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Protein

Docking protein 6

Gene

DOK6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance.1 Publication

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-8853659. RET signaling.
SignaLinkiQ6PKX4.
SIGNORiQ6PKX4.

Names & Taxonomyi

Protein namesi
Recommended name:
Docking protein 6
Alternative name(s):
Downstream of tyrosine kinase 6
Gene namesi
Name:DOK6
Synonyms:DOK5L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000206052.10.
HGNCiHGNC:28301. DOK6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi220164.
OpenTargetsiENSG00000206052.
PharmGKBiPA134866995.

Polymorphism and mutation databases

BioMutaiDOK6.
DMDMi84029601.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001872791 – 331Docking protein 6Add BLAST331

Post-translational modificationi

On Ret activation, phosphorylated on one or more C-terminal tyrosine residues by an Src family kinase.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6PKX4.
PeptideAtlasiQ6PKX4.
PRIDEiQ6PKX4.

PTM databases

iPTMnetiQ6PKX4.
PhosphoSitePlusiQ6PKX4.

Expressioni

Tissue specificityi

Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis.1 Publication

Gene expression databases

BgeeiENSG00000206052.
CleanExiHS_DOK6.
ExpressionAtlasiQ6PKX4. baseline and differential.
GenevisibleiQ6PKX4. HS.

Organism-specific databases

HPAiHPA041099.
HPA063534.

Interactioni

Subunit structurei

Interacts via its PTB domain with phosphorylated RET.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi128636. 5 interactors.
IntActiQ6PKX4. 17 interactors.
MINTiMINT-1492931.
STRINGi9606.ENSP00000372160.

Structurei

3D structure databases

ProteinModelPortaliQ6PKX4.
SMRiQ6PKX4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 112PHAdd BLAST105
Domaini132 – 237IRS-type PTBPROSITE-ProRule annotationAdd BLAST106

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi263 – 273DKFBH motifAdd BLAST11

Domaini

PTB domain mediates receptor interaction.By similarity

Sequence similaritiesi

Belongs to the DOK family. Type B subfamily.Curated

Phylogenomic databases

eggNOGiKOG4047. Eukaryota.
ENOG410XS2S. LUCA.
GeneTreeiENSGT00730000110348.
HOGENOMiHOG000247025.
HOVERGENiHBG002356.
InParanoidiQ6PKX4.
OMAiSYASEQS.
OrthoDBiEOG091G0M38.
PhylomeDBiQ6PKX4.
TreeFamiTF324994.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiView protein in InterPro
IPR002404. IRS_PTB.
IPR011993. PH-like_dom_sf.
IPR001849. PH_domain.
PfamiView protein in Pfam
PF02174. IRS. 1 hit.
SMARTiView protein in SMART
SM00233. PH. 1 hit.
SM00310. PTBI. 1 hit.
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiView protein in PROSITE
PS51064. IRS_PTB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6PKX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNFNDIVK QGYVKIRSRK LGIFRRCWLV FKKASSKGPR RLEKFPDEKA
60 70 80 90 100
AYFRNFHKVT ELHNIKNITR LPRETKKHAV AIIFHDETSK TFACESELEA
110 120 130 140 150
EEWCKHLCME CLGTRLNDIS LGEPDLLAAG VQREQNERFN VYLMPTPNLD
160 170 180 190 200
IYGECTMQIT HENIYLWDIH NAKVKLVMWP LSSLRRYGRD STWFTFESGR
210 220 230 240 250
MCDTGEGLFT FQTREGEMIY QKVHSATLAI AEQHERLMLE MEQKARLQTS
260 270 280 290 300
LTEPMTLSKS ISLPRSAYWH HITRQNSVGE IYSLQGHGFG SSKMSRAQTF
310 320 330
PSYAPEQSEE AQQPLSRSSS YGFSYSSSLI Q
Length:331
Mass (Da):38,318
Last modified:July 5, 2004 - v1
Checksum:i0C5EF2BF247091C1
GO

Sequence cautioni

The sequence BAB71577 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti238M → V in BAB71577 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY599248 mRNA. Translation: AAT09770.1.
AC026585 Genomic DNA. No translation available.
CH471117 Genomic DNA. Translation: EAW66514.1.
BC008583 mRNA. Translation: AAH08583.3.
BC019045 mRNA. Translation: AAH19045.2.
BC096744 mRNA. Translation: AAH96744.1.
AK057795 mRNA. Translation: BAB71577.1. Different initiation.
CCDSiCCDS32841.1.
RefSeqiNP_689934.2. NM_152721.5.
UniGeneiHs.278285.

Genome annotation databases

EnsembliENST00000382713; ENSP00000372160; ENSG00000206052.
GeneIDi220164.
KEGGihsa:220164.
UCSCiuc002lkl.4. human.

Similar proteinsi

Entry informationi

Entry nameiDOK6_HUMAN
AccessioniPrimary (citable) accession number: Q6PKX4
Secondary accession number(s): A6NNG3
, Q4V9S3, Q8WUZ8, Q96HI2, Q96LU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families