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Q6PLK3

- AOFB_PIG

UniProt

Q6PLK3 - AOFB_PIG

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Protein
Amine oxidase [flavin-containing] B
Gene
MAOB
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine By similarity.

Catalytic activityi

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Cofactori

FAD By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei156 – 1561Important for catalytic activity By similarity
Sitei365 – 3651Important for catalytic activity By similarity
Sitei382 – 3821Important for catalytic activity By similarity

GO - Molecular functioni

  1. oxidoreductase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Amine oxidase [flavin-containing] B (EC:1.4.3.4)
Alternative name(s):
Monoamine oxidase type B
Short name:
MAO-B
Gene namesi
Name:MAOB
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 489488Cytoplasmic By similarity
Add
BLAST
Transmembranei490 – 51627Helical; Anchor for type IV membrane protein; By similarity
Add
BLAST
Topological domaini517 – 5204Mitochondrial intermembrane By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 520519Amine oxidase [flavin-containing] B
PRO_0000099861Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Modified residuei52 – 521N6-acetyllysine By similarity
Modified residuei397 – 3971S-8alpha-FAD cysteine By similarity

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ6PLK3.
SMRiQ6PLK3. Positions 4-499.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi36 – 5217Arg/Lys-rich (basic)
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004255.
KOiK00274.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00757. AMINEOXDASEF.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6PLK3-1 [UniParc]FASTAAdd to Basket

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MSSKCDVVVV GGGISGMAAA KLLHDSGLNV IVLEARDRVG GRTYTVRNQQ    50
VKYVDLGGSY VGPTQNRILR LSKELGLETY KVNEVERLIH YVKGKSYPFR 100
GPLPPVRNPI TFLDLNNLWR TVDDMGREIP SDAPWKAPLA EQWDQMTMKE 150
LLDKLCWTES SKQLATLFVN LCVTAETHEV SALWFLWYVK QCGGTTRIIS 200
TTNGGQERKF VGGSGQVTER IKDLLGDRVK LERPVVHIDQ TGENVLVETL 250
NHEVYEAKYV ISAIPPVLGM KIHFSPPLPM MRNQLITRVP LGSVIKCIVY 300
YKEPFWRHKD YCGSMIIEGE EAPIAYTLDD SKPDGSCAAI IGFILAHKAR 350
KLARLTKEER LKKLCDLYAK VLGSKEALNP VHYEEKNWCE EQYSAGCYTT 400
YFPPGIMTQY GRVLRQPVGR IYFAGTETAT HWSGYMEGAV EAGERAAREI 450
LHAMGKIPED EIWQSEPESV DVPAKPITTT FLERHLPSVP GLLRLIGLTA 500
IFSATALGYL AHKRGLLVRV 520
Length:520
Mass (Da):58,265
Last modified:January 23, 2007 - v3
Checksum:i18106D07B6151357
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY596820 mRNA. Translation: AAT06259.1.
RefSeqiNP_001001864.1. NM_001001864.1.
UniGeneiSsc.7297.

Genome annotation databases

GeneIDi414909.
KEGGissc:414909.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY596820 mRNA. Translation: AAT06259.1 .
RefSeqi NP_001001864.1. NM_001001864.1.
UniGenei Ssc.7297.

3D structure databases

ProteinModelPortali Q6PLK3.
SMRi Q6PLK3. Positions 4-499.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 414909.
KEGGi ssc:414909.

Organism-specific databases

CTDi 4129.

Phylogenomic databases

HOVERGENi HBG004255.
KOi K00274.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01593. Amino_oxidase. 1 hit.
[Graphical view ]
PRINTSi PR00757. AMINEOXDASEF.
ProtoNeti Search...

Publicationsi

  1. "Cloning of the porcine MAO-A and -B gene."
    Bai C.Y., Zhao W., Meng H., Pan Y.C.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiAOFB_PIG
AccessioniPrimary (citable) accession number: Q6PLK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: January 23, 2007
Last modified: March 19, 2014
This is version 62 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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