Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3

Gene

OGFOD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Protein has several cofactor binding sites:
  • Fe2+Note: Binds 1 Fe2+ ion per subunit.
  • L-ascorbateBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi230Iron1
Metal bindingi232Iron1
Metal bindingi288Iron1
Active sitei298Sequence analysis1
Binding sitei2982-oxoglutarate1

GO - Molecular functioni

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
LigandIron, Metal-binding, Vitamin C

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 (EC:1.14.11.-)
Gene namesi
Name:OGFOD3
Synonyms:C17orf101
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000181396.12.
HGNCiHGNC:26174. OGFOD3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 42CytoplasmicSequence analysisAdd BLAST42
Transmembranei43 – 65Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini66 – 319LumenalSequence analysisAdd BLAST254

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000181396.
PharmGKBiPA164716907.

Polymorphism and mutation databases

BioMutaiOGFOD3.
DMDMi172046153.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003258851 – 3192-oxoglutarate and iron-dependent oxygenase domain-containing protein 3Add BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi215N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ6PK18.
MaxQBiQ6PK18.
PaxDbiQ6PK18.
PeptideAtlasiQ6PK18.
PRIDEiQ6PK18.

PTM databases

iPTMnetiQ6PK18.
PhosphoSitePlusiQ6PK18.

Expressioni

Gene expression databases

BgeeiENSG00000181396.
ExpressionAtlasiQ6PK18. baseline and differential.
GenevisibleiQ6PK18. HS.

Organism-specific databases

HPAiHPA052099.

Interactioni

Protein-protein interaction databases

BioGridi122821. 13 interactors.
IntActiQ6PK18. 1 interactor.
STRINGi9606.ENSP00000330075.

Structurei

3D structure databases

ProteinModelPortaliQ6PK18.
SMRiQ6PK18.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini207 – 309Fe2OG dioxygenaseAdd BLAST103

Sequence similaritiesi

Belongs to the OGFOD3 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHR9. Eukaryota.
ENOG410ZI9Q. LUCA.
GeneTreeiENSGT00390000005895.
HOGENOMiHOG000007407.
InParanoidiQ6PK18.
OMAiCNPDHGI.
OrthoDBiEOG091G0JBD.
PhylomeDBiQ6PK18.
TreeFamiTF329031.

Family and domain databases

InterProiView protein in InterPro
IPR005123. Oxoglu/Fe-dep_dioxygenase.
IPR006620. Pro_4_hyd_alph.
PfamiView protein in Pfam
PF13640. 2OG-FeII_Oxy_3. 1 hit.
SMARTiView protein in SMART
SM00702. P4Hc. 1 hit.
PROSITEiView protein in PROSITE
PS51471. FE2OG_OXY. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6PK18-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPQRRAATK APEGNGAAER RNRSSTKKDR APREVQRLWQ RPWLRTAGLG
60 70 80 90 100
AGFVLTALLL WSSLGADDGV AEVLARRGEV VAGRFIEVPC SEDYDSHRRF
110 120 130 140 150
EGCTPRKCGR GVTDVVITRE EAERIRSVAE KGLSLGGSDG GASILDLHSG
160 170 180 190 200
ALSVGKHFVN LYRYFGDKIQ NIFSEEDFRL YREVRQKVQL TIAEAFGISA
210 220 230 240 250
SSLHLTKPTF FSRINSTEAR TAHDEYWHAH VDKVTYGSFD YTSLLYLSNY
260 270 280 290 300
LEDFGGGRFM FMEEGANKTV EPRAGRVSFF TSGSENLHRV EKVHWGTRYA
310
ITIAFSCNPD HGIEDPAFP
Length:319
Mass (Da):35,646
Last modified:March 18, 2008 - v2
Checksum:i02F7FD0D5BA715B7
GO
Isoform 2 (identifier: Q6PK18-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     276-319: RVSFFTSGSE...DHGIEDPAFP → CFCFRMMSCG...ILEAESIAYC

Note: No experimental confirmation available.Curated
Show »
Length:331
Mass (Da):36,635
Checksum:i34B21A027FE805EE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: Q6PK18-2)
Sequence conflicti314P → S in AAH08897 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03994867D → E. Corresponds to variant dbSNP:rs8072110Ensembl.1
Natural variantiVAR_039949272P → R1 PublicationCorresponds to variant dbSNP:rs17852152Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032462276 – 319RVSFF…DPAFP → CFCFRMMSCGFQEVNGPRAS EAAGAKAGVRCPPGTHHPPE RGETHAILEAESIAYC in isoform 2. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025875 mRNA. Translation: BAB15267.1.
AC132938 Genomic DNA. No translation available.
BC008897 mRNA. Translation: AAH08897.1.
BC023602 mRNA. Translation: AAH23602.1.
CCDSiCCDS11811.1. [Q6PK18-1]
CCDS11812.1. [Q6PK18-2]
RefSeqiNP_078924.1. NM_024648.2. [Q6PK18-1]
NP_787098.3. NM_175902.4. [Q6PK18-2]
UniGeneiHs.187505.

Genome annotation databases

EnsembliENST00000313056; ENSP00000320116; ENSG00000181396. [Q6PK18-1]
ENST00000329197; ENSP00000330075; ENSG00000181396. [Q6PK18-2]
GeneIDi79701.
KEGGihsa:79701.
UCSCiuc002ket.3. human. [Q6PK18-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOGFD3_HUMAN
AccessioniPrimary (citable) accession number: Q6PK18
Secondary accession number(s): C9JDC8, Q8IZ37, Q9H6J2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: September 27, 2017
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families