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Q6PML9

- ZNT9_HUMAN

UniProt

Q6PML9 - ZNT9_HUMAN

Protein

Zinc transporter 9

Gene

SLC30A9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Plays a role in the p160 coactivator signaling pathway that mediates transcriptional activation by nuclear receptors. Plays a role in transcriptional activation of Wnt-responsive genes.By similarity

    GO - Molecular functioni

    1. cation transmembrane transporter activity Source: InterPro
    2. chromatin binding Source: Ensembl
    3. ligand-dependent nuclear receptor transcription coactivator activity Source: Ensembl
    4. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. nucleotide-excision repair Source: BHF-UCL
    2. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    3. transcription, DNA-templated Source: UniProtKB-KW
    4. zinc ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Transcription, Transcription regulation, Transport, Zinc transport

    Keywords - Ligandi

    Zinc

    Protein family/group databases

    TCDBi2.A.4.6.1. the cation diffusion facilitator (cdf) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc transporter 9
    Short name:
    ZnT-9
    Alternative name(s):
    Human embryonic lung protein
    Short name:
    HuEL
    Solute carrier family 30 member 9
    Gene namesi
    Name:SLC30A9
    Synonyms:C4orf1, HUEL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:1329. SLC30A9.

    Subcellular locationi

    Membrane Curated; Multi-pass membrane protein Curated. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoskeleton Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25909.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 568568Zinc transporter 9PRO_0000295805Add
    BLAST

    Proteomic databases

    MaxQBiQ6PML9.
    PaxDbiQ6PML9.
    PRIDEiQ6PML9.

    PTM databases

    PhosphoSiteiQ6PML9.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed in fetal and adult tissues and cancer cell lines.1 Publication

    Gene expression databases

    ArrayExpressiQ6PML9.
    BgeeiQ6PML9.
    CleanExiHS_SLC30A9.
    GenevestigatoriQ6PML9.

    Organism-specific databases

    HPAiHPA004014.

    Interactioni

    Subunit structurei

    Interacts with GRIP1, ESR1 and AR.By similarity

    Protein-protein interaction databases

    BioGridi115726. 3 interactions.
    IntActiQ6PML9. 3 interactions.
    STRINGi9606.ENSP00000264451.

    Structurei

    Secondary structure

    1
    568
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi129 – 1324
    Helixi133 – 1397
    Helixi144 – 1496
    Beta strandi167 – 1693
    Helixi170 – 18011
    Beta strandi181 – 1833
    Helixi184 – 20926

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2ENKNMR-A124-217[»]
    ProteinModelPortaliQ6PML9.
    SMRiQ6PML9. Positions 124-217, 252-484.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ6PML9.

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei239 – 25921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei314 – 33421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei342 – 36221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei392 – 41221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei424 – 44421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi462 – 4665LXXLL motif

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0053.
    HOGENOMiHOG000242618.
    HOVERGENiHBG104893.
    InParanoidiQ6PML9.
    KOiK14696.
    OMAiPKYTQNN.
    OrthoDBiEOG7PCJHN.
    PhylomeDBiQ6PML9.
    TreeFamiTF314526.

    Family and domain databases

    Gene3Di1.20.1510.10. 1 hit.
    3.90.530.10. 1 hit.
    InterProiIPR002524. Cation_efflux.
    IPR027469. Cation_efflux_TMD.
    IPR009061. DNA-bd_dom_put.
    IPR022656. XPA_C.
    [Graphical view]
    PfamiPF01545. Cation_efflux. 1 hit.
    [Graphical view]
    SUPFAMiSSF46955. SSF46955. 1 hit.
    TIGRFAMsiTIGR01297. CDF. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6PML9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPGLAAAAA HRCSWSSLCR LRLRCRAAAC NPSDRQEWQN LVTFGSFSNM    50
    VPCSHPYIGT LSQVKLYSTN VQKEGQGSQT LRVEKVPSFE TAEGIGTELK 100
    APLKQEPLQV RVKAVLKKRE YGSKYTQNNF ITGVRAINEF CLKSSDLEQL 150
    RKIRRRSPHE DTESFTVYLR SDVEAKSLEV WGSPEALARE KKLRKEAEIE 200
    YRERLFRNQK ILREYRDFLG NTKPRSRTAS VFFKGPGKVV MVAICINGLN 250
    CFFKFLAWIY TGSASMFSEA IHSLSDTCNQ GLLALGISKS VQTPDPSHPY 300
    GFSNMRYISS LISGVGIFMM GAGLSWYHGV MGLLHPQPIE SLLWAYCILA 350
    GSLVSEGATL LVAVNELRRN ARAKGMSFYK YVMESRDPST NVILLEDTAA 400
    VLGVIIAATC MGLTSITGNP LYDSLGSLGV GTLLGMVSAF LIYTNTEALL 450
    GRSIQPEQVQ RLTELLENDP SVRAIHDVKA TDLGLGKVRF KAEVDFDGRV 500
    VTRSYLEKQD FDQMLQEIQE VKTPEELETF MLKHGENIID TLGAEVDRLE 550
    KELKKRNPEV RHVDLEIL 568
    Length:568
    Mass (Da):63,515
    Last modified:July 5, 2004 - v1
    Checksum:iCA59839CA983FDC2
    GO

