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Q6PL18

- ATAD2_HUMAN

UniProt

Q6PL18 - ATAD2_HUMAN

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Protein
ATPase family AAA domain-containing protein 2
Gene
ATAD2, L16, PRO2000
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.1 Publication

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi467 – 4748ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATPase activity Source: UniProt
Complete GO annotation...

GO - Biological processi

  1. ATP catabolic process Source: UniProt
  2. positive regulation of transcription, DNA-templated Source: UniProt
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Hydrolase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase family AAA domain-containing protein 2 (EC:3.6.1.3)
Alternative name(s):
AAA nuclear coregulator cancer-associated protein
Short name:
ANCCA
Gene namesi
Name:ATAD2
ORF Names:L16, PRO2000
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:30123. ATAD2.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi473 – 4731K → T: Reduces the ability to mediate estradiol-dependent induction of CCND1 and E2F1; when associated with Q-532. 1 Publication
Mutagenesisi532 – 5321E → Q: Reduces the ability to mediate estradiol-dependent induction of CCND1 and E2F1; when associated with T-473. 1 Publication

Organism-specific databases

PharmGKBiPA134895566.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13901390ATPase family AAA domain-containing protein 2
PRO_0000084796Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei170 – 1701Phosphoserine1 Publication
Modified residuei327 – 3271Phosphoserine2 Publications
Modified residuei337 – 3371Phosphoserine1 Publication
Modified residuei746 – 7461Phosphoserine1 Publication
Modified residuei751 – 7511Phosphoserine1 Publication
Modified residuei1149 – 11491Phosphothreonine1 Publication
Modified residuei1152 – 11521Phosphothreonine1 Publication
Modified residuei1233 – 12331Phosphoserine1 Publication
Modified residuei1302 – 13021Phosphoserine3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6PL18.
PaxDbiQ6PL18.
PRIDEiQ6PL18.

PTM databases

PhosphoSiteiQ6PL18.

Expressioni

Tissue specificityi

Highly expressed in estrogen receptor positive breast tumors and in osteosarcoma tumors.3 Publications

Inductioni

Up-regulated in breast, uterus, colon, ovary, and stomach tumors. Induced in breast cancer cells overexpressing NCOA3 or treated with estrogen. Down-regulated in 5-fluorouracil-resistant derivatives of the colon cancer cell line HCT 116.3 Publications

Gene expression databases

ArrayExpressiQ6PL18.
BgeeiQ6PL18.
CleanExiHS_ATAD2.
GenevestigatoriQ6PL18.

Organism-specific databases

HPAiCAB056158.
HPA019860.
HPA029424.

Interactioni

Subunit structurei

Interacts with ESR1 and NCOA3 and these interactions are enhanced by estradiol. Interacts with acetylated lysine residues on histone H1.4, H2A, H2B and H3 (in vitro).2 Publications

Protein-protein interaction databases

BioGridi118827. 13 interactions.
DIPiDIP-46197N.
IntActiQ6PL18. 1 interaction.
STRINGi9606.ENSP00000287394.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi981 – 100121
Helixi1004 – 10096
Turni1015 – 10173
Helixi1021 – 10244
Helixi1031 – 10399
Helixi1046 – 106318
Beta strandi1066 – 10683
Helixi1069 – 109224
Helixi1095 – 110713

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DAIX-ray1.95A981-1108[»]
ProteinModelPortaliQ6PL18.
SMRiQ6PL18. Positions 981-1108.

Miscellaneous databases

EvolutionaryTraceiQ6PL18.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1001 – 107171Bromo
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili970 – 99425 Reviewed prediction
Add
BLAST
Coiled coili1086 – 111227 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi250 – 28536Asp-rich
Add
BLAST
Compositional biasi357 – 36610Poly-Ser

Sequence similaritiesi

Belongs to the AAA ATPase family.
Contains 1 bromo domain.

Keywords - Domaini

Bromodomain, Coiled coil

Phylogenomic databases

eggNOGiCOG0464.
HOVERGENiHBG080873.
InParanoidiQ6PL18.
OMAiPSVYENG.
OrthoDBiEOG76X5ZF.
PhylomeDBiQ6PL18.
TreeFamiTF314783.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
1.25.10.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011989. ARM-like.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR001487. Bromodomain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00382. AAA. 1 hit.
SM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEiPS00674. AAA. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6PL18-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVVLRSSLEL HNHSAASATG SLDLSSDFLS LEHIGRRRLR SAGAAQKKPA     50
ATTAKAGDGS SVKEVETYHR TRALRSLRKD AQNSSDSSFE KNVEITEQLA 100
NGRHFTRQLA RQQADKKKEE HREDKVIPVT RSLRARNIVQ STEHLHEDNG 150
DVEVRRSCRI RSRYSGVNQS MLFDKLITNT AEAVLQKMDD MKKMRRQRMR 200
ELEDLGVFNE TEESNLNMYT RGKQKDIQRT DEETTDNQEG SVESSEEGED 250
QEHEDDGEDE DDEDDDDDDD DDDDDDDEDD EDEEDGEEEN QKRYYLRQRK 300
ATVYYQAPLE KPRHQRKPNI FYSGPASPAR PRYRLSSAGP RSPYCKRMNR 350
RRHAIHSSDS TSSSSSEDEQ HFERRRKRSR NRAINRCLPL NFRKDELKGI 400
YKDRMKIGAS LADVDPMQLD SSVRFDSVGG LSNHIAALKE MVVFPLLYPE 450
VFEKFKIQPP RGCLFYGPPG TGKTLVARAL ANECSQGDKR VAFFMRKGAD 500
CLSKWVGESE RQLRLLFDQA YQMRPSIIFF DEIDGLAPVR SSRQDQIHSS 550
IVSTLLALMD GLDSRGEIVV IGATNRLDSI DPALRRPGRF DREFLFSLPD 600
KEARKEILKI HTRDWNPKPL DTFLEELAEN CVGYCGADIK SICAEAALCA 650
LRRRYPQIYT TSEKLQLDLS SINISAKDFE VAMQKMIPAS QRAVTSPGQA 700
LSTVVKPLLQ NTVDKILEAL QRVFPHAEFR TNKTLDSDIS CPLLESDLAY 750
SDDDVPSVYE NGLSQKSSHK AKDNFNFLHL NRNACYQPMS FRPRILIVGE 800
PGFGQGSHLA PAVIHALEKF TVYTLDIPVL FGVSTTSPEE TCAQVIREAK 850
RTAPSIVYVP HIHVWWEIVG PTLKATFTTL LQNIPSFAPV LLLATSDKPH 900
SALPEEVQEL FIRDYGEIFN VQLPDKEERT KFFEDLILKQ AAKPPISKKK 950
AVLQALEVLP VAPPPEPRSL TAEEVKRLEE QEEDTFRELR IFLRNVTHRL 1000
AIDKRFRVFT KPVDPDEVPD YVTVIKQPMD LSSVISKIDL HKYLTVKDYL 1050
RDIDLICSNA LEYNPDRDPG DRLIRHRACA LRDTAYAIIK EELDEDFEQL 1100
CEEIQESRKK RGCSSSKYAP SYYHVMPKQN STLVGDKRSD PEQNEKLKTP 1150
STPVACSTPA QLKRKIRKKS NWYLGTIKKR RKISQAKDDS QNAIDHKIES 1200
DTEETQDTSV DHNETGNTGE SSVEENEKQQ NASESKLELR NNSNTCNIEN 1250
ELEDSRKTTA CTELRDKIAC NGDASSSQII HISDENEGKE MCVLRMTRAR 1300
RSQVEQQQLI TVEKALAILS QPTPSLVVDH ERLKNLLKTV VKKSQNYNIF 1350
QLENLYAVIS QCIYRHRKDH DKTSLIQKME QEVENFSCSR 1390
Length:1,390
Mass (Da):158,554
Last modified:July 5, 2004 - v1
Checksum:iF43B30C77BB0F4BA
GO
Isoform 2 (identifier: Q6PL18-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-170: Missing.
     551-582: IVSTLLALMDGLDSRGEIVVIGATNRLDSIDP → YGWIGQQRGNCGHWCYEQARFYRSCFTKAWSL
     583-1390: Missing.

Note: No experimental confirmation available. Dubious isoform. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:412
Mass (Da):47,986
Checksum:i24E5F0638207B64A
GO

Sequence cautioni

The sequence AAH10686.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part (676-679).
The sequence AAF22032.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH19909.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1280 – 12801I → T.
Corresponds to variant rs3758122 [ dbSNP | Ensembl ].
VAR_047625

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 170170Missing in isoform 2.
VSP_015633Add
BLAST
Alternative sequencei551 – 58232IVSTL…DSIDP → YGWIGQQRGNCGHWCYEQAR FYRSCFTKAWSL in isoform 2.
VSP_015634Add
BLAST
Alternative sequencei583 – 1390808Missing in isoform 2.
VSP_015635Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY598335 mRNA. Translation: AAT06746.1.
CR749832 mRNA. Translation: CAH18688.1.
AL833653 mRNA. Translation: CAH56229.1.
BC010686 mRNA. Translation: AAH10686.1. Sequence problems.
BC019909 mRNA. Translation: AAH19909.1. Different initiation.
BC113656 mRNA. Translation: AAI13657.1.
AK097133 mRNA. Translation: BAC04959.1.
AF118088 mRNA. Translation: AAF22032.1. Different initiation.
CCDSiCCDS6343.1. [Q6PL18-1]
RefSeqiNP_054828.2. NM_014109.3. [Q6PL18-1]
UniGeneiHs.370834.

Genome annotation databases

EnsembliENST00000287394; ENSP00000287394; ENSG00000156802. [Q6PL18-1]
GeneIDi29028.
KEGGihsa:29028.
UCSCiuc003yqh.4. human. [Q6PL18-1]

Polymorphism databases

DMDMi74762365.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY598335 mRNA. Translation: AAT06746.1 .
CR749832 mRNA. Translation: CAH18688.1 .
AL833653 mRNA. Translation: CAH56229.1 .
BC010686 mRNA. Translation: AAH10686.1 . Sequence problems.
BC019909 mRNA. Translation: AAH19909.1 . Different initiation.
BC113656 mRNA. Translation: AAI13657.1 .
AK097133 mRNA. Translation: BAC04959.1 .
AF118088 mRNA. Translation: AAF22032.1 . Different initiation.
CCDSi CCDS6343.1. [Q6PL18-1 ]
RefSeqi NP_054828.2. NM_014109.3. [Q6PL18-1 ]
UniGenei Hs.370834.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3DAI X-ray 1.95 A 981-1108 [» ]
ProteinModelPortali Q6PL18.
SMRi Q6PL18. Positions 981-1108.
ModBasei Search...

Protein-protein interaction databases

BioGridi 118827. 13 interactions.
DIPi DIP-46197N.
IntActi Q6PL18. 1 interaction.
STRINGi 9606.ENSP00000287394.

Chemistry

ChEMBLi CHEMBL2150837.

PTM databases

PhosphoSitei Q6PL18.

Polymorphism databases

DMDMi 74762365.

Proteomic databases

MaxQBi Q6PL18.
PaxDbi Q6PL18.
PRIDEi Q6PL18.

Protocols and materials databases

DNASUi 29028.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000287394 ; ENSP00000287394 ; ENSG00000156802 . [Q6PL18-1 ]
GeneIDi 29028.
KEGGi hsa:29028.
UCSCi uc003yqh.4. human. [Q6PL18-1 ]

Organism-specific databases

CTDi 29028.
GeneCardsi GC08M124332.
H-InvDB HIX0007764.
HGNCi HGNC:30123. ATAD2.
HPAi CAB056158.
HPA019860.
HPA029424.
MIMi 611941. gene.
neXtProti NX_Q6PL18.
PharmGKBi PA134895566.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0464.
HOVERGENi HBG080873.
InParanoidi Q6PL18.
OMAi PSVYENG.
OrthoDBi EOG76X5ZF.
PhylomeDBi Q6PL18.
TreeFami TF314783.

Miscellaneous databases

ChiTaRSi ATAD2. human.
EvolutionaryTracei Q6PL18.
GenomeRNAii 29028.
NextBioi 51959.
PROi Q6PL18.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6PL18.
Bgeei Q6PL18.
CleanExi HS_ATAD2.
Genevestigatori Q6PL18.

Family and domain databases

Gene3Di 1.20.920.10. 1 hit.
1.25.10.10. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011989. ARM-like.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR001487. Bromodomain.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00004. AAA. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view ]
PRINTSi PR00503. BROMODOMAIN.
SMARTi SM00382. AAA. 1 hit.
SM00297. BROMO. 1 hit.
[Graphical view ]
SUPFAMi SSF47370. SSF47370. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEi PS00674. AAA. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer."
    Petroziello J., Yamane A., Westendorf L., Thompson M., McDonagh C., Cerveny C., Law C.-L., Wahl A., Carter P.
    Oncogene 23:7734-7745(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 47-1390 (ISOFORM 1).
    Tissue: Lymph node and Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cerebellum, Cervix and Eye.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-978 (ISOFORM 1).
    Tissue: Spleen.
  5. "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs."
    Yu Y., Zhang C., Zhou G., Wu S., Qu X., Wei H., Xing G., Dong C., Zhai Y., Wan J., Ouyang S., Li L., Zhang S., Zhou K., Zhang Y., Wu C., He F.
    Genome Res. 11:1392-1403(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 813-1390.
    Tissue: Fetal liver.
  6. "Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer."
    Wang Y., Klijn J.G., Zhang Y., Sieuwerts A.M., Look M.P., Yang F., Talantov D., Timmermans M., Meijer-van Gelder M.E., Yu J., Jatkoe T., Berns E.M.J.J., Atkins D., Foekens J.A.
    Lancet 365:671-679(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "A consensus prognostic gene expression classifier for ER positive breast cancer."
    Teschendorff A.E., Naderi A., Barbosa-Morais N.L., Pinder S.E., Ellis I.O., Aparicio S., Brenton J.D., Caldas C.
    Genome Biol. 7:R101.1-R101.13(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  9. "Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery."
    De Angelis P.M., Svendsrud D.H., Kravik K.L., Stokke T.
    Mol. Cancer 5:20-20(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  10. "Prognostic significance of drug-regulated genes in high-grade osteosarcoma."
    Fellenberg J., Bernd L., Delling G., Witte D., Zahlten-Hinguranage A.
    Mod. Pathol. 20:1085-1094(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  11. "ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification."
    Zou J.X., Revenko A.S., Li L.B., Gemo A.T., Chen H.-W.
    Proc. Natl. Acad. Sci. U.S.A. 104:18067-18072(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ESR1 AND NCOA3, SUBCELLULAR LOCATION, INDUCTION, MUTAGENESIS OF LYS-473 AND GLU-532.
  12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-746; SER-751; THR-1149; THR-1152 AND SER-1302, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-170 AND SER-1302, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-327; SER-337; SER-1233 AND SER-1302, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-327, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 981-1108, SUBUNIT.

Entry informationi

Entry nameiATAD2_HUMAN
AccessioniPrimary (citable) accession number: Q6PL18
Secondary accession number(s): Q14CR1
, Q658P2, Q68CQ0, Q6PJV6, Q8N890, Q9UHS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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