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Q6PK04

- CC137_HUMAN

UniProt

Q6PK04 - CC137_HUMAN

Protein

Coiled-coil domain-containing protein 137

Gene

CCDC137

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coiled-coil domain-containing protein 137
    Gene namesi
    Name:CCDC137
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:33451. CCDC137.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162381422.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289Coiled-coil domain-containing protein 137PRO_0000288452Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei19 – 191Phosphoserine2 Publications
    Modified residuei233 – 2331Phosphoserine3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6PK04.
    PaxDbiQ6PK04.
    PeptideAtlasiQ6PK04.
    PRIDEiQ6PK04.

    PTM databases

    PhosphoSiteiQ6PK04.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6PK04.
    BgeeiQ6PK04.
    CleanExiHS_CCDC137.
    GenevestigatoriQ6PK04.

    Organism-specific databases

    HPAiHPA053914.

    Interactioni

    Protein-protein interaction databases

    BioGridi130846. 5 interactions.
    IntActiQ6PK04. 3 interactions.
    MINTiMINT-6408365.
    STRINGi9606.ENSP00000329360.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PK04.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili155 – 19743Sequence AnalysisAdd
    BLAST
    Coiled coili247 – 27327Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG47711.
    HOGENOMiHOG000111387.
    HOVERGENiHBG090761.
    InParanoidiQ6PK04.
    OrthoDBiEOG7PGDS6.
    PhylomeDBiQ6PK04.
    TreeFamiTF332311.

    Family and domain databases

    InterProiIPR026680. CCDC137.
    [Graphical view]
    PANTHERiPTHR21838. PTHR21838. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6PK04-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGAGRGAAV SRVQAGPGSP RRARGRQQVQ PLGKQRPAPW PGLRSKEKKK    50
    VNCKPKNQDE QEIPFRLREI MRSRQEMKNP ISNKKRKKAA QVTFRKTLEK 100
    EAKGEEPDIA VPKFKQRKGE SDGAYIHRMQ QEAQHVLFLS KNQAIRQPEV 150
    QAAPKEKSEQ KKAKKAFQKR RLDKVRRKKE EKAADRLEQE LLRDTVKFGE 200
    VVLQPPELTA RPQRSVSKDQ PGRRSQMLRM LLSPGGVSQP LTASLARQRI 250
    VEEERERAVQ AYRALKQRQQ QLHGERPHLT SRKKPEPQL 289
    Length:289
    Mass (Da):33,231
    Last modified:July 5, 2004 - v1
    Checksum:iB8C4E6EC64360771
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti127 – 1271H → Q.
    Corresponds to variant rs7226091 [ dbSNP | Ensembl ].
    VAR_050739
    Natural varianti177 – 1771R → W.
    Corresponds to variant rs11150805 [ dbSNP | Ensembl ].
    VAR_050740
    Natural varianti229 – 2291R → Q.
    Corresponds to variant rs11546630 [ dbSNP | Ensembl ].
    VAR_050741
    Natural varianti282 – 2821R → W.
    Corresponds to variant rs11546631 [ dbSNP | Ensembl ].
    VAR_061582

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC009369 mRNA. Translation: AAH09369.1.
    CCDSiCCDS42400.1.
    RefSeqiNP_954981.1. NM_199287.2.
    UniGeneiHs.744125.

    Genome annotation databases

    EnsembliENST00000329214; ENSP00000329360; ENSG00000185298.
    ENST00000575223; ENSP00000458884; ENSG00000185298.
    GeneIDi339230.
    KEGGihsa:339230.
    UCSCiuc002kbc.4. human.

    Polymorphism databases

    DMDMi74737969.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC009369 mRNA. Translation: AAH09369.1 .
    CCDSi CCDS42400.1.
    RefSeqi NP_954981.1. NM_199287.2.
    UniGenei Hs.744125.

    3D structure databases

    ProteinModelPortali Q6PK04.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 130846. 5 interactions.
    IntActi Q6PK04. 3 interactions.
    MINTi MINT-6408365.
    STRINGi 9606.ENSP00000329360.

    PTM databases

    PhosphoSitei Q6PK04.

    Polymorphism databases

    DMDMi 74737969.

    Proteomic databases

    MaxQBi Q6PK04.
    PaxDbi Q6PK04.
    PeptideAtlasi Q6PK04.
    PRIDEi Q6PK04.

    Protocols and materials databases

    DNASUi 339230.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000329214 ; ENSP00000329360 ; ENSG00000185298 .
    ENST00000575223 ; ENSP00000458884 ; ENSG00000185298 .
    GeneIDi 339230.
    KEGGi hsa:339230.
    UCSCi uc002kbc.4. human.

    Organism-specific databases

    CTDi 339230.
    GeneCardsi GC17P079633.
    H-InvDB HIX0039147.
    HGNCi HGNC:33451. CCDC137.
    HPAi HPA053914.
    neXtProti NX_Q6PK04.
    PharmGKBi PA162381422.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47711.
    HOGENOMi HOG000111387.
    HOVERGENi HBG090761.
    InParanoidi Q6PK04.
    OrthoDBi EOG7PGDS6.
    PhylomeDBi Q6PK04.
    TreeFami TF332311.

    Miscellaneous databases

    GeneWikii CCDC137.
    GenomeRNAii 339230.
    NextBioi 97290.
    PROi Q6PK04.

    Gene expression databases

    ArrayExpressi Q6PK04.
    Bgeei Q6PK04.
    CleanExi HS_CCDC137.
    Genevestigatori Q6PK04.

    Family and domain databases

    InterProi IPR026680. CCDC137.
    [Graphical view ]
    PANTHERi PTHR21838. PTHR21838. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle.
    2. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-233, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-233, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    4. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-233, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCC137_HUMAN
    AccessioniPrimary (citable) accession number: Q6PK04
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3