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Q6PKC3 (TXD11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thioredoxin domain-containing protein 11
Alternative name(s):
EF-hand-binding protein 1
Gene names
Name:TXNDC11
Synonyms:EFP1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length985 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H2O2 generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H2O2 generation.

Subunit structure

Interacts with the cytoplasmic part of DUOX1 and DUOX2. Interacts with TPO and CYBA. Ref.5

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein Potential.

Tissue specificity

Widely expressed at low level. Expressed at higher level in thyroid and prostate. Ref.5

Sequence similarities

Belongs to the protein disulfide isomerase family.

Contains 2 thioredoxin domains.

Sequence caution

The sequence AAD20043.1 differs from that shown. Reason: Frameshift at position 618.

The sequence AAH13727.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAB55129.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAC11044.1 differs from that shown. Reason: Intron retention.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Q9WMX22EBI-749812,EBI-6863748From a different organism.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6PKC3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6PKC3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     265-291: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q6PKC3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     265-278: ALESTSSPRALVSF → DGVSPCRPGWSAVA
     279-985: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 985985Thioredoxin domain-containing protein 11
PRO_0000120173

Regions

Transmembrane65 – 8521Helical; Potential
Domain92 – 214123Thioredoxin 1
Domain649 – 799151Thioredoxin 2
Coiled coil821 – 91999 Potential

Amino acid modifications

Modified residue8281Phosphoserine Ref.6
Disulfide bond469 ↔ 472Redox-active By similarity
Disulfide bond719 ↔ 722Redox-active By similarity

Natural variations

Alternative sequence265 – 29127Missing in isoform 2.
VSP_014335
Alternative sequence265 – 27814ALEST…ALVSF → DGVSPCRPGWSAVA in isoform 3.
VSP_014336
Alternative sequence279 – 985707Missing in isoform 3.
VSP_014337
Natural variant7831V → L. Ref.2
Corresponds to variant rs3190321 [ dbSNP | Ensembl ].
VAR_022767

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2005. Version 2.
Checksum: 4A8C852F8E81B8BC

FASTA985110,529
        10         20         30         40         50         60 
MSECGGRGGG SSSSEDAEDE GGGGGGPAGS DCLSSSPTLA TASSAGRLRR GLRGAFLMAR 

        70         80         90        100        110        120 
QRPELLCGAV ALGCALLLAL KFTCSRAKDV IIPAKPPVSF FSLRSPVLDL FQGQLDYAEY 

       130        140        150        160        170        180 
VRRDSEVVLL FFYAPWCGQS IAARAEIEQA ASRLSDQVLF VAINCWWNQG KCRKQKHFFY 

       190        200        210        220        230        240 
FPVIYLYHRS FGPIEYKGPM SAVYIEKFVR RVMKPLLYIP SQSELLDFLS NYEPGVLGYF 

       250        260        270        280        290        300 
EFSGSPQPPG YLTFFTSALH SLKKALESTS SPRALVSFTG EWHLETKIYV LDYLGTVRFG 

       310        320        330        340        350        360 
VITNKHLAKL VSLVHSGSVY LHRHFNTSLV FPREVLNYTA ENICKWALEN QETLFRWLRP 

       370        380        390        400        410        420 
HGGKSLLLNN ELKKGPALFL FIPFNPLAES HPLIDEITEV ALEYNNCHGD QVVERLLQHL 

       430        440        450        460        470        480 
RRVDAPVLES LALEVPAQLP DPPTITASPC CNTVVLPQWH SFSRTHNVCE LCVNQTSGGM 

       490        500        510        520        530        540 
KPSSVSVPQC SFFEMAAALD SFYLKEQTFY HVASDSIECS NFLTSYSPFS YYTACCRTIS 

       550        560        570        580        590        600 
RGVSGFIDSE QGVFEAPTVA FSSLEKKCEV DAPSSVPHIE ENRYLFPEVD MTSTNFTGLS 

       610        620        630        640        650        660 
CRTNKTLNIY LLDSNLFWLY AERLGAPSST QVKEFAAIVD VKEESHYILD PKQALMKLTL 

       670        680        690        700        710        720 
ESFIQNFSVL YSPLKRHLIG SGSAQFPSQH LITEVTTDTF WEVVLQKQDV LLLYYAPWCG 

       730        740        750        760        770        780 
FCPSLNHIFI QLARNLPMDT FTVARIDVSQ NDLPWEFMVD RLPTVLFFPC NRKDLSVKYP 

       790        800        810        820        830        840 
EDVPITLPNL LRFILHHSDP ASSPQNVANS PTKECLQSEA VLQRGHISHL EREIQKLRAE 

       850        860        870        880        890        900 
ISSLQRAQVQ VESQLSSARR DEHRLRQQQR ALEEQHSLLH AHSEQLQALY EQKTRELQEL 

       910        920        930        940        950        960 
ARKLQELADA SENLLTENTW LKILVATMER KLEGRDGAES LAAQREVHPK QPEPSATPQL 

       970        980 
PGSSPPPANV SATLVSERNK ENRTD 

« Hide

Isoform 2 [UniParc].

