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Protein

Zinc transporter 9

Gene

SLC30A9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the p160 coactivator signaling pathway that mediates transcriptional activation by nuclear receptors. Plays a role in transcriptional activation of Wnt-responsive genes.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transcription, Transcription regulation, Transport, Zinc transport

Keywords - Ligandi

Zinc

Protein family/group databases

TCDBi2.A.4.6.1. the cation diffusion facilitator (cdf) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 9
Short name:
ZnT-9
Alternative name(s):
Human embryonic lung protein
Short name:
HuEL
Solute carrier family 30 member 9
Gene namesi
Name:SLC30A9
Synonyms:C4orf1, HUEL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:1329. SLC30A9.

Subcellular locationi

  • Membrane Curated; Multi-pass membrane protein Curated
  • Nucleus 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei239 – 25921HelicalSequence AnalysisAdd
BLAST
Transmembranei314 – 33421HelicalSequence AnalysisAdd
BLAST
Transmembranei342 – 36221HelicalSequence AnalysisAdd
BLAST
Transmembranei392 – 41221HelicalSequence AnalysisAdd
BLAST
Transmembranei424 – 44421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • cytoskeleton Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25909.

Polymorphism and mutation databases

BioMutaiSLC30A9.
DMDMi74722746.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568Zinc transporter 9PRO_0000295805Add
BLAST

Proteomic databases

MaxQBiQ6PML9.
PaxDbiQ6PML9.
PRIDEiQ6PML9.

PTM databases

PhosphoSiteiQ6PML9.

Expressioni

Tissue specificityi

Ubiquitously expressed in fetal and adult tissues and cancer cell lines.1 Publication

Gene expression databases

BgeeiQ6PML9.
CleanExiHS_SLC30A9.
ExpressionAtlasiQ6PML9. baseline and differential.
GenevisibleiQ6PML9. HS.

Organism-specific databases

HPAiHPA004014.

Interactioni

Subunit structurei

Interacts with GRIP1, ESR1 and AR.By similarity

Protein-protein interaction databases

BioGridi115726. 4 interactions.
IntActiQ6PML9. 3 interactions.
STRINGi9606.ENSP00000264451.

Structurei

Secondary structure

1
568
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi129 – 1324Combined sources
Helixi133 – 1397Combined sources
Helixi144 – 1496Combined sources
Beta strandi167 – 1693Combined sources
Helixi170 – 18011Combined sources
Beta strandi181 – 1833Combined sources
Helixi184 – 20926Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ENKNMR-A124-217[»]
ProteinModelPortaliQ6PML9.
SMRiQ6PML9. Positions 124-217, 252-484.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6PML9.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi462 – 4665LXXLL motif

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0053.
GeneTreeiENSGT00390000008346.
HOGENOMiHOG000242618.
HOVERGENiHBG104893.
InParanoidiQ6PML9.
KOiK14696.
OMAiFKLLAWV.
OrthoDBiEOG7PCJHN.
PhylomeDBiQ6PML9.
TreeFamiTF314526.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
3.90.530.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
IPR009061. DNA-bd_dom_put.
IPR022656. XPA_C.
[Graphical view]
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6PML9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPGLAAAAA HRCSWSSLCR LRLRCRAAAC NPSDRQEWQN LVTFGSFSNM
60 70 80 90 100
VPCSHPYIGT LSQVKLYSTN VQKEGQGSQT LRVEKVPSFE TAEGIGTELK
110 120 130 140 150
APLKQEPLQV RVKAVLKKRE YGSKYTQNNF ITGVRAINEF CLKSSDLEQL
160 170 180 190 200
RKIRRRSPHE DTESFTVYLR SDVEAKSLEV WGSPEALARE KKLRKEAEIE
210 220 230 240 250
YRERLFRNQK ILREYRDFLG NTKPRSRTAS VFFKGPGKVV MVAICINGLN
260 270 280 290 300
CFFKFLAWIY TGSASMFSEA IHSLSDTCNQ GLLALGISKS VQTPDPSHPY
310 320 330 340 350
GFSNMRYISS LISGVGIFMM GAGLSWYHGV MGLLHPQPIE SLLWAYCILA
360 370 380 390 400
GSLVSEGATL LVAVNELRRN ARAKGMSFYK YVMESRDPST NVILLEDTAA
410 420 430 440 450
VLGVIIAATC MGLTSITGNP LYDSLGSLGV GTLLGMVSAF LIYTNTEALL
460 470 480 490 500
GRSIQPEQVQ RLTELLENDP SVRAIHDVKA TDLGLGKVRF KAEVDFDGRV
510 520 530 540 550
VTRSYLEKQD FDQMLQEIQE VKTPEELETF MLKHGENIID TLGAEVDRLE
560
KELKKRNPEV RHVDLEIL
Length:568
Mass (Da):63,515
Last modified:July 5, 2004 - v1
Checksum:iCA59839CA983FDC2
GO

