK-related protein 2

Alternative name(s):
Membrane protein XPLAC
X Kell blood group-related, X-linked

Gene names

Name:	XKRX
Synonyms:	XKR2, XPLAC, XRG2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	449 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cell membrane; Multi-pass membrane protein Ref.1.
Tissue specificity	Expressed predominantly in the placenta, in syncytiotrophoblasts. Moderate levels in the adrenal gland, low levels in the trachea and very low levels in the bone marrow. Ref.1
Sequence similarities	Belongs to the XK family.
Sequence caution	The sequence AAI37011.1 differs from that shown. Reason: Erroneous initiation. The sequence AAI37012.1 differs from that shown. Reason: Erroneous initiation. The sequence AAT00456.1 differs from that shown. Reason: Erroneous initiation. The sequence AAT07088.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6PP77-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6PP77-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-204: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 449	449	XK-related protein 2		PRO_0000190772
Regions
	Transmembrane	35 – 55	21	Helical; Potential
	Transmembrane	68 – 88	21	Helical; Potential
	Transmembrane	98 – 118	21	Helical; Potential
	Transmembrane	174 – 194	21	Helical; Potential
	Transmembrane	202 – 222	21	Helical; Potential
	Transmembrane	241 – 261	21	Helical; Potential
	Transmembrane	269 – 289	21	Helical; Potential
	Transmembrane	306 – 326	21	Helical; Potential
	Transmembrane	357 – 377	21	Helical; Potential
	Transmembrane	382 – 402	21	Helical; Potential
Natural variations
	Alternative sequence	1 – 204	204	Missing in isoform 2.		VSP_037520
Experimental info
	Sequence conflict	340	1	V → A in BAG59304. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 11, 2005. Version 2. Checksum: 29DB15BC41796730	FASTA	449	52,052
	10 20 30 40 50 60 MDRVYEIPEE PNVDPVSSLE EDVIRGANPR FTFPFSILFS TFLYCGEAAS ALYMVRIYRK 70 80 90 100 110 120 NSETYWMTYT FSFFMFSSIM VQLTLIFVHR DLAKDKPLSL FMHLILLGPV IRCLEAMIKY 130 140 150 160 170 180 LTLWKKEEQE EPYVSLTRKK MLIDGEEVLI EWEVGHSIRT LAMHRNAYKR MSQIQAFLGS 190 200 210 220 230 240 VPQLTYQLYV SLISAEVPLG RVVLMVFSLV SVTYGATLCN MLAIQIKYDD YKIRLGPLEV 250 260 270 280 290 300 LCITIWRTLE ITSRLLILVL FSATLKLKAV PFLVLNFLII LFEPWIKFWR SGAQMPNNIE 310 320 330 340 350 360 KNFSRVGTLV VLISVTILYA GINFSCWSAL QLRLADRDLV DKGQNWGHMG LHYSVRLVEN 370 380 390 400 410 420 VIMVLVFKFF GVKVLLNYCH SLIALQLIIA YLISIGFMLL FFQYLHPLRS LFTHNVVDYL 430 440 HCVCCHQHPR TRVENSEPPF ETEARQSVV
	Isoform 2 [UniParc]. Checksum: B75209D4DE8BE985	FASTA	245	28,242
	10 20 30 40 50 60 MVFSLVSVTY GATLCNMLAI QIKYDDYKIR LGPLEVLCIT IWRTLEITSR LLILVLFSAT 70 80 90 100 110 120 LKLKAVPFLV LNFLIILFEP WIKFWRSGAQ MPNNIEKNFS RVGTLVVLIS VTILYAGINF 130 140 150 160 170 180 SCWSALQLRL ADRDLVDKGQ NWGHMGLHYS VRLVENVIMV LVFKFFGVKV LLNYCHSLIA 190 200 210 220 230 240 LQLIIAYLIS IGFMLLFFQY LHPLRSLFTH NVVDYLHCVC CHQHPRTRVE NSEPPFETEA RQSVV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of two new members, XPLAC and XTES, of the XK family." Calenda G., Peng J., Redman C.M., Sha Q., Wu X., Lee S. Gene 370:6-16(2006) [PubMed: 16431037] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Placenta.
[2]	"A superfamily of XK-related genes (XRG) widely expressed in vertebrates and invertebrates." Huang C.-H., Chen Y. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Tongue.
[4]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY589511 mRNA. Translation: AAT00456.1. Different initiation. AY534239 mRNA. Translation: AAT07088.1. Different initiation. AK296711 mRNA. Translation: BAG59304.1. Z73417 Genomic DNA. Translation: CAI41970.1. BC137010 mRNA. Translation: AAI37011.1. Different initiation. BC137011 mRNA. Translation: AAI37012.1. Different initiation.
IPI	IPI00401270. IPI00930497.
RefSeq	NP_997724.2. NM_212559.2.
UniGene	Hs.364911. Hs.726481.
3D structure databases
ProteinModelPortal	Q6PP77.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6PP77. 1 interaction.
STRING	Q6PP77.
Polymorphism databases
DMDM	77417617.
Proteomic databases
PRIDE	Q6PP77.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000328526; ENSP00000327570; ENSG00000182489. ENST00000372956; ENSP00000362047; ENSG00000182489.
GeneID	402415.
KEGG	hsa:402415.
NMPDR	fig|9606.3.peg.33093.
UCSC	uc004egn.1. human.
Organism-specific databases
CTD	402415.
GeneCards	GC0XM100168.
H-InvDB	HIX0056207.
HGNC	HGNC:29845. XKRX.
HPA	HPA031886.
MIM	300684. gene.
neXtProt	NX_Q6PP77.
PharmGKB	PA134962569.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG15054.
GeneTree	ENSGT00390000003231.
HOGENOM	HBG283821.
HOVERGEN	HBG055838.
InParanoid	Q6PP77.
OrthoDB	EOG4RBQJK.
Gene expression databases
ArrayExpress	Q6PP77.
Bgee	Q6PP77.
CleanEx	HS_XKRX.
Genevestigator	Q6PP77.
GermOnline	ENSG00000182489. Homo sapiens.
Family and domain databases
InterPro	IPR018629. Transport_prot_XK. [Graphical view]
Pfam	PF09815. XK-related. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	107493.
SOURCE	Search...

Entry information

Entry name

XKR2_HUMAN

Accession

Primary (citable) accession number: Q6PP77
Secondary accession number(s): B2RNN6, B4DKU2, Q5H9J6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2005
Last sequence update:	October 11, 2005
Last modified:	January 25, 2012
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.