Checksum: 7E051E7BFA61B4F8
Show »

FASTA958107,512
Isoform 3 [UniParc].

Checksum: C89C635153ADE9F9
Show »

FASTA27830,375

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Embryo and Teratocarcinoma.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT LEU-783.
Tissue: Placenta.
[3]Mei G., Yu W., Gibbs R.A.
Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 523-985.
Tissue: Brain.
[4]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 656-985.
[5]"Identification of a novel partner of duox: EFP1, a thioredoxin-related protein."
Wang D., De Deken X., Milenkovic M., Song Y., Pirson I., Dumont J.E., Miot F.
J. Biol. Chem. 280:3096-3103(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, INTERACTION WITH DUOX1; DUOX2; TPO AND CYBA.
[6]"Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction."
Tang L.-Y., Deng N., Wang L.-S., Dai J., Wang Z.-L., Jiang X.-S., Li S.-J., Li L., Sheng Q.-H., Wu D.-Q., Li L., Zeng R.
Mol. Cell. Proteomics 6:1952-1967(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-828, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK027464 mRNA. Translation: BAB55129.1. Different initiation.
AK027646 mRNA. Translation: BAB55262.1.
AK074534 mRNA. Translation: BAC11044.1. Sequence problems.
BC002856 mRNA. Translation: AAH02856.1.
BC013727 mRNA. Translation: AAH13727.1. Different initiation.
BC018635 mRNA. Translation: AAH18635.1.
AF131780 mRNA. Translation: AAD20043.1. Frameshift.
CR457152 mRNA. Translation: CAG33433.1.
CCDSCCDS32387.1. [Q6PKC3-2]
RefSeqNP_056998.4. NM_015914.5. [Q6PKC3-2]
UniGeneHs.313847.

3D structure databases

ProteinModelPortalQ6PKC3.
SMRQ6PKC3. Positions 127-245, 569-827.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119253. 18 interactions.
IntActQ6PKC3. 43 interactions.
MINTMINT-2872884.
STRING9606.ENSP00000283033.

PTM databases

PhosphoSiteQ6PKC3.

Polymorphism databases

DMDM68566185.

Proteomic databases

MaxQBQ6PKC3.
PaxDbQ6PKC3.
PRIDEQ6PKC3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000283033; ENSP00000283033; ENSG00000153066. [Q6PKC3-2]
ENST00000356957; ENSP00000349439; ENSG00000153066. [Q6PKC3-1]
GeneID51061.
KEGGhsa:51061.
UCSCuc002dbg.1. human. [Q6PKC3-2]
uc010buu.1. human. [Q6PKC3-1]

Organism-specific databases

CTD51061.
GeneCardsGC16M011772.
H-InvDBHIX0017349.
HGNCHGNC:28030. TXNDC11.
HPAHPA041174.
HPA041390.
neXtProtNX_Q6PKC3.
PharmGKBPA134915251.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0526.
HOGENOMHOG000132983.
HOVERGENHBG082866.
InParanoidQ6PKC3.
OMANFSVLYS.
OrthoDBEOG7ZSHSG.
PhylomeDBQ6PKC3.
TreeFamTF323602.

Gene expression databases

ArrayExpressQ6PKC3.
BgeeQ6PKC3.
CleanExHS_TXNDC11.
GenevestigatorQ6PKC3.

Family and domain databases

Gene3D3.40.30.10. 2 hits.
InterProIPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamPF00085. Thioredoxin. 2 hits.
[Graphical view]
SUPFAMSSF52833. SSF52833. 2 hits.
PROSITEPS51352. THIOREDOXIN_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi51061.
NextBio53645.
PROQ6PKC3.

Entry information

Entry nameTXD11_HUMAN
AccessionPrimary (citable) accession number: Q6PKC3
Secondary accession number(s): O95887 expand/collapse secondary AC list , Q6PJA6, Q8N2Q4, Q96K45, Q96K53
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM