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Q6PKX4

- DOK6_HUMAN

UniProt

Q6PKX4 - DOK6_HUMAN

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Protein
Docking protein 6
Gene
DOK6, DOK5L
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ6PKX4.

Names & Taxonomyi

Protein namesi
Recommended name:
Docking protein 6
Alternative name(s):
Downstream of tyrosine kinase 6
Gene namesi
Name:DOK6
Synonyms:DOK5L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:28301. DOK6.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134866995.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331Docking protein 6
PRO_0000187279Add
BLAST

Post-translational modificationi

On Ret activation, phosphorylated on one or more C-terminal tyrosine residues by an Src family kinase.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6PKX4.
PRIDEiQ6PKX4.

PTM databases

PhosphoSiteiQ6PKX4.

Expressioni

Tissue specificityi

Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis.1 Publication

Gene expression databases

BgeeiQ6PKX4.
CleanExiHS_DOK6.
GenevestigatoriQ6PKX4.

Organism-specific databases

HPAiCAB033084.
HPA041099.

Interactioni

Subunit structurei

Interacts via its PTB domain with phosphorylated RET.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
EGFRP005332EBI-2880244,EBI-297353

Protein-protein interaction databases

BioGridi128636. 3 interactions.
IntActiQ6PKX4. 3 interactions.
MINTiMINT-1492931.
STRINGi9606.ENSP00000372160.

Structurei

3D structure databases

ProteinModelPortaliQ6PKX4.
SMRiQ6PKX4. Positions 133-232.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 112105PH
Add
BLAST
Domaini132 – 237106IRS-type PTB
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi263 – 27311DKFBH motif
Add
BLAST

Domaini

PTB domain mediates receptor interaction By similarity.

Sequence similaritiesi

Belongs to the DOK family. Type B subfamily.
Contains 1 PH domain.

Phylogenomic databases

eggNOGiNOG256436.
HOGENOMiHOG000247025.
HOVERGENiHBG002356.
InParanoidiQ6PKX4.
OMAiERVMLEM.
OrthoDBiEOG7GTT3W.
PhylomeDBiQ6PKX4.
TreeFamiTF324994.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR002404. Insln_rcpt_S1.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PfamiPF02174. IRS. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00310. PTBI. 1 hit.
[Graphical view]
PROSITEiPS51064. IRS_PTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PKX4-1 [UniParc]FASTAAdd to Basket

« Hide

MASNFNDIVK QGYVKIRSRK LGIFRRCWLV FKKASSKGPR RLEKFPDEKA    50
AYFRNFHKVT ELHNIKNITR LPRETKKHAV AIIFHDETSK TFACESELEA 100
EEWCKHLCME CLGTRLNDIS LGEPDLLAAG VQREQNERFN VYLMPTPNLD 150
IYGECTMQIT HENIYLWDIH NAKVKLVMWP LSSLRRYGRD STWFTFESGR 200
MCDTGEGLFT FQTREGEMIY QKVHSATLAI AEQHERLMLE MEQKARLQTS 250
LTEPMTLSKS ISLPRSAYWH HITRQNSVGE IYSLQGHGFG SSKMSRAQTF 300
PSYAPEQSEE AQQPLSRSSS YGFSYSSSLI Q 331
Length:331
Mass (Da):38,318
Last modified:July 5, 2004 - v1
Checksum:i0C5EF2BF247091C1
GO

Sequence cautioni

The sequence BAB71577.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti238 – 2381M → V in BAB71577. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY599248 mRNA. Translation: AAT09770.1.
AC026585 Genomic DNA. No translation available.
CH471117 Genomic DNA. Translation: EAW66514.1.
BC008583 mRNA. Translation: AAH08583.3.
BC019045 mRNA. Translation: AAH19045.2.
BC096744 mRNA. Translation: AAH96744.1.
AK057795 mRNA. Translation: BAB71577.1. Different initiation.
CCDSiCCDS32841.1.
RefSeqiNP_689934.2. NM_152721.5.
UniGeneiHs.278285.

Genome annotation databases

EnsembliENST00000382713; ENSP00000372160; ENSG00000206052.
GeneIDi220164.
KEGGihsa:220164.
UCSCiuc002lkl.3. human.

Polymorphism databases

DMDMi84029601.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY599248 mRNA. Translation: AAT09770.1 .
AC026585 Genomic DNA. No translation available.
CH471117 Genomic DNA. Translation: EAW66514.1 .
BC008583 mRNA. Translation: AAH08583.3 .
BC019045 mRNA. Translation: AAH19045.2 .
BC096744 mRNA. Translation: AAH96744.1 .
AK057795 mRNA. Translation: BAB71577.1 . Different initiation.
CCDSi CCDS32841.1.
RefSeqi NP_689934.2. NM_152721.5.
UniGenei Hs.278285.

3D structure databases

ProteinModelPortali Q6PKX4.
SMRi Q6PKX4. Positions 133-232.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128636. 3 interactions.
IntActi Q6PKX4. 3 interactions.
MINTi MINT-1492931.
STRINGi 9606.ENSP00000372160.

PTM databases

PhosphoSitei Q6PKX4.

Polymorphism databases

DMDMi 84029601.

Proteomic databases

PaxDbi Q6PKX4.
PRIDEi Q6PKX4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000382713 ; ENSP00000372160 ; ENSG00000206052 .
GeneIDi 220164.
KEGGi hsa:220164.
UCSCi uc002lkl.3. human.

Organism-specific databases

CTDi 220164.
GeneCardsi GC18P067068.
HGNCi HGNC:28301. DOK6.
HPAi CAB033084.
HPA041099.
MIMi 611402. gene.
neXtProti NX_Q6PKX4.
PharmGKBi PA134866995.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG256436.
HOGENOMi HOG000247025.
HOVERGENi HBG002356.
InParanoidi Q6PKX4.
OMAi ERVMLEM.
OrthoDBi EOG7GTT3W.
PhylomeDBi Q6PKX4.
TreeFami TF324994.

Enzyme and pathway databases

SignaLinki Q6PKX4.

Miscellaneous databases

GenomeRNAii 220164.
NextBioi 91022.
PROi Q6PKX4.
SOURCEi Search...

Gene expression databases

Bgeei Q6PKX4.
CleanExi HS_DOK6.
Genevestigatori Q6PKX4.

Family and domain databases

Gene3Di 2.30.29.30. 2 hits.
InterProi IPR002404. Insln_rcpt_S1.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
Pfami PF02174. IRS. 1 hit.
PF00169. PH. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
SM00310. PTBI. 1 hit.
[Graphical view ]
PROSITEi PS51064. IRS_PTB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Dok-6, a novel p62 Dok family member, promotes Ret-mediated neurite outgrowth."
    Crowder R.J., Enomoto H., Yang M., Johnson E.M. Jr., Milbrandt J.
    J. Biol. Chem. 279:42072-42081(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH RET, PHOSPHORYLATION AT TYROSINE RESIDUES, TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Eye and Hippocampus.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 33-331.
    Tissue: Cerebellum.

Entry informationi

Entry nameiDOK6_HUMAN
AccessioniPrimary (citable) accession number: Q6PKX4
Secondary accession number(s): A6NNG3
, Q4V9S3, Q8WUZ8, Q96HI2, Q96LU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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