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Q6PKX4 (DOK6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Docking protein 6
Alternative name(s):
Downstream of tyrosine kinase 6
Gene names
Name:DOK6
Synonyms:DOK5L
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance. Ref.1

Subunit structure

Interacts via its PTB domain with phosphorylated RET. Ref.1

Tissue specificity

Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis. Ref.1

Domain

PTB domain mediates receptor interaction By similarity.

Post-translational modification

On Ret activation, phosphorylated on one or more C-terminal tyrosine residues by an Src family kinase. Ref.1

Sequence similarities

Belongs to the DOK family. Type B subfamily.

Contains 1 IRS-type PTB domain.

Contains 1 PH domain.

Sequence caution

The sequence BAB71577.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Binary interactions

With

Entry

#Exp.

IntAct

Notes

EGFRP005332EBI-2880244,EBI-297353

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 331331Docking protein 6
PRO_0000187279

Regions

Domain8 – 112105PH
Domain132 – 237106IRS-type PTB
Motif263 – 27311DKFBH motif

Experimental info

Sequence conflict2381M → V in BAB71577. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q6PKX4 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 0C5EF2BF247091C1

FASTA33138,318
        10         20         30         40         50         60 
MASNFNDIVK QGYVKIRSRK LGIFRRCWLV FKKASSKGPR RLEKFPDEKA AYFRNFHKVT 

        70         80         90        100        110        120 
ELHNIKNITR LPRETKKHAV AIIFHDETSK TFACESELEA EEWCKHLCME CLGTRLNDIS 

       130        140        150        160        170        180 
LGEPDLLAAG VQREQNERFN VYLMPTPNLD IYGECTMQIT HENIYLWDIH NAKVKLVMWP 

       190        200        210        220        230        240 
LSSLRRYGRD STWFTFESGR MCDTGEGLFT FQTREGEMIY QKVHSATLAI AEQHERLMLE 

       250        260        270        280        290        300 
MEQKARLQTS LTEPMTLSKS ISLPRSAYWH HITRQNSVGE IYSLQGHGFG SSKMSRAQTF 

       310        320        330 
PSYAPEQSEE AQQPLSRSSS YGFSYSSSLI Q 

« Hide

References

« Hide 'large scale' references
[1]"Dok-6, a novel p62 Dok family member, promotes Ret-mediated neurite outgrowth."
Crowder R.J., Enomoto H., Yang M., Johnson E.M. Jr., Milbrandt J.
J. Biol. Chem. 279:42072-42081(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH RET, PHOSPHORYLATION AT TYROSINE RESIDUES, TISSUE SPECIFICITY.
[2]"DNA sequence and analysis of human chromosome 18."
Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. expand/collapse author list , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.
Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain, Eye and Hippocampus.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 33-331.
Tissue: Cerebellum.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY599248 mRNA. Translation: AAT09770.1.
AC026585 Genomic DNA. No translation available.
CH471117 Genomic DNA. Translation: EAW66514.1.
BC008583 mRNA. Translation: AAH08583.3.
BC019045 mRNA. Translation: AAH19045.2.
BC096744 mRNA. Translation: AAH96744.1.
AK057795 mRNA. Translation: BAB71577.1. Different initiation.
RefSeqNP_689934.2. NM_152721.5.
UniGeneHs.278285.

3D structure databases

ProteinModelPortalQ6PKX4.
SMRQ6PKX4. Positions 6-235.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128636. 3 interactions.
IntActQ6PKX4. 3 interactions.
MINTMINT-1492931.
STRING9606.ENSP00000372160.

PTM databases

PhosphoSiteQ6PKX4.

Polymorphism databases

DMDM84029601.

Proteomic databases

PaxDbQ6PKX4.
PRIDEQ6PKX4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000382713; ENSP00000372160; ENSG00000206052.
GeneID220164.
KEGGhsa:220164.
UCSCuc002lkl.3. human.

Organism-specific databases

CTD220164.
GeneCardsGC18P067068.
HGNCHGNC:28301. DOK6.
HPACAB033084.
HPA041099.
MIM611402. gene.
neXtProtNX_Q6PKX4.
PharmGKBPA134866995.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG256436.
HOGENOMHOG000247025.
HOVERGENHBG002356.
InParanoidQ6PKX4.
OMAERVMLEM.
OrthoDBEOG7GTT3W.
PhylomeDBQ6PKX4.
TreeFamTF324994.

Enzyme and pathway databases

SignaLinkQ6PKX4.

Gene expression databases

BgeeQ6PKX4.
CleanExHS_DOK6.
GenevestigatorQ6PKX4.

Family and domain databases

Gene3D2.30.29.30. 2 hits.
InterProIPR002404. Insln_rcpt_S1.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
[Graphical view]
PfamPF02174. IRS. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTSM00233. PH. 1 hit.
SM00310. PTBI. 1 hit.
[Graphical view]
PROSITEPS51064. IRS_PTB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi220164.
NextBio91022.
PROQ6PKX4.
SOURCESearch...

Entry information

Entry nameDOK6_HUMAN
AccessionPrimary (citable) accession number: Q6PKX4
Secondary accession number(s): A6NNG3 expand/collapse secondary AC list , Q4V9S3, Q8WUZ8, Q96HI2, Q96LU2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM