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Protein

Coiled-coil domain-containing protein 137

Gene

CCDC137

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-32866-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 137
Gene namesi
Name:CCDC137
Synonyms:cPERP-B1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:33451. CCDC137.

Subcellular locationi

GO - Cellular componenti

  • chromosome Source: UniProtKB
  • nucleolus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Chromosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi339230.
OpenTargetsiENSG00000185298.
PharmGKBiPA162381422.

Polymorphism and mutation databases

BioMutaiCCDC137.
DMDMi74737969.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002884521 – 289Coiled-coil domain-containing protein 137Add BLAST289

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineCombined sources1
Modified residuei233PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6PK04.
MaxQBiQ6PK04.
PaxDbiQ6PK04.
PeptideAtlasiQ6PK04.
PRIDEiQ6PK04.

PTM databases

iPTMnetiQ6PK04.
PhosphoSitePlusiQ6PK04.

Expressioni

Gene expression databases

BgeeiENSG00000185298.
CleanExiHS_CCDC137.
ExpressionAtlasiQ6PK04. baseline and differential.
GenevisibleiQ6PK04. HS.

Organism-specific databases

HPAiHPA052637.
HPA053914.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TERF2Q155542EBI-714654,EBI-706637

Protein-protein interaction databases

BioGridi130846. 26 interactors.
IntActiQ6PK04. 8 interactors.
MINTiMINT-6408365.
STRINGi9606.ENSP00000329360.

Structurei

3D structure databases

ProteinModelPortaliQ6PK04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili155 – 197Sequence analysisAdd BLAST43
Coiled coili247 – 273Sequence analysisAdd BLAST27

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IENS. Eukaryota.
ENOG4111TSW. LUCA.
GeneTreeiENSGT00390000004169.
HOGENOMiHOG000111387.
HOVERGENiHBG090761.
InParanoidiQ6PK04.
PhylomeDBiQ6PK04.
TreeFamiTF332311.

Family and domain databases

InterProiIPR026680. CCDC137.
[Graphical view]
PANTHERiPTHR21838. PTHR21838. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6PK04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGAGRGAAV SRVQAGPGSP RRARGRQQVQ PLGKQRPAPW PGLRSKEKKK
60 70 80 90 100
VNCKPKNQDE QEIPFRLREI MRSRQEMKNP ISNKKRKKAA QVTFRKTLEK
110 120 130 140 150
EAKGEEPDIA VPKFKQRKGE SDGAYIHRMQ QEAQHVLFLS KNQAIRQPEV
160 170 180 190 200
QAAPKEKSEQ KKAKKAFQKR RLDKVRRKKE EKAADRLEQE LLRDTVKFGE
210 220 230 240 250
VVLQPPELTA RPQRSVSKDQ PGRRSQMLRM LLSPGGVSQP LTASLARQRI
260 270 280
VEEERERAVQ AYRALKQRQQ QLHGERPHLT SRKKPEPQL
Length:289
Mass (Da):33,231
Last modified:July 5, 2004 - v1
Checksum:iB8C4E6EC64360771
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050739127H → Q.Corresponds to variant rs7226091dbSNPEnsembl.1
Natural variantiVAR_050740177R → W.Corresponds to variant rs11150805dbSNPEnsembl.1
Natural variantiVAR_050741229R → Q.Corresponds to variant rs11546630dbSNPEnsembl.1
Natural variantiVAR_061582282R → W.Corresponds to variant rs11546631dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC009369 mRNA. Translation: AAH09369.1.
CCDSiCCDS42400.1.
RefSeqiNP_954981.1. NM_199287.2.
UniGeneiHs.744125.

Genome annotation databases

EnsembliENST00000329214; ENSP00000329360; ENSG00000185298.
ENST00000575223; ENSP00000458884; ENSG00000185298.
GeneIDi339230.
KEGGihsa:339230.
UCSCiuc002kbc.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC009369 mRNA. Translation: AAH09369.1.
CCDSiCCDS42400.1.
RefSeqiNP_954981.1. NM_199287.2.
UniGeneiHs.744125.

3D structure databases

ProteinModelPortaliQ6PK04.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130846. 26 interactors.
IntActiQ6PK04. 8 interactors.
MINTiMINT-6408365.
STRINGi9606.ENSP00000329360.

PTM databases

iPTMnetiQ6PK04.
PhosphoSitePlusiQ6PK04.

Polymorphism and mutation databases

BioMutaiCCDC137.
DMDMi74737969.

Proteomic databases

EPDiQ6PK04.
MaxQBiQ6PK04.
PaxDbiQ6PK04.
PeptideAtlasiQ6PK04.
PRIDEiQ6PK04.

Protocols and materials databases

DNASUi339230.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329214; ENSP00000329360; ENSG00000185298.
ENST00000575223; ENSP00000458884; ENSG00000185298.
GeneIDi339230.
KEGGihsa:339230.
UCSCiuc002kbc.5. human.

Organism-specific databases

CTDi339230.
DisGeNETi339230.
GeneCardsiCCDC137.
H-InvDBHIX0039147.
HGNCiHGNC:33451. CCDC137.
HPAiHPA052637.
HPA053914.
neXtProtiNX_Q6PK04.
OpenTargetsiENSG00000185298.
PharmGKBiPA162381422.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IENS. Eukaryota.
ENOG4111TSW. LUCA.
GeneTreeiENSGT00390000004169.
HOGENOMiHOG000111387.
HOVERGENiHBG090761.
InParanoidiQ6PK04.
PhylomeDBiQ6PK04.
TreeFamiTF332311.

Enzyme and pathway databases

BioCyciZFISH:G66-32866-MONOMER.

Miscellaneous databases

ChiTaRSiCCDC137. human.
GeneWikiiCCDC137.
GenomeRNAii339230.
PROiQ6PK04.

Gene expression databases

BgeeiENSG00000185298.
CleanExiHS_CCDC137.
ExpressionAtlasiQ6PK04. baseline and differential.
GenevisibleiQ6PK04. HS.

Family and domain databases

InterProiIPR026680. CCDC137.
[Graphical view]
PANTHERiPTHR21838. PTHR21838. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCC137_HUMAN
AccessioniPrimary (citable) accession number: Q6PK04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.