ID   CNST_HUMAN              Reviewed;         725 AA.
AC   Q6PJW8; Q5VSY9; Q5VTM7; Q8IYA9; Q8N3L5; Q8NB09; Q8TEI2; Q96MR5;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2011, sequence version 3.
DT   24-JAN-2024, entry version 145.
DE   RecName: Full=Consortin;
GN   Name=CNST; Synonyms=C1orf71;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT SER-87.
RC   TISSUE=Spleen, and Teratocarcinoma;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT SER-87.
RC   TISSUE=Skeletal muscle;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND VARIANT
RP   SER-87.
RC   TISSUE=Brain, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   FUNCTION, TOPOLOGY, AND SUBCELLULAR LOCATION.
RX   PubMed=19864490; DOI=10.1093/hmg/ddp490;
RA   del Castillo F.J., Cohen-Salmon M., Charollais A., Caille D., Lampe P.D.,
RA   Chavrier P., Meda P., Petit C.;
RT   "Consortin, a trans-Golgi network cargo receptor for the plasma membrane
RT   targeting and recycling of connexins.";
RL   Hum. Mol. Genet. 19:262-275(2010).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA   Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT   phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- FUNCTION: Required for targeting of connexins to the plasma membrane.
CC       {ECO:0000269|PubMed:19864490}.
CC   -!- SUBUNIT: Interacts with connexins GJA1/CX43, GJB1/CX32, GJB2/CX26,
CC       GJB3/CX31, GJB6/CX30 and GJC1/CX45. Also interacts with GGA1 and GGA2.
CC       Does not interact with PANX1 (By similarity). {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q6PJW8; Q9NUX5: POT1; NbExp=2; IntAct=EBI-750390, EBI-752420;
CC       Q6PJW8; P62136: PPP1CA; NbExp=4; IntAct=EBI-750390, EBI-357253;
CC       Q6PJW8; Q9HAT0: ROPN1; NbExp=5; IntAct=EBI-750390, EBI-1378139;
CC       Q6PJW8-3; P46379-2: BAG6; NbExp=3; IntAct=EBI-25836090, EBI-10988864;
CC       Q6PJW8-3; P55212: CASP6; NbExp=3; IntAct=EBI-25836090, EBI-718729;
CC       Q6PJW8-3; O75190-2: DNAJB6; NbExp=3; IntAct=EBI-25836090, EBI-12593112;
CC       Q6PJW8-3; P28799: GRN; NbExp=3; IntAct=EBI-25836090, EBI-747754;
CC       Q6PJW8-3; P30519: HMOX2; NbExp=3; IntAct=EBI-25836090, EBI-712096;
CC       Q6PJW8-3; P04792: HSPB1; NbExp=3; IntAct=EBI-25836090, EBI-352682;
CC       Q6PJW8-3; Q9UMF0: ICAM5; NbExp=3; IntAct=EBI-25836090, EBI-6398041;
CC       Q6PJW8-3; O60333-2: KIF1B; NbExp=3; IntAct=EBI-25836090, EBI-10975473;
CC       Q6PJW8-3; O14901: KLF11; NbExp=3; IntAct=EBI-25836090, EBI-948266;
CC       Q6PJW8-3; P13473-2: LAMP2; NbExp=3; IntAct=EBI-25836090, EBI-21591415;
CC       Q6PJW8-3; P62826: RAN; NbExp=3; IntAct=EBI-25836090, EBI-286642;
CC       Q6PJW8-3; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-25836090, EBI-396669;
CC       Q6PJW8-3; P02766: TTR; NbExp=3; IntAct=EBI-25836090, EBI-711909;
CC       Q6PJW8-3; O76024: WFS1; NbExp=3; IntAct=EBI-25836090, EBI-720609;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19864490};
CC       Single-pass membrane protein {ECO:0000269|PubMed:19864490}. Golgi
CC       apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:19864490};
CC       Single-pass membrane protein {ECO:0000269|PubMed:19864490}. Cytoplasmic
CC       vesicle, secretory vesicle {ECO:0000269|PubMed:19864490}. Note=Located
CC       predominantly in the trans-Golgi network. Probably trafficks between
CC       the trans-Golgi network and the cell membrane via the secretory
CC       pathway.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q6PJW8-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6PJW8-2; Sequence=VSP_025819, VSP_025820;
CC       Name=3;
CC         IsoId=Q6PJW8-3; Sequence=VSP_025817, VSP_025818;
CC   -!- SIMILARITY: Belongs to the CNST family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB84968.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=BAC03735.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=CAD38922.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK056563; BAB71218.1; -; mRNA.
