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Q6PML9 (ZNT9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc transporter 9

Short name=ZnT-9
Alternative name(s):
Human embryonic lung protein
Short name=HuEL
Solute carrier family 30 member 9
Gene names
Name:SLC30A9
Synonyms:C4orf1, HUEL
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length568 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in the p160 coactivator signaling pathway that mediates transcriptional activation by nuclear receptors By similarity. Plays a role in transcriptional activation of Wnt-responsive genes By similarity. Ref.1

Subunit structure

Interacts with GRIP1, ESR1 and AR By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential. Nucleus Ref.1.

Tissue specificity

Ubiquitously expressed in fetal and adult tissues and cancer cell lines. Ref.1

Sequence similarities

Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. [View classification]

Sequence caution

The sequence AAP83846.1 differs from that shown. Reason: Unlikely isoform. Aberrant splice sites.

The sequence AAY40966.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 568568Zinc transporter 9
PRO_0000295805

Regions

Transmembrane239 – 25921Helical; Potential
Transmembrane314 – 33421Helical; Potential
Transmembrane342 – 36221Helical; Potential
Transmembrane392 – 41221Helical; Potential
Transmembrane424 – 44421Helical; Potential
Motif462 – 4665LXXLL motif

Natural variations

Natural variant501M → V. Ref.1 Ref.3 Ref.6
Corresponds to variant rs1047626 [ dbSNP | Ensembl ].
VAR_052003
Natural variant971T → A. Ref.1 Ref.3 Ref.6
Corresponds to variant rs2581423 [ dbSNP | Ensembl ].
VAR_052004
Natural variant3531L → S.
Corresponds to variant rs1801962 [ dbSNP | Ensembl ].
VAR_052005

Experimental info

Sequence conflict1411C → Y in AAP83846. Ref.3
Sequence conflict3561E → V in AAP83846. Ref.3
Sequence conflict4011V → A in AAH22981. Ref.6

Secondary structure

........... 568
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q6PML9 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: CA59839CA983FDC2

FASTA56863,515
        10         20         30         40         50         60 
MLPGLAAAAA HRCSWSSLCR LRLRCRAAAC NPSDRQEWQN LVTFGSFSNM VPCSHPYIGT 

        70         80         90        100        110        120 
LSQVKLYSTN VQKEGQGSQT LRVEKVPSFE TAEGIGTELK APLKQEPLQV RVKAVLKKRE 

       130        140        150        160        170        180 
YGSKYTQNNF ITGVRAINEF CLKSSDLEQL RKIRRRSPHE DTESFTVYLR SDVEAKSLEV 

       190        200        210        220        230        240 
WGSPEALARE KKLRKEAEIE YRERLFRNQK ILREYRDFLG NTKPRSRTAS VFFKGPGKVV 

       250        260        270        280        290        300 
MVAICINGLN CFFKFLAWIY TGSASMFSEA IHSLSDTCNQ GLLALGISKS VQTPDPSHPY 

       310        320        330        340        350        360 
GFSNMRYISS LISGVGIFMM GAGLSWYHGV MGLLHPQPIE SLLWAYCILA GSLVSEGATL 

       370        380        390        400        410        420 
LVAVNELRRN ARAKGMSFYK YVMESRDPST NVILLEDTAA VLGVIIAATC MGLTSITGNP 

       430        440        450        460        470        480 
LYDSLGSLGV GTLLGMVSAF LIYTNTEALL GRSIQPEQVQ RLTELLENDP SVRAIHDVKA 

       490        500        510        520        530        540 
TDLGLGKVRF KAEVDFDGRV VTRSYLEKQD FDQMLQEIQE VKTPEELETF MLKHGENIID 

