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Protein

B- and T-lymphocyte attenuator

Gene

Btla

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
B- and T-lymphocyte attenuator
Alternative name(s):
B- and T-lymphocyte-associated protein
CD_antigen: CD272
Gene namesi
Name:Btla
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1303280. Btla.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 183154ExtracellularSequence analysisAdd
BLAST
Transmembranei184 – 20421HelicalSequence analysisAdd
BLAST
Topological domaini205 – 308104CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Chaini30 – 308279B- and T-lymphocyte attenuatorPRO_0000014525Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi40 ↔ 69PROSITE-ProRule annotation
Glycosylationi49 – 491N-linked (GlcNAc...)Sequence analysis
Disulfide bondi64 ↔ 124PROSITE-ProRule annotation
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence analysis
Disulfide bondi78 ↔ 85PROSITE-ProRule annotation
Glycosylationi81 – 811N-linked (GlcNAc...)Sequence analysis
Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence analysis
Glycosylationi165 – 1651N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11.By similarity
N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6PNM1.
PRIDEiQ6PNM1.

Interactioni

Subunit structurei

Interacts with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. Interacts with TNFRSF14/HVEM (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000050172.

Structurei

3D structure databases

ProteinModelPortaliQ6PNM1.
SMRiQ6PNM1. Positions 40-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 134103Ig-like V-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYZD. Eukaryota.
ENOG410ZATJ. LUCA.
HOGENOMiHOG000168895.
HOVERGENiHBG080937.
InParanoidiQ6PNM1.
KOiK06707.
PhylomeDBiQ6PNM1.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PNM1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKTVPAMLVT PRSFREFFIL LLGLWSILCK EPTKRIGEEC RVQLKIKRNS
60 70 80 90 100
SRSAWTGELF KIECPVTYCV HRPNVTWCKH NGTRCVPLEV GPQLHTSWVE
110 120 130 140 150
NDQASAFVLY FEPIHLSDDG VYTCSANLNS EVINSHSVVI HVTERTQNCS
160 170 180 190 200
EHPLITASDI PDATNASRPS TMEERPGRTW LLYALLPLGT SLLLLACVCL
210 220 230 240 250
LCFLRRIQGK EKKPSDLAGR ERETNLVDIP VSSRTNSQIL TSETGIYDND
260 270 280 290 300
PWSSRLGESE STISSQLEGN KQGIVYASLN HCVIGRTPRQ ASKIQEAPTE

YASICVRS
Length:308
Mass (Da):34,476
Last modified:July 5, 2004 - v1
Checksum:iC99E6EB8BE199467
GO
Isoform 2 (identifier: Q6PNM1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-167: Missing.

Note: No experimental confirmation available.
Show »
Length:296
Mass (Da):33,332
Checksum:i6CD12E0715D5F532
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41V → L in AAH92588 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei156 – 16712Missing in isoform 2. 1 PublicationVSP_014838Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY590499 mRNA. Translation: AAT00435.1.
BC092588 mRNA. Translation: AAH92588.1.
RefSeqiNP_998795.1. NM_213630.1. [Q6PNM1-1]
UniGeneiRn.124474.

Genome annotation databases

GeneIDi407756.
KEGGirno:407756.
UCSCiRGD:1303280. rat. [Q6PNM1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY590499 mRNA. Translation: AAT00435.1.
BC092588 mRNA. Translation: AAH92588.1.
RefSeqiNP_998795.1. NM_213630.1. [Q6PNM1-1]
UniGeneiRn.124474.

3D structure databases

ProteinModelPortaliQ6PNM1.
SMRiQ6PNM1. Positions 40-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000050172.

Proteomic databases

PaxDbiQ6PNM1.
PRIDEiQ6PNM1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi407756.
KEGGirno:407756.
UCSCiRGD:1303280. rat. [Q6PNM1-1]

Organism-specific databases

CTDi151888.
RGDi1303280. Btla.

Phylogenomic databases

eggNOGiENOG410IYZD. Eukaryota.
ENOG410ZATJ. LUCA.
HOGENOMiHOG000168895.
HOVERGENiHBG080937.
InParanoidiQ6PNM1.
KOiK06707.
PhylomeDBiQ6PNM1.

Miscellaneous databases

PROiQ6PNM1.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the rat BTLA receptor."
    Oaks M.K., Hallett K.M., Oaks T.M.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: Lewis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Spleen.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBTLA_RAT
AccessioniPrimary (citable) accession number: Q6PNM1
Secondary accession number(s): Q569B2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.