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Q6PK04

- CC137_HUMAN

UniProt

Q6PK04 - CC137_HUMAN

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Protein

Coiled-coil domain-containing protein 137

Gene

CCDC137

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 137
Gene namesi
Name:CCDC137
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:33451. CCDC137.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162381422.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Coiled-coil domain-containing protein 137PRO_0000288452Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191Phosphoserine2 Publications
Modified residuei233 – 2331Phosphoserine3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6PK04.
PaxDbiQ6PK04.
PeptideAtlasiQ6PK04.
PRIDEiQ6PK04.

PTM databases

PhosphoSiteiQ6PK04.

Expressioni

Gene expression databases

BgeeiQ6PK04.
CleanExiHS_CCDC137.
ExpressionAtlasiQ6PK04. baseline and differential.
GenevestigatoriQ6PK04.

Organism-specific databases

HPAiHPA053914.

Interactioni

Protein-protein interaction databases

BioGridi130846. 9 interactions.
IntActiQ6PK04. 3 interactions.
MINTiMINT-6408365.
STRINGi9606.ENSP00000329360.

Structurei

3D structure databases

ProteinModelPortaliQ6PK04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili155 – 19743Sequence AnalysisAdd
BLAST
Coiled coili247 – 27327Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG47711.
GeneTreeiENSGT00390000004169.
HOGENOMiHOG000111387.
HOVERGENiHBG090761.
InParanoidiQ6PK04.
OrthoDBiEOG7PGDS6.
PhylomeDBiQ6PK04.
TreeFamiTF332311.

Family and domain databases

InterProiIPR026680. CCDC137.
[Graphical view]
PANTHERiPTHR21838. PTHR21838. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6PK04-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGAGRGAAV SRVQAGPGSP RRARGRQQVQ PLGKQRPAPW PGLRSKEKKK
60 70 80 90 100
VNCKPKNQDE QEIPFRLREI MRSRQEMKNP ISNKKRKKAA QVTFRKTLEK
110 120 130 140 150
EAKGEEPDIA VPKFKQRKGE SDGAYIHRMQ QEAQHVLFLS KNQAIRQPEV
160 170 180 190 200
QAAPKEKSEQ KKAKKAFQKR RLDKVRRKKE EKAADRLEQE LLRDTVKFGE
210 220 230 240 250
VVLQPPELTA RPQRSVSKDQ PGRRSQMLRM LLSPGGVSQP LTASLARQRI
260 270 280
VEEERERAVQ AYRALKQRQQ QLHGERPHLT SRKKPEPQL
Length:289
Mass (Da):33,231
Last modified:July 5, 2004 - v1
Checksum:iB8C4E6EC64360771
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti127 – 1271H → Q.
Corresponds to variant rs7226091 [ dbSNP | Ensembl ].
VAR_050739
Natural varianti177 – 1771R → W.
Corresponds to variant rs11150805 [ dbSNP | Ensembl ].
VAR_050740
Natural varianti229 – 2291R → Q.
Corresponds to variant rs11546630 [ dbSNP | Ensembl ].
VAR_050741
Natural varianti282 – 2821R → W.
Corresponds to variant rs11546631 [ dbSNP | Ensembl ].
VAR_061582

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC009369 mRNA. Translation: AAH09369.1.
CCDSiCCDS42400.1.
RefSeqiNP_954981.1. NM_199287.2.
UniGeneiHs.744125.

Genome annotation databases

EnsembliENST00000329214; ENSP00000329360; ENSG00000185298.
ENST00000575223; ENSP00000458884; ENSG00000185298.
GeneIDi339230.
KEGGihsa:339230.
UCSCiuc002kbc.4. human.

Polymorphism databases

DMDMi74737969.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC009369 mRNA. Translation: AAH09369.1 .
CCDSi CCDS42400.1.
RefSeqi NP_954981.1. NM_199287.2.
UniGenei Hs.744125.

3D structure databases

ProteinModelPortali Q6PK04.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 130846. 9 interactions.
IntActi Q6PK04. 3 interactions.
MINTi MINT-6408365.
STRINGi 9606.ENSP00000329360.

PTM databases

PhosphoSitei Q6PK04.

Polymorphism databases

DMDMi 74737969.

Proteomic databases

MaxQBi Q6PK04.
PaxDbi Q6PK04.
PeptideAtlasi Q6PK04.
PRIDEi Q6PK04.

Protocols and materials databases

DNASUi 339230.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000329214 ; ENSP00000329360 ; ENSG00000185298 .
ENST00000575223 ; ENSP00000458884 ; ENSG00000185298 .
GeneIDi 339230.
KEGGi hsa:339230.
UCSCi uc002kbc.4. human.

Organism-specific databases

CTDi 339230.
GeneCardsi GC17P079633.
H-InvDB HIX0039147.
HGNCi HGNC:33451. CCDC137.
HPAi HPA053914.
neXtProti NX_Q6PK04.
PharmGKBi PA162381422.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47711.
GeneTreei ENSGT00390000004169.
HOGENOMi HOG000111387.
HOVERGENi HBG090761.
InParanoidi Q6PK04.
OrthoDBi EOG7PGDS6.
PhylomeDBi Q6PK04.
TreeFami TF332311.

Miscellaneous databases

GeneWikii CCDC137.
GenomeRNAii 339230.
NextBioi 97290.
PROi Q6PK04.

Gene expression databases

Bgeei Q6PK04.
CleanExi HS_CCDC137.
ExpressionAtlasi Q6PK04. baseline and differential.
Genevestigatori Q6PK04.

Family and domain databases

InterProi IPR026680. CCDC137.
[Graphical view ]
PANTHERi PTHR21838. PTHR21838. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  2. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-233, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-233, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  4. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-233, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCC137_HUMAN
AccessioniPrimary (citable) accession number: Q6PK04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3