    Sequence cautioni

    The sequence AAP83846.1 differs from that shown. Reason: Unlikely isoform. Aberrant splice sites.
    The sequence AAY40966.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti141 – 1411C → Y in AAP83846. 1 PublicationCurated
    Sequence conflicti356 – 3561E → V in AAP83846. 1 PublicationCurated
    Sequence conflicti401 – 4011V → A in AAH22981. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti50 – 501M → V.3 Publications
    Corresponds to variant rs1047626 [ dbSNP | Ensembl ].
    VAR_052003
    Natural varianti97 – 971T → A.3 Publications
    Corresponds to variant rs2581423 [ dbSNP | Ensembl ].
    VAR_052004
    Natural varianti353 – 3531L → S.
    Corresponds to variant rs1801962 [ dbSNP | Ensembl ].
    VAR_052005

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF006621 mRNA. Translation: AAB87763.2.
    AY319413 mRNA. Translation: AAP83846.1. Sequence problems.
    AY594282 mRNA. Translation: AAT02479.1.
    AC113151 Genomic DNA. Translation: AAY40966.1. Sequence problems.
    BC007732 mRNA. Translation: AAH07732.1.
    BC016949 mRNA. Translation: AAH16949.1.
    BC022981 mRNA. Translation: AAH22981.1.
    CCDSiCCDS3465.1.
    RefSeqiNP_006336.3. NM_006345.3.
    UniGeneiHs.479634.

    Genome annotation databases

    EnsembliENST00000264451; ENSP00000264451; ENSG00000014824.
    GeneIDi10463.
    KEGGihsa:10463.
    UCSCiuc003gwl.3. human.

    Polymorphism databases

    DMDMi74722746.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF006621 mRNA. Translation: AAB87763.2 .
    AY319413 mRNA. Translation: AAP83846.1 . Sequence problems.
    AY594282 mRNA. Translation: AAT02479.1 .
    AC113151 Genomic DNA. Translation: AAY40966.1 . Sequence problems.
    BC007732 mRNA. Translation: AAH07732.1 .
    BC016949 mRNA. Translation: AAH16949.1 .
    BC022981 mRNA. Translation: AAH22981.1 .
    CCDSi CCDS3465.1.
    RefSeqi NP_006336.3. NM_006345.3.
    UniGenei Hs.479634.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2ENK NMR - A 124-217 [» ]
    ProteinModelPortali Q6PML9.
    SMRi Q6PML9. Positions 124-217, 252-484.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115726. 3 interactions.
    IntActi Q6PML9. 3 interactions.
    STRINGi 9606.ENSP00000264451.

    Protein family/group databases

    TCDBi 2.A.4.6.1. the cation diffusion facilitator (cdf) family.

    PTM databases

    PhosphoSitei Q6PML9.

    Polymorphism databases

    DMDMi 74722746.

    Proteomic databases

    MaxQBi Q6PML9.
    PaxDbi Q6PML9.
    PRIDEi Q6PML9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264451 ; ENSP00000264451 ; ENSG00000014824 .
    GeneIDi 10463.
    KEGGi hsa:10463.
    UCSCi uc003gwl.3. human.

    Organism-specific databases

    CTDi 10463.
    GeneCardsi GC04P041992.
    H-InvDB HIX0004181.
    HGNCi HGNC:1329. SLC30A9.
    HPAi HPA004014.
    MIMi 604604. gene.
    neXtProti NX_Q6PML9.
    PharmGKBi PA25909.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0053.
    HOGENOMi HOG000242618.
    HOVERGENi HBG104893.
    InParanoidi Q6PML9.
    KOi K14696.
    OMAi PKYTQNN.
    OrthoDBi EOG7PCJHN.
    PhylomeDBi Q6PML9.
    TreeFami TF314526.

    Miscellaneous databases

    ChiTaRSi SLC30A9. human.
    EvolutionaryTracei Q6PML9.
    GenomeRNAii 10463.
    NextBioi 39677.
    PROi Q6PML9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6PML9.
    Bgeei Q6PML9.
    CleanExi HS_SLC30A9.
    Genevestigatori Q6PML9.

    Family and domain databases

    Gene3Di 1.20.1510.10. 1 hit.
    3.90.530.10. 1 hit.
    InterProi IPR002524. Cation_efflux.
    IPR027469. Cation_efflux_TMD.
    IPR009061. DNA-bd_dom_put.
    IPR022656. XPA_C.
    [Graphical view ]
    Pfami PF01545. Cation_efflux. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46955. SSF46955. 1 hit.
    TIGRFAMsi TIGR01297. CDF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The novel human HUEL (C4orf1) gene maps to chromosome 4p12-p13 and encodes a nuclear protein containing the nuclear receptor interaction motif."
      Sim D.L.C., Chow V.T.K.
      Genomics 59:224-233(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANTS VAL-50 AND ALA-97.
      Tissue: Lung.
    2. Chow V.T.K., Sim D.L.C.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 160; 174 AND 196.
      Tissue: Lung.
    3. "A human HUEL (C4orf1) isoform play the role in spermatogenesis."
      Xu Z.Y., Huang X.Y., Xu M., Yin L.L., Lu L., Li J.M., Zhou Z.M., Sha J.H.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS VAL-50 AND ALA-97.
      Tissue: Testis.
    4. Luo W., Sedehizade F., Hanck T., Reiser G.
      Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-50 AND ALA-97.
      Tissue: Cervix, Colon and Muscle.
    7. "Solution structure of a putative DNA-binding domain of the human solute carrier family 30 (zinc transporter) protein."
      RIKEN structural genomics initiative (RSGI)
      Submitted (FEB-2009) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 124-217.

    Entry informationi

    Entry nameiZNT9_HUMAN
    AccessioniPrimary (citable) accession number: Q6PML9
    Secondary accession number(s): Q4W5B6
    , Q7Z5I7, Q8TBB2, Q9Y6R2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3