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Protein

Zinc finger protein 773

Gene

ZNF773

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri191 – 21323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri219 – 24123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri247 – 26923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri275 – 29723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri303 – 32523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri331 – 35323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri359 – 38123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri387 – 40923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri415 – 43723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 773
Alternative name(s):
Zinc finger protein 419B
Gene namesi
Name:ZNF773
Synonyms:ZNF419B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:30487. ZNF773.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410357.

Polymorphism and mutation databases

BioMutaiZNF773.
DMDMi74758405.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 442442Zinc finger protein 773PRO_0000285303Add
BLAST

Proteomic databases

EPDiQ6PK81.
MaxQBiQ6PK81.
PaxDbiQ6PK81.
PeptideAtlasiQ6PK81.
PRIDEiQ6PK81.

PTM databases

iPTMnetiQ6PK81.
PhosphoSiteiQ6PK81.

Expressioni

Gene expression databases

BgeeiENSG00000152439.
CleanExiHS_ZNF773.
ExpressionAtlasiQ6PK81. baseline and differential.

Organism-specific databases

HPAiHPA003152.

Interactioni

Protein-protein interaction databases

BioGridi131939. 1 interaction.
IntActiQ6PK81. 2 interactions.
STRINGi9606.ENSP00000282292.

Structurei

3D structure databases

ProteinModelPortaliQ6PK81.
SMRiQ6PK81. Positions 109-440.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 8672KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri191 – 21323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri219 – 24123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri247 – 26923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri275 – 29723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri303 – 32523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri331 – 35323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri359 – 38123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri387 – 40923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri415 – 43723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6PK81.
KOiK09228.
OMAiMPYECSS.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6PK81.
TreeFamiTF339848.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PK81-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAATLRDPA QQGYVTFEDV AVYFSQEEWR LLDDAQRLLY RNVMLENFTL
60 70 80 90 100
LASLGLASSK THEITQLESW EEPFMPAWEV VTSAILRGSW QGAKAEAAAE
110 120 130 140 150
QSASVEVPSS NVQQHQKQHC GEKPLKRQEG RVPVLRSCRV HLSEKSLQSR
160 170 180 190 200
EVGKDLLTSS GVLKHQVTHT GEKSHRSSKS REAFHAGKRH YKCSECGKAF
210 220 230 240 250
GQKYLLVQHQ RLHTGEKPYE CSECGKLFSH KSNLFIHQIV HTGERPYGCS
260 270 280 290 300
DCGKSFSRNA DLIQHQRVHT GEKPFTCSEC GKAFRHNSTL VQHHRIHTGV
310 320 330 340 350
RPYECSECGK LFSFNSSLMK HQRVHTGERP YKCSECGKFY SHKSSLINHW
360 370 380 390 400
RVHTGERPYE CSECGKFFSQ SSSLMQHRKV HTGEKPFKCN ECGRFFSENS
410 420 430 440
SLVKHQRVHT GAKPYECREC GKFFRHSSSL VKHRRIHTGE IQ
Length:442
Mass (Da):50,502
Last modified:July 5, 2004 - v1
Checksum:i0CBC2E4427C3A01D
GO
Isoform 2 (identifier: Q6PK81-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-12: Missing.

Note: No experimental confirmation available.
Show »
Length:441
Mass (Da):50,374
Checksum:i3061BA247FD4B246
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei12 – 121Missing in isoform 2. 1 PublicationVSP_024870

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057209 mRNA. Translation: BAB71382.1.
BC005167 mRNA. Translation: AAH05167.1.
CCDSiCCDS33134.1. [Q6PK81-1]
CCDS77368.1. [Q6PK81-2]
RefSeqiNP_001291263.1. NM_001304334.1. [Q6PK81-2]
NP_940944.1. NM_198542.2. [Q6PK81-1]
UniGeneiHs.579576.

Genome annotation databases

EnsembliENST00000282292; ENSP00000282292; ENSG00000152439. [Q6PK81-1]
ENST00000598770; ENSP00000469416; ENSG00000152439. [Q6PK81-2]
GeneIDi374928.
KEGGihsa:374928.
UCSCiuc002qox.4. human. [Q6PK81-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057209 mRNA. Translation: BAB71382.1.
BC005167 mRNA. Translation: AAH05167.1.
CCDSiCCDS33134.1. [Q6PK81-1]
CCDS77368.1. [Q6PK81-2]
RefSeqiNP_001291263.1. NM_001304334.1. [Q6PK81-2]
NP_940944.1. NM_198542.2. [Q6PK81-1]
UniGeneiHs.579576.

3D structure databases

ProteinModelPortaliQ6PK81.
SMRiQ6PK81. Positions 109-440.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131939. 1 interaction.
IntActiQ6PK81. 2 interactions.
STRINGi9606.ENSP00000282292.

PTM databases

iPTMnetiQ6PK81.
PhosphoSiteiQ6PK81.

Polymorphism and mutation databases

BioMutaiZNF773.
DMDMi74758405.

Proteomic databases

EPDiQ6PK81.
MaxQBiQ6PK81.
PaxDbiQ6PK81.
PeptideAtlasiQ6PK81.
PRIDEiQ6PK81.

Protocols and materials databases

DNASUi374928.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282292; ENSP00000282292; ENSG00000152439. [Q6PK81-1]
ENST00000598770; ENSP00000469416; ENSG00000152439. [Q6PK81-2]
GeneIDi374928.
KEGGihsa:374928.
UCSCiuc002qox.4. human. [Q6PK81-1]

Organism-specific databases

CTDi374928.
GeneCardsiZNF773.
HGNCiHGNC:30487. ZNF773.
HPAiHPA003152.
neXtProtiNX_Q6PK81.
PharmGKBiPA162410357.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6PK81.
KOiK09228.
OMAiMPYECSS.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6PK81.
TreeFamiTF339848.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii374928.
PROiQ6PK81.

Gene expression databases

BgeeiENSG00000152439.
CleanExiHS_ZNF773.
ExpressionAtlasiQ6PK81. baseline and differential.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN773_HUMAN
AccessioniPrimary (citable) accession number: Q6PK81
Secondary accession number(s): Q96DL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.