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Protein

Zinc transporter 9

Gene

SLC30A9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the p160 coactivator signaling pathway that mediates transcriptional activation by nuclear receptors. Plays a role in transcriptional activation of Wnt-responsive genes.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transcription, Transcription regulation, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

SIGNORiQ6PML9.

Protein family/group databases

TCDBi2.A.4.6.1. the cation diffusion facilitator (cdf) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 9
Short name:
ZnT-9
Alternative name(s):
Human embryonic lung protein
Short name:
HuEL
Solute carrier family 30 member 9
Gene namesi
Name:SLC30A9
Synonyms:C4orf1, HUEL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:1329. SLC30A9.

Subcellular locationi

  • Membrane Curated; Multi-pass membrane protein Curated
  • Nucleus 1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Transmembranei314 – 334HelicalSequence analysisAdd BLAST21
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Transmembranei392 – 412HelicalSequence analysisAdd BLAST21
Transmembranei424 – 444HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • cytoskeleton Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10463.
OpenTargetsiENSG00000014824.
PharmGKBiPA25909.

Polymorphism and mutation databases

BioMutaiSLC30A9.
DMDMi74722746.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002958051 – 568Zinc transporter 9Add BLAST568

Proteomic databases

EPDiQ6PML9.
MaxQBiQ6PML9.
PaxDbiQ6PML9.
PeptideAtlasiQ6PML9.
PRIDEiQ6PML9.

PTM databases

iPTMnetiQ6PML9.
PhosphoSitePlusiQ6PML9.

Expressioni

Tissue specificityi

Ubiquitously expressed in fetal and adult tissues and cancer cell lines.1 Publication

Gene expression databases

BgeeiENSG00000014824.
CleanExiHS_SLC30A9.
ExpressionAtlasiQ6PML9. baseline and differential.
GenevisibleiQ6PML9. HS.

Organism-specific databases

HPAiHPA004014.

Interactioni

Subunit structurei

Interacts with GRIP1, ESR1 and AR.By similarity

Protein-protein interaction databases

BioGridi115726. 12 interactors.
IntActiQ6PML9. 5 interactors.
STRINGi9606.ENSP00000264451.

Structurei

Secondary structure

1568
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi129 – 132Combined sources4
Helixi133 – 139Combined sources7
Helixi144 – 149Combined sources6
Beta strandi167 – 169Combined sources3
Helixi170 – 180Combined sources11
Beta strandi181 – 183Combined sources3
Helixi184 – 209Combined sources26

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ENKNMR-A124-217[»]
ProteinModelPortaliQ6PML9.
SMRiQ6PML9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6PML9.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi462 – 466LXXLL motif5

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2802. Eukaryota.
COG0053. LUCA.
GeneTreeiENSGT00390000008346.
HOGENOMiHOG000242618.
HOVERGENiHBG104893.
InParanoidiQ6PML9.
KOiK14696.
OMAiGSHSMFA.
OrthoDBiEOG091G05KM.
PhylomeDBiQ6PML9.
TreeFamiTF314526.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
3.90.530.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
IPR009061. DNA-bd_dom_put.
IPR022656. XPA_C.
[Graphical view]
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6PML9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPGLAAAAA HRCSWSSLCR LRLRCRAAAC NPSDRQEWQN LVTFGSFSNM
60 70 80 90 100
VPCSHPYIGT LSQVKLYSTN VQKEGQGSQT LRVEKVPSFE TAEGIGTELK
110 120 130 140 150
APLKQEPLQV RVKAVLKKRE YGSKYTQNNF ITGVRAINEF CLKSSDLEQL
160 170 180 190 200
RKIRRRSPHE DTESFTVYLR SDVEAKSLEV WGSPEALARE KKLRKEAEIE
210 220 230 240 250
YRERLFRNQK ILREYRDFLG NTKPRSRTAS VFFKGPGKVV MVAICINGLN
260 270 280 290 300
CFFKFLAWIY TGSASMFSEA IHSLSDTCNQ GLLALGISKS VQTPDPSHPY
310 320 330 340 350
GFSNMRYISS LISGVGIFMM GAGLSWYHGV MGLLHPQPIE SLLWAYCILA
360 370 380 390 400
GSLVSEGATL LVAVNELRRN ARAKGMSFYK YVMESRDPST NVILLEDTAA
410 420 430 440 450
VLGVIIAATC MGLTSITGNP LYDSLGSLGV GTLLGMVSAF LIYTNTEALL
460 470 480 490 500
GRSIQPEQVQ RLTELLENDP SVRAIHDVKA TDLGLGKVRF KAEVDFDGRV
510 520 530 540 550
VTRSYLEKQD FDQMLQEIQE VKTPEELETF MLKHGENIID TLGAEVDRLE
560
KELKKRNPEV RHVDLEIL
Length:568
Mass (Da):63,515
Last modified:July 5, 2004 - v1
Checksum:iCA59839CA983FDC2
GO

