ID   DOK6_HUMAN              Reviewed;         331 AA.
AC   Q6PKX4; A6NNG3; Q4V9S3; Q8WUZ8; Q96HI2; Q96LU2;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   24-JAN-2024, entry version 151.
DE   RecName: Full=Docking protein 6;
DE   AltName: Full=Downstream of tyrosine kinase 6;
GN   Name=DOK6; Synonyms=DOK5L;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH RET, PHOSPHORYLATION
RP   AT TYROSINE RESIDUES, AND TISSUE SPECIFICITY.
RX   PubMed=15286081; DOI=10.1074/jbc.m403726200;
RA   Crowder R.J., Enomoto H., Yang M., Johnson E.M. Jr., Milbrandt J.;
RT   "Dok-6, a novel p62 Dok family member, promotes Ret-mediated neurite
RT   outgrowth.";
RL   J. Biol. Chem. 279:42072-42081(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16177791; DOI=10.1038/nature03983;
RA   Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA   Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA   Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA   Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA   Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA   Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA   Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA   Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 18.";
RL   Nature 437:551-555(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, Eye, and Hippocampus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 33-331.
RC   TISSUE=Cerebellum;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
CC   -!- FUNCTION: DOK proteins are enzymatically inert adaptor or scaffolding
CC       proteins. They provide a docking platform for the assembly of
CC       multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite
CC       growth. May have a role in brain development and/or maintenance.
CC       {ECO:0000269|PubMed:15286081}.
CC   -!- SUBUNIT: Interacts via its PTB domain with phosphorylated RET.
CC       {ECO:0000269|PubMed:15286081}.
CC   -!- INTERACTION:
CC       Q6PKX4; Q8NFV4-4: ABHD11; NbExp=3; IntAct=EBI-2880244, EBI-12318443;
CC       Q6PKX4; Q03989: ARID5A; NbExp=3; IntAct=EBI-2880244, EBI-948603;
CC       Q6PKX4; Q6P1W5: C1orf94; NbExp=3; IntAct=EBI-2880244, EBI-946029;
CC       Q6PKX4; P26998: CRYBB3; NbExp=3; IntAct=EBI-2880244, EBI-1965681;
CC       Q6PKX4; P00533: EGFR; NbExp=2; IntAct=EBI-2880244, EBI-297353;
CC       Q6PKX4; Q9NVL1-2: FAM86C1P; NbExp=3; IntAct=EBI-2880244, EBI-12845222;
CC       Q6PKX4; Q14847-2: LASP1; NbExp=3; IntAct=EBI-2880244, EBI-9088686;
CC       Q6PKX4; Q8TCE9: LGALS14; NbExp=3; IntAct=EBI-2880244, EBI-10274069;
CC       Q6PKX4; Q8N6F8: METTL27; NbExp=3; IntAct=EBI-2880244, EBI-8487781;
CC       Q6PKX4; Q16288: NTRK3; NbExp=3; IntAct=EBI-2880244, EBI-3936704;
CC       Q6PKX4; Q93062: RBPMS; NbExp=3; IntAct=EBI-2880244, EBI-740322;
CC       Q6PKX4; Q9BVN2: RUSC1; NbExp=3; IntAct=EBI-2880244, EBI-6257312;
CC       Q6PKX4; Q6NXT4-4: SLC30A6; NbExp=3; IntAct=EBI-2880244, EBI-13046630;
CC       Q6PKX4; Q96SF7: TBX15; NbExp=3; IntAct=EBI-2880244, EBI-10191361;
CC       Q6PKX4; Q08117-2: TLE5; NbExp=3; IntAct=EBI-2880244, EBI-11741437;
CC       Q6PKX4; Q70EL1-9: USP54; NbExp=3; IntAct=EBI-2880244, EBI-11975223;
CC   -!- TISSUE SPECIFICITY: Highly expressed in fetal and adult brain. Highly
CC       expressed in the cerebellum. Weak expression in kidney, spinal cord and
CC       testis. {ECO:0000269|PubMed:15286081}.
CC   -!- DOMAIN: PTB domain mediates receptor interaction. {ECO:0000250}.
CC   -!- PTM: On Ret activation, phosphorylated on one or more C-terminal
CC       tyrosine residues by an Src family kinase.
CC       {ECO:0000269|PubMed:15286081}.
CC   -!- SIMILARITY: Belongs to the DOK family. Type B subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB71577.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AY599248; AAT09770.1; -; mRNA.
DR   EMBL; AC026585; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471117; EAW66514.1; -; Genomic_DNA.
DR   EMBL; BC008583; AAH08583.3; -; mRNA.
DR   EMBL; BC019045; AAH19045.2; -; mRNA.
DR   EMBL; BC096744; AAH96744.1; -; mRNA.
DR   EMBL; AK057795; BAB71577.1; ALT_INIT; mRNA.
DR   CCDS; CCDS32841.1; -.
DR   RefSeq; NP_689934.2; NM_152721.5.
DR   AlphaFoldDB; Q6PKX4; -.
DR   SMR; Q6PKX4; -.
DR   BioGRID; 128636; 23.
DR   IntAct; Q6PKX4; 20.
DR   MINT; Q6PKX4; -.
DR   STRING; 9606.ENSP00000372160; -.
DR   iPTMnet; Q6PKX4; -.
DR   PhosphoSitePlus; Q6PKX4; -.
DR   BioMuta; DOK6; -.
DR   DMDM; 84029601; -.
DR   MassIVE; Q6PKX4; -.
DR   PaxDb; 9606-ENSP00000372160; -.
DR   PeptideAtlas; Q6PKX4; -.
DR   ProteomicsDB; 67247; -.
DR   Antibodypedia; 23216; 193 antibodies from 26 providers.
DR   DNASU; 220164; -.
DR   Ensembl; ENST00000382713.10; ENSP00000372160.5; ENSG00000206052.11.
DR   GeneID; 220164; -.
DR   KEGG; hsa:220164; -.
DR   MANE-Select; ENST00000382713.10; ENSP00000372160.5; NM_152721.6; NP_689934.2.
DR   UCSC; uc002lkl.4; human.
DR   AGR; HGNC:28301; -.
DR   CTD; 220164; -.
DR   DisGeNET; 220164; -.
DR   GeneCards; DOK6; -.
DR   HGNC; HGNC:28301; DOK6.
DR   HPA; ENSG00000206052; Tissue enhanced (brain, parathyroid gland, retina).
DR   MIM; 611402; gene.
DR   neXtProt; NX_Q6PKX4; -.
DR   OpenTargets; ENSG00000206052; -.
DR   PharmGKB; PA134866995; -.
DR   VEuPathDB; HostDB:ENSG00000206052; -.
DR   eggNOG; KOG4047; Eukaryota.
DR   GeneTree; ENSGT00940000158760; -.
DR   HOGENOM; CLU_057256_0_0_1; -.
DR   InParanoid; Q6PKX4; -.
DR   OMA; NIFRRCW; -.
DR   OrthoDB; 2996885at2759; -.
DR   PhylomeDB; Q6PKX4; -.
DR   TreeFam; TF324994; -.
DR   PathwayCommons; Q6PKX4; -.
DR   Reactome; R-HSA-8853659; RET signaling.
DR   SignaLink; Q6PKX4; -.
DR   SIGNOR; Q6PKX4; -.
DR   BioGRID-ORCS; 220164; 6 hits in 1142 CRISPR screens.
DR   ChiTaRS; DOK6; human.
DR   GenomeRNAi; 220164; -.
DR   Pharos; Q6PKX4; Tbio.
DR   PRO; PR:Q6PKX4; -.
DR   Proteomes; UP000005640; Chromosome 18.
DR   RNAct; Q6PKX4; Protein.
DR   Bgee; ENSG00000206052; Expressed in cortical plate and 154 other cell types or tissues.
DR   ExpressionAtlas; Q6PKX4; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; IBA:GO_Central.
DR   GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR   CDD; cd14678; PH_DOK4_DOK5_DOK6; 1.
DR   CDD; cd13164; PTB_DOK4_DOK5_DOK6; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR   InterPro; IPR037816; DOK4/5/6_PH.
DR   InterPro; IPR002404; IRS_PTB.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR21258:SF43; DOCKING PROTEIN 6; 1.
DR   PANTHER; PTHR21258; DOCKING PROTEIN RELATED; 1.
DR   Pfam; PF02174; IRS; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM01244; IRS; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00310; PTBI; 1.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   PROSITE; PS51064; IRS_PTB; 1.
DR   Genevisible; Q6PKX4; HS.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..331
FT                   /note="Docking protein 6"
FT                   /id="PRO_0000187279"
FT   DOMAIN          8..112
FT                   /note="PH"
FT   DOMAIN          132..237
FT                   /note="IRS-type PTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00389"
FT   REGION          293..331
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           263..273
FT                   /note="DKFBH motif"
FT   CONFLICT        238
FT                   /note="M -> V (in Ref. 5; BAB71577)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   331 AA;  38318 MW;  0C5EF2BF247091C1 CRC64;
     MASNFNDIVK QGYVKIRSRK LGIFRRCWLV FKKASSKGPR RLEKFPDEKA AYFRNFHKVT
     ELHNIKNITR LPRETKKHAV AIIFHDETSK TFACESELEA EEWCKHLCME CLGTRLNDIS
     LGEPDLLAAG VQREQNERFN VYLMPTPNLD IYGECTMQIT HENIYLWDIH NAKVKLVMWP
     LSSLRRYGRD STWFTFESGR MCDTGEGLFT FQTREGEMIY QKVHSATLAI AEQHERLMLE
     MEQKARLQTS LTEPMTLSKS ISLPRSAYWH HITRQNSVGE IYSLQGHGFG SSKMSRAQTF
     PSYAPEQSEE AQQPLSRSSS YGFSYSSSLI Q
//