Q6PL18 (ATAD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATPase family AAA domain-containing protein 2
EC=3.6.1.3

Alternative name(s):
AAA nuclear coregulator cancer-associated protein
Short name=ANCCA

Gene names

Name:	ATAD2
ORF Names:	L16, PRO2000

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1390 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. Ref.13
Catalytic activity	ATP + H2O = ADP + phosphate.
Subunit structure	Interacts with ESR1 and NCOA3 and these interactions are enhanced by estradiol. Ref.13
Subcellular location	Nucleus Ref.13.
Tissue specificity	Highly expressed in estrogen receptor positive breast tumors and in osteosarcoma tumors. Ref.7 Ref.9 Ref.12
Induction	Up-regulated in breast, uterus, colon, ovary, and stomach tumors. Induced in breast cancer cells overexpressing NCOA3 or treated with estrogen. Down-regulated in 5-fluorouracil-resistant derivatives of the colon cancer cell line HCT116. Ref.1 Ref.10 Ref.13
Sequence similarities	Belongs to the AAA ATPase family. Contains 1 bromo domain.
Sequence caution	The sequence AAF22032.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH10686.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part (676-679). The sequence AAH19909.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Bromodomain Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Activator Hydrolase
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from direct assay. Source: HPA
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6PL18-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6PL18-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-170: Missing.
     551-582: IVSTLLALMDGLDSRGEIVVIGATNRLDSIDP → YGWIGQQRGNCGHWCYEQARFYRSCFTKAWSL
     583-1390: Missing.

Note: No experimental confirmation available. Dubious isoform. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1390

1390

ATPase family AAA domain-containing protein 2

PRO_0000084796

Regions

Domain

1001 – 1071

71

Bromo

Nucleotide binding

467 – 474

8

ATP Potential

Coiled coil

970 – 994

25

Potential

Coiled coil

1086 – 1112

27

Potential

Compositional bias

250 – 285

36

Asp-rich

Compositional bias

357 – 366

10

Poly-Ser

Amino acid modifications

Modified residue

132

1

Phosphoserine Ref.11

Modified residue

170

1

Phosphoserine Ref.17

Modified residue

342

1

Phosphoserine Ref.8

Modified residue

746

1

Phosphoserine Ref.15

Modified residue

751

1

Phosphoserine Ref.6 Ref.15

Modified residue

1149

1

Phosphothreonine Ref.15

Modified residue

1152

1

Phosphothreonine Ref.15

Modified residue

1158

1

Phosphothreonine Ref.15 Ref.16

Modified residue

1243

1

Phosphoserine Ref.8 Ref.16

Modified residue

1302

1

Phosphoserine Ref.14 Ref.15 Ref.17

Natural variations

Alternative sequence

1 – 170

170

Missing in isoform 2.

VSP_015633

Alternative sequence

551 – 582

32

IVSTL…DSIDP → YGWIGQQRGNCGHWCYEQAR FYRSCFTKAWSL in isoform 2.

VSP_015634

Alternative sequence

583 – 1390

808

Missing in isoform 2.

VSP_015635

Natural variant

1280

1

I → T.
Corresponds to variant rs3758122 [ dbSNP | Ensembl ].

VAR_047625

Experimental info

Mutagenesis

473

1

K → T: Reduces the ability to mediate estradiol-dependent induction of CCND1 and E2F1; when associated with Q-532. Ref.13

Mutagenesis

532

1

E → Q: Reduces the ability to mediate estradiol-dependent induction of CCND1 and E2F1; when associated with T-473. Ref.13

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1390

Helix Strand Turn

Details...

