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Protein

Dehydrogenase/reductase SDR family member 4-like 2

Gene

DHRS4L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable oxidoreductase.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei167 – 1671SubstrateBy similarity
Active sitei180 – 1801Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi34 – 5825NADPBy similarityAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 4-like 2 (EC:1.1.-.-)
Alternative name(s):
Short chain dehydrogenase/reductase family 25C member 3
Gene namesi
Name:DHRS4L2
Synonyms:SDR25C3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19731. DHRS4L2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi74749268.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 230210Dehydrogenase/reductase SDR family member 4-like 2PRO_0000312103Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi181 – 1811N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ6PKH6.
PaxDbiQ6PKH6.
PRIDEiQ6PKH6.

PTM databases

iPTMnetiQ6PKH6.
PhosphoSiteiQ6PKH6.

Expressioni

Gene expression databases

BgeeiQ6PKH6.
ExpressionAtlasiQ6PKH6. baseline and differential.
GenevisibleiQ6PKH6. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000334801.

Structurei

3D structure databases

ProteinModelPortaliQ6PKH6.
SMRiQ6PKH6. Positions 23-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
HOVERGENiHBG105779.
InParanoidiQ6PKH6.
PhylomeDBiQ6PKH6.
TreeFamiTF315405.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR029511. DHRS4-like.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PTHR24322:SF198. PTHR24322:SF198. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PKH6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARLLGLCAW ARKSVRLASS RMTRRDPLTN KVALVTASTD GIGFAIARRL
60 70 80 90 100
AQDRAHVVVS SRKQQNVDQA VATLQGEGLS VTGTVCHVGK AEDRERLVAM
110 120 130 140 150
AVKLHGGIDI LVSNAAVNPF FGSLMDVTEE VWDKTLDINV KAPALMTKAV
160 170 180 190 200
VPEMEKRGGG SVVIVSSIAA FSPSPGFSPY NVSKTALLGL NNTLAIELAP
210 220 230
RNIRVNCLHL DLSRLASAGC SGWTRKKRKA
Length:230
Mass (Da):24,586
Last modified:July 5, 2004 - v1
Checksum:iB9B9D33B3685DE64
GO
Isoform 2 (identifier: Q6PKH6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-230: CSGWTRKKRKA → WLGEPEDCAGIVSFLCSEDAS

Show »
Length:240
Mass (Da):25,493
Checksum:iA65992B3C5D32BB7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171L → M.
Corresponds to variant rs2273947 [ dbSNP | Ensembl ].
VAR_037395

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei220 – 23011CSGWTRKKRKA → WLGEPEDCAGIVSFLCSEDA S in isoform 2. 1 PublicationVSP_029697Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC000663 mRNA. Translation: AAH00663.2.
DQ088988 mRNA. Translation: AAZ85982.1.
UniGeneiHs.743442.

Genome annotation databases

EnsembliENST00000335125; ENSP00000334801; ENSG00000187630.
UCSCiuc001wli.5. human. [Q6PKH6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC000663 mRNA. Translation: AAH00663.2.
DQ088988 mRNA. Translation: AAZ85982.1.
UniGeneiHs.743442.

3D structure databases

ProteinModelPortaliQ6PKH6.
SMRiQ6PKH6. Positions 23-208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000334801.

PTM databases

iPTMnetiQ6PKH6.
PhosphoSiteiQ6PKH6.

Polymorphism and mutation databases

DMDMi74749268.

Proteomic databases

EPDiQ6PKH6.
PaxDbiQ6PKH6.
PRIDEiQ6PKH6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335125; ENSP00000334801; ENSG00000187630.
UCSCiuc001wli.5. human. [Q6PKH6-1]

Organism-specific databases

GeneCardsiDHRS4L2.
HGNCiHGNC:19731. DHRS4L2.
MIMi615196. gene.
neXtProtiNX_Q6PKH6.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
HOVERGENiHBG105779.
InParanoidiQ6PKH6.
PhylomeDBiQ6PKH6.
TreeFamiTF315405.

Miscellaneous databases

ChiTaRSiDHRS4L2. human.
PROiQ6PKH6.
SOURCEiSearch...

Gene expression databases

BgeeiQ6PKH6.
ExpressionAtlasiQ6PKH6. baseline and differential.
GenevisibleiQ6PKH6. HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR029511. DHRS4-like.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PTHR24322:SF198. PTHR24322:SF198. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  2. "Non-EST based prediction of exon skipping and intron retention events using Pfam information."
    Hiller M., Huse K., Platzer M., Backofen R.
    Nucleic Acids Res. 33:5611-5621(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 123-230 (ISOFORM 2).

Entry informationi

Entry nameiDR4L2_HUMAN
AccessioniPrimary (citable) accession number: Q6PKH6
Secondary accession number(s): Q3YLD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 5, 2004
Last modified: April 13, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.