DR   EMBL; AK074142; BAB84968.1; ALT_FRAME; mRNA.
DR   EMBL; AK091739; BAC03735.1; ALT_FRAME; mRNA.
DR   EMBL; AL834246; CAD38922.2; ALT_INIT; mRNA.
DR   EMBL; AL591623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL646019; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC010228; AAH10228.1; -; mRNA.
DR   EMBL; BC036200; AAH36200.1; -; mRNA.
DR   CCDS; CCDS1628.1; -. [Q6PJW8-1]
DR   CCDS; CCDS44343.1; -. [Q6PJW8-2]
DR   RefSeq; NP_001132931.1; NM_001139459.1. [Q6PJW8-2]
DR   RefSeq; NP_689822.2; NM_152609.2. [Q6PJW8-1]
DR   RefSeq; XP_005273138.2; XM_005273081.3.
DR   RefSeq; XP_011542412.1; XM_011544110.2. [Q6PJW8-1]
DR   RefSeq; XP_011542413.1; XM_011544111.1. [Q6PJW8-1]
DR   AlphaFoldDB; Q6PJW8; -.
DR   SMR; Q6PJW8; -.
DR   BioGRID; 127882; 29.
DR   ELM; Q6PJW8; -.
DR   IntAct; Q6PJW8; 25.
DR   STRING; 9606.ENSP00000355470; -.
DR   iPTMnet; Q6PJW8; -.
DR   PhosphoSitePlus; Q6PJW8; -.
DR   SwissPalm; Q6PJW8; -.
DR   BioMuta; CNST; -.
DR   DMDM; 317373449; -.
DR   EPD; Q6PJW8; -.
DR   jPOST; Q6PJW8; -.
DR   MassIVE; Q6PJW8; -.
DR   MaxQB; Q6PJW8; -.
DR   PaxDb; 9606-ENSP00000355470; -.
DR   PeptideAtlas; Q6PJW8; -.
DR   ProteomicsDB; 67225; -. [Q6PJW8-1]
DR   ProteomicsDB; 67226; -. [Q6PJW8-2]
DR   ProteomicsDB; 67227; -. [Q6PJW8-3]
DR   Pumba; Q6PJW8; -.
DR   Antibodypedia; 2026; 25 antibodies from 11 providers.
DR   DNASU; 163882; -.
DR   Ensembl; ENST00000366512.7; ENSP00000355469.3; ENSG00000162852.14. [Q6PJW8-2]
DR   Ensembl; ENST00000366513.9; ENSP00000355470.4; ENSG00000162852.14. [Q6PJW8-1]
DR   GeneID; 163882; -.
DR   KEGG; hsa:163882; -.
DR   MANE-Select; ENST00000366513.9; ENSP00000355470.4; NM_152609.3; NP_689822.2.
DR   UCSC; uc001ibo.5; human. [Q6PJW8-1]
DR   AGR; HGNC:26486; -.
DR   CTD; 163882; -.
DR   DisGeNET; 163882; -.
DR   GeneCards; CNST; -.
DR   HGNC; HGNC:26486; CNST.
DR   HPA; ENSG00000162852; Low tissue specificity.
DR   MIM; 613439; gene.
DR   neXtProt; NX_Q6PJW8; -.
DR   OpenTargets; ENSG00000162852; -.
DR   PharmGKB; PA165751017; -.
DR   VEuPathDB; HostDB:ENSG00000162852; -.
DR   eggNOG; ENOG502QSMS; Eukaryota.
DR   GeneTree; ENSGT00390000005861; -.
DR   HOGENOM; CLU_023107_0_0_1; -.
DR   InParanoid; Q6PJW8; -.
DR   OMA; AKFCTTH; -.
DR   OrthoDB; 4250979at2759; -.
DR   PhylomeDB; Q6PJW8; -.
DR   TreeFam; TF351172; -.
DR   PathwayCommons; Q6PJW8; -.
DR   SignaLink; Q6PJW8; -.
DR   BioGRID-ORCS; 163882; 14 hits in 1153 CRISPR screens.
DR   ChiTaRS; CNST; human.
DR   GeneWiki; C1orf71; -.
DR   GenomeRNAi; 163882; -.
DR   Pharos; Q6PJW8; Tdark.
DR   PRO; PR:Q6PJW8; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q6PJW8; Protein.
DR   Bgee; ENSG00000162852; Expressed in middle temporal gyrus and 186 other cell types or tissues.
DR   ExpressionAtlas; Q6PJW8; baseline and differential.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR   GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR   GO; GO:0032991; C:protein-containing complex; IDA:LIFEdb.
DR   GO; GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
DR   GO; GO:0030133; C:transport vesicle; IDA:UniProtKB.
DR   GO; GO:0071253; F:connexin binding; ISS:UniProtKB.
DR   GO; GO:0019902; F:phosphatase binding; IDA:UniProtKB.
DR   GO; GO:0042998; P:positive regulation of Golgi to plasma membrane protein transport; IMP:UniProtKB.
DR   InterPro; IPR042318; Consortin.
DR   InterPro; IPR028129; Consortin_C.
DR   PANTHER; PTHR28581; CONSORTIN; 1.
DR   PANTHER; PTHR28581:SF1; CONSORTIN; 1.
DR   Pfam; PF15281; Consortin_C; 1.
DR   Genevisible; Q6PJW8; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cell membrane; Cytoplasmic vesicle; Golgi apparatus;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..725
FT                   /note="Consortin"
FT                   /id="PRO_0000288906"
FT   TOPO_DOM        1..664
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        665..685
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        686..725
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          1..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          103..124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          296..353
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          375..397
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          485..510
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        55..72
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        311..353
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         235..263
FT                   /note="ETKWKTVQPHTVTALRNSEKGFNGEDFER -> GKYRPTWNVELAVIQQVTI
FT                   YKINIFDLVL (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_025817"
FT   VAR_SEQ         264..725
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_025818"
FT   VAR_SEQ         614..616
FT                   /note="VPT -> NQR (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_025819"
FT   VAR_SEQ         617..725
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_025820"
FT   VARIANT         28
FT                   /note="S -> N (in dbSNP:rs35286882)"
FT                   /id="VAR_032530"
FT   VARIANT         87
FT                   /note="L -> S (in dbSNP:rs6702823)"
FT                   /evidence="ECO:0000269|PubMed:14702039,
FT                   ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17974005"
FT                   /id="VAR_032531"
FT   VARIANT         183
FT                   /note="Q -> R (in dbSNP:rs12091148)"
FT                   /id="VAR_056762"
FT   VARIANT         399
FT                   /note="R -> C (in dbSNP:rs12075111)"
FT                   /id="VAR_032532"
FT   CONFLICT        246
FT                   /note="V -> L (in Ref. 1; BAB84968)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        331
FT                   /note="E -> Q (in Ref. 2; CAD38922)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        393..394
FT                   /note="AC -> GR (in Ref. 2; CAD38922)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        689
FT                   /note="F -> L (in Ref. 1; BAC03735)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   725 AA;  79597 MW;  C32AF9E17D98C389 CRC64;
     MDDSDTPTYY LQIEPQDGCH PGDSVERSVT CLPSASDENE NQLDGDGHEH LTSSDSAMGK
     PQVSEQDSLN NNESCTLSCE VAAGENLQNT LCEASRDEQA FLGKDKKIPG KRSPRSKKGT
     AKKIPPGLFS GDIAPLMQEK VLSAVTYAVD DEEAAEVNAN EQPEAPKLVL QSLFSLIRGE
     VEQLDSRALP LCLHQIAESY FQEEDYEKAM KFIQLERLYH EQLLANLSAI QEQWETKWKT
     VQPHTVTALR NSEKGFNGED FERLTKICAT HQDPLLSKHK IAAVEKSQER KCSTQLLVSE
     DPKEGGATTK ESESKTCLGT ESSKESQHTV EPLGSSPCCH QMDVQTDSPS LSVTAGKDHM
     EELLCSAEAT LALHTQSSET AGSPSGPDSS EDACEDDSRL QLAQTEACQD VARIEGIAED
     PKVFLSSKSK TEPLISPGCD RIPPALISEG KYSQAQRKEL RLPLRDASEA LPTDQLENNE
     LNELQQPDLT DSDGKSPQAQ ADSDGSENVL CGNNQISDLG ILLPEVCMAP EEKGDKDDQL
     NKETEDYLNS LLEGCLKDTE DSLSYEDNQD DDSDLLQDLS PEEASYSLQE NLPSDESCLS
     LDDLAKRIEI AEVVPTEGLV SILKKRNDTV GDHPAQMQHK PSKRRVRFQE IDDSLDQDEV
     GGGSCILLVL LCIATVFLSV GGTALYCTFG DMESPVCTDF ADNMDFYYTK LLQGVAELKH
     WIYLS
//