Helix

981 – 1001

21

Helix

1004 – 1009

6

Turn

1015 – 1017

3

Helix

1021 – 1024

4

Helix

1031 – 1039

9

Helix

1046 – 1063

18

Helix

1072 – 1092

21

Helix

1095 – 1108

14

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: F43B30C77BB0F4BA	FASTA	1,390	158,554
	10 20 30 40 50 60 MVVLRSSLEL HNHSAASATG SLDLSSDFLS LEHIGRRRLR SAGAAQKKPA ATTAKAGDGS 70 80 90 100 110 120 SVKEVETYHR TRALRSLRKD AQNSSDSSFE KNVEITEQLA NGRHFTRQLA RQQADKKKEE 130 140 150 160 170 180 HREDKVIPVT RSLRARNIVQ STEHLHEDNG DVEVRRSCRI RSRYSGVNQS MLFDKLITNT 190 200 210 220 230 240 AEAVLQKMDD MKKMRRQRMR ELEDLGVFNE TEESNLNMYT RGKQKDIQRT DEETTDNQEG 250 260 270 280 290 300 SVESSEEGED QEHEDDGEDE DDEDDDDDDD DDDDDDDEDD EDEEDGEEEN QKRYYLRQRK 310 320 330 340 350 360 ATVYYQAPLE KPRHQRKPNI FYSGPASPAR PRYRLSSAGP RSPYCKRMNR RRHAIHSSDS 370 380 390 400 410 420 TSSSSSEDEQ HFERRRKRSR NRAINRCLPL NFRKDELKGI YKDRMKIGAS LADVDPMQLD 430 440 450 460 470 480 SSVRFDSVGG LSNHIAALKE MVVFPLLYPE VFEKFKIQPP RGCLFYGPPG TGKTLVARAL 490 500 510 520 530 540 ANECSQGDKR VAFFMRKGAD CLSKWVGESE RQLRLLFDQA YQMRPSIIFF DEIDGLAPVR 550 560 570 580 590 600 SSRQDQIHSS IVSTLLALMD GLDSRGEIVV IGATNRLDSI DPALRRPGRF DREFLFSLPD 610 620 630 640 650 660 KEARKEILKI HTRDWNPKPL DTFLEELAEN CVGYCGADIK SICAEAALCA LRRRYPQIYT 670 680 690 700 710 720 TSEKLQLDLS SINISAKDFE VAMQKMIPAS QRAVTSPGQA LSTVVKPLLQ NTVDKILEAL 730 740 750 760 770 780 QRVFPHAEFR TNKTLDSDIS CPLLESDLAY SDDDVPSVYE NGLSQKSSHK AKDNFNFLHL 790 800 810 820 830 840 NRNACYQPMS FRPRILIVGE PGFGQGSHLA PAVIHALEKF TVYTLDIPVL FGVSTTSPEE 850 860 870 880 890 900 TCAQVIREAK RTAPSIVYVP HIHVWWEIVG PTLKATFTTL LQNIPSFAPV LLLATSDKPH 910 920 930 940 950 960 SALPEEVQEL FIRDYGEIFN VQLPDKEERT KFFEDLILKQ AAKPPISKKK AVLQALEVLP 970 980 990 1000 1010 1020 VAPPPEPRSL TAEEVKRLEE QEEDTFRELR IFLRNVTHRL AIDKRFRVFT KPVDPDEVPD 1030 1040 1050 1060 1070 1080 YVTVIKQPMD LSSVISKIDL HKYLTVKDYL RDIDLICSNA LEYNPDRDPG DRLIRHRACA 1090 1100 1110 1120 1130 1140 LRDTAYAIIK EELDEDFEQL CEEIQESRKK RGCSSSKYAP SYYHVMPKQN STLVGDKRSD 1150 1160 1170 1180 1190 1200 PEQNEKLKTP STPVACSTPA QLKRKIRKKS NWYLGTIKKR RKISQAKDDS QNAIDHKIES 1210 1220 1230 1240 1250 1260 DTEETQDTSV DHNETGNTGE SSVEENEKQQ NASESKLELR NNSNTCNIEN ELEDSRKTTA 1270 1280 1290 1300 1310 1320 CTELRDKIAC NGDASSSQII HISDENEGKE MCVLRMTRAR RSQVEQQQLI TVEKALAILS 1330 1340 1350 1360 1370 1380 QPTPSLVVDH ERLKNLLKTV VKKSQNYNIF QLENLYAVIS QCIYRHRKDH DKTSLIQKME 1390 QEVENFSCSR
	Isoform 2 [UniParc]. Checksum: 24E5F0638207B64A	FASTA	412	47,986
	10 20 30 40 50 60 MLFDKLITNT AEAVLQKMDD MKKMRRQRMR ELEDLGVFNE TEESNLNMYT RGKQKDIQRT 70 80 90 100 110 120 DEETTDNQEG SVESSEEGED QEHEDDGEDE DDEDDDDDDD DDDDDDDEDD EDEEDGEEEN 130 140 150 160 170 180 QKRYYLRQRK ATVYYQAPLE KPRHQRKPNI FYSGPASPAR PRYRLSSAGP RSPYCKRMNR 190 200 210 220 230 240 RRHAIHSSDS TSSSSSEDEQ HFERRRKRSR NRAINRCLPL NFRKDELKGI YKDRMKIGAS 250 260 270 280 290 300 LADVDPMQLD SSVRFDSVGG LSNHIAALKE MVVFPLLYPE VFEKFKIQPP RGCLFYGPPG 310 320 330 340 350 360 TGKTLVARAL ANECSQGDKR VAFFMRKGAD CLSKWVGESE RQLRLLFDQA YQMRPSIIFF 370 380 390 400 410 DEIDGLAPVR SSRQDQIHSS YGWIGQQRGN CGHWCYEQAR FYRSCFTKAW SL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer." Petroziello J., Yamane A., Westendorf L., Thompson M., McDonagh C., Cerveny C., Law C.-L., Wahl A., Carter P. Oncogene 23:7734-7745(2004) [PubMed: 15334068] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 47-1390 (ISOFORM 1). Tissue: Lymph node and Testis.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Cerebellum, Cervix and Eye.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-978 (ISOFORM 1). Tissue: Spleen.
[5]	"Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs." Yu Y., Zhang C., Zhou G., Wu S., Qu X., Wei H., Xing G., Dong C., Zhai Y., Wan J., Ouyang S., Li L., Zhang S., Zhou K., Zhang Y., Wu C., He F. Genome Res. 11:1392-1403(2001) [PubMed: 11483580] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 813-1390. Tissue: Fetal liver.
[6]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-751, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer." Wang Y., Klijn J.G., Zhang Y., Sieuwerts A.M., Look M.P., Yang F., Talantov D., Timmermans M., Meijer-van Gelder M.E., Yu J., Jatkoe T., Berns E.M.J.J., Atkins D., Foekens J.A. Lancet 365:671-679(2005) [PubMed: 15721472] [Abstract] Cited for: TISSUE SPECIFICITY.
[8]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342 AND SER-1243, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"A consensus prognostic gene expression classifier for ER positive breast cancer." Teschendorff A.E., Naderi A., Barbosa-Morais N.L., Pinder S.E., Ellis I.O., Aparicio S., Brenton J.D., Caldas C. Genome Biol. 7:R101.1-R101.13(2006) [PubMed: 17076897] [Abstract] Cited for: TISSUE SPECIFICITY.
[10]	"Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery." De Angelis P.M., Svendsrud D.H., Kravik K.L., Stokke T. Mol. Cancer 5:20-20(2006) [PubMed: 16709241] [Abstract] Cited for: INDUCTION.
[11]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Prognostic significance of drug-regulated genes in high-grade osteosarcoma." Fellenberg J., Bernd L., Delling G., Witte D., Zahlten-Hinguranage A. Mod. Pathol. 20:1085-1094(2007) [PubMed: 17660802] [Abstract] Cited for: TISSUE SPECIFICITY.
[13]	"ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification." Zou J.X., Revenko A.S., Li L.B., Gemo A.T., Chen H.-W. Proc. Natl. Acad. Sci. U.S.A. 104:18067-18072(2007) [PubMed: 17998543] [Abstract] Cited for: FUNCTION, INTERACTION WITH ESR1 AND NCOA3, SUBCELLULAR LOCATION, INDUCTION, MUTAGENESIS OF LYS-473 AND GLU-532.
[14]	"Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis." Wang B., Malik R., Nigg E.A., Korner R. Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1302, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[15]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-746; SER-751; THR-1149; THR-1152; THR-1158 AND SER-1302, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[16]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1158 AND SER-1243, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[17]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-170 AND SER-1302, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[18]	"Crystal structure of the bromodomain of the human ATAD2." Structural genomics consortium (SGC) Submitted (FEB-2009) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 981-1108.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY598335 mRNA. Translation: AAT06746.1.
CR749832 mRNA. Translation: CAH18688.1.
AL833653 mRNA. Translation: CAH56229.1.
BC010686 mRNA. Translation: AAH10686.1. Sequence problems.
BC019909 mRNA. Translation: AAH19909.1. Different initiation.
BC113656 mRNA. Translation: AAI13657.1.
AK097133 mRNA. Translation: BAC04959.1.
AF118088 mRNA. Translation: AAF22032.1. Different initiation.