Sequence cautioni

The sequence AAP83846.1 differs from that shown.Unlikely isoform. Aberrant splice sites.Curated
The sequence AAY40966.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti141 – 1411C → Y in AAP83846 (Ref. 3) Curated
Sequence conflicti356 – 3561E → V in AAP83846 (Ref. 3) Curated
Sequence conflicti401 – 4011V → A in AAH22981 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti50 – 501M → V.3 Publications
Corresponds to variant rs1047626 [ dbSNP | Ensembl ].
VAR_052003
Natural varianti97 – 971T → A.3 Publications
Corresponds to variant rs2581423 [ dbSNP | Ensembl ].
VAR_052004
Natural varianti353 – 3531L → S.
Corresponds to variant rs1801962 [ dbSNP | Ensembl ].
VAR_052005

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006621 mRNA. Translation: AAB87763.2.
AY319413 mRNA. Translation: AAP83846.1. Sequence problems.
AY594282 mRNA. Translation: AAT02479.1.
AC113151 Genomic DNA. Translation: AAY40966.1. Sequence problems.
BC007732 mRNA. Translation: AAH07732.1.
BC016949 mRNA. Translation: AAH16949.1.
BC022981 mRNA. Translation: AAH22981.1.
CCDSiCCDS3465.1.
RefSeqiNP_006336.3. NM_006345.3.
UniGeneiHs.479634.

Genome annotation databases

EnsembliENST00000264451; ENSP00000264451; ENSG00000014824.
GeneIDi10463.
KEGGihsa:10463.
UCSCiuc003gwl.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006621 mRNA. Translation: AAB87763.2.
AY319413 mRNA. Translation: AAP83846.1. Sequence problems.
AY594282 mRNA. Translation: AAT02479.1.
AC113151 Genomic DNA. Translation: AAY40966.1. Sequence problems.
BC007732 mRNA. Translation: AAH07732.1.
BC016949 mRNA. Translation: AAH16949.1.
BC022981 mRNA. Translation: AAH22981.1.
CCDSiCCDS3465.1.
RefSeqiNP_006336.3. NM_006345.3.
UniGeneiHs.479634.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ENKNMR-A124-217[»]
ProteinModelPortaliQ6PML9.
SMRiQ6PML9. Positions 124-217, 252-484.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115726. 4 interactions.
IntActiQ6PML9. 3 interactions.
STRINGi9606.ENSP00000264451.

Protein family/group databases

TCDBi2.A.4.6.1. the cation diffusion facilitator (cdf) family.

PTM databases

PhosphoSiteiQ6PML9.

Polymorphism and mutation databases

BioMutaiSLC30A9.
DMDMi74722746.

Proteomic databases

MaxQBiQ6PML9.
PaxDbiQ6PML9.
PRIDEiQ6PML9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264451; ENSP00000264451; ENSG00000014824.
GeneIDi10463.
KEGGihsa:10463.
UCSCiuc003gwl.3. human.

Organism-specific databases

CTDi10463.
GeneCardsiGC04P041992.
H-InvDBHIX0004181.
HGNCiHGNC:1329. SLC30A9.
HPAiHPA004014.
MIMi604604. gene.
neXtProtiNX_Q6PML9.
PharmGKBiPA25909.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0053.
GeneTreeiENSGT00390000008346.
HOGENOMiHOG000242618.
HOVERGENiHBG104893.
InParanoidiQ6PML9.
KOiK14696.
OMAiFKLLAWV.
OrthoDBiEOG7PCJHN.
PhylomeDBiQ6PML9.
TreeFamiTF314526.

Miscellaneous databases

ChiTaRSiSLC30A9. human.
EvolutionaryTraceiQ6PML9.
GenomeRNAii10463.
NextBioi39677.
PROiQ6PML9.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PML9.
CleanExiHS_SLC30A9.
ExpressionAtlasiQ6PML9. baseline and differential.
GenevisibleiQ6PML9. HS.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
3.90.530.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
IPR009061. DNA-bd_dom_put.
IPR022656. XPA_C.
[Graphical view]
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
TIGRFAMsiTIGR01297. CDF. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The novel human HUEL (C4orf1) gene maps to chromosome 4p12-p13 and encodes a nuclear protein containing the nuclear receptor interaction motif."
    Sim D.L.C., Chow V.T.K.
    Genomics 59:224-233(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANTS VAL-50 AND ALA-97.
    Tissue: Lung.
  2. Chow V.T.K., Sim D.L.C.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 160; 174 AND 196.
    Tissue: Lung.
  3. "A human HUEL (C4orf1) isoform play the role in spermatogenesis."
    Xu Z.Y., Huang X.Y., Xu M., Yin L.L., Lu L., Li J.M., Zhou Z.M., Sha J.H.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS VAL-50 AND ALA-97.
    Tissue: Testis.
  4. Luo W., Sedehizade F., Hanck T., Reiser G.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-50 AND ALA-97.
    Tissue: Cervix, Colon and Muscle.
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  8. "Solution structure of a putative DNA-binding domain of the human solute carrier family 30 (zinc transporter) protein."
    RIKEN structural genomics initiative (RSGI)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 124-217.

Entry informationi

Entry nameiZNT9_HUMAN
AccessioniPrimary (citable) accession number: Q6PML9
Secondary accession number(s): Q4W5B6
, Q7Z5I7, Q8TBB2, Q9Y6R2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 5, 2004
Last modified: July 22, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.