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Protein

DmX-like protein 1

Gene

Dmxl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
DmX-like protein 1
Short name:
X-like 1 protein
Gene namesi
Name:Dmxl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2443926. Dmxl1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 30133013DmX-like protein 1PRO_0000223323Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei322 – 3221PhosphoserineBy similarity
Modified residuei420 – 4201PhosphoserineCombined sources
Modified residuei423 – 4231PhosphoserineCombined sources
Modified residuei434 – 4341PhosphoserineCombined sources
Modified residuei572 – 5721PhosphoserineCombined sources
Modified residuei916 – 9161PhosphoserineCombined sources
Modified residuei922 – 9221PhosphoserineCombined sources
Modified residuei1829 – 18291PhosphoserineBy similarity
Modified residuei1896 – 18961PhosphoserineBy similarity
Modified residuei1903 – 19031PhosphoserineCombined sources
Modified residuei1965 – 19651PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PNC0.
MaxQBiQ6PNC0.
PaxDbiQ6PNC0.
PRIDEiQ6PNC0.

PTM databases

iPTMnetiQ6PNC0.
PhosphoSiteiQ6PNC0.

Expressioni

Gene expression databases

BgeeiQ6PNC0.
CleanExiMM_DMXL1.
ExpressionAtlasiQ6PNC0. baseline and differential.
GenevisibleiQ6PNC0. MM.

Interactioni

Protein-protein interaction databases

BioGridi232188. 1 interaction.
STRINGi10090.ENSMUSP00000045559.

Structurei

3D structure databases

ProteinModelPortaliQ6PNC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati108 – 14538WD 1Add
BLAST
Repeati164 – 20441WD 2Add
BLAST
Repeati227 – 27549WD 3Add
BLAST
Repeati474 – 51441WD 4Add
BLAST
Repeati578 – 61942WD 5Add
BLAST
Repeati842 – 89352WD 6Add
BLAST
Repeati970 – 100839WD 7Add
BLAST
Repeati1145 – 119349WD 8Add
BLAST
Repeati1208 – 124841WD 9Add
BLAST
Repeati2728 – 276942WD 10Add
BLAST
Repeati2771 – 281040WD 11Add
BLAST
Repeati2822 – 286443WD 12Add
BLAST
Repeati2870 – 290940WD 13Add
BLAST
Repeati2912 – 295140WD 14Add
BLAST
Repeati2964 – 300239WD 15Add
BLAST

Sequence similaritiesi

Contains 15 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1064. Eukaryota.
ENOG410XPUM. LUCA.
GeneTreeiENSGT00390000000096.
HOGENOMiHOG000018348.
HOVERGENiHBG079593.
InParanoidiQ6PNC0.
OrthoDBiEOG7QZG8R.
PhylomeDBiQ6PNC0.

