Q6PKC0 (Q6PKC0_HUMAN) Unreviewed, UniProtKB/TrEMBL
Last modified
September 21, 2011.
Version 56.
History...
Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order
Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize orderNames and origin
| Protein names | Recommended name: GMP reductase RuleBase RU003929 EC=1.7.1.7 RuleBase RU003929 | ||
| Gene names |
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| Organism | Homo sapiens (Human) EMBL AAH03053.1 | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 409 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity. RuleBase RU003929 |
| Catalytic activity | Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. RuleBase RU003929 |
| Sequence similarities | Belongs to the IMPDH/GMPR family. RuleBase RU003927 |
Ontologies
| Keywords | |
|---|---|
| Ligand | Metal-binding RuleBase RU003929 NADP RuleBase RU003929 Potassium RuleBase RU003929 |
| Molecular function | Oxidoreductase RuleBase RU003927 |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | nucleotide metabolic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | GMP reductase activity Inferred from electronic annotation. Source: EC metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. Weissenbach J.Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta EMBL AAH03053.1. |
| [3] | Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AL096870 Genomic DNA. No translation available. BC003053 mRNA. Translation: AAH03053.1. |
| IPI | IPI00449197. |
| UniGene | Hs.368855. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1B3O based on UniProtKB P12268. |
| ProteinModelPortal | Q6PKC0. |
| SMR | Q6PKC0. Positions 10-286, 320-400. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q6PKC0. |
Proteomic databases | |
| PRIDE | Q6PKC0. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000348719; ENSP00000334409; ENSG00000100938. |
| UCSC | uc001wnu.2. human. |
Organism-specific databases | |
| HGNC | HGNC:4377. GMPR2. |
| GenAtlas | Search... |
Phylogenomic databases | |
| GeneTree | ENSGT00530000062923. |
| HOGENOM | HBG298985. |
| HOVERGEN | HBG051744. |
| OMA | FRNSKQM. |
| PhylomeDB | Q6PKC0. |
Gene expression databases | |
| ArrayExpress | Q6PKC0. |
| Bgee | Q6PKC0. |
Family and domain databases | |
| InterPro | IPR013785. Aldolase_TIM. IPR005993. GMP_reduct1. IPR015875. IMP_DH/GMP_Rdtase_CS. IPR001093. IMP_DH_GMPRt. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 2 hits. |
| Pfam | PF00478. IMPDH. 2 hits. [Graphical view] |
| TIGRFAMs | TIGR01305. GMP_reduct_1. 1 hit. |
| PROSITE | PS00487. IMP_DH_GMP_RED. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | Q6PKC0_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q6PKC0 | ||||||||
| Entry history |
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| Entry status | Unreviewed (UniProtKB/TrEMBL) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||

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