       550        560 
TLGAEVDRLE KELKKRNPEV RHVDLEIL 

« Hide

References

« Hide 'large scale' references
[1]"The novel human HUEL (C4orf1) gene maps to chromosome 4p12-p13 and encodes a nuclear protein containing the nuclear receptor interaction motif."
Sim D.L.C., Chow V.T.K.
Genomics 59:224-233(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANTS VAL-50 AND ALA-97.
Tissue: Lung.
[2]Chow V.T.K., Sim D.L.C.
Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 160; 174 AND 196.
Tissue: Lung.
[3]"A human HUEL (C4orf1) isoform play the role in spermatogenesis."
Xu Z.Y., Huang X.Y., Xu M., Yin L.L., Lu L., Li J.M., Zhou Z.M., Sha J.H.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS VAL-50 AND ALA-97.
Tissue: Testis.
[4]Luo W., Sedehizade F., Hanck T., Reiser G.
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-50 AND ALA-97.
Tissue: Cervix, Colon and Muscle.
[7]"Solution structure of a putative DNA-binding domain of the human solute carrier family 30 (zinc transporter) protein."
RIKEN structural genomics initiative (RSGI)
Submitted (FEB-2009) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 124-217.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF006621 mRNA. Translation: AAB87763.2.
AY319413 mRNA. Translation: AAP83846.1. Sequence problems.
AY594282 mRNA. Translation: AAT02479.1.
AC113151 Genomic DNA. Translation: AAY40966.1. Sequence problems.
BC007732 mRNA. Translation: AAH07732.1.
BC016949 mRNA. Translation: AAH16949.1.
BC022981 mRNA. Translation: AAH22981.1.
RefSeqNP_006336.3. NM_006345.3.
UniGeneHs.479634.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2ENKNMR-A124-217[»]
ProteinModelPortalQ6PML9.
SMRQ6PML9. Positions 124-217, 252-484.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115726. 3 interactions.
IntActQ6PML9. 3 interactions.
STRING9606.ENSP00000264451.

Protein family/group databases

TCDB2.A.4.6.1. the cation diffusion facilitator (cdf) family.

PTM databases

PhosphoSiteQ6PML9.

Polymorphism databases

DMDM74722746.

Proteomic databases

PaxDbQ6PML9.
PRIDEQ6PML9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000264451; ENSP00000264451; ENSG00000014824.
GeneID10463.
KEGGhsa:10463.
UCSCuc003gwl.3. human.

Organism-specific databases

CTD10463.
GeneCardsGC04P041992.
H-InvDBHIX0004181.
HGNCHGNC:1329. SLC30A9.
HPAHPA004014.
MIM604604. gene.
neXtProtNX_Q6PML9.
PharmGKBPA25909.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0053.
HOGENOMHOG000242618.
HOVERGENHBG104893.
InParanoidQ6PML9.
KOK14696.
OMAPKYTQNN.
OrthoDBEOG7PCJHN.
PhylomeDBQ6PML9.
TreeFamTF314526.

Gene expression databases

ArrayExpressQ6PML9.
BgeeQ6PML9.
CleanExHS_SLC30A9.
GenevestigatorQ6PML9.

Family and domain databases

Gene3D1.20.1510.10. 1 hit.
3.90.530.10. 1 hit.
InterProIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
IPR009061. DNA-bd_dom_put.
IPR022656. XPA_C.
[Graphical view]
PfamPF01545. Cation_efflux. 1 hit.
[Graphical view]
SUPFAMSSF46955. SSF46955. 1 hit.
TIGRFAMsTIGR01297. CDF. 1 hit.
ProtoNetSearch...

Other

ChiTaRSSLC30A9. human.
EvolutionaryTraceQ6PML9.
GenomeRNAi10463.
NextBio39677.
PROQ6PML9.
SOURCESearch...

Entry information

Entry nameZNT9_HUMAN
AccessionPrimary (citable) accession number: Q6PML9
Secondary accession number(s): Q4W5B6 expand/collapse secondary AC list , Q7Z5I7, Q8TBB2, Q9Y6R2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM