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Q6PML9

- ZNT9_HUMAN

UniProt

Q6PML9 - ZNT9_HUMAN

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Protein
Zinc transporter 9
Gene
SLC30A9, C4orf1, HUEL
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role in the p160 coactivator signaling pathway that mediates transcriptional activation by nuclear receptors By similarity. Plays a role in transcriptional activation of Wnt-responsive genes By similarity.1 Publication

GO - Molecular functioni

  1. cation transmembrane transporter activity Source: InterPro
  2. chromatin binding Source: Ensembl
  3. ligand-dependent nuclear receptor transcription coactivator activity Source: Ensembl
  4. sequence-specific DNA binding transcription factor activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. nucleotide-excision repair Source: BHF-UCL
  2. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  3. transcription, DNA-templated Source: UniProtKB-KW
  4. zinc ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transcription, Transcription regulation, Transport, Zinc transport

Keywords - Ligandi

Zinc

Protein family/group databases

TCDBi2.A.4.6.1. the cation diffusion facilitator (cdf) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 9
Short name:
ZnT-9
Alternative name(s):
Human embryonic lung protein
Short name:
HuEL
Solute carrier family 30 member 9
Gene namesi
Name:SLC30A9
Synonyms:C4orf1, HUEL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:1329. SLC30A9.

Subcellular locationi

Membrane; Multi-pass membrane protein Reviewed prediction. Nucleus 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei239 – 25921Helical; Reviewed prediction
Add
BLAST
Transmembranei314 – 33421Helical; Reviewed prediction
Add
BLAST
Transmembranei342 – 36221Helical; Reviewed prediction
Add
BLAST
Transmembranei392 – 41221Helical; Reviewed prediction
Add
BLAST
Transmembranei424 – 44421Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cytoskeleton Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25909.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568Zinc transporter 9
PRO_0000295805Add
BLAST

Proteomic databases

MaxQBiQ6PML9.
PaxDbiQ6PML9.
PRIDEiQ6PML9.

PTM databases

PhosphoSiteiQ6PML9.

Expressioni

Tissue specificityi

Ubiquitously expressed in fetal and adult tissues and cancer cell lines.1 Publication

Gene expression databases

ArrayExpressiQ6PML9.
BgeeiQ6PML9.
CleanExiHS_SLC30A9.
GenevestigatoriQ6PML9.

Organism-specific databases

HPAiHPA004014.

Interactioni

Subunit structurei

Interacts with GRIP1, ESR1 and AR By similarity.

Protein-protein interaction databases

BioGridi115726. 3 interactions.
IntActiQ6PML9. 3 interactions.
STRINGi9606.ENSP00000264451.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi129 – 1324
Helixi133 – 1397
Helixi144 – 1496
Beta strandi167 – 1693
Helixi170 – 18011
Beta strandi181 – 1833
Helixi184 – 20926

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ENKNMR-A124-217[»]
ProteinModelPortaliQ6PML9.
SMRiQ6PML9. Positions 124-217, 252-484.

Miscellaneous databases

EvolutionaryTraceiQ6PML9.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi462 – 4665LXXLL motif

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0053.
HOGENOMiHOG000242618.
HOVERGENiHBG104893.
InParanoidiQ6PML9.
KOiK14696.
OMAiPKYTQNN.
OrthoDBiEOG7PCJHN.
PhylomeDBiQ6PML9.
TreeFamiTF314526.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
3.90.530.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
IPR009061. DNA-bd_dom_put.
IPR022656. XPA_C.
[Graphical view]
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6PML9-1 [UniParc]FASTAAdd to Basket

« Hide

MLPGLAAAAA HRCSWSSLCR LRLRCRAAAC NPSDRQEWQN LVTFGSFSNM    50
VPCSHPYIGT LSQVKLYSTN VQKEGQGSQT LRVEKVPSFE TAEGIGTELK 100
APLKQEPLQV RVKAVLKKRE YGSKYTQNNF ITGVRAINEF CLKSSDLEQL 150
RKIRRRSPHE DTESFTVYLR SDVEAKSLEV WGSPEALARE KKLRKEAEIE 200
YRERLFRNQK ILREYRDFLG NTKPRSRTAS VFFKGPGKVV MVAICINGLN 250
CFFKFLAWIY TGSASMFSEA IHSLSDTCNQ GLLALGISKS VQTPDPSHPY 300
GFSNMRYISS LISGVGIFMM GAGLSWYHGV MGLLHPQPIE SLLWAYCILA 350
GSLVSEGATL LVAVNELRRN ARAKGMSFYK YVMESRDPST NVILLEDTAA 400
VLGVIIAATC MGLTSITGNP LYDSLGSLGV GTLLGMVSAF LIYTNTEALL 450
GRSIQPEQVQ RLTELLENDP SVRAIHDVKA TDLGLGKVRF KAEVDFDGRV 500
VTRSYLEKQD FDQMLQEIQE VKTPEELETF MLKHGENIID TLGAEVDRLE 550
KELKKRNPEV RHVDLEIL 568
Length:568
Mass (Da):63,515
Last modified:July 5, 2004 - v1
Checksum:iCA59839CA983FDC2
GO

Sequence cautioni

The sequence AAP83846.1 differs from that shown. Reason: Unlikely isoform. Aberrant splice sites.
The sequence AAY40966.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti50 – 501M → V.3 Publications
Corresponds to variant rs1047626 [ dbSNP | Ensembl ].
VAR_052003
Natural varianti97 – 971T → A.3 Publications
Corresponds to variant rs2581423 [ dbSNP | Ensembl ].
VAR_052004
Natural varianti353 – 3531L → S.
Corresponds to variant rs1801962 [ dbSNP | Ensembl ].
VAR_052005

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti141 – 1411C → Y in AAP83846. 1 Publication
Sequence conflicti356 – 3561E → V in AAP83846. 1 Publication
Sequence conflicti401 – 4011V → A in AAH22981. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF006621 mRNA. Translation: AAB87763.2.
AY319413 mRNA. Translation: AAP83846.1. Sequence problems.
AY594282 mRNA. Translation: AAT02479.1.
AC113151 Genomic DNA. Translation: AAY40966.1. Sequence problems.
BC007732 mRNA. Translation: AAH07732.1.
BC016949 mRNA. Translation: AAH16949.1.
BC022981 mRNA. Translation: AAH22981.1.
CCDSiCCDS3465.1.
RefSeqiNP_006336.3. NM_006345.3.
UniGeneiHs.479634.

Genome annotation databases

EnsembliENST00000264451; ENSP00000264451; ENSG00000014824.
GeneIDi10463.
KEGGihsa:10463.
UCSCiuc003gwl.3. human.

Polymorphism databases

DMDMi74722746.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF006621 mRNA. Translation: AAB87763.2 .
AY319413 mRNA. Translation: AAP83846.1 . Sequence problems.
AY594282 mRNA. Translation: AAT02479.1 .
AC113151 Genomic DNA. Translation: AAY40966.1 . Sequence problems.
BC007732 mRNA. Translation: AAH07732.1 .
BC016949 mRNA. Translation: AAH16949.1 .
BC022981 mRNA. Translation: AAH22981.1 .
CCDSi CCDS3465.1.
RefSeqi NP_006336.3. NM_006345.3.
UniGenei Hs.479634.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2ENK NMR - A 124-217 [» ]
ProteinModelPortali Q6PML9.
SMRi Q6PML9. Positions 124-217, 252-484.
ModBasei Search...

Protein-protein interaction databases

BioGridi 115726. 3 interactions.
IntActi Q6PML9. 3 interactions.
STRINGi 9606.ENSP00000264451.

Protein family/group databases

TCDBi 2.A.4.6.1. the cation diffusion facilitator (cdf) family.

PTM databases

PhosphoSitei Q6PML9.

Polymorphism databases

DMDMi 74722746.

Proteomic databases

MaxQBi Q6PML9.
PaxDbi Q6PML9.
PRIDEi Q6PML9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264451 ; ENSP00000264451 ; ENSG00000014824 .
GeneIDi 10463.
KEGGi hsa:10463.
UCSCi uc003gwl.3. human.

Organism-specific databases

CTDi 10463.
GeneCardsi GC04P041992.
H-InvDB HIX0004181.
HGNCi HGNC:1329. SLC30A9.
HPAi HPA004014.
MIMi 604604. gene.
neXtProti NX_Q6PML9.
PharmGKBi PA25909.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0053.
HOGENOMi HOG000242618.
HOVERGENi HBG104893.
InParanoidi Q6PML9.
KOi K14696.
OMAi PKYTQNN.
OrthoDBi EOG7PCJHN.
PhylomeDBi Q6PML9.
TreeFami TF314526.

Miscellaneous databases

ChiTaRSi SLC30A9. human.
EvolutionaryTracei Q6PML9.
GenomeRNAii 10463.
NextBioi 39677.
PROi Q6PML9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6PML9.
Bgeei Q6PML9.
CleanExi HS_SLC30A9.
Genevestigatori Q6PML9.

Family and domain databases

Gene3Di 1.20.1510.10. 1 hit.
3.90.530.10. 1 hit.
InterProi IPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
IPR009061. DNA-bd_dom_put.
IPR022656. XPA_C.
[Graphical view ]
Pfami PF01545. Cation_efflux. 1 hit.
[Graphical view ]
SUPFAMi SSF46955. SSF46955. 1 hit.
TIGRFAMsi TIGR01297. CDF. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The novel human HUEL (C4orf1) gene maps to chromosome 4p12-p13 and encodes a nuclear protein containing the nuclear receptor interaction motif."
    Sim D.L.C., Chow V.T.K.
    Genomics 59:224-233(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANTS VAL-50 AND ALA-97.
    Tissue: Lung.
  2. Chow V.T.K., Sim D.L.C.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 160; 174 AND 196.
    Tissue: Lung.
  3. "A human HUEL (C4orf1) isoform play the role in spermatogenesis."
    Xu Z.Y., Huang X.Y., Xu M., Yin L.L., Lu L., Li J.M., Zhou Z.M., Sha J.H.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS VAL-50 AND ALA-97.
    Tissue: Testis.
  4. Luo W., Sedehizade F., Hanck T., Reiser G.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-50 AND ALA-97.
    Tissue: Cervix, Colon and Muscle.
  7. "Solution structure of a putative DNA-binding domain of the human solute carrier family 30 (zinc transporter) protein."
    RIKEN structural genomics initiative (RSGI)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 124-217.

Entry informationi

Entry nameiZNT9_HUMAN
AccessioniPrimary (citable) accession number: Q6PML9
Secondary accession number(s): Q4W5B6
, Q7Z5I7, Q8TBB2, Q9Y6R2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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