Family and domain databases

Gene3Di2.130.10.10. 5 hits.
InterProiIPR022033. Rav1p_C.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12234. Rav1p_C. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 10 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 4 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PNC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLHQVLTGA VNPGDHCFAV GSVGEQRFTA YASGCDIVIL GSNFERLQII
60 70 80 90 100
PGAKHGNIQV GCVDCSMQQG KIAASYGNVI SVFEPVSLPK KRKNLEFYSQ
110 120 130 140 150
WQKSGQFFLD SIAHNITWDP AGNRLLTGSS CLQLWCNSRK QTEDENPDKT
160 170 180 190 200
DLNFGNWMCI WHCKTASQVH LMKFSPDGEF FATAGKDDCL LKVWYNVENW
210 220 230 240 250
RPAVTSPDKN SEKQSQGEID FSFVYLAHPR AVNGFSWRKT SKYMPRASVC
260 270 280 290 300
NVLLTCCKDN VCRLWVETFL PNDCFLYGSD CNHWCEPVSL TNNLKRNASS
310 320 330 340 350
KDRVQSALEV NLRPFRRGRS RSLALVAHTG YLPHQQDPHH AHRNTPLHAN
360 370 380 390 400
ALCHFHIAAS INPATDIPLL PSITSLSLNE NEEKCGPFVV HWLNNKELHF
410 420 430 440 450
TLSMEVFLQQ LRKSFEQPSS EASVEDSIQA DLKSDEELDD GVDDLKINHE
460 470 480 490 500
KKELDEDKML PSSSFTPLSS AAVDHQIEVL LSEWSKNADM LFSIHPMDGS
510 520 530 540 550
LLVWHVDWLD EYQPGMFRQV QVSFVSRIPV AFPTGDANSL CKSIVMYACT
560 570 580 590 600
KNVDLAIQQG KQRPTGLTRS TSMLISSAHS KSSNNLKLSI FTPNVMMISK
610 620 630 640 650
HADGSLNQWL VSFAEESAFS TVLSISHKSR YCGHRFHLND LACHSVLPLL
660 670 680 690 700
LTTSHHNALR TPNVGNQKQA HDAVNTEECS LAQQNKSNVD MAFQDPNAIY
710 720 730 740 750
SELILWRVDP VGPLSFSGGV SELARINSLH VSAFSNVAWL PTLIPSYCLG
760 770 780 790 800
AYCNSPSACF VASDGQYLRL YEAVIDAKKL LYELSNPEIS KYVGEVFNIV
810 820 830 840 850
SQQSTARPGC IIALDSITKL HGRKTQLLHV FQEDFILNNL EKKRLGVDNI
860 870 880 890 900
LLDSDSSCNG FSEKFYLVVI ECTEDNRSLL RMWDLHLRST PVSLDERIDT
910 920 930 940 950
KISEASWLPE EHYSSSPEKI LSPFSQKFQA CRANLQSTSK LSLFSEMVYS
960 970 980 990 1000
KELDLPEGVE IISVKPSAGH LSSSSIYPVC SAPYLLATSC SDDKVRFWRC
1010 1020 1030 1040 1050
RVTNGESATS KNGKLDVVYV WEEWPLLIED GLENNSSVTV PGRPVEVSCA
1060 1070 1080 1090 1100
HTSRLAVAYK QPTGNSRSQE FVMHVSIFEC ESTGGSCWIL EQTIHLDELS
1110 1120 1130 1140 1150
TVLDSGISID SNLVAYNKQE TYLVSKESIT SNTKHLVHLD WMSREDGSHI
1160 1170 1180 1190 1200
LTVGIGSKLF MYGPMAGKVQ DQTGKENQAF PLWDSTKIVP LSKFVLLRSV
1210 1220 1230 1240 1250
DLVSSVEGAP PFPVSLSWVR DGILVVGMDC EMHVYSQWQP SNKQEPVISE
1260 1270 1280 1290 1300
SYNGSTPSIL SLIKQSNSSS SGLHPPKKTL TRSMTSLAQK ICGKKSIFDP
1310 1320 1330 1340 1350
SVDMEDSGLF EAAHVLSPTL PQYHPLQLLE LMDLGKVRRA KAILSHLVKC
1360 1370 1380 1390 1400
IAGEVVALNE AESNHERRLR SLTISASGST TRDPQAFNKA DSRDYTEIDS
1410 1420 1430 1440 1450
VPPLPLYALL AADDDSYCSS LEKTGSESSL KKSKQLSKES YDELFQTSVL
