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Q6PK04 (CC137_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Coiled-coil domain-containing protein 137
Gene names
Name:CCDC137
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainCoiled coil
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionpoly(A) RNA binding

Inferred from direct assay PubMed 22658674PubMed 22681889. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Coiled-coil domain-containing protein 137
PRO_0000288452

Regions

Coiled coil155 – 19743 Potential
Coiled coil247 – 27327 Potential

Amino acid modifications

Modified residue191Phosphoserine Ref.5 Ref.7
Modified residue2331Phosphoserine Ref.2 Ref.3 Ref.4

Natural variations

Natural variant1271H → Q.
Corresponds to variant rs7226091 [ dbSNP | Ensembl ].
VAR_050739
Natural variant1771R → W.
Corresponds to variant rs11150805 [ dbSNP | Ensembl ].
VAR_050740
Natural variant2291R → Q.
Corresponds to variant rs11546630 [ dbSNP | Ensembl ].
VAR_050741
Natural variant2821R → W.
Corresponds to variant rs11546631 [ dbSNP | Ensembl ].
VAR_061582

Sequences

Sequence LengthMass (Da)Tools
Q6PK04 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: B8C4E6EC64360771

FASTA28933,231
        10         20         30         40         50         60 
MAGAGRGAAV SRVQAGPGSP RRARGRQQVQ PLGKQRPAPW PGLRSKEKKK VNCKPKNQDE 

        70         80         90        100        110        120 
QEIPFRLREI MRSRQEMKNP ISNKKRKKAA QVTFRKTLEK EAKGEEPDIA VPKFKQRKGE 

       130        140        150        160        170        180 
SDGAYIHRMQ QEAQHVLFLS KNQAIRQPEV QAAPKEKSEQ KKAKKAFQKR RLDKVRRKKE 

       190        200        210        220        230        240 
EKAADRLEQE LLRDTVKFGE VVLQPPELTA RPQRSVSKDQ PGRRSQMLRM LLSPGGVSQP 

       250        260        270        280 
LTASLARQRI VEEERERAVQ AYRALKQRQQ QLHGERPHLT SRKKPEPQL 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Muscle.
[2]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-233, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[3]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-233, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[4]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-233, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[5]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC009369 mRNA. Translation: AAH09369.1.
RefSeqNP_954981.1. NM_199287.2.
UniGeneHs.744125.

3D structure databases

ProteinModelPortalQ6PK04.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid130846. 5 interactions.
IntActQ6PK04. 3 interactions.
MINTMINT-6408365.
STRING9606.ENSP00000329360.

PTM databases

PhosphoSiteQ6PK04.

Polymorphism databases

DMDM74737969.

Proteomic databases

PaxDbQ6PK04.
PeptideAtlasQ6PK04.
PRIDEQ6PK04.

Protocols and materials databases

DNASU339230.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000329214; ENSP00000329360; ENSG00000185298.
ENST00000575223; ENSP00000458884; ENSG00000185298.
GeneID339230.
KEGGhsa:339230.
UCSCuc002kbc.4. human.

Organism-specific databases

CTD339230.
GeneCardsGC17P079633.
H-InvDBHIX0039147.
HGNCHGNC:33451. CCDC137.
HPAHPA053914.
neXtProtNX_Q6PK04.
PharmGKBPA162381422.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47711.
HOGENOMHOG000111387.
HOVERGENHBG090761.
InParanoidQ6PK04.
OrthoDBEOG7PGDS6.
PhylomeDBQ6PK04.
TreeFamTF332311.

Gene expression databases

ArrayExpressQ6PK04.
BgeeQ6PK04.
CleanExHS_CCDC137.
GenevestigatorQ6PK04.

Family and domain databases

InterProIPR026680. CCDC137.
[Graphical view]
PANTHERPTHR21838. PTHR21838. 1 hit.
ProtoNetSearch...

Other

GeneWikiCCDC137.
GenomeRNAi339230.
NextBio97290.
PROQ6PK04.

Entry information

Entry nameCC137_HUMAN
AccessionPrimary (citable) accession number: Q6PK04
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM