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Protein

Docking protein 6

Gene

DOK6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance.1 Publication

Enzyme and pathway databases

SignaLinkiQ6PKX4.

Names & Taxonomyi

Protein namesi
Recommended name:
Docking protein 6
Alternative name(s):
Downstream of tyrosine kinase 6
Gene namesi
Name:DOK6
Synonyms:DOK5L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:28301. DOK6.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134866995.

Polymorphism and mutation databases

BioMutaiDOK6.
DMDMi84029601.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331Docking protein 6PRO_0000187279Add
BLAST

Post-translational modificationi

On Ret activation, phosphorylated on one or more C-terminal tyrosine residues by an Src family kinase.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6PKX4.
PRIDEiQ6PKX4.

PTM databases

PhosphoSiteiQ6PKX4.

Expressioni

Tissue specificityi

Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis.1 Publication

Gene expression databases

BgeeiQ6PKX4.
CleanExiHS_DOK6.
GenevestigatoriQ6PKX4.

Organism-specific databases

HPAiCAB033084.
HPA041099.

Interactioni

Subunit structurei

Interacts via its PTB domain with phosphorylated RET.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
C1orf94Q6P1W53EBI-2880244,EBI-946029
EGFRP005332EBI-2880244,EBI-297353
RBPMSQ930623EBI-2880244,EBI-740322

Protein-protein interaction databases

BioGridi128636. 5 interactions.
IntActiQ6PKX4. 5 interactions.
MINTiMINT-1492931.
STRINGi9606.ENSP00000372160.

Structurei

3D structure databases

ProteinModelPortaliQ6PKX4.
SMRiQ6PKX4. Positions 133-232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 112105PHAdd
BLAST
Domaini132 – 237106IRS-type PTBPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi263 – 27311DKFBH motifAdd
BLAST

Domaini

PTB domain mediates receptor interaction.By similarity

Sequence similaritiesi

Belongs to the DOK family. Type B subfamily.Curated
Contains 1 IRS-type PTB domain.PROSITE-ProRule annotation
Contains 1 PH domain.Curated

Phylogenomic databases

eggNOGiNOG256436.
GeneTreeiENSGT00730000110348.
HOGENOMiHOG000247025.
HOVERGENiHBG002356.
InParanoidiQ6PKX4.
OMAiHHITRQS.
OrthoDBiEOG7GTT3W.
PhylomeDBiQ6PKX4.
TreeFamiTF324994.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR002404. Insln_rcpt_S1.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PfamiPF02174. IRS. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00310. PTBI. 1 hit.
[Graphical view]
PROSITEiPS51064. IRS_PTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6PKX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNFNDIVK QGYVKIRSRK LGIFRRCWLV FKKASSKGPR RLEKFPDEKA
60 70 80 90 100
AYFRNFHKVT ELHNIKNITR LPRETKKHAV AIIFHDETSK TFACESELEA
110 120 130 140 150
EEWCKHLCME CLGTRLNDIS LGEPDLLAAG VQREQNERFN VYLMPTPNLD
160 170 180 190 200
IYGECTMQIT HENIYLWDIH NAKVKLVMWP LSSLRRYGRD STWFTFESGR
210 220 230 240 250
MCDTGEGLFT FQTREGEMIY QKVHSATLAI AEQHERLMLE MEQKARLQTS
260 270 280 290 300
LTEPMTLSKS ISLPRSAYWH HITRQNSVGE IYSLQGHGFG SSKMSRAQTF
310 320 330
PSYAPEQSEE AQQPLSRSSS YGFSYSSSLI Q
Length:331
Mass (Da):38,318
Last modified:July 5, 2004 - v1
Checksum:i0C5EF2BF247091C1
GO

Sequence cautioni

The sequence BAB71577.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti238 – 2381M → V in BAB71577 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY599248 mRNA. Translation: AAT09770.1.
AC026585 Genomic DNA. No translation available.
CH471117 Genomic DNA. Translation: EAW66514.1.
BC008583 mRNA. Translation: AAH08583.3.
BC019045 mRNA. Translation: AAH19045.2.
BC096744 mRNA. Translation: AAH96744.1.
AK057795 mRNA. Translation: BAB71577.1. Different initiation.
CCDSiCCDS32841.1.
RefSeqiNP_689934.2. NM_152721.5.
UniGeneiHs.278285.

Genome annotation databases

EnsembliENST00000382713; ENSP00000372160; ENSG00000206052.
GeneIDi220164.
KEGGihsa:220164.
UCSCiuc002lkl.3. human.

Polymorphism and mutation databases

BioMutaiDOK6.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY599248 mRNA. Translation: AAT09770.1.
AC026585 Genomic DNA. No translation available.
CH471117 Genomic DNA. Translation: EAW66514.1.
BC008583 mRNA. Translation: AAH08583.3.
BC019045 mRNA. Translation: AAH19045.2.
BC096744 mRNA. Translation: AAH96744.1.
AK057795 mRNA. Translation: BAB71577.1. Different initiation.
CCDSiCCDS32841.1.
RefSeqiNP_689934.2. NM_152721.5.
UniGeneiHs.278285.

3D structure databases

ProteinModelPortaliQ6PKX4.
SMRiQ6PKX4. Positions 133-232.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128636. 5 interactions.
IntActiQ6PKX4. 5 interactions.
MINTiMINT-1492931.
STRINGi9606.ENSP00000372160.

PTM databases

PhosphoSiteiQ6PKX4.

Polymorphism and mutation databases

BioMutaiDOK6.
DMDMi84029601.

Proteomic databases

PaxDbiQ6PKX4.
PRIDEiQ6PKX4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382713; ENSP00000372160; ENSG00000206052.
GeneIDi220164.
KEGGihsa:220164.
UCSCiuc002lkl.3. human.

Organism-specific databases

CTDi220164.
GeneCardsiGC18P067068.
HGNCiHGNC:28301. DOK6.
HPAiCAB033084.
HPA041099.
MIMi611402. gene.
neXtProtiNX_Q6PKX4.
PharmGKBiPA134866995.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG256436.
GeneTreeiENSGT00730000110348.
HOGENOMiHOG000247025.
HOVERGENiHBG002356.
InParanoidiQ6PKX4.
OMAiHHITRQS.
OrthoDBiEOG7GTT3W.
PhylomeDBiQ6PKX4.
TreeFamiTF324994.

Enzyme and pathway databases

SignaLinkiQ6PKX4.

Miscellaneous databases

GenomeRNAii220164.
NextBioi91022.
PROiQ6PKX4.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PKX4.
CleanExiHS_DOK6.
GenevestigatoriQ6PKX4.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR002404. Insln_rcpt_S1.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PfamiPF02174. IRS. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00310. PTBI. 1 hit.
[Graphical view]
PROSITEiPS51064. IRS_PTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Dok-6, a novel p62 Dok family member, promotes Ret-mediated neurite outgrowth."
    Crowder R.J., Enomoto H., Yang M., Johnson E.M. Jr., Milbrandt J.
    J. Biol. Chem. 279:42072-42081(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH RET, PHOSPHORYLATION AT TYROSINE RESIDUES, TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Eye and Hippocampus.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 33-331.
    Tissue: Cerebellum.

Entry informationi

Entry nameiDOK6_HUMAN
AccessioniPrimary (citable) accession number: Q6PKX4
Secondary accession number(s): A6NNG3
, Q4V9S3, Q8WUZ8, Q96HI2, Q96LU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: July 5, 2004
Last modified: April 29, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.