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Protein

Protein TMED8

Gene

TMED8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TMED8
Gene namesi
Name:TMED8
Synonyms:FAM15B
ORF Names:L10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:18633. TMED8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134948632.

Polymorphism and mutation databases

BioMutaiTMED8.
DMDMi62287887.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Protein TMED8PRO_0000055638Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei169 – 1691N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ6PL24.
MaxQBiQ6PL24.
PaxDbiQ6PL24.
PRIDEiQ6PL24.

PTM databases

iPTMnetiQ6PL24.
PhosphoSiteiQ6PL24.

Expressioni

Gene expression databases

BgeeiQ6PL24.
CleanExiHS_TMED8.
GenevisibleiQ6PL24. HS.

Organism-specific databases

HPAiHPA001205.

Interactioni

Protein-protein interaction databases

BioGridi129608. 7 interactions.
IntActiQ6PL24. 1 interaction.
STRINGi9606.ENSP00000216468.

Structurei

3D structure databases

ProteinModelPortaliQ6PL24.
SMRiQ6PL24. Positions 173-324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini159 – 323165GOLDPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi242 – 25413Poly-GluAdd
BLAST

Sequence similaritiesi

Contains 1 GOLD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3878. Eukaryota.
ENOG410XS5V. LUCA.
GeneTreeiENSGT00530000063651.
HOGENOMiHOG000136725.
HOVERGENiHBG059866.
InParanoidiQ6PL24.
OMAiIWTFAKM.
OrthoDBiEOG7KDFB4.
PhylomeDBiQ6PL24.
TreeFamiTF321667.

Family and domain databases

InterProiIPR009038. GOLD_dom.
[Graphical view]
PfamiPF13897. GOLD_2. 1 hit.
[Graphical view]
SUPFAMiSSF101576. SSF101576. 2 hits.
PROSITEiPS50866. GOLD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PL24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLQAAEGP GSWSPTARPG SAGGVGDCQG VEGSQAAASE NEDLENKDTS
60 70 80 90 100
LLASATDPEP CSSPHRPQMV SPVSKDATED LRKATGPLEA QALVKQDLLP
110 120 130 140 150
ADQAQVLNEM AKYQVPQRSG DIVMIQSEHT GAIDVLSADL ESADLLGDHR
160 170 180 190 200
KVSPPLMAPP CIWTFAKVKE FKSKLGKEKN SRLVVKRGEV VTIRVPTHPE
210 220 230 240 250
GKRVCWEFAT DDYDIGFGVY FDWTPVTSTD ITVQVSDSSD DEDEEEEEEE
260 270 280 290 300
EIEEPVPAGD VERGSRSSLR GRYGEVMPVY RRDSHRDVQA GSHDYPGEGI
310 320
YLLKFDNSYS LLRNKTLYFH IYYTS
Length:325
Mass (Da):35,740
Last modified:July 5, 2004 - v1
Checksum:i5E4880F39E5145E9
GO

Sequence cautioni

The sequence AAF62560.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51Q → K.
Corresponds to variant rs3742737 [ dbSNP | Ensembl ].
VAR_049112

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598329 mRNA. Translation: AAT06740.1.
AK095650 mRNA. Translation: BAG53098.1.
AC007954 Genomic DNA. Translation: AAF62560.1. Sequence problems.
BC101510 mRNA. Translation: AAI01511.1.
CCDSiCCDS32125.1.
RefSeqiNP_998766.1. NM_213601.1.
XP_005267601.1. XM_005267544.3.
UniGeneiHs.200413.
Hs.26403.

Genome annotation databases

EnsembliENST00000216468; ENSP00000216468; ENSG00000100580.
GeneIDi283578.
KEGGihsa:283578.
UCSCiuc001xto.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598329 mRNA. Translation: AAT06740.1.
AK095650 mRNA. Translation: BAG53098.1.
AC007954 Genomic DNA. Translation: AAF62560.1. Sequence problems.
BC101510 mRNA. Translation: AAI01511.1.
CCDSiCCDS32125.1.
RefSeqiNP_998766.1. NM_213601.1.
XP_005267601.1. XM_005267544.3.
UniGeneiHs.200413.
Hs.26403.

3D structure databases

ProteinModelPortaliQ6PL24.
SMRiQ6PL24. Positions 173-324.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129608. 7 interactions.
IntActiQ6PL24. 1 interaction.
STRINGi9606.ENSP00000216468.

PTM databases

iPTMnetiQ6PL24.
PhosphoSiteiQ6PL24.

Polymorphism and mutation databases

BioMutaiTMED8.
DMDMi62287887.

Proteomic databases

EPDiQ6PL24.
MaxQBiQ6PL24.
PaxDbiQ6PL24.
PRIDEiQ6PL24.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216468; ENSP00000216468; ENSG00000100580.
GeneIDi283578.
KEGGihsa:283578.
UCSCiuc001xto.2. human.

Organism-specific databases

CTDi283578.
GeneCardsiTMED8.
H-InvDBHIX0011847.
HGNCiHGNC:18633. TMED8.
HPAiHPA001205.
neXtProtiNX_Q6PL24.
PharmGKBiPA134948632.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3878. Eukaryota.
ENOG410XS5V. LUCA.
GeneTreeiENSGT00530000063651.
HOGENOMiHOG000136725.
HOVERGENiHBG059866.
InParanoidiQ6PL24.
OMAiIWTFAKM.
OrthoDBiEOG7KDFB4.
PhylomeDBiQ6PL24.
TreeFamiTF321667.

Miscellaneous databases

GenomeRNAii283578.
NextBioi94060.
PROiQ6PL24.

Gene expression databases

BgeeiQ6PL24.
CleanExiHS_TMED8.
GenevisibleiQ6PL24. HS.

Family and domain databases

InterProiIPR009038. GOLD_dom.
[Graphical view]
PfamiPF13897. GOLD_2. 1 hit.
[Graphical view]
SUPFAMiSSF101576. SSF101576. 2 hits.
PROSITEiPS50866. GOLD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer."
    Petroziello J., Yamane A., Westendorf L., Thompson M., McDonagh C., Cerveny C., Law C.-L., Wahl A., Carter P.
    Oncogene 23:7734-7745(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-169, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTMED8_HUMAN
AccessioniPrimary (citable) accession number: Q6PL24
Secondary accession number(s): B3KTI6, Q3MJB0, Q9P1V9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.