IPI

IPI00170548.
IPI00470801.

RefSeq

NP_054828.2. NM_014109.3.

UniGene

Hs.370834.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3DAI	X-ray	1.95	A	981-1108	[»]

ProteinModelPortal

Q6PL18.

SMR

Q6PL18. Positions 420-727, 794-862, 981-1108.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-46197N.

STRING

Q6PL18.

PTM databases

PhosphoSite

Q6PL18.

Polymorphism databases

DMDM

74762365.

Proteomic databases

PRIDE

Q6PL18.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000287394; ENSP00000287394; ENSG00000156802.

GeneID

29028.

KEGG

hsa:29028.

UCSC

uc003yqh.2. human.

Organism-specific databases

CTD

29028.

GeneCards

GC08M124401.

H-InvDB

HIX0007764.

HGNC

HGNC:30123. ATAD2.

HPA

HPA019860.
HPA029424.

MIM

611941. gene.

neXtProt

NX_Q6PL18.

PharmGKB

PA134895566.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG08683.

GeneTree

ENSGT00550000074694.

HOVERGEN

HBG080873.

InParanoid

Q6PL18.

OMA

MNRRRHA.

OrthoDB

EOG441Q9S.

PhylomeDB

Q6PL18.

Gene expression databases

ArrayExpress

Q6PL18.

Bgee

Q6PL18.

CleanEx

HS_ATAD2.

Genevestigator

Q6PL18.

GermOnline

ENSG00000156802. Homo sapiens.

Family and domain databases

InterPro

IPR003593. ATPase_AAA+_core.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR001487. Bromodomain.
[Graphical view]

Gene3D

G3DSA:1.20.920.10. Bromodomain. 1 hit.

Pfam

PF00004. AAA. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view]

PRINTS

PR00503. BROMODOMAIN.

SMART

SM00382. AAA. 1 hit.
SM00297. BROMO. 1 hit.
[Graphical view]

SUPFAM

SSF47370. Bromodomain. 1 hit.

PROSITE

PS00674. AAA. 1 hit.
PS00633. BROMODOMAIN_1. False negative.
PS50014. BROMODOMAIN_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

51959.

SOURCE

Search...

Entry information

Entry name

ATAD2_HUMAN

Accession

Primary (citable) accession number: Q6PL18
Secondary accession number(s): Q14CR1 , Q658P2, Q68CQ0, Q6PJV6, Q8N890, Q9UHS5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.