Sequence cautioni

The sequence AAP83846 differs from that shown. Unlikely isoform. Aberrant splice sites.Curated
The sequence AAY40966 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti141C → Y in AAP83846 (Ref. 3) Curated1
Sequence conflicti356E → V in AAP83846 (Ref. 3) Curated1
Sequence conflicti401V → A in AAH22981 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05200350M → V.3 PublicationsCorresponds to variant rs1047626dbSNPEnsembl.1
Natural variantiVAR_05200497T → A.3 PublicationsCorresponds to variant rs2581423dbSNPEnsembl.1
Natural variantiVAR_052005353L → S.Corresponds to variant rs1801962dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006621 mRNA. Translation: AAB87763.2.
AY319413 mRNA. Translation: AAP83846.1. Sequence problems.
AY594282 mRNA. Translation: AAT02479.1.
AC113151 Genomic DNA. Translation: AAY40966.1. Sequence problems.
BC007732 mRNA. Translation: AAH07732.1.
BC016949 mRNA. Translation: AAH16949.1.
BC022981 mRNA. Translation: AAH22981.1.
CCDSiCCDS3465.1.
RefSeqiNP_006336.3. NM_006345.3.
UniGeneiHs.479634.

Genome annotation databases

EnsembliENST00000264451; ENSP00000264451; ENSG00000014824.
GeneIDi10463.
KEGGihsa:10463.
UCSCiuc003gwl.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006621 mRNA. Translation: AAB87763.2.
AY319413 mRNA. Translation: AAP83846.1. Sequence problems.
AY594282 mRNA. Translation: AAT02479.1.
AC113151 Genomic DNA. Translation: AAY40966.1. Sequence problems.
BC007732 mRNA. Translation: AAH07732.1.
BC016949 mRNA. Translation: AAH16949.1.
BC022981 mRNA. Translation: AAH22981.1.
CCDSiCCDS3465.1.
RefSeqiNP_006336.3. NM_006345.3.
UniGeneiHs.479634.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ENKNMR-A124-217[»]
ProteinModelPortaliQ6PML9.
SMRiQ6PML9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115726. 12 interactors.
IntActiQ6PML9. 5 interactors.
STRINGi9606.ENSP00000264451.

Protein family/group databases

TCDBi2.A.4.6.1. the cation diffusion facilitator (cdf) family.

PTM databases

iPTMnetiQ6PML9.
PhosphoSitePlusiQ6PML9.

Polymorphism and mutation databases

BioMutaiSLC30A9.
DMDMi74722746.

Proteomic databases

EPDiQ6PML9.
MaxQBiQ6PML9.
PaxDbiQ6PML9.
PeptideAtlasiQ6PML9.
PRIDEiQ6PML9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264451; ENSP00000264451; ENSG00000014824.
GeneIDi10463.
KEGGihsa:10463.
UCSCiuc003gwl.4. human.

Organism-specific databases

CTDi10463.
DisGeNETi10463.
GeneCardsiSLC30A9.
H-InvDBHIX0004181.
HGNCiHGNC:1329. SLC30A9.
HPAiHPA004014.
MIMi604604. gene.
neXtProtiNX_Q6PML9.
OpenTargetsiENSG00000014824.
PharmGKBiPA25909.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2802. Eukaryota.
COG0053. LUCA.
GeneTreeiENSGT00390000008346.
HOGENOMiHOG000242618.
HOVERGENiHBG104893.
InParanoidiQ6PML9.
KOiK14696.
OMAiGSHSMFA.
OrthoDBiEOG091G05KM.
PhylomeDBiQ6PML9.
TreeFamiTF314526.

Enzyme and pathway databases

SIGNORiQ6PML9.

Miscellaneous databases

ChiTaRSiSLC30A9. human.
EvolutionaryTraceiQ6PML9.
GenomeRNAii10463.
PROiQ6PML9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000014824.
CleanExiHS_SLC30A9.
ExpressionAtlasiQ6PML9. baseline and differential.
GenevisibleiQ6PML9. HS.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
3.90.530.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
IPR009061. DNA-bd_dom_put.
IPR022656. XPA_C.
[Graphical view]
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
TIGRFAMsiTIGR01297. CDF. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZNT9_HUMAN
AccessioniPrimary (citable) accession number: Q6PML9
Secondary accession number(s): Q4W5B6
, Q7Z5I7, Q8TBB2, Q9Y6R2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.