Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

La-related protein 1

Gene

LARP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein that promotes translation of specific classes of mRNAs downstream of the mTORC1 complex. Associates with the mRNA 5'cap in an MTOR-dependent manner and associates with mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding for ribosomal proteins and several components of the translation machinery. Associates with actively translating ribosomes via interaction with PABPC1/PABP and stimulates translation of mRNAs containing a 5'TOP, thereby regulating cell growth and proliferation. Positively regulates the replication of dengue virus (DENV) (PubMed:26735137).4 Publications

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • eukaryotic initiation factor 4E binding Source: UniProtKB
  • mRNA 3'-UTR binding Source: UniProtKB
  • mRNA 5'-UTR binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB
  • RNA cap binding Source: UniProtKB
  • translation activator activity Source: UniProtKB
  • translation initiation factor binding Source: UniProtKB

GO - Biological processi

  • cell proliferation Source: UniProtKB
  • positive regulation of macroautophagy Source: BHF-UCL
  • positive regulation of viral genome replication Source: UniProtKB
  • TOR signaling Source: UniProtKB
  • translational initiation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
La-related protein 1
Alternative name(s):
La ribonucleoprotein domain family member 1
Gene namesi
Name:LARP1
Synonyms:KIAA0731, LARP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:29531. LARP1.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • cytoplasm Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi23367.
OpenTargetsiENSG00000155506.
PharmGKBiPA142671564.

Polymorphism and mutation databases

DMDMi73621135.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002076092 – 1096La-related protein 1Add BLAST1095

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei75PhosphoserineCombined sources1
Modified residuei90PhosphoserineCombined sources1
Modified residuei143PhosphoserineCombined sources1
Modified residuei165PhosphoserineCombined sources1
Modified residuei215PhosphoserineCombined sources1
Modified residuei220PhosphoserineCombined sources1
Modified residuei223PhosphothreonineBy similarity1
Modified residuei225PhosphoserineBy similarity1
Modified residuei228PhosphoserineBy similarity1
Modified residuei240Omega-N-methylarginineBy similarity1
Cross-linki311Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei324PhosphoserineBy similarity1
Modified residuei327PhosphoserineBy similarity1
Modified residuei376PhosphothreonineCombined sources1
Modified residuei517PhosphoserineCombined sources1
Modified residuei521PhosphoserineCombined sources1
Modified residuei526PhosphothreonineCombined sources1 Publication1
Modified residuei548PhosphoserineCombined sources1
Modified residuei591PhosphoserineCombined sources1
Modified residuei627PhosphoserineCombined sources1
Modified residuei631PhosphoserineCombined sources1
Modified residuei649PhosphothreonineCombined sources1
Modified residuei724PhosphothreonineCombined sources1
Modified residuei766PhosphoserineCombined sources1
Modified residuei774PhosphoserineCombined sources1 Publication1
Modified residuei777PhosphotyrosineCombined sources1
Modified residuei785PhosphothreonineCombined sources1
Modified residuei788PhosphothreonineCombined sources1
Modified residuei824PhosphoserineCombined sources1
Modified residuei845PhosphothreonineCombined sources1
Modified residuei851PhosphoserineCombined sources1
Modified residuei853PhosphoserineBy similarity1
Modified residuei865PhosphothreonineBy similarity1
Modified residuei868PhosphoserineBy similarity1
Modified residuei892N6-acetyllysineCombined sources1
Modified residuei1017N6-acetyllysineCombined sources1
Modified residuei1040PhosphoserineCombined sources1
Modified residuei1089PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ6PKG0.
MaxQBiQ6PKG0.
PaxDbiQ6PKG0.
PeptideAtlasiQ6PKG0.
PRIDEiQ6PKG0.

PTM databases

iPTMnetiQ6PKG0.
PhosphoSitePlusiQ6PKG0.
SwissPalmiQ6PKG0.

Miscellaneous databases

PMAP-CutDBQ6PKG0.

Expressioni

Inductioni

Up-regulated in a number of hepatocellular carcinoma cell lines and liver cancer lesions, as well as in patients with hepatocellular carcinoma with a lower survival rate (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000155506.
CleanExiHS_LARP1.
ExpressionAtlasiQ6PKG0. baseline and differential.
GenevisibleiQ6PKG0. HS.

Organism-specific databases

HPAiCAB015222.
HPA051397.
HPA054819.

Interactioni

Subunit structurei

Interacts with PABPC1/PABP. Associates with the mTORC1 complex. Interacts with EIF4E. Found in a complex with PABPC1 and RYDEN (PubMed:26735137).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC155Q8N6L03EBI-1052114,EBI-749265

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • eukaryotic initiation factor 4E binding Source: UniProtKB
  • translation initiation factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116947. 104 interactors.
IntActiQ6PKG0. 46 interactors.
MINTiMINT-1631511.
STRINGi9606.ENSP00000336721.