1460 1470 1480 1490 1500
MSDNHMLETD EENTQPRVID LSQYSPTYFG PEHAQVLSGH LLHSSLPGLT
1510 1520 1530 1540 1550
RMEQMSLMAL ADTIATTSTD IGESRDRNQG GETLDECGLK FLLAVRLHTF
1560 1570 1580 1590 1600
LTTSLPAYRA QLLHQGLSTG HFAWAFHSVA EEELLNMLPA MQKDDPTWSE
1610 1620 1630 1640 1650
LRAMGVGWWV RNARILRRCI EKVAKAAFHR NNDPLDAAIF YLAMKKKAVI
1660 1670 1680 1690 1700
WGLYRSQKDT KMTQFFGHNF EEERWRKAAL KNAFSLLGKQ RFEHSAAFFL
1710 1720 1730 1740 1750
LGGCLKDAIE VCLEKLNDIQ LALVIARLFE SEFDKSATYK SILRKKVLGI
1760 1770 1780 1790 1800
GSPASELSSS SINAHHDPFL RSMAHWILED YSAALETLIK QPVTEDEDQV
1810 1820 1830 1840 1850
MMSACNPIVF NFYNYLRTHP LLLRRHFGSS SETFSTHMTL AGKSGLAGTI
1860 1870 1880 1890 1900
NLSERRLFFT TASAHLKAGC PMLALEVLSK MPKVSKKAKP CCRGSSFLTS
1910 1920 1930 1940 1950
KDSSLKLDVR EDKCCAADWS PSLTNGLESS SEGSSERHSH STLSFDWSQP
1960 1970 1980 1990 2000
SVVFQDDSLE LKWDSDNDEE NEDPPISMKE IRPLQRKTVK EIDELSSYTD
2010 2020 2030 2040 2050
SLSTLDENDI LNPSEDIIAV QLKFRACLKI LTVELRTLST GYEIDGGKLR
2060 2070 2080 2090 2100
YQLYHWLEKE VVALQRTCDF CSDADQLQTT FSQSADESGS TEDADDLHHQ
2110 2120 2130 2140 2150
TKVKQLRESF QEKRQWLLKY QSLLRMFLSY CVLHGSHGGG LASVRMELIL
2160 2170 2180 2190 2200
LLQESQQETA EPIFSNPLSE QTSVPLLFAC TASAKTVVAN PLLHLSNLTH
2210 2220 2230 2240 2250
DILHAIINFD SPPHPDSQTN KVYVMHTLAA SLSACIYQCL CGSHNYSSFQ
2260 2270 2280 2290 2300
TNQFTGMVYQ TVLLAHRHSL RTGSLDESVT PNTSPAQWPG INFLIQLLNS
2310 2320 2330 2340 2350
SGEEAQSGLT VLLCEILTAV YLSLFIHGLA THSSNELFRI VAHPLNEKMW
2360 2370 2380 2390 2400
SAVFGGGAHV PSKGQANSKA LSVEGEKQNR HISPSKVSAR ESPVSSSSGN
2410 2420 2430 2440 2450
QEPPAVKEKF VPPELSIWDY FIAKPFLPPS QSRAEYDSEE SLESDDEEEE
2460 2470 2480 2490 2500
DDDDALPSGL QLHEHSNSNS FSWSLMRLAM VQLVLNNLKT FYPFAGHDLA
2510 2520 2530 2540 2550
ELPVSSPLCH AVLKTLQCWE QVLLRRLEIH GGPPQNYISS HTSEENVSAG
2560 2570 2580 2590 2600
PAILRHKALL EPTNTPFKSK NHLALSVKRL WQYLVKQEEI QETFIRNIFT
2610 2620 2630 2640 2650
KKRCLNEIEA DLGYPGGKAR IIHKESDIIT AFAVNRANRN CIAIASSHDV
2660 2670 2680 2690 2700
QELDVSAILA TQIYTWVDDD TETETKGSED FLVIHARDDL SAVQGSTPYT
2710 2720 2730 2740 2750
HSNPGTPINM PWLGSTQTGR GASVMLKKAI NNVRRMTSHP TLPYYLTGAQ
2760 2770 2780 2790 2800
DGSVRMFEWG HSQQITCFRS GGNSRITRMR FNYQGNKFGI VDADGYLSLY
2810 2820 2830 2840 2850
QTNWKCCPVT GSMPKPYLAW QCHNKTANDF VFVSSSSLIA TAGLSSDNRN
2860 2870 2880 2890 2900
ICLWDTLVAP ANSLVHAFTC HDSGATVLAY APKHQLLISG GRKGFTCIFD
2910 2920 2930 2940 2950
LRQRQQRQLF QSHDSPVKAI AIDPTEEYFV TGSAEGNIKI WSLSSFSLLH
2960 2970 2980 2990 3000
TFINEHARQS IFRNIGTGVM QIETGPANHI FSCGADGTMK MRILPDQFSP
3010
LNEVLKNDVK FML
Length:3,013
Mass (Da):336,008
Last modified:July 5, 2004 - v1
Checksum:i3C57BD3218EE748D
GO

Sequence cautioni

The sequence BAE38824.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2812 – 28121S → N in BAE38824 (PubMed:16141072).Curated
Sequence conflicti2944 – 29441S → L in BAE38824 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY590892 mRNA. Translation: AAT01618.1.
BC056490 mRNA. Translation: AAH56490.1.
AK050888 mRNA. Translation: BAC34446.1.
AK166520 mRNA. Translation: BAE38824.1. Different initiation.
CCDSiCCDS37816.2.
RefSeqiNP_001074840.2. NM_001081371.2.
UniGeneiMm.257790.

Genome annotation databases

EnsembliENSMUST00000180611; ENSMUSP00000137871; ENSMUSG00000037416.
GeneIDi240283.
KEGGimmu:240283.
UCSCiuc008ewo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY590892 mRNA. Translation: AAT01618.1.
BC056490 mRNA. Translation: AAH56490.1.
AK050888 mRNA. Translation: BAC34446.1.
AK166520 mRNA. Translation: BAE38824.1. Different initiation.
CCDSiCCDS37816.2.
RefSeqiNP_001074840.2. NM_001081371.2.
UniGeneiMm.257790.

3D structure databases

ProteinModelPortaliQ6PNC0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232188. 1 interaction.
STRINGi10090.ENSMUSP00000045559.

PTM databases

iPTMnetiQ6PNC0.
PhosphoSiteiQ6PNC0.

Proteomic databases

EPDiQ6PNC0.
MaxQBiQ6PNC0.
PaxDbiQ6PNC0.
PRIDEiQ6PNC0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000180611; ENSMUSP00000137871; ENSMUSG00000037416.
GeneIDi240283.
KEGGimmu:240283.
UCSCiuc008ewo.2. mouse.

Organism-specific databases

CTDi1657.
MGIiMGI:2443926. Dmxl1.

Phylogenomic databases

eggNOGiKOG1064. Eukaryota.
ENOG410XPUM. LUCA.
GeneTreeiENSGT00390000000096.
HOGENOMiHOG000018348.
HOVERGENiHBG079593.
InParanoidiQ6PNC0.
OrthoDBiEOG7QZG8R.
PhylomeDBiQ6PNC0.

Miscellaneous databases

PROiQ6PNC0.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PNC0.
CleanExiMM_DMXL1.
ExpressionAtlasiQ6PNC0. baseline and differential.
GenevisibleiQ6PNC0. MM.

Family and domain databases

Gene3Di2.130.10.10. 5 hits.
InterProiIPR022033. Rav1p_C.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12234. Rav1p_C. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 10 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 4 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mus musculus mRNA for Dmx-like 1 protein."
    Bikar S.E., Kraemer C., Schmidt E.R.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/Sv.
    Tissue: Embryonic stem cell.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1916-3013.
    Strain: C57BL/6J.
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2719-3013.
    Strain: C57BL/6J.
    Tissue: Embryo and Mammary gland.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-434, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-420; SER-423; SER-434; SER-572; SER-916; SER-922; SER-1903 AND SER-1965, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiDMXL1_MOUSE
AccessioniPrimary (citable) accession number: Q6PNC0
Secondary accession number(s): Q3TLG8, Q6PHM6, Q8BQF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.