Q6PKC0 (Q6PKC0_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
GMP reductase RuleBase RU003929
EC=1.7.1.7 RuleBase RU003929

Gene names

Name:

GMPR2 EMBL AAH03053.1 Ensembl ENSP00000334409

Organism

Homo sapiens (Human) EMBL AAH03053.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	409 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity. RuleBase RU003929
Catalytic activity	Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. RuleBase RU003929
Sequence similarities	Belongs to the IMPDH/GMPR family. RuleBase RU003927

Ontologies

Keywords
Ligand	Metal-binding RuleBase RU003929 NADP RuleBase RU003929 Potassium RuleBase RU003929
Molecular function	Oxidoreductase RuleBase RU003927
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	nucleotide metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	GMP reductase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6PKC0 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 73B70E7FA0BE4A57	FASTA	409	45,008
	10 20 30 40 50 60 MPHIDNDVKL DFKDVLLRPK RSTLKSRSEV DLTRSFSFRN SKQTYSGVPI IAANMDTVGT 70 80 90 100 110 120 FEMAKVLCKF SLFTAVHKHY SLVQWQEFAG QNPDCLEHLA ASSGTGSSDF EQLEQILEAI 130 140 150 160 170 180 PQVKYICLDV ANGYSEHFVE FVKDVRKRFP QHTIMAGNVV TGEMVEELIL SGADIIKVGI 190 200 210 220 230 240 GPGSVCTTRK KTGVGYPQLS AVMECADAAH GLKGHIISDG GCSCPGDVAK AFGAGADFVM 250 260 270 280 290 300 LGGMLAGHSE SGGELIERDG KKYKLFYGMS SEMAMKKYAG GVAEYRYVWR PRSLVIVWRQ 310 320 330 340 350 360 NSWLLRGGWY SSQRSMVNRG SMLGSVEKSL GLRNPEGEDN KVFPTLRASE GKTVEVPFKG 370 380 390 400 DVEHTIRDIL GGIRSTCTYV GAAKLKELSR RTTFIRVTQQ VNPIFSEAC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta EMBL AAH03053.1.
[3]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL096870 Genomic DNA. No translation available. BC003053 mRNA. Translation: AAH03053.1.
IPI	IPI00449197.
UniGene	Hs.368855.
3D structure databases
HSSP	HSSP built from PDB template 1B3O based on UniProtKB P12268.
ProteinModelPortal	Q6PKC0.
SMR	Q6PKC0. Positions 10-286, 320-400.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6PKC0.
Proteomic databases
PRIDE	Q6PKC0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000348719; ENSP00000334409; ENSG00000100938.
UCSC	uc001wnu.2. human.
Organism-specific databases
HGNC	HGNC:4377. GMPR2.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00530000062923.
HOGENOM	HBG298985.
HOVERGEN	HBG051744.
OMA	FRNSKQM.
PhylomeDB	Q6PKC0.
Gene expression databases
ArrayExpress	Q6PKC0.
Bgee	Q6PKC0.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR005993. GMP_reduct1. IPR015875. IMP_DH/GMP_Rdtase_CS. IPR001093. IMP_DH_GMPRt. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 2 hits.
Pfam	PF00478. IMPDH. 2 hits. [Graphical view]
TIGRFAMs	TIGR01305. GMP_reduct_1. 1 hit.
PROSITE	PS00487. IMP_DH_GMP_RED. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q6PKC0_HUMAN

Accession

Primary (citable) accession number: Q6PKC0

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	September 21, 2011
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.