Q6PKX4 (DOK6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Docking protein 6

Alternative name(s):
Downstream of tyrosine kinase 6

Gene names

Name:	DOK6
Synonyms:	DOK5L

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance. Ref.1
Subunit structure	Interacts via its PTB domain with phosphorylated RET. Ref.1
Tissue specificity	Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis. Ref.1
Domain	PTB domain mediates receptor interaction By similarity.
Post-translational modification	On Ret activation, phosphorylated on one or more C-terminal tyrosine residues by an Src family kinase. Ref.1
Sequence similarities	Belongs to the DOK family. Type B subfamily. Contains 1 IRS-type PTB domain. Contains 1 PH domain.
Sequence caution	The sequence BAB71577.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 331	331	Docking protein 6		PRO_0000187279
Regions
	Domain	8 – 112	105	PH
	Domain	132 – 237	106	IRS-type PTB
	Motif	263 – 273	11	DKFBH motif
Experimental info
	Sequence conflict	238	1	M → V in BAB71577. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q6PKX4 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 0C5EF2BF247091C1	FASTA	331	38,318
	10 20 30 40 50 60 MASNFNDIVK QGYVKIRSRK LGIFRRCWLV FKKASSKGPR RLEKFPDEKA AYFRNFHKVT 70 80 90 100 110 120 ELHNIKNITR LPRETKKHAV AIIFHDETSK TFACESELEA EEWCKHLCME CLGTRLNDIS 130 140 150 160 170 180 LGEPDLLAAG VQREQNERFN VYLMPTPNLD IYGECTMQIT HENIYLWDIH NAKVKLVMWP 190 200 210 220 230 240 LSSLRRYGRD STWFTFESGR MCDTGEGLFT FQTREGEMIY QKVHSATLAI AEQHERLMLE 250 260 270 280 290 300 MEQKARLQTS LTEPMTLSKS ISLPRSAYWH HITRQNSVGE IYSLQGHGFG SSKMSRAQTF 310 320 330 PSYAPEQSEE AQQPLSRSSS YGFSYSSSLI Q

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Dok-6, a novel p62 Dok family member, promotes Ret-mediated neurite outgrowth." Crowder R.J., Enomoto H., Yang M., Johnson E.M. Jr., Milbrandt J. J. Biol. Chem. 279:42072-42081(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH RET, PHOSPHORYLATION AT TYROSINE RESIDUES, TISSUE SPECIFICITY.
[2]	"DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S. Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain, Eye and Hippocampus.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 33-331. Tissue: Cerebellum.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY599248 mRNA. Translation: AAT09770.1. AC026585 Genomic DNA. No translation available. CH471117 Genomic DNA. Translation: EAW66514.1. BC008583 mRNA. Translation: AAH08583.3. BC019045 mRNA. Translation: AAH19045.2. BC096744 mRNA. Translation: AAH96744.1. AK057795 mRNA. Translation: BAB71577.1. Different initiation.
IPI	IPI00400860.
RefSeq	NP_689934.2. NM_152721.5.
UniGene	Hs.278285.
3D structure databases
ProteinModelPortal	Q6PKX4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6PKX4. 1 interaction.
MINT	MINT-1492931.
STRING	9606.ENSP00000372160.
PTM databases
PhosphoSite	Q6PKX4.
Polymorphism databases
DMDM	84029601.
Proteomic databases
PaxDb	Q6PKX4.
PRIDE	Q6PKX4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000382713; ENSP00000372160; ENSG00000206052.
GeneID	220164.
KEGG	hsa:220164.
UCSC	uc002lkl.3. human.
Organism-specific databases
CTD	220164.
GeneCards	GC18P067068.
HGNC	HGNC:28301. DOK6.
HPA	CAB033084.
MIM	611402. gene.
neXtProt	NX_Q6PKX4.
PharmGKB	PA134866995.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG256436.
HOGENOM	HOG000247025.
HOVERGEN	HBG002356.
InParanoid	Q6PKX4.
OMA	TSLSEPM.
OrthoDB	EOG47PX68.
Enzyme and pathway databases
Pathway_Interaction_DB	ret_pathway. Signaling events regulated by Ret tyrosine kinase.
SignaLink	Q6PKX4.
Gene expression databases
Bgee	Q6PKX4.
CleanEx	HS_DOK6.
Genevestigator	Q6PKX4.
GermOnline	ENSG00000206052. Homo sapiens.
Family and domain databases
Gene3D	2.30.29.30. 2 hits.
InterPro	IPR002404. Insln_rcpt_S1. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. [Graphical view]
Pfam	PF02174. IRS. 1 hit. PF00169. PH. 1 hit. [Graphical view]
SMART	SM00233. PH. 1 hit. SM00310. PTBI. 1 hit. [Graphical view]
PROSITE	PS51064. IRS_PTB. 1 hit. PS50003. PH_DOMAIN. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	220164.
NextBio	91022.
SOURCE	Search...

Entry information

Entry name

DOK6_HUMAN

Accession

Primary (citable) accession number: Q6PKX4
Secondary accession number(s): A6NNG3 , Q4V9S3, Q8WUZ8, Q96HI2, Q96LU2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
Last sequence update:	July 5, 2004
Last modified:	May 29, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.