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Q6PKX4

- DOK6_HUMAN

UniProt

Q6PKX4 - DOK6_HUMAN

Protein

Docking protein 6

Gene

DOK6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Enzyme and pathway databases

    SignaLinkiQ6PKX4.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Docking protein 6
    Alternative name(s):
    Downstream of tyrosine kinase 6
    Gene namesi
    Name:DOK6
    Synonyms:DOK5L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:28301. DOK6.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134866995.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 331331Docking protein 6PRO_0000187279Add
    BLAST

    Post-translational modificationi

    On Ret activation, phosphorylated on one or more C-terminal tyrosine residues by an Src family kinase.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ6PKX4.
    PRIDEiQ6PKX4.

    PTM databases

    PhosphoSiteiQ6PKX4.

    Expressioni

    Tissue specificityi

    Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis.1 Publication

    Gene expression databases

    BgeeiQ6PKX4.
    CleanExiHS_DOK6.
    GenevestigatoriQ6PKX4.

    Organism-specific databases

    HPAiCAB033084.
    HPA041099.

    Interactioni

    Subunit structurei

    Interacts via its PTB domain with phosphorylated RET.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    EGFRP005332EBI-2880244,EBI-297353

    Protein-protein interaction databases

    BioGridi128636. 3 interactions.
    IntActiQ6PKX4. 3 interactions.
    MINTiMINT-1492931.
    STRINGi9606.ENSP00000372160.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PKX4.
    SMRiQ6PKX4. Positions 133-232.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 112105PHAdd
    BLAST
    Domaini132 – 237106IRS-type PTBPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi263 – 27311DKFBH motifAdd
    BLAST

    Domaini

    PTB domain mediates receptor interaction.By similarity

    Sequence similaritiesi

    Belongs to the DOK family. Type B subfamily.Curated
    Contains 1 IRS-type PTB domain.PROSITE-ProRule annotation
    Contains 1 PH domain.Curated

    Phylogenomic databases

    eggNOGiNOG256436.
    HOGENOMiHOG000247025.
    HOVERGENiHBG002356.
    InParanoidiQ6PKX4.
    OMAiERVMLEM.
    OrthoDBiEOG7GTT3W.
    PhylomeDBiQ6PKX4.
    TreeFamiTF324994.

    Family and domain databases

    Gene3Di2.30.29.30. 2 hits.
    InterProiIPR002404. Insln_rcpt_S1.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view]
    PfamiPF02174. IRS. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    SM00310. PTBI. 1 hit.
    [Graphical view]
    PROSITEiPS51064. IRS_PTB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6PKX4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASNFNDIVK QGYVKIRSRK LGIFRRCWLV FKKASSKGPR RLEKFPDEKA    50
    AYFRNFHKVT ELHNIKNITR LPRETKKHAV AIIFHDETSK TFACESELEA 100
    EEWCKHLCME CLGTRLNDIS LGEPDLLAAG VQREQNERFN VYLMPTPNLD 150
    IYGECTMQIT HENIYLWDIH NAKVKLVMWP LSSLRRYGRD STWFTFESGR 200
    MCDTGEGLFT FQTREGEMIY QKVHSATLAI AEQHERLMLE MEQKARLQTS 250
    LTEPMTLSKS ISLPRSAYWH HITRQNSVGE IYSLQGHGFG SSKMSRAQTF 300
    PSYAPEQSEE AQQPLSRSSS YGFSYSSSLI Q 331
    Length:331
    Mass (Da):38,318
    Last modified:July 5, 2004 - v1
    Checksum:i0C5EF2BF247091C1
    GO

    Sequence cautioni

    The sequence BAB71577.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti238 – 2381M → V in BAB71577. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY599248 mRNA. Translation: AAT09770.1.
    AC026585 Genomic DNA. No translation available.
    CH471117 Genomic DNA. Translation: EAW66514.1.
    BC008583 mRNA. Translation: AAH08583.3.
    BC019045 mRNA. Translation: AAH19045.2.
    BC096744 mRNA. Translation: AAH96744.1.
    AK057795 mRNA. Translation: BAB71577.1. Different initiation.
    CCDSiCCDS32841.1.
    RefSeqiNP_689934.2. NM_152721.5.
    UniGeneiHs.278285.

    Genome annotation databases

    EnsembliENST00000382713; ENSP00000372160; ENSG00000206052.
    GeneIDi220164.
    KEGGihsa:220164.
    UCSCiuc002lkl.3. human.

    Polymorphism databases

    DMDMi84029601.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY599248 mRNA. Translation: AAT09770.1 .
    AC026585 Genomic DNA. No translation available.
    CH471117 Genomic DNA. Translation: EAW66514.1 .
    BC008583 mRNA. Translation: AAH08583.3 .
    BC019045 mRNA. Translation: AAH19045.2 .
    BC096744 mRNA. Translation: AAH96744.1 .
    AK057795 mRNA. Translation: BAB71577.1 . Different initiation.
    CCDSi CCDS32841.1.
    RefSeqi NP_689934.2. NM_152721.5.
    UniGenei Hs.278285.

    3D structure databases

    ProteinModelPortali Q6PKX4.
    SMRi Q6PKX4. Positions 133-232.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128636. 3 interactions.
    IntActi Q6PKX4. 3 interactions.
    MINTi MINT-1492931.
    STRINGi 9606.ENSP00000372160.

    PTM databases

    PhosphoSitei Q6PKX4.

    Polymorphism databases

    DMDMi 84029601.

    Proteomic databases

    PaxDbi Q6PKX4.
    PRIDEi Q6PKX4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000382713 ; ENSP00000372160 ; ENSG00000206052 .
    GeneIDi 220164.
    KEGGi hsa:220164.
    UCSCi uc002lkl.3. human.

    Organism-specific databases

    CTDi 220164.
    GeneCardsi GC18P067068.
    HGNCi HGNC:28301. DOK6.
    HPAi CAB033084.
    HPA041099.
    MIMi 611402. gene.
    neXtProti NX_Q6PKX4.
    PharmGKBi PA134866995.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG256436.
    HOGENOMi HOG000247025.
    HOVERGENi HBG002356.
    InParanoidi Q6PKX4.
    OMAi ERVMLEM.
    OrthoDBi EOG7GTT3W.
    PhylomeDBi Q6PKX4.
    TreeFami TF324994.

    Enzyme and pathway databases

    SignaLinki Q6PKX4.

    Miscellaneous databases

    GenomeRNAii 220164.
    NextBioi 91022.
    PROi Q6PKX4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6PKX4.
    CleanExi HS_DOK6.
    Genevestigatori Q6PKX4.

    Family and domain databases

    Gene3Di 2.30.29.30. 2 hits.
    InterProi IPR002404. Insln_rcpt_S1.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view ]
    Pfami PF02174. IRS. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    SM00310. PTBI. 1 hit.
    [Graphical view ]
    PROSITEi PS51064. IRS_PTB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Dok-6, a novel p62 Dok family member, promotes Ret-mediated neurite outgrowth."
      Crowder R.J., Enomoto H., Yang M., Johnson E.M. Jr., Milbrandt J.
      J. Biol. Chem. 279:42072-42081(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH RET, PHOSPHORYLATION AT TYROSINE RESIDUES, TISSUE SPECIFICITY.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Eye and Hippocampus.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 33-331.
      Tissue: Cerebellum.

    Entry informationi

    Entry nameiDOK6_HUMAN
    AccessioniPrimary (citable) accession number: Q6PKX4
    Secondary accession number(s): A6NNG3
    , Q4V9S3, Q8WUZ8, Q96HI2, Q96LU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3