ID   CC137_HUMAN             Reviewed;         289 AA.
AC   Q6PK04;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 139.
DE   RecName: Full=Coiled-coil domain-containing protein 137;
GN   Name=CCDC137; Synonyms=cPERP-B {ECO:0000303|PubMed:20813266};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Muscle;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-233, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18220336; DOI=10.1021/pr0705441;
RA   Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III;
RT   "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient
RT   phosphoproteomic analysis.";
RL   J. Proteome Res. 7:1346-1351(2008).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-233, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-233, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Leukemic T-cell;
RX   PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA   Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA   Rodionov V., Han D.K.;
RT   "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT   reveals system-wide modulation of protein-protein interactions.";
RL   Sci. Signal. 2:RA46-RA46(2009).
RN   [5]
RP   SUBCELLULAR LOCATION.
RX   PubMed=20813266; DOI=10.1016/j.cell.2010.07.047;
RA   Ohta S., Bukowski-Wills J.C., Sanchez-Pulido L., Alves Fde L., Wood L.,
RA   Chen Z.A., Platani M., Fischer L., Hudson D.F., Ponting C.P., Fukagawa T.,
RA   Earnshaw W.C., Rappsilber J.;
RT   "The protein composition of mitotic chromosomes determined using
RT   multiclassifier combinatorial proteomics.";
RL   Cell 142:810-821(2010).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA   Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA   Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT   "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT   site occupancy during mitosis.";
RL   Sci. Signal. 3:RA3-RA3(2010).
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [8]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA   Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA   Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT   "System-wide temporal characterization of the proteome and phosphoproteome
RT   of human embryonic stem cell differentiation.";
RL   Sci. Signal. 4:RS3-RS3(2011).
RN   [9]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
CC   -!- INTERACTION:
CC       Q6PK04; Q15554: TERF2; NbExp=2; IntAct=EBI-714654, EBI-706637;
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:20813266}.
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DR   EMBL; BC009369; AAH09369.1; -; mRNA.
DR   CCDS; CCDS42400.1; -.
DR   RefSeq; NP_954981.1; NM_199287.2.
DR   AlphaFoldDB; Q6PK04; -.
DR   SMR; Q6PK04; -.
DR   BioGRID; 130846; 356.
DR   IntAct; Q6PK04; 47.
DR   MINT; Q6PK04; -.
DR   STRING; 9606.ENSP00000329360; -.
DR   iPTMnet; Q6PK04; -.
DR   MetOSite; Q6PK04; -.
DR   PhosphoSitePlus; Q6PK04; -.
DR   SwissPalm; Q6PK04; -.
DR   BioMuta; CCDC137; -.
DR   DMDM; 74737969; -.
DR   EPD; Q6PK04; -.
DR   jPOST; Q6PK04; -.
DR   MassIVE; Q6PK04; -.
DR   MaxQB; Q6PK04; -.
DR   PaxDb; 9606-ENSP00000329360; -.
DR   PeptideAtlas; Q6PK04; -.
DR   ProteomicsDB; 67229; -.
DR   Pumba; Q6PK04; -.
DR   Antibodypedia; 66426; 94 antibodies from 18 providers.
DR   DNASU; 339230; -.
DR   Ensembl; ENST00000329214.13; ENSP00000329360.8; ENSG00000185298.13.
DR   Ensembl; ENST00000575223.5; ENSP00000458884.1; ENSG00000185298.13.
DR   GeneID; 339230; -.
DR   KEGG; hsa:339230; -.
DR   MANE-Select; ENST00000329214.13; ENSP00000329360.8; NM_199287.3; NP_954981.1.
DR   UCSC; uc002kbc.5; human.
DR   AGR; HGNC:33451; -.
DR   CTD; 339230; -.
DR   DisGeNET; 339230; -.
DR   GeneCards; CCDC137; -.
DR   HGNC; HGNC:33451; CCDC137.
DR   HPA; ENSG00000185298; Low tissue specificity.
DR   neXtProt; NX_Q6PK04; -.
DR   OpenTargets; ENSG00000185298; -.
DR   PharmGKB; PA162381422; -.
DR   VEuPathDB; HostDB:ENSG00000185298; -.
DR   eggNOG; ENOG502S2F4; Eukaryota.
DR   GeneTree; ENSGT00390000004169; -.
DR   InParanoid; Q6PK04; -.
DR   OMA; SKERMKM; -.
DR   OrthoDB; 4253449at2759; -.
DR   PhylomeDB; Q6PK04; -.
DR   TreeFam; TF332311; -.
DR   PathwayCommons; Q6PK04; -.
DR   SignaLink; Q6PK04; -.
DR   BioGRID-ORCS; 339230; 133 hits in 1158 CRISPR screens.
DR   ChiTaRS; CCDC137; human.
DR   GeneWiki; CCDC137; -.
DR   GenomeRNAi; 339230; -.
DR   Pharos; Q6PK04; Tdark.
DR   PRO; PR:Q6PK04; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q6PK04; Protein.
DR   Bgee; ENSG00000185298; Expressed in lower esophagus mucosa and 155 other cell types or tissues.
DR   ExpressionAtlas; Q6PK04; baseline and differential.
DR   GO; GO:0005694; C:chromosome; IDA:UniProtKB.
DR   GO; GO:0001650; C:fibrillar center; IDA:HPA.
DR   GO; GO:0005730; C:nucleolus; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR   InterPro; IPR026680; CCDC137.
DR   PANTHER; PTHR21838:SF2; COILED-COIL DOMAIN-CONTAINING PROTEIN 137; 1.
DR   PANTHER; PTHR21838; UNCHARACTERIZED; 1.
DR   Genevisible; Q6PK04; HS.
PE   1: Evidence at protein level;
KW   Chromosome; Coiled coil; Phosphoprotein; Reference proteome.
FT   CHAIN           1..289
FT                   /note="Coiled-coil domain-containing protein 137"
FT                   /id="PRO_0000288452"
FT   REGION          1..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          149..184
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          204..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          265..289
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          155..197
FT                   /evidence="ECO:0000255"
FT   COILED          247..273
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        41..64
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        269..289
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         19
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:20068231,
FT                   ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163"
FT   MOD_RES         233
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:18220336,
FT                   ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332"
FT   VARIANT         127
FT                   /note="H -> Q (in dbSNP:rs7226091)"
FT                   /id="VAR_050739"
FT   VARIANT         177
FT                   /note="R -> W (in dbSNP:rs11150805)"
FT                   /id="VAR_050740"
FT   VARIANT         229
FT                   /note="R -> Q (in dbSNP:rs11546630)"
FT                   /id="VAR_050741"
FT   VARIANT         282
FT                   /note="R -> W (in dbSNP:rs11546631)"
FT                   /id="VAR_061582"
SQ   SEQUENCE   289 AA;  33231 MW;  B8C4E6EC64360771 CRC64;
     MAGAGRGAAV SRVQAGPGSP RRARGRQQVQ PLGKQRPAPW PGLRSKEKKK VNCKPKNQDE
     QEIPFRLREI MRSRQEMKNP ISNKKRKKAA QVTFRKTLEK EAKGEEPDIA VPKFKQRKGE
     SDGAYIHRMQ QEAQHVLFLS KNQAIRQPEV QAAPKEKSEQ KKAKKAFQKR RLDKVRRKKE
     EKAADRLEQE LLRDTVKFGE VVLQPPELTA RPQRSVSKDQ PGRRSQMLRM LLSPGGVSQP
     LTASLARQRI VEEERERAVQ AYRALKQRQQ QLHGERPHLT SRKKPEPQL
//