Q6PK04 (CC137_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Coiled-coil domain-containing protein 137

Gene names

Name:

CCDC137

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	289 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 289	289	Coiled-coil domain-containing protein 137		PRO_0000288452
Regions
	Coiled coil	155 – 197	43	Potential
	Coiled coil	247 – 273	27	Potential
Amino acid modifications
	Modified residue	19	1	Phosphoserine Ref.5 Ref.7
	Modified residue	233	1	Phosphoserine Ref.2 Ref.3 Ref.4
Natural variations
	Natural variant	127	1	H → Q. Corresponds to variant rs7226091 [ dbSNP | Ensembl ].		VAR_050739
	Natural variant	177	1	R → W. Corresponds to variant rs11150805 [ dbSNP | Ensembl ].		VAR_050740
	Natural variant	229	1	R → Q. Corresponds to variant rs11546630 [ dbSNP | Ensembl ].		VAR_050741
	Natural variant	282	1	R → W. Corresponds to variant rs11546631 [ dbSNP | Ensembl ].		VAR_061582

Sequences

	Sequence		Length	Mass (Da)
	Q6PK04 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: B8C4E6EC64360771	FASTA	289	33,231
	10 20 30 40 50 60 MAGAGRGAAV SRVQAGPGSP RRARGRQQVQ PLGKQRPAPW PGLRSKEKKK VNCKPKNQDE 70 80 90 100 110 120 QEIPFRLREI MRSRQEMKNP ISNKKRKKAA QVTFRKTLEK EAKGEEPDIA VPKFKQRKGE 130 140 150 160 170 180 SDGAYIHRMQ QEAQHVLFLS KNQAIRQPEV QAAPKEKSEQ KKAKKAFQKR RLDKVRRKKE 190 200 210 220 230 240 EKAADRLEQE LLRDTVKFGE VVLQPPELTA RPQRSVSKDQ PGRRSQMLRM LLSPGGVSQP 250 260 270 280 LTASLARQRI VEEERERAVQ AYRALKQRQQ QLHGERPHLT SRKKPEPQL

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle.
[2]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-233, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[3]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-233, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[4]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-233, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[5]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC009369 mRNA. Translation: AAH09369.1.
IPI	IPI00401962.
RefSeq	NP_954981.1. NM_199287.2.
UniGene	Hs.741339.
3D structure databases
ProteinModelPortal	Q6PK04.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6PK04. 2 interactions.
STRING	9606.ENSP00000329360.
PTM databases
PhosphoSite	Q6PK04.
Polymorphism databases
DMDM	74737969.
Proteomic databases
PaxDb	Q6PK04.
PeptideAtlas	Q6PK04.
PRIDE	Q6PK04.
Protocols and materials databases
DNASU	339230.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000329214; ENSP00000329360; ENSG00000185298. ENST00000575223; ENSP00000458884; ENSG00000185298.
GeneID	339230.
KEGG	hsa:339230.
UCSC	uc002kbc.4. human.
Organism-specific databases
CTD	339230.
GeneCards	GC17P079633.
H-InvDB	HIX0039147.
HGNC	HGNC:33451. CCDC137.
HPA	HPA053914.
neXtProt	NX_Q6PK04.
PharmGKB	PA162381422.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG47711.
HOGENOM	HOG000111387.
HOVERGEN	HBG090761.
InParanoid	Q6PK04.
OMA	GKKSLML.
OrthoDB	EOG4TTGK9.
PhylomeDB	Q6PK04.
Gene expression databases
ArrayExpress	Q6PK04.
Bgee	Q6PK04.
CleanEx	HS_CCDC137.
Genevestigator	Q6PK04.
Family and domain databases
InterPro	IPR026680. CCDC137. [Graphical view]
PANTHER	PTHR21838. PTHR21838. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	339230.
NextBio	97290.

Entry information

Entry name

CC137_HUMAN

Accession

Primary (citable) accession number: Q6PK04

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.