Structurei

Secondary structure

11096
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi875 – 880Combined sources6
Helixi887 – 904Combined sources18
Helixi910 – 922Combined sources13
Turni923 – 925Combined sources3
Helixi929 – 944Combined sources16
Helixi949 – 964Combined sources16
Helixi968 – 983Combined sources16
Helixi988 – 999Combined sources12
Helixi1001 – 1004Combined sources4
Helixi1009 – 1018Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ZC4X-ray1.86A/B/C/D873-1023[»]
5C0VX-ray2.20A/B/C/D873-1023[»]
ProteinModelPortaliQ6PKG0.
SMRiQ6PKG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini397 – 487HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST91

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1044 – 1050Poly-Gly7

Sequence similaritiesi

Belongs to the LARP family.Curated
Contains 1 HTH La-type RNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2590. Eukaryota.
COG5193. LUCA.
GeneTreeiENSGT00390000000523.
HOGENOMiHOG000113283.
HOVERGENiHBG054322.
InParanoidiQ6PKG0.
KOiK18757.
OMAiQHSDTQT.
OrthoDBiEOG091G02X0.
PhylomeDBiQ6PKG0.
TreeFamiTF314516.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR006607. DM15.
IPR006630. Lupus_La_RNA-bd.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05383. La. 1 hit.
[Graphical view]
SMARTiSM00684. DM15. 3 hits.
SM00715. LA. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50961. HTH_LA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PKG0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATQVEPLLP GGATLLQAEE HGGLVRKKPP PAPEGKGEPG PNDVRGGEPD
60 70 80 90 100
GSARRPRPPC AKPHKEGTGQ QERESPRPLQ LPGAEGPAIS DGEEGGGEPG
110 120 130 140 150
AGGGAAGAAG AGRRDFVEAP PPKVNPWTKN ALPPVLTTVN GQSPPEHSAP
160 170 180 190 200
AKVVRAAVPK QRKGSKVGDF GDAINWPTPG EIAHKSVQPQ SHKPQPTRKL
210 220 230 240 250
PPKKDMKEQE KGEGSDSKES PKTKSDESGE EKNGDEDCQR GGQKKKGNKH
260 270 280 290 300
KWVPLQIDMK PEVPREKLAS RPTRPPEPRH IPANRGEIKG SESATYVPVA
310 320 330 340 350
PPTPAWQPEI KPEPAWHDQD ETSSVKSDGA GGARASFRGR GRGRGRGRGR
360 370 380 390 400
GRGGTRTHFD YQFGYRKFDG VEGPRTPKYM NNITYYFDNV SSTELYSVDQ
410 420 430 440 450
ELLKDYIKRQ IEYYFSVDNL ERDFFLRRKM DADGFLPITL IASFHRVQAL
460 470 480 490 500
TTDISLIFAA LKDSKVVEIV DEKVRRREEP EKWPLPPIVD YSQTDFSQLL
510 520 530 540 550
NCPEFVPRQH YQKETESAPG SPRAVTPVPT KTEEVSNLKT LPKGLSASLP
560 570 580 590 600
DLDSENWIEV KKRPRPSPAR PKKSEESRFS HLTSLPQQLP SQQLMSKDQD
610 620 630 640 650
EQEELDFLFD EEMEQMDGRK NTFTAWSDEE SDYEIDDRDV NKILIVTQTP
660 670 680 690 700
HYMRRHPGGD RTGNHTSRAK MSAELAKVIN DGLFYYEQDL WAEKFEPEYS
710 720 730 740 750
QIKQEVENFK KVNMISREQF DTLTPEPPVD PNQEVPPGPP RFQQVPTDAL
760 770 780 790 800
ANKLFGAPEP STIARSLPTT VPESPNYRNT RTPRTPRTPQ LKDSSQTSRF
810 820 830 840 850
YPVVKEGRTL DAKMPRKRKT RHSSNPPLES HVGWVMDSRE HRPRTASISS
860 870 880 890 900
SPSEGTPTVG SYGCTPQSLP KFQHPSHELL KENGFTQHVY HKYRRRCLNE
910 920 930 940 950
RKRLGIGQSQ EMNTLFRFWS FFLRDHFNKK MYEEFKQLAL EDAKEGYRYG
960 970 980 990 1000
LECLFRYYSY GLEKKFRLDI FKDFQEETVK DYEAGQLYGL EKFWAFLKYS
1010 1020 1030 1040 1050
KAKNLDIDPK LQEYLGKFRR LEDFRVDPPM GEEGNHKRHS VVAGGGGGEG
1060 1070 1080 1090
RKRCPSQSSS RPAAMISQPP TPPTGQPVRE DAKWTSQHSN TQTLGK
Length:1,096
Mass (Da):123,510
Last modified:August 16, 2005 - v2
Checksum:iCA3E9D30BBC101B7
GO
Isoform 2 (identifier: Q6PKG0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.
     78-144: PLQLPGAEGP...VLTTVNGQSP → MLWRVLLSKR...PFPVLAPFSN

Show »
Length:1,019
Mass (Da):116,465
Checksum:i64982CA22171B0E6
GO

Sequence cautioni

The sequence AAH33856 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA34451 differs from that shown. Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti778 – 780RNT → TRP in AAH33856 (PubMed:15489334).Curated3
Sequence conflicti979V → L in CAB61364 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0151141 – 77Missing in isoform 2. 1 PublicationAdd BLAST77
Alternative sequenceiVSP_01511578 – 144PLQLP…NGQSP → MLWRVLLSKRPPFPHPELDF QEAPIPSCPGRLPGRKNSVA LAAAPRKEPTGDREKPLPFP VLAPFSN in isoform 2. 1 PublicationAdd BLAST67

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC001460 mRNA. Translation: AAH01460.2.
BC033856 mRNA. Translation: AAH33856.1. Different initiation.
AK091465 mRNA. Translation: BAC03668.1.
AB018274 mRNA. Translation: BAA34451.1. Sequence problems.
AL133034 mRNA. Translation: CAB61364.1.
CCDSiCCDS4328.1. [Q6PKG0-3]
PIRiT42646.
RefSeqiNP_056130.2. NM_015315.4. [Q6PKG0-3]
XP_005268461.1. XM_005268404.3. [Q6PKG0-1]
UniGeneiHs.292078.

Genome annotation databases

EnsembliENST00000336314; ENSP00000336721; ENSG00000155506. [Q6PKG0-3]
GeneIDi23367.
KEGGihsa:23367.
UCSCiuc003lvo.4. human. [Q6PKG0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC001460 mRNA. Translation: AAH01460.2.
BC033856 mRNA. Translation: AAH33856.1. Different initiation.
AK091465 mRNA. Translation: BAC03668.1.
AB018274 mRNA. Translation: BAA34451.1. Sequence problems.
AL133034 mRNA. Translation: CAB61364.1.
CCDSiCCDS4328.1. [Q6PKG0-3]
PIRiT42646.
RefSeqiNP_056130.2. NM_015315.4. [Q6PKG0-3]
XP_005268461.1. XM_005268404.3. [Q6PKG0-1]
UniGeneiHs.292078.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ZC4X-ray1.86A/B/C/D873-1023[»]
5C0VX-ray2.20A/B/C/D873-1023[»]
ProteinModelPortaliQ6PKG0.
SMRiQ6PKG0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116947. 104 interactors.
IntActiQ6PKG0. 46 interactors.
MINTiMINT-1631511.
STRINGi9606.ENSP00000336721.

PTM databases

iPTMnetiQ6PKG0.
PhosphoSitePlusiQ6PKG0.
SwissPalmiQ6PKG0.

Polymorphism and mutation databases

DMDMi73621135.

Proteomic databases

EPDiQ6PKG0.
MaxQBiQ6PKG0.
PaxDbiQ6PKG0.
PeptideAtlasiQ6PKG0.
PRIDEiQ6PKG0.

Protocols and materials databases

DNASUi23367.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336314; ENSP00000336721; ENSG00000155506. [Q6PKG0-3]
GeneIDi23367.
KEGGihsa:23367.
UCSCiuc003lvo.4. human. [Q6PKG0-1]

Organism-specific databases

CTDi23367.
DisGeNETi23367.
GeneCardsiLARP1.
HGNCiHGNC:29531. LARP1.
HPAiCAB015222.
HPA051397.
HPA054819.
MIMi612059. gene.
neXtProtiNX_Q6PKG0.
OpenTargetsiENSG00000155506.
PharmGKBiPA142671564.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2590. Eukaryota.
COG5193. LUCA.
GeneTreeiENSGT00390000000523.
HOGENOMiHOG000113283.
HOVERGENiHBG054322.
InParanoidiQ6PKG0.
KOiK18757.
OMAiQHSDTQT.
OrthoDBiEOG091G02X0.
PhylomeDBiQ6PKG0.
TreeFamiTF314516.

Miscellaneous databases

ChiTaRSiLARP1. human.
GeneWikiiLARP1.
GenomeRNAii23367.
PMAP-CutDBQ6PKG0.
PROiQ6PKG0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000155506.
CleanExiHS_LARP1.
ExpressionAtlasiQ6PKG0. baseline and differential.
GenevisibleiQ6PKG0. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR006607. DM15.
IPR006630. Lupus_La_RNA-bd.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05383. La. 1 hit.
[Graphical view]
SMARTiSM00684. DM15. 3 hits.
SM00715. LA. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50961. HTH_LA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLARP1_HUMAN
AccessioniPrimary (citable) accession number: Q6PKG0
Secondary accession number(s): O94836
, Q8N4M2, Q8NB73, Q9UFD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: November 2, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.